Evidence Based Medicine on FHIR Implementation Guide
1.0.0-ballot2 - STU 1 ballot
Evidence Based Medicine on FHIR Implementation Guide
1.0.0-ballot2 - STU 1 ballot
Evidence Based Medicine on FHIR Implementation Guide, published by HL7 International / Clinical Decision Support. This guide is not an authorized publication; it is the continuous build for version 1.0.0-ballot2 built by the FHIR (HL7® FHIR® Standard) CI Build. This version is based on the current content of https://github.com/HL7/ebm/ and changes regularly. See the Directory of published versions
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<div xmlns="http://www.w3.org/1999/xhtml"><p class="res-header-id"><b>Generated Narrative: Citation 179616</b></p><a name="179616"> </a><a name="hc179616"> </a><a name="179616-en-US"> </a><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">version: 10; Last updated: 2025-03-27 12:33:42+0000</p><p style="margin-bottom: 0px">Profile: <a href="StructureDefinition-journal-article-citation.html">JournalArticleCitation</a></p></div><p><b>url</b>: <a href="Citation-179616.html">Citation 26244877 Chemohormonal Therapy in Metastatic Hormone-Sensitive Prostate Cancer.</a></p><p><b>identifier</b>: FEvIR Object Identifier/https://fevir.net/FOI/179616, <code>https://pubmed.ncbi.nlm.nih.gov</code>/26244877, <a href="http://terminology.hl7.org/6.2.0/NamingSystem-uri.html" title="As defined by RFC 3986 (http://www.ietf.org/rfc/rfc3986.txt)(with many schemes defined in many RFCs). For OIDs and UUIDs, use the URN form (urn:oid:(note: lowercase) and urn:uuid:). See http://www.ietf.org/rfc/rfc3001.txt and http://www.ietf.org/rfc/rfc4122.txt
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Note that this OID is created to aid with interconversion between CDA and FHIR - FHIR uses urn:ietf:rfc:3986 as equivalent to this OID. URIs as identifiers appear more commonly in FHIR.
This OID may also be used in CD.codeSystem.">Uniform Resource Identifier (URI)</a>/urn:oid:2.16.840.1.113883.4.642.40.44.15.17</p><p><b>version</b>: 1.0.0-ballot2</p><p><b>title</b>: 26244877 Chemohormonal Therapy in Metastatic Hormone-Sensitive Prostate Cancer.</p><p><b>status</b>: Active</p><p><b>date</b>: 2025-03-27 17:53:24+0000</p><p><b>publisher</b>: HL7 International / Clinical Decision Support</p><p><b>contact</b>: HL7 International / Clinical Decision Support: <a href="http://www.hl7.org/Special/committees/dss">http://www.hl7.org/Special/committees/dss</a></p><p><b>description</b>: </p><div><p>This Citation Resource is referenced in an example for the EBMonFHIR Implementation Guide.</p>
</div><h3>UseContexts</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Code</b></td><td><b>Value[x]</b></td></tr><tr><td style="display: none">*</td><td><a href="http://hl7.org/fhir/R5/codesystem-citation-classification-type.html#citation-classification-type-fevir-platform-use">Citation Classification Type fevir-platform-use</a>: FEvIR Platform Use</td><td><span title="Codes:{http://hl7.org/fhir/citation-artifact-classifier medline-base}">Medline Base</span></td></tr></table><p><b>jurisdiction</b>: <span title="Codes:{http://unstats.un.org/unsd/methods/m49/m49.htm 001}">World</span></p><p><b>copyright</b>: </p><div><p>https://creativecommons.org/licenses/by-nc-sa/4.0/</p>
</div><p><b>approvalDate</b>: 2015-08-25</p><p><b>lastReviewDate</b>: 2024-08-05</p><p><b>author</b>: Computable Publishing®: MEDLINE-to-FEvIR Converter: </p><blockquote><p><b>classification</b></p><p><b>type</b>: <span title="Codes:{http://hl7.org/fhir/citation-classification-type citation-source}">Citation Source</span></p><p><b>classifier</b>: <span title="Codes:">MEDLINE</span></p></blockquote><blockquote><p><b>classification</b></p><p><b>type</b>: <span title="Codes:{http://hl7.org/fhir/citation-classification-type medline-owner}">MEDLINE Citation Owner</span></p><p><b>classifier</b>: <span title="Codes:{https://www.nlm.nih.gov/bsd/licensee/elements_descriptions.html#owner_value NLM}">National Library of Medicine, Index Section</span></p></blockquote><p><b>currentState</b>: <span title="Codes:{http://hl7.org/fhir/citation-status-type medline-medline}">Medline Citation Status of Medline</span>, <span title="Codes:{http://hl7.org/fhir/citation-status-type pubmed-publication-status-ppublish}">PubMed PublicationStatus of ppublish</span></p><blockquote><p><b>statusDate</b></p><p><b>activity</b>: <span title="Codes:{http://hl7.org/fhir/citation-status-type pubmed-pubstatus-entrez}">PubMed Pubstatus of Entrez</span></p><p><b>period</b>: ?? --> 2015-08-06 06:00:00+0000</p></blockquote><blockquote><p><b>statusDate</b></p><p><b>activity</b>: <span title="Codes:{http://hl7.org/fhir/citation-status-type pubmed-pubstatus-pubmed}">PubMed Pubstatus of Pubmed</span></p><p><b>period</b>: ?? --> 2015-08-06 06:00:00+0000</p></blockquote><blockquote><p><b>statusDate</b></p><p><b>activity</b>: <span title="Codes:{http://hl7.org/fhir/citation-status-type pubmed-pubstatus-medline}">PubMed Pubstatus of Medline</span></p><p><b>period</b>: ?? --> 2015-08-26 06:00:00+0000</p></blockquote><blockquote><p><b>statusDate</b></p><p><b>activity</b>: <span title="Codes:{http://hl7.org/fhir/citation-status-type pubmed-pubstatus-pmc-release}">PubMed Pubstatus of PMC release</span></p><p><b>period</b>: ?? --> 2016-02-20</p></blockquote><blockquote><p><b>citedArtifact</b></p><p><b>identifier</b>: <code>https://pubmed.ncbi.nlm.nih.gov</code>/26244877, mid/NIHMS719565, <code>https://www.ncbi.nlm.nih.gov/pmc/</code>/PMC4562797, <code>https://doi.org</code>/10.1056/NEJMoa1503747</p><p><b>relatedIdentifier</b>: <code>https://clinicaltrials.gov</code>/NCT00309985</p><h3>Titles</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Type</b></td><td><b>Language</b></td><td><b>Text</b></td></tr><tr><td style="display: none">*</td><td><span title="Codes:{http://hl7.org/fhir/title-type primary}">Primary title</span></td><td><span title="Codes:{urn:ietf:bcp:47 en}">English</span></td><td><div><p>Chemohormonal Therapy in Metastatic Hormone-Sensitive Prostate Cancer.</p>
</div></td></tr></table><h3>Abstracts</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Type</b></td><td><b>Text</b></td></tr><tr><td style="display: none">*</td><td><span title="Codes:{http://hl7.org/fhir/cited-artifact-abstract-type primary-human-use}">Primary human use</span></td><td><div><p><strong>BACKGROUND:</strong> Androgen-deprivation therapy (ADT) has been the backbone of treatment for metastatic prostate cancer since the 1940s. We assessed whether concomitant treatment with ADT plus docetaxel would result in longer overall survival than that with ADT alone.
<strong>METHODS:</strong> We assigned men with metastatic, hormone-sensitive prostate cancer to receive either ADT plus docetaxel (at a dose of 75 mg per square meter of body-surface area every 3 weeks for six cycles) or ADT alone. The primary objective was to test the hypothesis that the median overall survival would be 33.3% longer among patients receiving docetaxel added to ADT early during therapy than among patients receiving ADT alone.
<strong>RESULTS:</strong> A total of 790 patients (median age, 63 years) underwent randomization. After a median follow-up of 28.9 months, the median overall survival was 13.6 months longer with ADT plus docetaxel (combination therapy) than with ADT alone (57.6 months vs. 44.0 months; hazard ratio for death in the combination group, 0.61; 95% confidence interval [CI], 0.47 to 0.80; P<0.001). The median time to biochemical, symptomatic, or radiographic progression was 20.2 months in the combination group, as compared with 11.7 months in the ADT-alone group (hazard ratio, 0.61; 95% CI, 0.51 to 0.72; P<0.001). The rate of a prostate-specific antigen level of less than 0.2 ng per milliliter at 12 months was 27.7% in the combination group versus 16.8% in the ADT-alone group (P<0.001). In the combination group, the rate of grade 3 or 4 febrile neutropenia was 6.2%, the rate of grade 3 or 4 infection with neutropenia was 2.3%, and the rate of grade 3 sensory neuropathy and of grade 3 motor neuropathy was 0.5%.
