Evidence Based Medicine on FHIR Implementation Guide
2.0.0-ballot - ballot
Evidence Based Medicine on FHIR Implementation Guide
2.0.0-ballot - ballot
Evidence Based Medicine on FHIR Implementation Guide, published by HL7 International / Clinical Decision Support. This guide is not an authorized publication; it is the continuous build for version 2.0.0-ballot built by the FHIR (HL7® FHIR® Standard) CI Build. This version is based on the current content of https://github.com/HL7/ebm/ and changes regularly. See the Directory of published versions
| Active as of 2024-12-19 |
<Citation xmlns="http://hl7.org/fhir">
<id value="153881"/>
<meta>
<versionId value="1"/>
<lastUpdated value="2023-08-10T21:44:41.656Z"/>
</meta>
<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><p class="res-header-id"><b>Generated Narrative: Citation 153881</b></p><a name="153881"> </a><a name="hc153881"> </a><a name="153881-en-US"> </a><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">version: 1; Last updated: 2023-08-10 21:44:41+0000</p></div><p><b>url</b>: <a href="Citation-153881.html">Citation Delany-Moretlwe 2022 clinical trial</a></p><p><b>identifier</b>: FEvIR Object Identifier/153881, <code>https://pubmed.ncbi.nlm.nih.gov</code>/35378077, <a href="http://terminology.hl7.org/6.1.0/NamingSystem-uri.html" title="As defined by RFC 3986 (http://www.ietf.org/rfc/rfc3986.txt)(with many schemes defined in many RFCs). For OIDs and UUIDs, use the URN form (urn:oid:(note: lowercase) and urn:uuid:). See http://www.ietf.org/rfc/rfc3001.txt and http://www.ietf.org/rfc/rfc4122.txt
This oid is used as an identifier II.root to indicate the the extension is an absolute URI (technically, an IRI). Typically, this is used for OIDs and GUIDs. Note that when this OID is used with OIDs and GUIDs, the II.extension should start with urn:oid or urn:uuid:
Note that this OID is created to aid with interconversion between CDA and FHIR - FHIR uses urn:ietf:rfc:3986 as equivalent to this OID. URIs as identifiers appear more commonly in FHIR.
This OID may also be used in CD.codeSystem.">Uniform Resource Identifier (URI)</a>/urn:oid:2.16.840.1.113883.4.642.40.44.15.26</p><p><b>version</b>: 2.0.0-ballot</p><p><b>title</b>: Delany-Moretlwe 2022 clinical trial</p><p><b>status</b>: Active</p><p><b>date</b>: 2024-12-19 14:29:51+0000</p><p><b>publisher</b>: HL7 International / Clinical Decision Support</p><p><b>contact</b>: HL7 International / Clinical Decision Support: <a href="http://www.hl7.org/Special/committees/dss">http://www.hl7.org/Special/committees/dss</a></p><p><b>description</b>: </p><div><p>This Citation Resource is referenced in an example for the EBMonFHIR Implementation Guide.</p>
</div><h3>UseContexts</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Code</b></td><td><b>Value[x]</b></td></tr><tr><td style="display: none">*</td><td><a href="http://hl7.org/fhir/R5/codesystem-citation-classification-type.html#citation-classification-type-fevir-platform-use">Citation Classification Type fevir-platform-use</a>: FEvIR Platform Use</td><td><span title="Codes:{http://hl7.org/fhir/citation-artifact-classifier project-specific}">Project Specific</span></td></tr></table><p><b>jurisdiction</b>: <span title="Codes:{http://unstats.un.org/unsd/methods/m49/m49.htm 001}">World</span></p><p><b>copyright</b>: </p><div><p>https://creativecommons.org/licenses/by-nc-sa/4.0/</p>
</div><p><b>approvalDate</b>: 2022-05-10</p><p><b>lastReviewDate</b>: 2023-03-17</p><p><b>author</b>: Brian S. Alper: , Computable Publishing®: MEDLINE-to-FEvIR Converter: </p><blockquote><p><b>classification</b></p><p><b>type</b>: <span title="Codes:{http://hl7.org/fhir/citation-classification-type citation-source}">Citation Source</span></p><p><b>classifier</b>: <span title="Codes:">MEDLINE</span></p></blockquote><blockquote><p><b>classification</b></p><p><b>type</b>: <span title="Codes:{http://hl7.org/fhir/citation-classification-type medline-owner}">MEDLINE Citation Owner</span></p><p><b>classifier</b>: <span title="Codes:{https://www.nlm.nih.gov/bsd/licensee/elements_descriptions.html#owner_value NLM}">National Library of Medicine, Index Section</span></p></blockquote><p><b>currentState</b>: <span title="Codes:{http://hl7.org/fhir/citation-status-type medline-medline}">Medline Citation Status of Medline</span>, <span title="Codes:{http://hl7.org/fhir/citation-status-type pubmed-publication-status-ppublish}">PubMed PublicationStatus of ppublish</span></p><blockquote><p><b>statusDate</b></p><p><b>activity</b>: <span title="Codes:{http://hl7.org/fhir/citation-status-type pubmed-pubstatus-received}">PubMed Pubstatus of Received</span></p><p><b>period</b>: ?? --> 2022-02-27</p></blockquote><blockquote><p><b>statusDate</b></p><p><b>activity</b>: <span title="Codes:{http://hl7.org/fhir/citation-status-type pubmed-pubstatus-revised}">PubMed Pubstatus of Revised</span></p><p><b>period</b>: ?? --> 2022-03-12</p></blockquote><blockquote><p><b>statusDate</b></p><p><b>activity</b>: <span title="Codes:{http://hl7.org/fhir/citation-status-type pubmed-pubstatus-accepted}">PubMed Pubstatus of Accepted</span></p><p><b>period</b>: ?? --> 2022-03-14</p></blockquote><blockquote><p><b>statusDate</b></p><p><b>activity</b>: <span title="Codes:{http://hl7.org/fhir/citation-status-type pubmed-pubstatus-pubmed}">PubMed Pubstatus of Pubmed</span></p><p><b>period</b>: ?? --> 2022-04-05 06:00:00+0000</p></blockquote><blockquote><p><b>statusDate</b></p><p><b>activity</b>: <span title="Codes:{http://hl7.org/fhir/citation-status-type pubmed-pubstatus-medline}">PubMed Pubstatus of Medline</span></p><p><b>period</b>: ?? --> 2022-05-11 06:00:00+0000</p></blockquote><blockquote><p><b>statusDate</b></p><p><b>activity</b>: <span title="Codes:{http://hl7.org/fhir/citation-status-type pubmed-pubstatus-entrez}">PubMed Pubstatus of Entrez</span></p><p><b>period</b>: ?? --> 2022-04-04 20:10:00+0000</p></blockquote><blockquote><p><b>citedArtifact</b></p><p><b>identifier</b>: <code>https://pubmed.ncbi.nlm.nih.gov</code>/35378077, <code>https://www.ncbi.nlm.nih.gov/pmc/</code>/PMC9077443, <code>https://doi.org</code>/10.1016/S0140-6736(22)00538-4, pii/S0140-6736(22)00538-4</p><p><b>relatedIdentifier</b>: <code>https://clinicaltrials.gov</code>/NCT03164564</p><h3>Titles</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Type</b></td><td><b>Language</b></td><td><b>Text</b></td></tr><tr><td style="display: none">*</td><td><span title="Codes:{http://hl7.org/fhir/title-type primary}">Primary title</span></td><td><span title="Codes:{urn:ietf:bcp:47 en}">English</span></td><td><div><p>Cabotegravir for the prevention of HIV-1 in women: results from HPTN 084, a phase 3, randomised clinical trial.</p>
</div></td></tr></table><h3>Abstracts</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Text</b></td><td><b>Copyright</b></td></tr><tr><td style="display: none">*</td><td><div><p><strong>BACKGROUND:</strong> Oral pre-exposure prophylaxis has been introduced in more than 70 countries, including many in sub-Saharan Africa, but women experience considerable barriers to daily pill-taking, such as stigma, judgement, and the fear of violence. Safe and effective long-acting agents for HIV prevention are needed for women. We aimed to evaluate the safety and efficacy of injectable cabotegravir compared with daily oral tenofovir diphosphate plus emtricitabine (TDF-FTC) for HIV prevention in HIV-uninfected women.
<strong>METHODS:</strong> HPTN 084 was a phase 3, randomised, double-blind, double-dummy, active-controlled, superiority trial in 20 clinical research sites in seven countries in sub-Saharan Africa. Participants were eligible for enrolment if they were assigned female sex at birth, were aged 18-45 years, reported at least two episodes of vaginal intercourse in the previous 30 days, were at risk of HIV infection based on an HIV risk score, and agreed to use a long-acting reversible contraceptive method. Participants were randomly assigned (1:1) to either active cabotegravir with TDF-FTC placebo (cabotegravir group) or active TDF-FTC with cabotegravir placebo (TDF-FTC group). Study staff and participants were masked to study group allocation, with the exception of the site pharmacist who was responsible for study product preparation. Participants were prescribed 5 weeks of daily oral product followed by intramuscular injections every 8 weeks after an initial 4-week interval load, alongside daily oral pills. Participants who discontinued injections were offered open-label daily TDF-FTC for 48 weeks. The primary endpoints of the study were incident HIV infection in the intention-to-treat population, and clinical and laboratory events that were grade 2 or higher in all women who had received at least one dose of study product. This study is registered with ClinicalTrials.gov, NCT03164564.
<strong>FINDINGS:</strong> From Nov 27, 2017, to Nov 4, 2020, we enrolled 3224 participants (1614 in the cabotegravir group and 1610 in the TDF-FTC group). Median age was 25 years (IQR 22-30); 1755 (54·7%) of 3209 had two or more partners in the preceding month. 40 incident infections were observed over 3898 person-years (HIV incidence 1·0% [95% CI 0·73-1·40]); four in the cabotegravir group (HIV incidence 0·2 cases per 100 person-years [0·06-0·52]) and 36 in the TDF-FTC group (1·85 cases per 100 person-years [1·3-2·57]; hazard ratio 0·12 [0·05-0·31]; p<0·0001; risk difference -1·6% [-1·0% to -2·3%]. In a random subset of 405 TDF-FTC participants, 812 (42·1%) of 1929 plasma samples had tenofovir concentrations consistent with daily use. Injection coverage was 93% of the total number of person-years. Adverse event rates were similar across both groups, apart from injection site reactions, which were more frequent in the cabotegravir group than in the TDF-FTC group (577 [38·0%] of 1519 vs 162 [10·7%] of 1516]) but did not result in injection discontinuation. Confirmed pregnancy incidence was 1·3 per 100 person-years (0·9-1·7); no congenital birth anomalies were reported.
<strong>INTERPRETATION:</strong> Although both products for HIV prevention were generally safe, well tolerated, and effective, cabotegravir was superior to TDF-FTC in preventing HIV infection in women.
