Evidence Based Medicine on FHIR Implementation Guide
2.0.0-ballot - ballot
Evidence Based Medicine on FHIR Implementation Guide
2.0.0-ballot - ballot
Evidence Based Medicine on FHIR Implementation Guide, published by HL7 International / Clinical Decision Support. This guide is not an authorized publication; it is the continuous build for version 2.0.0-ballot built by the FHIR (HL7® FHIR® Standard) CI Build. This version is based on the current content of https://github.com/HL7/ebm/ and changes regularly. See the Directory of published versions
| Active as of 2024-12-19 |
Generated Narrative: Citation 179559
version: 5; Last updated: 2023-12-02 22:30:09+0000
Profile: DatasetCitation
identifier: FEvIR Object Identifier/179559, Uniform Resource Identifier (URI)/urn:oid:2.16.840.1.113883.4.642.40.44.15.24
version: 2.0.0-ballot
title: DatasetCitation: Extrachromosomal DNA Amplification Contributes to Small Cell Lung Cancer Heterogeneity and is Associated with Worse Outcomes
status: Active
date: 2024-12-19 14:29:51+0000
publisher: HL7 International / Clinical Decision Support
contact: HL7 International / Clinical Decision Support: http://www.hl7.org/Special/committees/dss
description:
This Citation Resource is referenced in an example for the EBMonFHIR Implementation Guide.
jurisdiction: World
copyright:
https://creativecommons.org/licenses/by-nc-sa/4.0/
author: Brian S. Alper:
| Style | Text |
| Computable Publishing | Extrachromosomal DNA Amplification Contributes to Small Cell Lung Cancer Heterogeneity and is Associated with Worse Outcomes [Dataset]. Contributors: Anish Thomas, Lorinc S. Pongor, Rajesh Kumar, Parth Desai [Authors]. In: database of Genotypes and Phenotypes, Accession Number phs003190.v1.p1. Published October 16, 2023. Available at: https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs003190.v1.p1. |
citedArtifact
identifier: dbGaP Study Accession/phs003190.v1.p1
Titles
Type Language Text Primary title English Extrachromosomal DNA Amplification Contributes to Small Cell Lung Cancer Heterogeneity and is Associated with Worse Outcomes
Abstracts
Type Language Text Study Description English Small-cell lung cancer (SCLC) is a very aggressive neuroendocrine lung cancer often associated with oncogenic MYC amplifications, which are known to drive SCLC heterogeneity marked by neuroendocrine (NE) and non-neuroendocrine (non-NE) cell states. The genetic mechanisms of MYC amplification and phenotypic plasticity between cell states is not known. Using data from cell-lines and a few patient-derived samples along with integrated whole-genome sequencing, long-range optical mapping, single-cell DNA sequencing, and fluorescence in situ hybridization, we have attempted to successfully characterize extrachromosomal DNA (ecDNA) as the primary source of MYC amplifications and driver fusions in SCLC.
Study Design: Cross-Sectional Study Type: Observational Total number of consented subjects: 5
publicationForm
PublishedIns
Type Identifier Title Publisher PublisherLocation Database Abbreviation/dbGaP database of Genotypes and Phenotypes NLM Bethesda, MD, USA citedMedium: Internet
articleDate: 2023-10-16
accessionNumber: phs003190.v1.p1
pageCount: Total number of consented subjects: 5
copyright:
Data access provided by: dbGaP Authorized Access. For publicly available data (public ftp), Connect to the public download site. The site contains release notes and manifests. The site also contains data dictionaries, variable summaries, documents, and truncated analyses, whenever available.
webLocation
classifier: Webpage
url: https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs003190.v1.p1
webLocation
classifier: public download site
url: https://ftp.ncbi.nlm.nih.gov/dbgap/studies/phs003190/phs003190.v1.p1
classification
type: Knowledge Artifact Type
classifier: Dataset
classification
type: Study Design
classifier: Cross-Sectional, Observational Research
classification
type: Primary Phenotype
classifier: Small Cell Lung Carcinoma
contributorship
complete: true
entry
contributor: Practitioner Anish Thomas
affiliation: Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA
contributionType: Principal Investigator
role: Author/Creator
entry
contributor: Practitioner Lorinc S. Pongor
affiliation: Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA
contributionType: Co-Investigator
role: Author/Creator
entry
contributor: Practitioner Rajesh Kumar
affiliation: Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA
contributionType: Co-Investigator
role: Author/Creator
entry
contributor: Practitioner Parth Desai
affiliation: Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA
contributionType: Co-Investigator
role: Author/Creator
Generated Narrative: Practitioner #contributor0
name: Anish Thomas
Generated Narrative: Practitioner #contributor1
name: Lorinc S. Pongor
Generated Narrative: Practitioner #contributor2
name: Rajesh Kumar
Generated Narrative: Practitioner #contributor3
name: Parth Desai
IG © 2024+ HL7 International / Clinical Decision Support. Package hl7.fhir.uv.ebm#2.0.0-ballot based on FHIR 6.0.0-ballot2. Generated 2024-12-19
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