<strong>CONCLUSIONS:</strong> Six cycles of docetaxel at the beginning of ADT for metastatic prostate cancer resulted in significantly longer overall survival than that with ADT alone. (Funded by the National Cancer Institute and others; ClinicalTrials.gov number, NCT00309985.).</p>
</div></td></tr></table><blockquote><p><b>relatesTo</b></p><p><b>TargetUri</b>: <a href="https://pubmed.ncbi.nlm.nih.gov/0/">https://pubmed.ncbi.nlm.nih.gov/0/</a></p><p><b>type</b>: cites</p><p><b>classifier</b>: <span title="Codes:{http://hl7.org/fhir/citation-artifact-classifier D016428}">Journal Article</span></p><p><b>citation</b>: </p><div><p>Huggins C, Hodges CV. Studies on prostatic cancer. I. The effect of castration, of estrogen and of androgen injection on serum phosphatases in metastatic carcinoma of the prostate. Cancer Res. 1941;1:293–7.</p>
</div></blockquote><blockquote><p><b>relatesTo</b></p><p><b>TargetUri</b>: <a href="https://pubmed.ncbi.nlm.nih.gov/10801170/">https://pubmed.ncbi.nlm.nih.gov/10801170/</a></p><p><b>type</b>: cites</p><p><b>classifier</b>: <span title="Codes:{http://hl7.org/fhir/citation-artifact-classifier D016428}">Journal Article</span></p><p><b>citation</b>: </p><div><p>Prostate Cancer Trialists’ Collaborative Group. Maximum androgen blockade in advanced prostate cancer: an overview of the randomised trials. Lancet. 2000;355:1491–8.</p>
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</div></blockquote><blockquote><p><b>relatesTo</b></p><p><b>TargetUri</b>: <a href="https://pubmed.ncbi.nlm.nih.gov/23550669/">https://pubmed.ncbi.nlm.nih.gov/23550669/</a></p><p><b>type</b>: cites</p><p><b>classifier</b>: <span title="Codes:{http://hl7.org/fhir/citation-artifact-classifier D016428}">Journal Article</span></p><p><b>citation</b>: </p><div><p>Hussain M, Tangen CM, Berry DL, et al. Intermittent versus continuous androgen deprivation in prostate cancer. N Engl J Med. 2013;368:1314–25.</p>
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</div></blockquote><blockquote><p><b>relatesTo</b></p><p><b>TargetUri</b>: <a href="https://pubmed.ncbi.nlm.nih.gov/26251343/">https://pubmed.ncbi.nlm.nih.gov/26251343/</a></p><p><b>type</b>: comment-in</p><p><b>classifier</b>: <span title="Codes:{https://www.nlm.nih.gov/mesh D016420}">Comment</span></p><p><b>citation</b>: </p><div><p>BMJ. 2015 Aug 05;351:h4253. doi: 10.1136/bmj.h4253.</p>
</div></blockquote><blockquote><p><b>relatesTo</b></p><p><b>TargetUri</b>: <a href="https://pubmed.ncbi.nlm.nih.gov/26305034/">https://pubmed.ncbi.nlm.nih.gov/26305034/</a></p><p><b>type</b>: comment-in</p><p><b>classifier</b>: <span title="Codes:{https://www.nlm.nih.gov/mesh D016420}">Comment</span></p><p><b>citation</b>: </p><div><p>Nat Rev Clin Oncol. 2015 Oct;12(10):563. doi: 10.1038/nrclinonc.2015.145.</p>
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</div></blockquote><blockquote><p><b>relatesTo</b></p><p><b>TargetUri</b>: <a href="https://pubmed.ncbi.nlm.nih.gov/26789883/">https://pubmed.ncbi.nlm.nih.gov/26789883/</a></p><p><b>type</b>: comment-in</p><p><b>classifier</b>: <span title="Codes:{https://www.nlm.nih.gov/mesh D016420}">Comment</span></p><p><b>citation</b>: </p><div><p>N Engl J Med. 2016 Jan 21;374(3):287. doi: 10.1056/NEJMc1511800.</p>
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</div></blockquote><blockquote><p><b>relatesTo</b></p><p><b>TargetUri</b>: <a href="https://pubmed.ncbi.nlm.nih.gov/26972499/">https://pubmed.ncbi.nlm.nih.gov/26972499/</a></p><p><b>type</b>: comment-in</p><p><b>classifier</b>: <span title="Codes:{https://www.nlm.nih.gov/mesh D016420}">Comment</span></p><p><b>citation</b>: </p><div><p>Eur Urol. 2016 Apr;69(4):755-6. doi: 10.1016/j.eururo.2016.01.020.</p>
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</div></blockquote><blockquote><p><b>relatesTo</b></p><p><b>TargetUri</b>: <a href="https://pubmed.ncbi.nlm.nih.gov/28159490/">https://pubmed.ncbi.nlm.nih.gov/28159490/</a></p><p><b>type</b>: comment-in</p><p><b>classifier</b>: <span title="Codes:{https://www.nlm.nih.gov/mesh D016420}">Comment</span></p><p><b>citation</b>: </p><div><p>Urol Oncol. 2017 Mar;35(3):123. doi: 10.1016/j.urolonc.2016.12.021.</p>