<strong>FUNDING:</strong> National Institute of Allergy and Infectious Diseases, ViiV Healthcare, and the Bill & Melinda Gates Foundation. Additional support was provided through the National Institute of Mental Health, the National Institute on Drug Abuse, and the Eunice Kennedy Shriver National Institute of Child Health and Human Development. ViiV Healthcare and Gilead Sciences provided pharmaceutical support.</p>
</div></td><td><div><p>Copyright © 2022 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license. Published by Elsevier Ltd.. All rights reserved.</p>
</div></td></tr></table><blockquote><p><b>relatesTo</b></p><p><b>type</b>: cites</p><p><b>citation</b>: </p><div><p>UNAIDS Confronting inequalities: lessons for pandemic responses from 40 years of AIDS. July 14, 2021. https://www.unaids.org/en/resources/documents/2021/2021-global-aids-update-slideset</p>
</div></blockquote><blockquote><p><b>relatesTo</b></p><p><b>type</b>: cites</p><p><b>citation</b>: </p><div><p>WHO . World Health Organization; Geneva: 2015. Policy brief: pre-exposure prophylaxis (PrEP): WHO expands recommendation on oral pre-exposure prophylaxis of HIV infection (PrEP)</p>
</div></blockquote><blockquote><p><b>relatesTo</b></p><p><b>type</b>: cites</p><p><b>classifier</b>: <span title="Codes:{http://hl7.org/fhir/citation-artifact-classifier D016428}">Journal Article</span></p><p><b>citation</b>: </p><div><p>Celum CL, Delany-Moretlwe S, Baeten JM, et al. HIV pre-exposure prophylaxis for adolescent girls and young women in Africa: from efficacy trials to delivery. J Int AIDS Soc. 2019;22(suppl 4)</p>
</div><h3>Documents</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Url</b></td></tr><tr><td style="display: none">*</td><td><a href="https://pubmed.ncbi.nlm.nih.gov/31328444/">https://pubmed.ncbi.nlm.nih.gov/31328444/</a></td></tr></table><p><b>resourceReference</b>: Identifier: <code>https://pubmed.ncbi.nlm.nih.gov</code>/31328444</p></blockquote><blockquote><p><b>relatesTo</b></p><p><b>type</b>: cites</p><p><b>classifier</b>: <span title="Codes:{http://hl7.org/fhir/citation-artifact-classifier D016428}">Journal Article</span></p><p><b>citation</b>: </p><div><p>Velloza J, Khoza N, Scorgie F, et al. The influence of HIV-related stigma on PrEP disclosure and adherence among adolescent girls and young women in HPTN 082: a qualitative study. J Int AIDS Soc. 2020;23</p>
</div><h3>Documents</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Url</b></td></tr><tr><td style="display: none">*</td><td><a href="https://pubmed.ncbi.nlm.nih.gov/32144874/">https://pubmed.ncbi.nlm.nih.gov/32144874/</a></td></tr></table><p><b>resourceReference</b>: Identifier: <code>https://pubmed.ncbi.nlm.nih.gov</code>/32144874</p></blockquote><blockquote><p><b>relatesTo</b></p><p><b>type</b>: cites</p><p><b>classifier</b>: <span title="Codes:{http://hl7.org/fhir/citation-artifact-classifier D016428}">Journal Article</span></p><p><b>citation</b>: </p><div><p>Cottrell ML, Yang KH, Prince HM, et al. A translational pharmacology approach to predicting outcomes of preexposure prophylaxis against HIV in men and women using tenofovir disoproxil fumarate with or without emtricitabine. J Infect Dis. 2016;214:55–64.</p>
</div><h3>Documents</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Url</b></td></tr><tr><td style="display: none">*</td><td><a href="https://pubmed.ncbi.nlm.nih.gov/26917574/">https://pubmed.ncbi.nlm.nih.gov/26917574/</a></td></tr></table><p><b>resourceReference</b>: Identifier: <code>https://pubmed.ncbi.nlm.nih.gov</code>/26917574</p></blockquote><blockquote><p><b>relatesTo</b></p><p><b>type</b>: cites</p><p><b>classifier</b>: <span title="Codes:{http://hl7.org/fhir/citation-artifact-classifier D016428}">Journal Article</span></p><p><b>citation</b>: </p><div><p>Andrews CD, Yueh YL, Spreen WR, et al. A long-acting integrase inhibitor protects female macaques from repeated high-dose intravaginal SHIV challenge. Sci Transl Med. 2015;7</p>
</div><h3>Documents</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Url</b></td></tr><tr><td style="display: none">*</td><td><a href="https://pubmed.ncbi.nlm.nih.gov/25589630/">https://pubmed.ncbi.nlm.nih.gov/25589630/</a></td></tr></table><p><b>resourceReference</b>: Identifier: <code>https://pubmed.ncbi.nlm.nih.gov</code>/25589630</p></blockquote><blockquote><p><b>relatesTo</b></p><p><b>type</b>: cites</p><p><b>classifier</b>: <span title="Codes:{http://hl7.org/fhir/citation-artifact-classifier D016428}">Journal Article</span></p><p><b>citation</b>: </p><div><p>Radzio J, Spreen W, Yueh YL, et al. The long-acting integrase inhibitor GSK744 protects macaques from repeated intravaginal SHIV challenge. Sci Transl Med. 2015;7</p>
</div><h3>Documents</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Url</b></td></tr><tr><td style="display: none">*</td><td><a href="https://pubmed.ncbi.nlm.nih.gov/25589631/">https://pubmed.ncbi.nlm.nih.gov/25589631/</a></td></tr></table><p><b>resourceReference</b>: Identifier: <code>https://pubmed.ncbi.nlm.nih.gov</code>/25589631</p></blockquote><blockquote><p><b>relatesTo</b></p><p><b>type</b>: cites</p><p><b>classifier</b>: <span title="Codes:{http://hl7.org/fhir/citation-artifact-classifier D016428}">Journal Article</span></p><p><b>citation</b>: </p><div><p>Markowitz M, Frank I, Grant RM, et al. Safety and tolerability of long-acting cabotegravir injections in HIV-uninfected men (ECLAIR): a multicentre, double-blind, randomised, placebo-controlled, phase 2a trial. Lancet HIV. 2017;4:e331–e340.</p>
</div><h3>Documents</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Url</b></td></tr><tr><td style="display: none">*</td><td><a href="https://pubmed.ncbi.nlm.nih.gov/28546090/">https://pubmed.ncbi.nlm.nih.gov/28546090/</a></td></tr></table><p><b>resourceReference</b>: Identifier: <code>https://pubmed.ncbi.nlm.nih.gov</code>/28546090</p></blockquote><blockquote><p><b>relatesTo</b></p><p><b>type</b>: cites</p><p><b>classifier</b>: <span title="Codes:{http://hl7.org/fhir/citation-artifact-classifier D016428}">Journal Article</span></p><p><b>citation</b>: </p><div><p>Landovitz RJ, Li S, Grinsztejn B, et al. Safety, tolerability, and pharmacokinetics of long-acting injectable cabotegravir in low-risk HIV-uninfected individuals: HPTN 077, a phase 2a randomized controlled trial. PLoS Med. 2018;15</p>
</div><h3>Documents</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Url</b></td></tr><tr><td style="display: none">*</td><td><a href="https://pubmed.ncbi.nlm.nih.gov/30408115/">https://pubmed.ncbi.nlm.nih.gov/30408115/</a></td></tr></table><p><b>resourceReference</b>: Identifier: <code>https://pubmed.ncbi.nlm.nih.gov</code>/30408115</p></blockquote><blockquote><p><b>relatesTo</b></p><p><b>type</b>: cites</p><p><b>classifier</b>: <span title="Codes:{http://hl7.org/fhir/citation-artifact-classifier D016428}">Journal Article</span></p><p><b>citation</b>: </p><div><p>Landovitz RJ, Donnell D, Clement ME, et al. Cabotegravir for HIV prevention in cisgender men and transgender women. N Engl J Med. 2021;385:595–608.</p>
</div><h3>Documents</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Url</b></td></tr><tr><td style="display: none">*</td><td><a href="https://pubmed.ncbi.nlm.nih.gov/34379922/">https://pubmed.ncbi.nlm.nih.gov/34379922/</a></td></tr></table><p><b>resourceReference</b>: Identifier: <code>https://pubmed.ncbi.nlm.nih.gov</code>/34379922</p></blockquote><blockquote><p><b>relatesTo</b></p><p><b>type</b>: cites</p><p><b>classifier</b>: <span title="Codes:{http://hl7.org/fhir/citation-artifact-classifier D016428}">Journal Article</span></p><p><b>citation</b>: </p><div><p>Balkus JE, Brown E, Palanee T, et al. An empiric HIV risk scoring tool to predict HIV-1 acquisition in African women. J Acquir Immune Defic Syndr. 2016;72:333–343.</p>
</div><h3>Documents</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Url</b></td></tr><tr><td style="display: none">*</td><td><a href="https://pubmed.ncbi.nlm.nih.gov/26918545/">https://pubmed.ncbi.nlm.nih.gov/26918545/</a></td></tr></table><p><b>resourceReference</b>: Identifier: <code>https://pubmed.ncbi.nlm.nih.gov</code>/26918545</p></blockquote><blockquote><p><b>relatesTo</b></p><p><b>type</b>: cites</p><p><b>classifier</b>: <span title="Codes:{http://hl7.org/fhir/citation-artifact-classifier D016428}">Journal Article</span></p><p><b>citation</b>: </p><div><p>Eshleman SH, Fogel JM, Piwowar-Manning E, et al. Characterization of HIV infections in women who received injectable cabotegravir or tenofovir disoproxil fumarate/emtricitabine for HIV prevention: HPTN 084. J Infect Dis (in press).</p>
</div><h3>Documents</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Url</b></td></tr><tr><td style="display: none">*</td><td><a href="https://pubmed.ncbi.nlm.nih.gov/35301540/">https://pubmed.ncbi.nlm.nih.gov/35301540/</a></td></tr></table><p><b>resourceReference</b>: Identifier: <code>https://pubmed.ncbi.nlm.nih.gov</code>/35301540</p></blockquote><blockquote><p><b>relatesTo</b></p><p><b>type</b>: cites</p><p><b>classifier</b>: <span title="Codes:{http://hl7.org/fhir/citation-artifact-classifier D016428}">Journal Article</span></p><p><b>citation</b>: </p><div><p>Castillo-Mancilla JR, Zheng JH, Rower JE, et al. Tenofovir, emtricitabine, and tenofovir diphosphate in dried blood spots for determining recent and cumulative drug exposure. AIDS Res Hum Retroviruses. 2013;29:384–390.</p>
</div><h3>Documents</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Url</b></td></tr><tr><td style="display: none">*</td><td><a href="https://pubmed.ncbi.nlm.nih.gov/22935078/">https://pubmed.ncbi.nlm.nih.gov/22935078/</a></td></tr></table><p><b>resourceReference</b>: Identifier: <code>https://pubmed.ncbi.nlm.nih.gov</code>/22935078</p></blockquote><blockquote><p><b>relatesTo</b></p><p><b>type</b>: cites</p><p><b>classifier</b>: <span title="Codes:{http://hl7.org/fhir/citation-artifact-classifier D016428}">Journal Article</span></p><p><b>citation</b>: </p><div><p>Anderson PL, Liu AY, Castillo-Mancilla JR, et al. Intracellular tenofovir-diphosphate and emtricitabine-triphosphate in dried blood spots following directly observed therapy. Antimicrob Agents Chemother. 2017;62:e01710–e01717.</p>
</div><h3>Documents</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Url</b></td></tr><tr><td style="display: none">*</td><td><a href="https://pubmed.ncbi.nlm.nih.gov/29038282/">https://pubmed.ncbi.nlm.nih.gov/29038282/</a></td></tr></table><p><b>resourceReference</b>: Identifier: <code>https://pubmed.ncbi.nlm.nih.gov</code>/29038282</p></blockquote><blockquote><p><b>relatesTo</b></p><p><b>type</b>: cites</p><p><b>classifier</b>: <span title="Codes:{http://hl7.org/fhir/citation-artifact-classifier D016428}">Journal Article</span></p><p><b>citation</b>: </p><div><p>Hendrix CW, Andrade A, Bumpus NN, et al. Dose frequency ranging pharmacokinetic study of tenofovir-emtricitabine after directly observed dosing in healthy volunteers to establish adherence benchmarks (HPTN 066) AIDS Res Hum Retroviruses. 2016;32:32–43.</p>
</div><h3>Documents</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Url</b></td></tr><tr><td style="display: none">*</td><td><a href="https://pubmed.ncbi.nlm.nih.gov/26414912/">https://pubmed.ncbi.nlm.nih.gov/26414912/</a></td></tr></table><p><b>resourceReference</b>: Identifier: <code>https://pubmed.ncbi.nlm.nih.gov</code>/26414912</p></blockquote><blockquote><p><b>relatesTo</b></p><p><b>type</b>: cites</p><p><b>classifier</b>: <span title="Codes:{http://hl7.org/fhir/citation-artifact-classifier D016428}">Journal Article</span></p><p><b>citation</b>: </p><div><p>Donnell D, Baeten JM, Bumpus NN, et al. HIV protective efficacy and correlates of tenofovir blood concentrations in a clinical trial of PrEP for HIV prevention. J Acquir Immune Defic Syndr. 2014;66:340–348.</p>
</div><h3>Documents</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Url</b></td></tr><tr><td style="display: none">*</td><td><a href="https://pubmed.ncbi.nlm.nih.gov/24784763/">https://pubmed.ncbi.nlm.nih.gov/24784763/</a></td></tr></table><p><b>resourceReference</b>: Identifier: <code>https://pubmed.ncbi.nlm.nih.gov</code>/24784763</p></blockquote><blockquote><p><b>relatesTo</b></p><p><b>type</b>: cites</p><p><b>classifier</b>: <span title="Codes:{http://hl7.org/fhir/citation-artifact-classifier D016428}">Journal Article</span></p><p><b>citation</b>: </p><div><p>Marzinke MA, Grinsztejn B, Fogel JM, et al. Characterization of human immunodeficiency virus (HIV) infection in cisgender men and transgender women who have sex with men receiving injectable cabotegravir for HIV prevention: HPTN 083. J Infect Dis. 2021;224:1581–1592.</p>
</div><h3>Documents</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Url</b></td></tr><tr><td style="display: none">*</td><td><a href="https://pubmed.ncbi.nlm.nih.gov/33740057/">https://pubmed.ncbi.nlm.nih.gov/33740057/</a></td></tr></table><p><b>resourceReference</b>: Identifier: <code>https://pubmed.ncbi.nlm.nih.gov</code>/33740057</p></blockquote><blockquote><p><b>relatesTo</b></p><p><b>type</b>: cites</p><p><b>citation</b>: </p><div><p>US Department of Health and Human Services Division of AIDS (DAIDS) table for grading the severity of adult and pediatric adverse events, corrected version 2.1. July, 2017. https://rsc.niaid.nih.gov/sites/default/files/daidsgradingcorrectedv21.pdf</p>
</div></blockquote><blockquote><p><b>relatesTo</b></p><p><b>type</b>: cites</p><p><b>citation</b>: </p><div><p>Emerson SS, Fleming TR. Parameter estimation following group sequential hypothesis testing. Biometrika. 1990;77:875–892.</p>
</div></blockquote><blockquote><p><b>relatesTo</b></p><p><b>type</b>: cites</p><p><b>classifier</b>: <span title="Codes:{http://hl7.org/fhir/citation-artifact-classifier D016428}">Journal Article</span></p><p><b>citation</b>: </p><div><p>Corey L, Gilbert PB, Juraska M, et al. Two randomized trials of neutralizing antibodies to prevent HIV-1 acquisition. N Engl J Med. 2021;384:1003–1014.</p>
</div><h3>Documents</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Url</b></td></tr><tr><td style="display: none">*</td><td><a href="https://pubmed.ncbi.nlm.nih.gov/33730454/">https://pubmed.ncbi.nlm.nih.gov/33730454/</a></td></tr></table><p><b>resourceReference</b>: Identifier: <code>https://pubmed.ncbi.nlm.nih.gov</code>/33730454</p></blockquote><blockquote><p><b>relatesTo</b></p><p><b>type</b>: cites</p><p><b>classifier</b>: <span title="Codes:{http://hl7.org/fhir/citation-artifact-classifier D016428}">Journal Article</span></p><p><b>citation</b>: </p><div><p>Gray GE, Bekker LG, Laher F, et al. Vaccine efficacy of ALVAC-HIV and bivalent subtype C gp120-MF59 in adults. N Engl J Med. 2021;384:1089–1100.</p>
</div><h3>Documents</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Url</b></td></tr><tr><td style="display: none">*</td><td><a href="https://pubmed.ncbi.nlm.nih.gov/33761206/">https://pubmed.ncbi.nlm.nih.gov/33761206/</a></td></tr></table><p><b>resourceReference</b>: Identifier: <code>https://pubmed.ncbi.nlm.nih.gov</code>/33761206</p></blockquote><blockquote><p><b>relatesTo</b></p><p><b>type</b>: cites</p><p><b>citation</b>: </p><div><p>Palanee-Phillips T, Baeten J, Heller K, et al. HIV incidence remains high in women in South Africa: data from the ECHO trial. 10th International AIDS Society Conference on HIV Science; July 21–24, 2019 (abstr LBPEC23).</p>
</div></blockquote><blockquote><p><b>relatesTo</b></p><p><b>type</b>: cites</p><p><b>classifier</b>: <span title="Codes:{http://hl7.org/fhir/citation-artifact-classifier D016428}">Journal Article</span></p><p><b>citation</b>: </p><div><p>Pillay D, Stankevitz K, Lanham M, et al. Factors influencing uptake, continuation, and discontinuation of oral PrEP among clients at sex worker and MSM facilities in South Africa. PLoS One. 2020;15</p>
</div><h3>Documents</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Url</b></td></tr><tr><td style="display: none">*</td><td><a href="https://pubmed.ncbi.nlm.nih.gov/32352969/">https://pubmed.ncbi.nlm.nih.gov/32352969/</a></td></tr></table><p><b>resourceReference</b>: Identifier: <code>https://pubmed.ncbi.nlm.nih.gov</code>/32352969</p></blockquote><blockquote><p><b>relatesTo</b></p><p><b>type</b>: cites</p><p><b>classifier</b>: <span title="Codes:{http://hl7.org/fhir/citation-artifact-classifier D016428}">Journal Article</span></p><p><b>citation</b>: </p><div><p>Bärnighausen K, Geldsetzer P, Matse S, et al. Qualitative accounts of PrEP discontinuation from the general population in Eswatini. Cult Health Sex. 2021;23:1198–1214.</p>
</div><h3>Documents</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Url</b></td></tr><tr><td style="display: none">*</td><td><a href="https://pubmed.ncbi.nlm.nih.gov/32633617/">https://pubmed.ncbi.nlm.nih.gov/32633617/</a></td></tr></table><p><b>resourceReference</b>: Identifier: <code>https://pubmed.ncbi.nlm.nih.gov</code>/32633617</p></blockquote><blockquote><p><b>relatesTo</b></p><p><b>type</b>: cites</p><p><b>classifier</b>: <span title="Codes:{http://hl7.org/fhir/citation-artifact-classifier D016428}">Journal Article</span></p><p><b>citation</b>: </p><div><p>Quaife M, Eakle R, Cabrera Escobar MA, et al. Divergent preferences for HIV prevention: a discrete choice experiment for multipurpose HIV prevention products in South Africa. Med Decis Making. 2018;38:120–133.</p>
</div><h3>Documents</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Url</b></td></tr><tr><td style="display: none">*</td><td><a href="https://pubmed.ncbi.nlm.nih.gov/28863752/">https://pubmed.ncbi.nlm.nih.gov/28863752/</a></td></tr></table><p><b>resourceReference</b>: Identifier: <code>https://pubmed.ncbi.nlm.nih.gov</code>/28863752</p></blockquote><blockquote><p><b>relatesTo</b></p><p><b>type</b>: cites</p><p><b>classifier</b>: <span title="Codes:{http://hl7.org/fhir/citation-artifact-classifier D016428}">Journal Article</span></p><p><b>citation</b>: </p><div><p>Minnis AM, Browne EN, Boeri M, et al. Young women's stated preferences for biomedical HIV prevention: results of a discrete choice experiment in Kenya and South Africa. J Acquir Immune Defic Syndr. 2019;80:394–403.</p>
</div><h3>Documents</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Url</b></td></tr><tr><td style="display: none">*</td><td><a href="https://pubmed.ncbi.nlm.nih.gov/30633040/">https://pubmed.ncbi.nlm.nih.gov/30633040/</a></td></tr></table><p><b>resourceReference</b>: Identifier: <code>https://pubmed.ncbi.nlm.nih.gov</code>/30633040</p></blockquote><blockquote><p><b>relatesTo</b></p><p><b>type</b>: cites</p><p><b>classifier</b>: <span title="Codes:{http://hl7.org/fhir/citation-artifact-classifier D016428}">Journal Article</span></p><p><b>citation</b>: </p><div><p>Laher F, Salami T, Hornschuh S, et al. Willingness to use HIV prevention methods among vaccine efficacy trial participants in Soweto, South Africa: discretion is important. BMC Public Health. 2020;20</p>
</div><h3>Documents</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Url</b></td></tr><tr><td style="display: none">*</td><td><a href="https://pubmed.ncbi.nlm.nih.gov/33160341/">https://pubmed.ncbi.nlm.nih.gov/33160341/</a></td></tr></table><p><b>resourceReference</b>: Identifier: <code>https://pubmed.ncbi.nlm.nih.gov</code>/33160341</p></blockquote><blockquote><p><b>relatesTo</b></p><p><b>type</b>: cites</p><p><b>classifier</b>: <span title="Codes:{http://hl7.org/fhir/citation-artifact-classifier D016428}">Journal Article</span></p><p><b>citation</b>: </p><div><p>Marrazzo JM, Ramjee G, Richardson BA, et al. Tenofovir-based preexposure prophylaxis for HIV infection among African women. N Engl J Med. 2015;372:509–518.</p>
</div><h3>Documents</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Url</b></td></tr><tr><td style="display: none">*</td><td><a href="https://pubmed.ncbi.nlm.nih.gov/25651245/">https://pubmed.ncbi.nlm.nih.gov/25651245/</a></td></tr></table><p><b>resourceReference</b>: Identifier: <code>https://pubmed.ncbi.nlm.nih.gov</code>/25651245</p></blockquote><blockquote><p><b>relatesTo</b></p><p><b>type</b>: cites</p><p><b>classifier</b>: <span title="Codes:{http://hl7.org/fhir/citation-artifact-classifier D016428}">Journal Article</span></p><p><b>citation</b>: </p><div><p>Baeten JM, Brown ER, Hillier SL. Dapivirine vaginal ring for HIV-1 prevention. N Engl J Med. 2017;376:995–996.</p>