</div></blockquote><blockquote><p><b>publicationForm</b></p><blockquote><p><b>publishedIn</b></p><p><b>type</b>: <span title="Codes:{http://hl7.org/fhir/published-in-type D020492}">Periodical</span></p><p><b>identifier</b>: Electronic ISSN Type/1533-4406, ISOAbbreviation/N Engl J Med, ISSN Linking/0028-4793, Medline Title Abbreviation/N Engl J Med, NLM Unique ID/0255562</p><p><b>title</b>: The New England journal of medicine</p><p><b>publisherLocation</b>: United States</p></blockquote><p><b>citedMedium</b>: <span title="Codes:{http://hl7.org/fhir/cited-medium internet}">Internet</span></p><p><b>volume</b>: 373</p><p><b>issue</b>: 8</p><p><b>articleDate</b>: 2015-08-20</p><p><b>publicationDateText</b>: 2015-Aug-20</p><p><b>pageString</b>: 737-46</p></blockquote><blockquote><p><b>publicationForm</b></p><p><b>citedMedium</b>: <span title="Codes:{http://hl7.org/fhir/cited-medium internet-without-issue}">Internet without issue</span></p><p><b>articleDate</b>: 2015-08-05</p></blockquote><blockquote><p><b>webLocation</b></p><p><b>classifier</b>: <span title="Codes:{http://hl7.org/fhir/artifact-url-classifier abstract}">Abstract</span></p><p><b>url</b>: <a href="https://pubmed.ncbi.nlm.nih.gov/26244877/">https://pubmed.ncbi.nlm.nih.gov/26244877/</a></p></blockquote><blockquote><p><b>webLocation</b></p><p><b>classifier</b>: <span title="Codes:{http://hl7.org/fhir/artifact-url-classifier doi-based}">DOI Based</span></p><p><b>url</b>: <a href="https://doi.org/10.1056/NEJMoa1503747">https://doi.org/10.1056/NEJMoa1503747</a></p></blockquote><blockquote><p><b>classification</b></p><p><b>type</b>: <span title="Codes:{http://hl7.org/fhir/cited-artifact-classification-type publishing-model}">Publishing Model</span></p><p><b>classifier</b>: <span title="Codes:{http://hl7.org/fhir/citation-artifact-classifier Print-Electronic}">Print Electronic</span></p></blockquote><blockquote><p><b>classification</b></p><p><b>type</b>: <span 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D016428}">Journal Article</span></p><p><b>artifactAssessment</b>: Classifier added by Computable Publishing LLC</p></blockquote><blockquote><p><b>classification</b></p><p><b>type</b>: <span title="Codes:{http://hl7.org/fhir/cited-artifact-classification-type citation-subset}">Citation subset</span></p><p><b>classifier</b>: <span title="Codes:{https://www.nlm.nih.gov/bsd/licensee/elements_descriptions.html#citationsubset IM}">IM</span></p></blockquote><blockquote><p><b>contributorship</b></p><p><b>complete</b>: true</p><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a href="#hc179616/contributor0">Sweeney CJ</a></p><p><b>forenameInitials</b>: CJ</p><p><b>affiliation</b>: From the Department of Medicine (C.J.S.) and the Department of Biostatistics and Computational Biology (Y.-H.C.), Dana-Farber Cancer Institute, Boston; Harvard Medical School, Boston (C.J.S.); Johns Hopkins University, Baltimore (M.C., M.E.); University of Wisconsin Carbone Cancer Center (G.L., D.F.J.) and School of Medicine and Public Health (D.F.J.), Madison; Fox Chase Cancer Center, Temple University Health System, Philadelphia (Y.-N.W.); Indiana University Melvin and Bren Simon Cancer Center, Indianapolis (N.H.); Mayo Clinic, Rochester, MN (M.K.); University Hospitals Case Medical Center, Seidman Cancer Center (M.M.C.), and Cleveland Clinic Taussig Cancer Institute (J.A.G.) - both in Cleveland; University of Virginia Cancer Center, Charlottesville (R.D.); Comprehensive Cancer Centers of Nevada, Las Vegas (N.J.V.); Siteman Cancer Center, Washington University School of Medicine, St. Louis (J.P.); NorthShore University HealthSystem, Evanston, IL (D.S.); University of Michigan Comprehensive Cancer Center, Ann Arbor (M.H.); and Rutgers Cancer Institute of New Jersey, New Brunswick (R.S.D.).