</div><h3>Documents</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Url</b></td></tr><tr><td style="display: none">*</td><td><a href="https://pubmed.ncbi.nlm.nih.gov/28273023/">https://pubmed.ncbi.nlm.nih.gov/28273023/</a></td></tr></table><p><b>resourceReference</b>: Identifier: <code>https://pubmed.ncbi.nlm.nih.gov</code>/28273023</p></blockquote><blockquote><p><b>relatesTo</b></p><p><b>type</b>: cites</p><p><b>classifier</b>: <span title="Codes:{http://hl7.org/fhir/citation-artifact-classifier D016428}">Journal Article</span></p><p><b>citation</b>: </p><div><p>Venter WDF, Moorhouse M, Sokhela S, et al. Dolutegravir plus two different prodrugs of tenofovir to treat HIV. N Engl J Med. 2019;381:803–815.</p>
</div><h3>Documents</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Url</b></td></tr><tr><td style="display: none">*</td><td><a href="https://pubmed.ncbi.nlm.nih.gov/31339677/">https://pubmed.ncbi.nlm.nih.gov/31339677/</a></td></tr></table><p><b>resourceReference</b>: Identifier: <code>https://pubmed.ncbi.nlm.nih.gov</code>/31339677</p></blockquote><blockquote><p><b>relatesTo</b></p><p><b>type</b>: cites</p><p><b>classifier</b>: <span title="Codes:{http://hl7.org/fhir/citation-artifact-classifier D016428}">Journal Article</span></p><p><b>citation</b>: </p><div><p>Landovitz RJ, Zangeneh SZ, Chau G, et al. Cabotegravir is not associated with weight gain in human immunodeficiency virus-uninfected individuals in HPTN 077. Clin Infect Dis. 2020;70:319–322.</p>
</div><h3>Documents</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Url</b></td></tr><tr><td style="display: none">*</td><td><a href="https://pubmed.ncbi.nlm.nih.gov/31125395/">https://pubmed.ncbi.nlm.nih.gov/31125395/</a></td></tr></table><p><b>resourceReference</b>: Identifier: <code>https://pubmed.ncbi.nlm.nih.gov</code>/31125395</p></blockquote><blockquote><p><b>relatesTo</b></p><p><b>type</b>: cites</p><p><b>citation</b>: </p><div><p>Eshleman S, Fogel JM, Halvas EK, et al. CAB-LA PrEP: early detection of HIV infection may reduce InSTI resistance risk. 29th Conference on Retroviruses and Opportunistic Infections; Feb 12–16, 2022 (abstr Oral-08).</p>
</div></blockquote><blockquote><p><b>relatesTo</b></p><p><b>type</b>: comment-in</p><p><b>classifier</b>: <span title="Codes:{https://meshb.nlm.nih.gov/ D016420}">Comment</span></p><p><b>citation</b>: </p><div><p>Lancet. 2022 May 7;399(10337):1754-1755</p>
</div><h3>Documents</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Url</b></td></tr><tr><td style="display: none">*</td><td><a href="https://pubmed.ncbi.nlm.nih.gov/35378079/">https://pubmed.ncbi.nlm.nih.gov/35378079/</a></td></tr></table><p><b>resourceReference</b>: Identifier: <code>https://pubmed.ncbi.nlm.nih.gov</code>/35378079</p></blockquote><blockquote><p><b>relatesTo</b></p><p><b>type</b>: correction-in</p><p><b>classifier</b>: <span title="Codes:{https://meshb.nlm.nih.gov/ D016425}">Published Erratum</span></p><p><b>citation</b>: </p><div><p>Lancet. 2022 May 7;399(10337):1778</p>
</div><h3>Documents</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Url</b></td></tr><tr><td style="display: none">*</td><td><a href="https://pubmed.ncbi.nlm.nih.gov/35526551/">https://pubmed.ncbi.nlm.nih.gov/35526551/</a></td></tr></table><p><b>resourceReference</b>: Identifier: <code>https://pubmed.ncbi.nlm.nih.gov</code>/35526551</p></blockquote><blockquote><p><b>relatesTo</b></p><p><b>type</b>: comment-in</p><p><b>classifier</b>: <span title="Codes:{https://meshb.nlm.nih.gov/ D016420}">Comment</span></p><p><b>citation</b>: </p><div><p>Nat Med. 2022 Aug;28(8):1542-1543</p>
</div><h3>Documents</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Url</b></td></tr><tr><td style="display: none">*</td><td><a href="https://pubmed.ncbi.nlm.nih.gov/35869309/">https://pubmed.ncbi.nlm.nih.gov/35869309/</a></td></tr></table><p><b>resourceReference</b>: Identifier: <code>https://pubmed.ncbi.nlm.nih.gov</code>/35869309</p></blockquote><blockquote><p><b>relatesTo</b></p><p><b>type</b>: comment-in</p><p><b>classifier</b>: <span title="Codes:{https://meshb.nlm.nih.gov/ D016420}">Comment</span></p><p><b>citation</b>: </p><div><p>Nature. 2022 Aug;608(7923):460-461</p>
</div><h3>Documents</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Url</b></td></tr><tr><td style="display: none">*</td><td><a href="https://pubmed.ncbi.nlm.nih.gov/35931763/">https://pubmed.ncbi.nlm.nih.gov/35931763/</a></td></tr></table><p><b>resourceReference</b>: Identifier: <code>https://pubmed.ncbi.nlm.nih.gov</code>/35931763</p></blockquote><blockquote><p><b>relatesTo</b></p><p><b>type</b>: comment-in</p><p><b>classifier</b>: <span title="Codes:{https://meshb.nlm.nih.gov/ D016420}">Comment</span></p><p><b>citation</b>: </p><div><p>Nature. 2022 Aug;608(7922):239</p>
</div><h3>Documents</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Url</b></td></tr><tr><td style="display: none">*</td><td><a href="https://pubmed.ncbi.nlm.nih.gov/35945377/">https://pubmed.ncbi.nlm.nih.gov/35945377/</a></td></tr></table><p><b>resourceReference</b>: Identifier: <code>https://pubmed.ncbi.nlm.nih.gov</code>/35945377</p></blockquote><blockquote><p><b>publicationForm</b></p><blockquote><p><b>publishedIn</b></p><p><b>type</b>: <span title="Codes:{http://hl7.org/fhir/published-in-type D020492}">Periodical</span></p><p><b>identifier</b>: Electronic ISSN Type/1474-547X, ISOAbbreviation/Lancet, ISSN Linking/0140-6736, Medline Title Abbreviation/Lancet, NLM Unique ID/2985213R</p><p><b>title</b>: Lancet (London, England)</p><p><b>publisherLocation</b>: England</p></blockquote><p><b>citedMedium</b>: <span title="Codes:{http://hl7.org/fhir/cited-medium internet}">Internet</span></p><p><b>volume</b>: 399</p><p><b>issue</b>: 10337</p><p><b>articleDate</b>: 2022-05-07</p><p><b>publicationDateText</b>: 2022-May-07</p><p><b>language</b>: <span title="Codes:{urn:ietf:bcp:47 en}">English</span></p><p><b>pageString</b>: 1779-1789</p></blockquote><blockquote><p><b>publicationForm</b></p><p><b>citedMedium</b>: <span title="Codes:{http://hl7.org/fhir/cited-medium internet-without-issue}">Internet without issue</span></p><p><b>articleDate</b>: 2022-04-01</p></blockquote><blockquote><p><b>webLocation</b></p><p><b>classifier</b>: <span title="Codes:{http://hl7.org/fhir/artifact-url-classifier abstract}">Abstract</span></p><p><b>url</b>: <a href="https://pubmed.ncbi.nlm.nih.gov/35378077/">https://pubmed.ncbi.nlm.nih.gov/35378077/</a></p></blockquote><blockquote><p><b>webLocation</b></p><p><b>classifier</b>: <span title="Codes:{http://hl7.org/fhir/artifact-url-classifier doi-based}">DOI Based</span></p><p><b>url</b>: <a href="https://doi.org/10.1016/S0140-6736(22)00538-4">https://doi.org/10.1016/S0140-6736(22)00538-4</a></p></blockquote><blockquote><p><b>classification</b></p><p><b>type</b>: <span title="Codes:{http://hl7.org/fhir/cited-artifact-classification-type publishing-model}">Publishing Model</span></p><p><b>classifier</b>: <span title="Codes:{http://hl7.org/fhir/citation-artifact-classifier Print-Electronic}">Print Electronic</span></p></blockquote><blockquote><p><b>classification</b></p><p><b>type</b>: <span title="Codes:{http://hl7.org/fhir/cited-artifact-classification-type chemical}">Chemical</span></p><p><b>classifier</b>: <span title="Codes:{https://meshb.nlm.nih.gov/ D019380}">Anti-HIV Agents</span>, <span title="Codes:{https://meshb.nlm.nih.gov/ D054659}">Diketopiperazines</span>, <span title="Codes:{https://meshb.nlm.nih.gov/ D011728}">Pyridones</span>, <span title="Codes:{https://www.cas.org/support/documentation/chemical-substances G70B4ETF4S}, {https://meshb.nlm.nih.gov/ D000068679}">Emtricitabine</span>, <span title="Codes:{https://www.cas.org/support/documentation/chemical-substances HMH0132Z1Q}, {https://meshb.nlm.nih.gov/ C584914}">cabotegravir</span></p></blockquote><blockquote><p><b>classification</b></p><p><b>type</b>: <span title="Codes:{http://hl7.org/fhir/cited-artifact-classification-type mesh-heading}">MeSH Heading</span></p><p><b>artifactAssessment</b>: <a href="#hc153881/meshHeading0">ArtifactAssessment: artifact[x] = this resource</a></p></blockquote><blockquote><p><b>classification</b></p><p><b>type</b>: <span title="Codes:{http://hl7.org/fhir/cited-artifact-classification-type publication-type}">Publication Type</span></p><p><b>classifier</b>: <span title="Codes:{https://meshb.nlm.nih.gov/ D017428}">Clinical Trial, Phase III</span>, <span title="Codes:{https://meshb.nlm.nih.gov/ D016428}">Journal Article</span>, <span title="Codes:{https://meshb.nlm.nih.gov/ D016449}">Randomized Controlled Trial</span></p></blockquote><blockquote><p><b>classification</b></p><p><b>type</b>: <span title="Codes:{http://hl7.org/fhir/cited-artifact-classification-type knowledge-artifact-type}">Knowledge Artifact Type</span></p><p><b>classifier</b>: <span title="Codes:{http://hl7.org/fhir/citation-artifact-classifier D016428}">Journal Article</span></p><p><b>artifactAssessment</b>: Classifier added by Computable Publishing LLC</p></blockquote><blockquote><p><b>classification</b></p><p><b>type</b>: <span title="Codes:{http://hl7.org/fhir/cited-artifact-classification-type citation-subset}">Citation Subset</span></p><p><b>classifier</b>: <span title="Codes:{https://www.nlm.nih.gov/bsd/licensee/elements_descriptions.html#citationsubset IM}">IM</span></p></blockquote><blockquote><p><b>contributorship</b></p><p><b>complete</b>: true</p><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a href="#hc153881/author0">Delany-Moretlwe S</a></p><p><b>forenameInitials</b>: S</p><p><b>affiliation</b>: Wits Reproductive Health and HIV Institute, University of the Witwatersrand, Johannesburg, South Africa. Electronic address: sdelany@wrhi.ac.za.</p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a href="#hc153881/author1">Hughes JP</a></p><p><b>forenameInitials</b>: JP</p><p><b>affiliation</b>: Statistical Centre for HIV/AIDS Research and Prevention, Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.</p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a href="#hc153881/author2">Bock P</a></p><p><b>forenameInitials</b>: P</p><p><b>affiliation</b>: Desmond Tutu TB Centre, University of Stellenbosch, Stellenbosch, South Africa.</p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a href="#hc153881/author3">Ouma SG</a></p><p><b>forenameInitials</b>: SG</p><p><b>affiliation</b>: Kisumu Clinical Research Site, Centre for Global Health Research, Kenya Medical Research Institute, Kisumu, Kenya.</p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a href="#hc153881/author4">Hunidzarira P</a></p><p><b>forenameInitials</b>: P</p><p><b>affiliation</b>: Clinical Trials Research Centre, University of Zimbabwe, Harare, Zimbabwe.</p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a href="#hc153881/author5">Kalonji D</a></p><p><b>forenameInitials</b>: D</p><p><b>affiliation</b>: HIV and other Infectious Diseases Research Unit, South African Medical Research Council, Durban, South Africa.</p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a href="#hc153881/author6">Kayange N</a></p><p><b>forenameInitials</b>: N</p><p><b>affiliation</b>: Blantyre Clinical Research Site, College of Medicine, University of Malawi, Blantyre, Malawi.</p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a href="#hc153881/author7">Makhema J</a></p><p><b>forenameInitials</b>: J</p><p><b>affiliation</b>: Botswana Harvard AIDS Institute Partnership (BHP), Gaborone, Botswana.</p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a href="#hc153881/author8">Mandima P</a></p><p><b>forenameInitials</b>: P</p><p><b>affiliation</b>: Clinical Trials Research Centre, University of Zimbabwe, Harare, Zimbabwe.</p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a href="#hc153881/author9">Mathew C</a></p><p><b>forenameInitials</b>: C</p><p><b>affiliation</b>: Wits Reproductive Health and HIV Institute, University of the Witwatersrand, Johannesburg, South Africa.</p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a href="#hc153881/author10">Spooner E</a></p><p><b>forenameInitials</b>: E</p><p><b>affiliation</b>: HIV and other Infectious Diseases Research Unit, South African Medical Research Council, Durban, South Africa.</p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a href="#hc153881/author11">Mpendo J</a></p><p><b>forenameInitials</b>: J</p><p><b>affiliation</b>: International AIDS Vaccine Initiative, Uganda Virus Research Institute, Entebbe, Uganda.</p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a href="#hc153881/author12">Mukwekwerere P</a></p><p><b>forenameInitials</b>: P</p><p><b>affiliation</b>: Clinical Trials Research Centre, University of Zimbabwe, Harare, Zimbabwe.</p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a href="#hc153881/author13">Mgodi N</a></p><p><b>forenameInitials</b>: N</p><p><b>affiliation</b>: Clinical Trials Research Centre, University of Zimbabwe, Harare, Zimbabwe.</p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a href="#hc153881/author14">Ntege PN</a></p><p><b>forenameInitials</b>: PN</p><p><b>affiliation</b>: Baylor College of Medicine Children's Foundation Uganda, Kampala, Uganda.</p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a href="#hc153881/author15">Nair G</a></p><p><b>forenameInitials</b>: G</p><p><b>affiliation</b>: Desmond Tutu Health Foundation, University of Cape Town, Cape Town, South Africa.</p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a href="#hc153881/author16">Nakabiito C</a></p><p><b>forenameInitials</b>: C</p><p><b>affiliation</b>: Makerere University-Johns Hopkins University Research Collaboration, Kampala, Uganda.</p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a href="#hc153881/author17">Nuwagaba-Biribonwoha H</a></p><p><b>forenameInitials</b>: H</p><p><b>affiliation</b>: Eswatini Prevention Center, International Center for AIDS Care and Treatment Program at Columbia University Mailman School of Public Health, New York, NY, USA.</p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a href="#hc153881/author18">Panchia R</a></p><p><b>forenameInitials</b>: R</p><p><b>affiliation</b>: Perinatal HIV Research Unit, University of the Witwatersrand, Johannesburg, South Africa.</p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a href="#hc153881/author19">Singh N</a></p><p><b>forenameInitials</b>: N</p><p><b>affiliation</b>: HIV and other Infectious Diseases Research Unit, South African Medical Research Council, Durban, South Africa.</p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a href="#hc153881/author20">Siziba B</a></p><p><b>forenameInitials</b>: B</p><p><b>affiliation</b>: Clinical Trials Research Centre, University of Zimbabwe, Harare, Zimbabwe.</p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a href="#hc153881/author21">Farrior J</a></p><p><b>forenameInitials</b>: J</p><p><b>affiliation</b>: FHI 360, Durham, NC, USA.</p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a href="#hc153881/author22">Rose S</a></p><p><b>forenameInitials</b>: S</p><p><b>affiliation</b>: FHI 360, Durham, NC, USA.</p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a href="#hc153881/author23">Anderson PL</a></p><p><b>forenameInitials</b>: PL</p><p><b>affiliation</b>: Anschutz Medical Campus, University of Colorado, Aurora, CO, USA.</p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a href="#hc153881/author24">Eshleman SH</a></p><p><b>forenameInitials</b>: SH</p><p><b>affiliation</b>: Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.</p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a href="#hc153881/author25">Marzinke MA</a></p><p><b>forenameInitials</b>: MA</p><p><b>affiliation</b>: Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.</p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a href="#hc153881/author26">Hendrix CW</a></p><p><b>forenameInitials</b>: CW</p><p><b>affiliation</b>: Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.</p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a href="#hc153881/author27">Beigel-Orme S</a></p><p><b>forenameInitials</b>: S</p><p><b>affiliation</b>: Statistical Centre for HIV/AIDS Research and Prevention, Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.</p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a href="#hc153881/author28">Hosek S</a></p><p><b>forenameInitials</b>: S</p><p><b>affiliation</b>: Department of Psychiatry, Stroger Hospital of Cook County, Chicago, IL, USA.</p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a href="#hc153881/author29">Tolley E</a></p><p><b>forenameInitials</b>: E</p><p><b>affiliation</b>: FHI 360, Durham, NC, USA.</p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a href="#hc153881/author30">Sista N</a></p><p><b>forenameInitials</b>: N</p><p><b>affiliation</b>: FHI 360, Durham, NC, USA.</p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a href="#hc153881/author31">Adeyeye A</a></p><p><b>forenameInitials</b>: A</p><p><b>affiliation</b>: Division of AIDS, National Institute of Allergy and Infectious Diseases, Rockville, MD, USA.</p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a href="#hc153881/author32">Rooney JF</a></p><p><b>forenameInitials</b>: JF</p><p><b>affiliation</b>: Gilead Sciences, Foster City, CA, USA.</p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a href="#hc153881/author33">Rinehart A</a></p><p><b>forenameInitials</b>: A</p><p><b>affiliation</b>: ViiV Healthcare, Durham, NC, USA.</p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a href="#hc153881/author34">Spreen WR</a></p><p><b>forenameInitials</b>: WR</p><p><b>affiliation</b>: ViiV Healthcare, Durham, NC, USA.</p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a href="#hc153881/author35">Smith K</a></p><p><b>forenameInitials</b>: K</p><p><b>affiliation</b>: ViiV Healthcare, Durham, NC, USA.</p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a href="#hc153881/author36">Hanscom B</a></p><p><b>forenameInitials</b>: B</p><p><b>affiliation</b>: Statistical Centre for HIV/AIDS Research and Prevention, Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.</p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a href="#hc153881/author37">Cohen MS</a></p><p><b>forenameInitials</b>: MS</p><p><b>affiliation</b>: University of North Carolina (UNC) at Chapel Hill, Chapel Hill, NC, USA.</p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a href="#hc153881/author38">Hosseinipour MC</a></p><p><b>forenameInitials</b>: MC</p><p><b>affiliation</b>: University of North Carolina (UNC) at Chapel Hill, Chapel Hill, NC, USA; UNC Project-Malawi, Lilongwe, Malawi.</p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a href="#hc153881/author39">HPTN 084 study group</a></p></blockquote></blockquote></blockquote><hr/><blockquote><p class="res-header-id"><b>Generated Narrative: Practitioner #author0</b></p><a name="153881/author0"> </a><a name="hc153881/author0"> </a><a name="153881/author0-en-US"> </a><p><b>name</b>: Sinead Delany-Moretlwe </p></blockquote><hr/><blockquote><p class="res-header-id"><b>Generated Narrative: Practitioner #author1</b></p><a name="153881/author1"> </a><a name="hc153881/author1"> </a><a name="153881/author1-en-US"> </a><p><b>name</b>: James P Hughes </p></blockquote><hr/><blockquote><p class="res-header-id"><b>Generated Narrative: Practitioner #author2</b></p><a name="153881/author2"> </a><a name="hc153881/author2"> </a><a name="153881/author2-en-US"> </a><p><b>name</b>: Peter Bock </p></blockquote><hr/><blockquote><p class="res-header-id"><b>Generated Narrative: Practitioner #author3</b></p><a name="153881/author3"> </a><a name="hc153881/author3"> </a><a name="153881/author3-en-US"> </a><p><b>name</b>: Samuel Gurrion Ouma </p></blockquote><hr/><blockquote><p class="res-header-id"><b>Generated Narrative: Practitioner #author4</b></p><a name="153881/author4"> </a><a name="hc153881/author4"> </a><a name="153881/author4-en-US"> </a><p><b>name</b>: Portia Hunidzarira </p></blockquote><hr/><blockquote><p class="res-header-id"><b>Generated Narrative: Practitioner #author5</b></p><a name="153881/author5"> </a><a name="hc153881/author5"> </a><a name="153881/author5-en-US"> </a><p><b>name</b>: Dishiki Kalonji </p></blockquote><hr/><blockquote><p