</p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a href="#hc179616/contributor1">Chen YH</a></p><p><b>forenameInitials</b>: YH</p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a href="#hc179616/contributor2">Carducci M</a></p><p><b>forenameInitials</b>: M</p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a href="#hc179616/contributor3">Liu G</a></p><p><b>forenameInitials</b>: G</p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a href="#hc179616/contributor4">Jarrard DF</a></p><p><b>forenameInitials</b>: DF</p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a href="#hc179616/contributor5">Eisenberger M</a></p><p><b>forenameInitials</b>: M</p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a href="#hc179616/contributor6">Wong YN</a></p><p><b>forenameInitials</b>: YN</p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a href="#hc179616/contributor7">Hahn N</a></p><p><b>forenameInitials</b>: N</p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a href="#hc179616/contributor8">Kohli M</a></p><p><b>forenameInitials</b>: M</p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a href="#hc179616/contributor9">Cooney MM</a></p><p><b>forenameInitials</b>: MM</p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a href="#hc179616/contributor10">Dreicer R</a></p><p><b>forenameInitials</b>: R</p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a href="#hc179616/contributor11">Vogelzang NJ</a></p><p><b>forenameInitials</b>: NJ</p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a href="#hc179616/contributor12">Picus J</a></p><p><b>forenameInitials</b>: J</p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a href="#hc179616/contributor13">Shevrin D</a></p><p><b>forenameInitials</b>: D</p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a href="#hc179616/contributor14">Hussain M</a></p><p><b>forenameInitials</b>: M</p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a href="#hc179616/contributor15">Garcia JA</a></p><p><b>forenameInitials</b>: JA</p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a href="#hc179616/contributor16">DiPaola RS</a></p><p><b>forenameInitials</b>: RS</p></blockquote></blockquote></blockquote><hr/><blockquote><p class="res-header-id"><b>Generated Narrative: Practitioner #contributor0</b></p><a name="179616/contributor0"> </a><a name="hc179616/contributor0"> </a><a name="179616/contributor0-en-US"> </a><p><b>name</b>: Christopher J Sweeney </p></blockquote><hr/><blockquote><p class="res-header-id"><b>Generated Narrative: Practitioner #contributor1</b></p><a name="179616/contributor1"> </a><a name="hc179616/contributor1"> </a><a name="179616/contributor1-en-US"> </a><p><b>name</b>: Yu-Hui Chen </p></blockquote><hr/><blockquote><p class="res-header-id"><b>Generated Narrative: Practitioner #contributor2</b></p><a name="179616/contributor2"> </a><a name="hc179616/contributor2"> </a><a name="179616/contributor2-en-US"> </a><p><b>name</b>: Michael Carducci </p></blockquote><hr/><blockquote><p class="res-header-id"><b>Generated Narrative: Practitioner #contributor3</b></p><a name="179616/contributor3"> </a><a name="hc179616/contributor3"> </a><a name="179616/contributor3-en-US"> </a><p><b>name</b>: Glenn Liu </p></blockquote><hr/><blockquote><p class="res-header-id"><b>Generated Narrative: Practitioner #contributor4</b></p><a name="179616/contributor4"> </a><a name="hc179616/contributor4"> </a><a name="179616/contributor4-en-US"> </a><p><b>name</b>: David F Jarrard </p></blockquote><hr/><blockquote><p class="res-header-id"><b>Generated Narrative: Practitioner #contributor5</b></p><a name="179616/contributor5"> </a><a name="hc179616/contributor5"> </a><a name="179616/contributor5-en-US"> </a><p><b>name</b>: Mario Eisenberger </p></blockquote><hr/><blockquote><p class="res-header-id"><b>Generated Narrative: Practitioner #contributor6</b></p><a name="179616/contributor6"> </a><a name="hc179616/contributor6"> </a><a name="179616/contributor6-en-US"> </a><p><b>name</b>: Yu-Ning Wong </p></blockquote><hr/><blockquote><p class="res-header-id"><b>Generated Narrative: Practitioner #contributor7</b></p><a name="179616/contributor7"> </a><a name="hc179616/contributor7"> </a><a name="179616/contributor7-en-US"> </a><p><b>name</b>: Noah Hahn </p></blockquote><hr/><blockquote><p class="res-header-id"><b>Generated Narrative: Practitioner #contributor8</b></p><a name="179616/contributor8"> </a><a name="hc179616/contributor8"> </a><a name="179616/contributor8-en-US"> </a><p><b>name</b>: Manish Kohli </p></blockquote><hr/><blockquote><p class="res-header-id"><b>Generated Narrative: Practitioner #contributor9</b></p><a name="179616/contributor9"> </a><a name="hc179616/contributor9"> </a><a name="179616/contributor9-en-US"> </a><p><b>name</b>: Matthew M Cooney </p></blockquote><hr/><blockquote><p class="res-header-id"><b>Generated Narrative: Practitioner #contributor10</b></p><a name="179616/contributor10"> </a><a name="hc179616/contributor10"> </a><a name="179616/contributor10-en-US"> </a><p><b>name</b>: Robert Dreicer </p></blockquote><hr/><blockquote><p class="res-header-id"><b>Generated Narrative: Practitioner #contributor11</b></p><a name="179616/contributor11"> </a><a name="hc179616/contributor11"> </a><a name="179616/contributor11-en-US"> </a><p><b>name</b>: Nicholas J Vogelzang </p></blockquote><hr/><blockquote><p class="res-header-id"><b>Generated Narrative: Practitioner #contributor12</b></p><a name="179616/contributor12"> </a><a name="hc179616/contributor12"> </a><a name="179616/contributor12-en-US"> </a><p><b>name</b>: Joel Picus </p></blockquote><hr/><blockquote><p class="res-header-id"><b>Generated Narrative: Practitioner #contributor13</b></p><a name="179616/contributor13"> </a><a name="hc179616/contributor13"> </a><a name="179616/contributor13-en-US"> </a><p><b>name</b>: Daniel Shevrin </p></blockquote><hr/><blockquote><p class="res-header-id"><b>Generated Narrative: Practitioner #contributor14</b></p><a name="179616/contributor14"> </a><a name="hc179616/contributor14"> </a><a name="179616/contributor14-en-US"> </a><p><b>name</b>: Maha Hussain </p></blockquote><hr/><blockquote><p class="res-header-id"><b>Generated Narrative: Practitioner #contributor15</b></p><a name="179616/contributor15"> </a><a name="hc179616/contributor15"> </a><a name="179616/contributor15-en-US"> </a><p><b>name</b>: Jorge A Garcia </p></blockquote><hr/><blockquote><p class="res-header-id"><b>Generated Narrative: Practitioner #contributor16</b></p><a name="179616/contributor16"> </a><a name="hc179616/contributor16"> </a><a name="179616/contributor16-en-US"> </a><p><b>name</b>: Robert S DiPaola </p></blockquote><hr/><blockquote><p class="res-header-id"><b>Generated Narrative: ArtifactAssessment #meshHeading0</b></p><a name="179616/meshHeading0"> </a><a name="hc179616/meshHeading0"> </a><a name="179616/meshHeading0-en-US"> </a><p><b>artifact</b>: <a href="#hc179616">Citation 26244877 Chemohormonal Therapy in Metastatic Hormone-Sensitive Prostate Cancer.</a></p><blockquote><p><b>content</b></p><p><b>type</b>: <span title="Codes:{http://hl7.org/fhir/cited-artifact-classification-type mesh-heading}">components (if present) include qualifier codings</span></p><p><b>classifier</b>: <span title="Codes:{https://www.nlm.nih.gov/mesh D000328}">Adult</span></p><p><b>freeToShare</b>: true</p><h3>Components</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style="display: none">*</td><td><span title="Codes:">qualifier</span></td><td><span title="Codes:">is not a major topic</span></td></tr></table></blockquote><blockquote><p><b>content</b></p><p><b>type</b>: <span title="Codes:{http://hl7.org/fhir/cited-artifact-classification-type 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<text
value="**BACKGROUND:** Androgen-deprivation therapy (ADT) has been the backbone of treatment for metastatic prostate cancer since the 1940s. We assessed whether concomitant treatment with ADT plus docetaxel would result in longer overall survival than that with ADT alone.