class="res-header-id"><b>Generated Narrative: Practitioner #author6</b></p><a name="153881/author6"> </a><a name="hc153881/author6"> </a><a name="153881/author6-en-US"> </a><p><b>name</b>: Noel Kayange </p></blockquote><hr/><blockquote><p class="res-header-id"><b>Generated Narrative: Practitioner #author7</b></p><a name="153881/author7"> </a><a name="hc153881/author7"> </a><a name="153881/author7-en-US"> </a><p><b>name</b>: Joseph Makhema </p></blockquote><hr/><blockquote><p class="res-header-id"><b>Generated Narrative: Practitioner #author8</b></p><a name="153881/author8"> </a><a name="hc153881/author8"> </a><a name="153881/author8-en-US"> </a><p><b>name</b>: Patricia Mandima </p></blockquote><hr/><blockquote><p class="res-header-id"><b>Generated Narrative: Practitioner #author9</b></p><a name="153881/author9"> </a><a name="hc153881/author9"> </a><a name="153881/author9-en-US"> </a><p><b>name</b>: Carrie Mathew </p></blockquote><hr/><blockquote><p class="res-header-id"><b>Generated Narrative: Practitioner #author10</b></p><a name="153881/author10"> </a><a name="hc153881/author10"> </a><a name="153881/author10-en-US"> </a><p><b>name</b>: Elizabeth Spooner </p></blockquote><hr/><blockquote><p class="res-header-id"><b>Generated Narrative: Practitioner #author11</b></p><a name="153881/author11"> </a><a name="hc153881/author11"> </a><a name="153881/author11-en-US"> </a><p><b>name</b>: Juliet Mpendo </p></blockquote><hr/><blockquote><p class="res-header-id"><b>Generated Narrative: Practitioner #author12</b></p><a name="153881/author12"> </a><a name="hc153881/author12"> </a><a name="153881/author12-en-US"> </a><p><b>name</b>: Pamela Mukwekwerere </p></blockquote><hr/><blockquote><p class="res-header-id"><b>Generated Narrative: Practitioner #author13</b></p><a name="153881/author13"> </a><a name="hc153881/author13"> </a><a name="153881/author13-en-US"> </a><p><b>name</b>: Nyaradzo Mgodi </p></blockquote><hr/><blockquote><p class="res-header-id"><b>Generated Narrative: Practitioner #author14</b></p><a name="153881/author14"> </a><a name="hc153881/author14"> </a><a name="153881/author14-en-US"> </a><p><b>name</b>: Patricia Nahirya Ntege </p></blockquote><hr/><blockquote><p class="res-header-id"><b>Generated Narrative: Practitioner #author15</b></p><a name="153881/author15"> </a><a name="hc153881/author15"> </a><a name="153881/author15-en-US"> </a><p><b>name</b>: Gonasagrie Nair </p></blockquote><hr/><blockquote><p class="res-header-id"><b>Generated Narrative: Practitioner #author16</b></p><a name="153881/author16"> </a><a name="hc153881/author16"> </a><a name="153881/author16-en-US"> </a><p><b>name</b>: Clemensia Nakabiito </p></blockquote><hr/><blockquote><p class="res-header-id"><b>Generated Narrative: Practitioner #author17</b></p><a name="153881/author17"> </a><a name="hc153881/author17"> </a><a name="153881/author17-en-US"> </a><p><b>name</b>: Harriet Nuwagaba-Biribonwoha </p></blockquote><hr/><blockquote><p class="res-header-id"><b>Generated Narrative: Practitioner #author18</b></p><a name="153881/author18"> </a><a name="hc153881/author18"> </a><a name="153881/author18-en-US"> </a><p><b>name</b>: Ravindre Panchia </p></blockquote><hr/><blockquote><p class="res-header-id"><b>Generated Narrative: Practitioner #author19</b></p><a name="153881/author19"> </a><a name="hc153881/author19"> </a><a name="153881/author19-en-US"> </a><p><b>name</b>: Nishanta Singh </p></blockquote><hr/><blockquote><p class="res-header-id"><b>Generated Narrative: Practitioner #author20</b></p><a name="153881/author20"> </a><a name="hc153881/author20"> </a><a name="153881/author20-en-US"> </a><p><b>name</b>: Bekezela Siziba </p></blockquote><hr/><blockquote><p class="res-header-id"><b>Generated Narrative: Practitioner #author21</b></p><a name="153881/author21"> </a><a name="hc153881/author21"> </a><a name="153881/author21-en-US"> </a><p><b>name</b>: Jennifer Farrior </p></blockquote><hr/><blockquote><p class="res-header-id"><b>Generated Narrative: Practitioner #author22</b></p><a name="153881/author22"> </a><a name="hc153881/author22"> </a><a name="153881/author22-en-US"> </a><p><b>name</b>: Scott Rose </p></blockquote><hr/><blockquote><p class="res-header-id"><b>Generated Narrative: Practitioner #author23</b></p><a name="153881/author23"> </a><a name="hc153881/author23"> </a><a name="153881/author23-en-US"> </a><p><b>name</b>: Peter L Anderson </p></blockquote><hr/><blockquote><p class="res-header-id"><b>Generated Narrative: Practitioner #author24</b></p><a name="153881/author24"> </a><a name="hc153881/author24"> </a><a name="153881/author24-en-US"> </a><p><b>name</b>: Susan H Eshleman </p></blockquote><hr/><blockquote><p class="res-header-id"><b>Generated Narrative: Practitioner #author25</b></p><a name="153881/author25"> </a><a name="hc153881/author25"> </a><a name="153881/author25-en-US"> </a><p><b>name</b>: Mark A Marzinke </p></blockquote><hr/><blockquote><p class="res-header-id"><b>Generated Narrative: Practitioner #author26</b></p><a name="153881/author26"> </a><a name="hc153881/author26"> </a><a name="153881/author26-en-US"> </a><p><b>name</b>: Craig W Hendrix </p></blockquote><hr/><blockquote><p class="res-header-id"><b>Generated Narrative: Practitioner #author27</b></p><a name="153881/author27"> </a><a name="hc153881/author27"> </a><a name="153881/author27-en-US"> </a><p><b>name</b>: Stephanie Beigel-Orme </p></blockquote><hr/><blockquote><p class="res-header-id"><b>Generated Narrative: Practitioner #author28</b></p><a name="153881/author28"> </a><a name="hc153881/author28"> </a><a name="153881/author28-en-US"> </a><p><b>name</b>: Sybil Hosek </p></blockquote><hr/><blockquote><p class="res-header-id"><b>Generated Narrative: Practitioner #author29</b></p><a name="153881/author29"> </a><a name="hc153881/author29"> </a><a name="153881/author29-en-US"> </a><p><b>name</b>: Elizabeth Tolley </p></blockquote><hr/><blockquote><p class="res-header-id"><b>Generated Narrative: Practitioner #author30</b></p><a name="153881/author30"> </a><a name="hc153881/author30"> </a><a name="153881/author30-en-US"> </a><p><b>name</b>: Nirupama Sista </p></blockquote><hr/><blockquote><p class="res-header-id"><b>Generated Narrative: Practitioner #author31</b></p><a name="153881/author31"> </a><a name="hc153881/author31"> </a><a name="153881/author31-en-US"> </a><p><b>name</b>: Adeola Adeyeye </p></blockquote><hr/><blockquote><p class="res-header-id"><b>Generated Narrative: Practitioner #author32</b></p><a name="153881/author32"> </a><a name="hc153881/author32"> </a><a name="153881/author32-en-US"> </a><p><b>name</b>: James F Rooney </p></blockquote><hr/><blockquote><p class="res-header-id"><b>Generated Narrative: Practitioner #author33</b></p><a name="153881/author33"> </a><a name="hc153881/author33"> </a><a name="153881/author33-en-US"> </a><p><b>name</b>: Alex Rinehart </p></blockquote><hr/><blockquote><p class="res-header-id"><b>Generated Narrative: Practitioner #author34</b></p><a name="153881/author34"> </a><a name="hc153881/author34"> </a><a name="153881/author34-en-US"> </a><p><b>name</b>: William R Spreen </p></blockquote><hr/><blockquote><p class="res-header-id"><b>Generated Narrative: Practitioner #author35</b></p><a name="153881/author35"> </a><a name="hc153881/author35"> </a><a name="153881/author35-en-US"> </a><p><b>name</b>: Kimberly Smith </p></blockquote><hr/><blockquote><p class="res-header-id"><b>Generated Narrative: Practitioner #author36</b></p><a name="153881/author36"> </a><a name="hc153881/author36"> </a><a name="153881/author36-en-US"> </a><p><b>name</b>: Brett Hanscom </p></blockquote><hr/><blockquote><p class="res-header-id"><b>Generated Narrative: Practitioner #author37</b></p><a name="153881/author37"> </a><a name="hc153881/author37"> </a><a name="153881/author37-en-US"> </a><p><b>name</b>: Myron S Cohen </p></blockquote><hr/><blockquote><p class="res-header-id"><b>Generated Narrative: Practitioner #author38</b></p><a name="153881/author38"> </a><a name="hc153881/author38"> </a><a name="153881/author38-en-US"> </a><p><b>name</b>: Mina C Hosseinipour </p></blockquote><hr/><blockquote><p class="res-header-id"><b>Generated Narrative: Organization #author39</b></p><a name="153881/author39"> </a><a name="hc153881/author39"> </a><a name="153881/author39-en-US"> </a><p><b>name</b>: HPTN 084 study group</p></blockquote><hr/><blockquote><p class="res-header-id"><b>Generated Narrative: ArtifactAssessment #meshHeading0</b></p><a name="153881/meshHeading0"> </a><a name="hc153881/meshHeading0"> </a><a name="153881/meshHeading0-en-US"> </a><p><b>artifact</b>: <a href="#hc153881">Citation Delany-Moretlwe 2022 clinical trial</a></p><blockquote><p><b>content</b></p><p><b>informationType</b>: Classifier</p><p><b>type</b>: <span title="Codes:{http://hl7.org/fhir/cited-artifact-classification-type mesh-heading}">components (if present) include qualifier codings</span></p><p><b>classifier</b>: <span title="Codes:{https://meshb.nlm.nih.gov/ D000328}">Adult</span></p><p><b>freeToShare</b>: true</p><h3>Components</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style="display: none">*</td><td><span title="Codes:">qualifier</span></td><td><span title="Codes:">is not a major topic</span></td></tr></table></blockquote><blockquote><p><b>content</b></p><p><b>informationType</b>: Classifier</p><p><b>type</b>: <span title="Codes:{http://hl7.org/fhir/cited-artifact-classification-type mesh-heading}">components (if present) include qualifier codings</span></p><p><b>classifier</b>: <span title="Codes:{https://meshb.nlm.nih.gov/ D019380}">Anti-HIV Agents</span></p><p><b>freeToShare</b>: true</p><h3>Components</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style="display: none">*</td><td><span title="Codes:">qualifier</span></td><td><span title="Codes:">is Major topic</span></td></tr></table></blockquote><blockquote><p><b>content</b></p><p><b>informationType</b>: Classifier</p><p><b>type</b>: <span title="Codes:{http://hl7.org/fhir/cited-artifact-classification-type mesh-heading}">components (if present) include qualifier codings</span></p><p><b>classifier</b>: <span