**METHODS:** We assigned men with metastatic, hormone-sensitive prostate cancer to receive either ADT plus docetaxel (at a dose of 75 mg per square meter of body-surface area every 3 weeks for six cycles) or ADT alone. The primary objective was to test the hypothesis that the median overall survival would be 33.3% longer among patients receiving docetaxel added to ADT early during therapy than among patients receiving ADT alone.
**RESULTS:** A total of 790 patients (median age, 63 years) underwent randomization. After a median follow-up of 28.9 months, the median overall survival was 13.6 months longer with ADT plus docetaxel (combination therapy) than with ADT alone (57.6 months vs. 44.0 months; hazard ratio for death in the combination group, 0.61; 95% confidence interval [CI], 0.47 to 0.80; P&lt;0.001). The median time to biochemical, symptomatic, or radiographic progression was 20.2 months in the combination group, as compared with 11.7 months in the ADT-alone group (hazard ratio, 0.61; 95% CI, 0.51 to 0.72; P&lt;0.001). The rate of a prostate-specific antigen level of less than 0.2 ng per milliliter at 12 months was 27.7% in the combination group versus 16.8% in the ADT-alone group (P&lt;0.001). In the combination group, the rate of grade 3 or 4 febrile neutropenia was 6.2%, the rate of grade 3 or 4 infection with neutropenia was 2.3%, and the rate of grade 3 sensory neuropathy and of grade 3 motor neuropathy was 0.5%.
**CONCLUSIONS:** Six cycles of docetaxel at the beginning of ADT for metastatic prostate cancer resulted in significantly longer overall survival than that with ADT alone. (Funded by the National Cancer Institute and others; ClinicalTrials.gov number, NCT00309985.)."/>
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value="http://hl7.org/fhir/cited-artifact-classification-type"/>
<code value="publication-type"/>
<display value="Publication type"/>
</coding>
</type>
<classifier>
<coding>
<system value="https://www.nlm.nih.gov/mesh"/>
<code value="D016428"/>
<display value="Journal Article"/>
<userSelected value="false"/>
</coding>
</classifier>
<classifier>
<coding>
<system value="https://www.nlm.nih.gov/mesh"/>
<code value="D016448"/>
<display value="Multicenter Study"/>
<userSelected value="false"/>
</coding>
</classifier>
<classifier>
<coding>
<system value="https://www.nlm.nih.gov/mesh"/>
<code value="D016449"/>
<display value="Randomized Controlled Trial"/>
<userSelected value="false"/>
</coding>
</classifier>
<classifier>
<coding>
<system value="https://www.nlm.nih.gov/mesh"/>
<code value="D052061"/>
<display value="Research Support, N.I.H., Extramural"/>
<userSelected value="false"/>
</coding>
</classifier>
<classifier>
<coding>
<system value="https://www.nlm.nih.gov/mesh"/>
<code value="D013485"/>
<display value="Research Support, Non-U.S. Gov't"/>
<userSelected value="false"/>
</coding>
</classifier>
</classification>
<classification>
<type>
<coding>
<system
value="http://hl7.org/fhir/cited-artifact-classification-type"/>
<code value="knowledge-artifact-type"/>
<display value="Knowledge Artifact Type"/>
<userSelected value="false"/>
</coding>
</type>
<classifier>
<coding>
<system value="http://hl7.org/fhir/citation-artifact-classifier"/>
<code value="D016428"/>
<display value="Journal Article"/>
<userSelected value="false"/>
</coding>
</classifier>
<artifactAssessment>
<display value="Classifier added by Computable Publishing LLC"/>
</artifactAssessment>
</classification>
<classification>
<type>
<coding>
<system
value="http://hl7.org/fhir/cited-artifact-classification-type"/>
<code value="citation-subset"/>
<display value="Citation subset"/>
<userSelected value="false"/>
</coding>
</type>
<classifier>
<coding>
<system
value="https://www.nlm.nih.gov/bsd/licensee/elements_descriptions.html#citationsubset"/>
<code value="IM"/>
<display value="IM"/>
<userSelected value="false"/>
</coding>
</classifier>
</classification>
<contributorship>
<complete value="true"/>
<entry>
<contributor>
<reference value="#contributor0"/>
<type value="Practitioner"/>
<display value="Sweeney CJ"/>
</contributor>
<forenameInitials value="CJ"/>