title="Codes:{https://meshb.nlm.nih.gov/ D002648}">Child</span></p><p><b>freeToShare</b>: true</p><h3>Components</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style="display: none">*</td><td><span title="Codes:">qualifier</span></td><td><span title="Codes:">is not a major topic</span></td></tr></table></blockquote><blockquote><p><b>content</b></p><p><b>informationType</b>: Classifier</p><p><b>type</b>: <span title="Codes:{http://hl7.org/fhir/cited-artifact-classification-type mesh-heading}">components (if present) include qualifier codings</span></p><p><b>classifier</b>: <span title="Codes:{https://meshb.nlm.nih.gov/ D054659}">Diketopiperazines</span></p><p><b>freeToShare</b>: true</p><h3>Components</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style="display: none">*</td><td><span title="Codes:">qualifier</span></td><td><span title="Codes:">is not a major topic</span></td></tr></table></blockquote><blockquote><p><b>content</b></p><p><b>informationType</b>: Classifier</p><p><b>type</b>: <span title="Codes:{http://hl7.org/fhir/cited-artifact-classification-type mesh-heading}">components (if present) include qualifier codings</span></p><p><b>classifier</b>: <span title="Codes:{https://meshb.nlm.nih.gov/ D000068679}">Emtricitabine</span></p><p><b>freeToShare</b>: true</p><blockquote><p><b>component</b></p><p><b>type</b>: <span title="Codes:">qualifier</span></p><p><b>classifier</b>: <span title="Codes:">is not a major topic</span></p></blockquote><blockquote><p><b>component</b></p><p><b>type</b>: <span title="Codes:">qualifier</span></p><p><b>classifier</b>: <span title="Codes:{https://meshb.nlm.nih.gov/ Q000627}">therapeutic use</span></p><h3>Components</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style="display: none">*</td><td><span title="Codes:">is Major topic</span></td><td><span title="Codes:{https://ncithesaurus.nci.nih.gov/ncitbrowser C49487}">No</span></td></tr></table></blockquote></blockquote><blockquote><p><b>content</b></p><p><b>informationType</b>: Classifier</p><p><b>type</b>: <span title="Codes:{http://hl7.org/fhir/cited-artifact-classification-type mesh-heading}">components (if present) include qualifier codings</span></p><p><b>classifier</b>: <span title="Codes:{https://meshb.nlm.nih.gov/ D005260}">Female</span></p><p><b>freeToShare</b>: true</p><h3>Components</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style="display: none">*</td><td><span title="Codes:">qualifier</span></td><td><span title="Codes:">is not a major topic</span></td></tr></table></blockquote><blockquote><p><b>content</b></p><p><b>informationType</b>: Classifier</p><p><b>type</b>: <span title="Codes:{http://hl7.org/fhir/cited-artifact-classification-type mesh-heading}">components (if present) include qualifier codings</span></p><p><b>classifier</b>: <span title="Codes:{https://meshb.nlm.nih.gov/ D015658}">HIV Infections</span></p><p><b>freeToShare</b>: true</p><blockquote><p><b>component</b></p><p><b>type</b>: <span title="Codes:">qualifier</span></p><p><b>classifier</b>: <span title="Codes:">is Major topic</span></p></blockquote><blockquote><p><b>component</b></p><p><b>type</b>: <span title="Codes:">qualifier</span></p><p><b>classifier</b>: <span title="Codes:{https://meshb.nlm.nih.gov/ Q000139}">chemically induced</span></p><h3>Components</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style="display: none">*</td><td><span title="Codes:">is Major topic</span></td><td><span title="Codes:{https://ncithesaurus.nci.nih.gov/ncitbrowser C49487}">No</span></td></tr></table></blockquote><blockquote><p><b>component</b></p><p><b>type</b>: <span title="Codes:">qualifier</span></p><p><b>classifier</b>: <span title="Codes:{https://meshb.nlm.nih.gov/ Q000453}">epidemiology</span></p><h3>Components</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style="display: none">*</td><td><span title="Codes:">is Major topic</span></td><td><span title="Codes:{https://ncithesaurus.nci.nih.gov/ncitbrowser C49487}">No</span></td></tr></table></blockquote><blockquote><p><b>component</b></p><p><b>type</b>: <span title="Codes:">qualifier</span></p><p><b>classifier</b>: <span title="Codes:{https://meshb.nlm.nih.gov/ Q000517}">prevention & control</span></p><h3>Components</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style="display: none">*</td><td><span title="Codes:">is Major topic</span></td><td><span title="Codes:{https://ncithesaurus.nci.nih.gov/ncitbrowser C49487}">No</span></td></tr></table></blockquote></blockquote><blockquote><p><b>content</b></p><p><b>informationType</b>: Classifier</p><p><b>type</b>: <span title="Codes:{http://hl7.org/fhir/cited-artifact-classification-type mesh-heading}">components (if present) include qualifier codings</span></p><p><b>classifier</b>: <span title="Codes:{https://meshb.nlm.nih.gov/ D006679}">HIV Seropositivity</span></p><p><b>freeToShare</b>: true</p><blockquote><p><b>component</b></p><p><b>type</b>: <span title="Codes:">qualifier</span></p><p><b>classifier</b>: <span title="Codes:">is Major topic</span></p></blockquote><blockquote><p><b>component</b></p><p><b>type</b>: <span title="Codes:">qualifier</span></p><p><b>classifier</b>: <span title="Codes:{https://meshb.nlm.nih.gov/ Q000188}">drug therapy</span></p><h3>Components</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style="display: none">*</td><td><span title="Codes:">is Major topic</span></td><td><span title="Codes:{https://ncithesaurus.nci.nih.gov/ncitbrowser C49487}">No</span></td></tr></table></blockquote></blockquote><blockquote><p><b>content</b></p><p><b>informationType</b>: Classifier</p><p><b>type</b>: <span title="Codes:{http://hl7.org/fhir/cited-artifact-classification-type mesh-heading}">components (if present) include qualifier codings</span></p><p><b>classifier</b>: <span title="Codes:{https://meshb.nlm.nih.gov/ D015497}">HIV-1</span></p><p><b>freeToShare</b>: true</p><h3>Components</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style="display: none">*</td><td><span title="Codes:">qualifier</span></td><td><span title="Codes:">is Major topic</span></td></tr></table></blockquote><blockquote><p><b>content</b></p><p><b>informationType</b>: Classifier</p><p><b>type</b>: <span title="Codes:{http://hl7.org/fhir/cited-artifact-classification-type mesh-heading}">components (if present) include qualifier codings</span></p><p><b>classifier</b>: <span title="Codes:{https://meshb.nlm.nih.gov/ D006801}">Humans</span></p><p><b>freeToShare</b>: true</p><h3>Components</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style="display: none">*</td><td><span title="Codes:">qualifier</span></td><td><span title="Codes:">is not a major topic</span></td></tr></table></blockquote><blockquote><p><b>content</b></p><p><b>informationType</b>: Classifier</p><p><b>type</b>: <span title="Codes:{http://hl7.org/fhir/cited-artifact-classification-type mesh-heading}">components (if present) include qualifier codings</span></p><p><b>classifier</b>: <span title="Codes:{https://meshb.nlm.nih.gov/ D007231}">Infant, Newborn</span></p><p><b>freeToShare</b>: true</p><h3>Components</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style="display: none">*</td><td><span title="Codes:">qualifier</span></td><td><span title="Codes:">is not a major topic</span></td></tr></table></blockquote><blockquote><p><b>content</b></p><p><b>informationType</b>: Classifier</p><p><b>type</b>: <span title="Codes:{http://hl7.org/fhir/cited-artifact-classification-type mesh-heading}">components (if present) include qualifier codings</span></p><p><b>classifier</b>: <span title="Codes:{https://meshb.nlm.nih.gov/ D011247}">Pregnancy</span></p><p><b>freeToShare</b>: true</p><h3>Components</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style="display: none">*</td><td><span title="Codes:">qualifier</span></td><td><span title="Codes:">is not a major topic</span></td></tr></table></blockquote><blockquote><p><b>content</b></p><p><b>informationType</b>: Classifier</p><p><b>type</b>: <span title="Codes:{http://hl7.org/fhir/cited-artifact-classification-type mesh-heading}">components (if present) include qualifier codings</span></p><p><b>classifier</b>: <span title="Codes:{https://meshb.nlm.nih.gov/ D011728}">Pyridones</span></p><p><b>freeToShare</b>: true</p><blockquote><p><b>component</b></p><p><b>type</b>: <span title="Codes:">qualifier</span></p><p><b>classifier</b>: <span title="Codes:">is not a major topic</span></p></blockquote><blockquote><p><b>component</b></p><p><b>type</b>: <span title="Codes:">qualifier</span></p><p><b>classifier</b>: <span title="Codes:{https://meshb.nlm.nih.gov/ Q000627}">therapeutic use</span></p><h3>Components</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style="display: none">*</td><td><span title="Codes:">is Major topic</span></td><td><span title="Codes:{https://ncithesaurus.nci.nih.gov/ncitbrowser C49487}">No</span></td></tr></table></blockquote></blockquote></blockquote></div>
</text>
<contained>
<Practitioner>
<id value="author0"/>
<name>
<family value="Delany-Moretlwe"/>
<given value="Sinead"/>
</name>
</Practitioner>
</contained>
<contained>
<Practitioner>
<id value="author1"/>
<name>
<family value="Hughes"/>
<given value="James P"/>
</name>
</Practitioner>
</contained>
<contained>
<Practitioner>
<id value="author2"/>
<name>
<family value="Bock"/>
<given value="Peter"/>
</name>
</Practitioner>
</contained>
<contained>
<Practitioner>
<id value="author3"/>
<name>
<family value="Ouma"/>
<given value="Samuel Gurrion"/>
</name>
</Practitioner>
</contained>
<contained>
<Practitioner>
<id value="author4"/>
<name>
<family value="Hunidzarira"/>
<given value="Portia"/>
</name>
</Practitioner>
</contained>
<contained>
<Practitioner>
<id value="author5"/>
<name>
<family value="Kalonji"/>
<given value="Dishiki"/>
</name>
</Practitioner>
</contained>
<contained>
<Practitioner>
<id value="author6"/>
<name>
<family value="Kayange"/>
<given value="Noel"/>
</name>
</Practitioner>
</contained>
<contained>
<Practitioner>
<id value="author7"/>
<name>
<family value="Makhema"/>
<given value="Joseph"/>
</name>
</Practitioner>
</contained>
<contained>
<Practitioner>
<id value="author8"/>
<name>