<affiliation>
<display
value="From the Department of Medicine (C.J.S.) and the Department of Biostatistics and Computational Biology (Y.-H.C.), Dana-Farber Cancer Institute, Boston; Harvard Medical School, Boston (C.J.S.); Johns Hopkins University, Baltimore (M.C., M.E.); University of Wisconsin Carbone Cancer Center (G.L., D.F.J.) and School of Medicine and Public Health (D.F.J.), Madison; Fox Chase Cancer Center, Temple University Health System, Philadelphia (Y.-N.W.); Indiana University Melvin and Bren Simon Cancer Center, Indianapolis (N.H.); Mayo Clinic, Rochester, MN (M.K.); University Hospitals Case Medical Center, Seidman Cancer Center (M.M.C.), and Cleveland Clinic Taussig Cancer Institute (J.A.G.) - both in Cleveland; University of Virginia Cancer Center, Charlottesville (R.D.); Comprehensive Cancer Centers of Nevada, Las Vegas (N.J.V.); Siteman Cancer Center, Washington University School of Medicine, St. Louis (J.P.); NorthShore University HealthSystem, Evanston, IL (D.S.); University of Michigan Comprehensive Cancer Center, Ann Arbor (M.H.); and Rutgers Cancer Institute of New Jersey, New Brunswick (R.S.D.)."/>
</affiliation>
</entry>
<entry>
<contributor>
<reference value="#contributor1"/>
<type value="Practitioner"/>
<display value="Chen YH"/>
</contributor>
<forenameInitials value="YH"/>
</entry>
<entry>
<contributor>
<reference value="#contributor2"/>
<type value="Practitioner"/>
<display value="Carducci M"/>
</contributor>
<forenameInitials value="M"/>
</entry>
<entry>
<contributor>
<reference value="#contributor3"/>
<type value="Practitioner"/>
<display value="Liu G"/>
</contributor>
<forenameInitials value="G"/>
</entry>
<entry>
<contributor>
<reference value="#contributor4"/>
<type value="Practitioner"/>
<display value="Jarrard DF"/>
</contributor>
<forenameInitials value="DF"/>
</entry>
<entry>
<contributor>
<reference value="#contributor5"/>
<type value="Practitioner"/>
<display value="Eisenberger M"/>
</contributor>
<forenameInitials value="M"/>
</entry>
<entry>
<contributor>
<reference value="#contributor6"/>
<type value="Practitioner"/>
<display value="Wong YN"/>
</contributor>
<forenameInitials value="YN"/>
</entry>
<entry>
<contributor>
<reference value="#contributor7"/>
<type value="Practitioner"/>
<display value="Hahn N"/>
</contributor>
<forenameInitials value="N"/>
</entry>
<entry>
<contributor>
<reference value="#contributor8"/>
<type value="Practitioner"/>
<display value="Kohli M"/>
</contributor>
<forenameInitials value="M"/>
</entry>
<entry>
<contributor>
<reference value="#contributor9"/>
<type value="Practitioner"/>
<display value="Cooney MM"/>
</contributor>
<forenameInitials value="MM"/>
</entry>
<entry>
<contributor>
<reference value="#contributor10"/>
<type value="Practitioner"/>
<display value="Dreicer R"/>
</contributor>
<forenameInitials value="R"/>
</entry>
<entry>
<contributor>
<reference value="#contributor11"/>
<type value="Practitioner"/>
<display value="Vogelzang NJ"/>
</contributor>
<forenameInitials value="NJ"/>
</entry>
<entry>
<contributor>
<reference value="#contributor12"/>
<type value="Practitioner"/>
<display value="Picus J"/>
</contributor>
<forenameInitials value="J"/>
</entry>
<entry>
<contributor>
<reference value="#contributor13"/>
<type value="Practitioner"/>
<display value="Shevrin D"/>
</contributor>
<forenameInitials value="D"/>
</entry>
<entry>
<contributor>
<reference value="#contributor14"/>
<type value="Practitioner"/>
<display value="Hussain M"/>
</contributor>
<forenameInitials value="M"/>
</entry>
<entry>
<contributor>
<reference value="#contributor15"/>
<type value="Practitioner"/>
<display value="Garcia JA"/>
</contributor>
<forenameInitials value="JA"/>
</entry>
<entry>
<contributor>
<reference value="#contributor16"/>
<type value="Practitioner"/>
<display value="DiPaola RS"/>
</contributor>
<forenameInitials value="RS"/>
</entry>
</contributorship>
</citedArtifact>
</Citation>
IG © 2024+ HL7 International / Clinical Decision Support. Package hl7.fhir.uv.ebm#1.0.0-ballot2 based on FHIR 6.0.0-ballot2. Generated 2025-03-27
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