<family value="Mandima"/>
<given value="Patricia"/>
</name>
</Practitioner>
</contained>
<contained>
<Practitioner>
<id value="author9"/>
<name>
<family value="Mathew"/>
<given value="Carrie"/>
</name>
</Practitioner>
</contained>
<contained>
<Practitioner>
<id value="author10"/>
<name>
<family value="Spooner"/>
<given value="Elizabeth"/>
</name>
</Practitioner>
</contained>
<contained>
<Practitioner>
<id value="author11"/>
<name>
<family value="Mpendo"/>
<given value="Juliet"/>
</name>
</Practitioner>
</contained>
<contained>
<Practitioner>
<id value="author12"/>
<name>
<family value="Mukwekwerere"/>
<given value="Pamela"/>
</name>
</Practitioner>
</contained>
<contained>
<Practitioner>
<id value="author13"/>
<name>
<family value="Mgodi"/>
<given value="Nyaradzo"/>
</name>
</Practitioner>
</contained>
<contained>
<Practitioner>
<id value="author14"/>
<name>
<family value="Ntege"/>
<given value="Patricia Nahirya"/>
</name>
</Practitioner>
</contained>
<contained>
<Practitioner>
<id value="author15"/>
<name>
<family value="Nair"/>
<given value="Gonasagrie"/>
</name>
</Practitioner>
</contained>
<contained>
<Practitioner>
<id value="author16"/>
<name>
<family value="Nakabiito"/>
<given value="Clemensia"/>
</name>
</Practitioner>
</contained>
<contained>
<Practitioner>
<id value="author17"/>
<name>
<family value="Nuwagaba-Biribonwoha"/>
<given value="Harriet"/>
</name>
</Practitioner>
</contained>
<contained>
<Practitioner>
<id value="author18"/>
<name>
<family value="Panchia"/>
<given value="Ravindre"/>
</name>
</Practitioner>
</contained>
<contained>
<Practitioner>
<id value="author19"/>
<name>
<family value="Singh"/>
<given value="Nishanta"/>
</name>
</Practitioner>
</contained>
<contained>
<Practitioner>
<id value="author20"/>
<name>
<family value="Siziba"/>
<given value="Bekezela"/>
</name>
</Practitioner>
</contained>
<contained>
<Practitioner>
<id value="author21"/>
<name>
<family value="Farrior"/>
<given value="Jennifer"/>
</name>
</Practitioner>
</contained>
<contained>
<Practitioner>
<id value="author22"/>
<name>
<family value="Rose"/>
<given value="Scott"/>
</name>
</Practitioner>
</contained>
<contained>
<Practitioner>
<id value="author23"/>
<name>
<family value="Anderson"/>
<given value="Peter L"/>
</name>
</Practitioner>
</contained>
<contained>
<Practitioner>
<id value="author24"/>
<name>
<family value="Eshleman"/>
<given value="Susan H"/>
</name>
</Practitioner>
</contained>
<contained>
<Practitioner>
<id value="author25"/>
<name>
<family value="Marzinke"/>
<given value="Mark A"/>
</name>
</Practitioner>
</contained>
<contained>
<Practitioner>
<id value="author26"/>
<name>
<family value="Hendrix"/>
<given value="Craig W"/>
</name>
</Practitioner>
</contained>
<contained>
<Practitioner>
<id value="author27"/>
<name>
<family value="Beigel-Orme"/>
<given value="Stephanie"/>
</name>
</Practitioner>
</contained>
<contained>
<Practitioner>
<id value="author28"/>
<name>
<family value="Hosek"/>
<given value="Sybil"/>
</name>
</Practitioner>
</contained>
<contained>
<Practitioner>
<id value="author29"/>
<name>
<family value="Tolley"/>
<given value="Elizabeth"/>
</name>
</Practitioner>
</contained>
<contained>
<Practitioner>
<id value="author30"/>
<name>
<family value="Sista"/>
<given value="Nirupama"/>
</name>
</Practitioner>
</contained>
<contained>
<Practitioner>
<id value="author31"/>
<name>
<family value="Adeyeye"/>
<given value="Adeola"/>
</name>
</Practitioner>
</contained>
<contained>
<Practitioner>
<id value="author32"/>
<name>
<family value="Rooney"/>
<given value="James F"/>
</name>
</Practitioner>
</contained>
<contained>
<Practitioner>
<id value="author33"/>
<name>
<family value="Rinehart"/>
<given value="Alex"/>
</name>
</Practitioner>
</contained>
<contained>
<Practitioner>
<id value="author34"/>
<name>
<family value="Spreen"/>
<given value="William R"/>
</name>
</Practitioner>
</contained>
<contained>
<Practitioner>
<id value="author35"/>
<name>
<family value="Smith"/>
<given value="Kimberly"/>
</name>
</Practitioner>
</contained>
<contained>
<Practitioner>
<id value="author36"/>
<name>
<family value="Hanscom"/>
<given value="Brett"/>
</name>
</Practitioner>
</contained>
<contained>
<Practitioner>
<id value="author37"/>
<name>
<family value="Cohen"/>
<given value="Myron S"/>
</name>
</Practitioner>
</contained>
<contained>
<Practitioner>
<id value="author38"/>
<name>
<family value="Hosseinipour"/>
<given value="Mina C"/>
</name>
</Practitioner>
</contained>
<contained>
<Organization>
<id value="author39"/>
<name value="HPTN 084 study group"/>
</Organization>
</contained>
<contained>
<ArtifactAssessment>
<id value="meshHeading0"/>
<artifactReference>
<reference value="#"/>
<type value="Citation"/>
</artifactReference>
<content>
<informationType value="classifier"/>
<type>
<coding>
<system
value="http://hl7.org/fhir/cited-artifact-classification-type"/>
<code value="mesh-heading"/>
<display value="MeSH heading"/>
</coding>
<text value="components (if present) include qualifier codings"/>
</type>
<classifier>
<coding>
<system value="https://meshb.nlm.nih.gov/"/>
<code value="D000328"/>
<display value="Adult"/>
<userSelected value="false"/>
</coding>
</classifier>
<freeToShare value="true"/>
<component>
<type>
<text value="qualifier"/>
</type>
<classifier>
<text value="is not a major topic"/>
</classifier>
</component>
</content>
<content>
<informationType value="classifier"/>
<type>
<coding>
<system
value="http://hl7.org/fhir/cited-artifact-classification-type"/>
<code value="mesh-heading"/>
<display value="MeSH heading"/>
</coding>
<text value="components (if present) include qualifier codings"/>
</type>
<classifier>
<coding>
<system value="https://meshb.nlm.nih.gov/"/>
<code value="D019380"/>
<display value="Anti-HIV Agents"/>
<userSelected value="false"/>
</coding>
</classifier>
<freeToShare value="true"/>
<component>
<type>
<text value="qualifier"/>
</type>
<classifier>
<text value="is Major topic"/>
</classifier>
</component>
</content>
<content>
<informationType value="classifier"/>
<type>
<coding>
<system
value="http://hl7.org/fhir/cited-artifact-classification-type"/>
<code value="mesh-heading"/>
<display value="MeSH heading"/>
</coding>
<text value="components (if present) include qualifier codings"/>
</type>
<classifier>
<coding>
<system value="https://meshb.nlm.nih.gov/"/>
<code value="D002648"/>
<display value="Child"/>
<userSelected value="false"/>
</coding>
</classifier>
<freeToShare value="true"/>
<component>
<type>
<text value="qualifier"/>
</type>
<classifier>
<text value="is not a major topic"/>
</classifier>
</component>
</content>
<content>
<informationType value="classifier"/>
<type>
<coding>
<system
value="http://hl7.org/fhir/cited-artifact-classification-type"/>
<code value="mesh-heading"/>
<display value="MeSH heading"/>
</coding>
<text value="components (if present) include qualifier codings"/>
</type>
<classifier>
<coding>
<system value="https://meshb.nlm.nih.gov/"/>
<code value="D054659"/>
<display value="Diketopiperazines"/>
<userSelected value="false"/>
</coding>
</classifier>
<freeToShare value="true"/>
<component>
<type>
<text value="qualifier"/>
</type>
<classifier>
<text value="is not a major topic"/>
</classifier>
</component>
</content>
<content>
<informationType value="classifier"/>
<type>
<coding>
<system
value="http://hl7.org/fhir/cited-artifact-classification-type"/>
<code value="mesh-heading"/>
<display value="MeSH heading"/>
</coding>
<text value="components (if present) include qualifier codings"/>
</type>
<classifier>
<coding>
<system value="https://meshb.nlm.nih.gov/"/>
<code value="D000068679"/>
<display value="Emtricitabine"/>
<userSelected value="false"/>
</coding>
</classifier>
<freeToShare value="true"/>
<component>
<type>
<text value="qualifier"/>
</type>
<classifier>
<text value="is not a major topic"/>
</classifier>
</component>
<component>
<type>
<text value="qualifier"/>
</type>
<classifier>
<coding>
<system value="https://meshb.nlm.nih.gov/"/>
<code value="Q000627"/>
<display value="therapeutic use"/>
</coding>
</classifier>
<component>
<type>
<text value="is Major topic"/>
</type>
<classifier>
<coding>
<system value="https://ncithesaurus.nci.nih.gov/ncitbrowser"/>
<code value="C49487"/>
<display value="No"/>
</coding>
</classifier>
</component>
</component>
</content>
<content>
<informationType value="classifier"/>
<type>
<coding>
<system
value="http://hl7.org/fhir/cited-artifact-classification-type"/>
<code value="mesh-heading"/>
<display value="MeSH heading"/>
</coding>
<text value="components (if present) include qualifier codings"/>
</type>
<classifier>
<coding>
<system value="https://meshb.nlm.nih.gov/"/>
<code value="D005260"/>
<display value="Female"/>
<userSelected value="false"/>
</coding>
</classifier>
<freeToShare value="true"/>
<component>
<type>
<text value="qualifier"/>
</type>
<classifier>
<text value="is not a major topic"/>
</classifier>
</component>
</content>
<content>
<informationType value="classifier"/>
<type>
<coding>
<system
value="http://hl7.org/fhir/cited-artifact-classification-type"/>
<code value="mesh-heading"/>
<display value="MeSH heading"/>
</coding>
<text value="components (if present) include qualifier codings"/>
</type>
<classifier>
<coding>
<system value="https://meshb.nlm.nih.gov/"/>
<code value="D015658"/>
<display value="HIV Infections"/>
<userSelected value="false"/>
</coding>
</classifier>
<freeToShare value="true"/>
<component>
<type>
<text value="qualifier"/>
</type>
<classifier>
<text value="is Major topic"/>
</classifier>
</component>
<component>
<type>
<text value="qualifier"/>
</type>
<classifier>
<coding>
<system value="https://meshb.nlm.nih.gov/"/>
<code value="Q000139"/>
<display value="chemically induced"/>
</coding>
</classifier>
<component>
<type>
<text value="is Major topic"/>
</type>
<classifier>
<coding>
<system value="https://ncithesaurus.nci.nih.gov/ncitbrowser"/>
<code value="C49487"/>
<display value="No"/>
</coding>
</classifier>
</component>
</component>
<component>
<type>
<text value="qualifier"/>
</type>
<classifier>
<coding>
<system value="https://meshb.nlm.nih.gov/"/>
<code value="Q000453"/>
<display value="epidemiology"/>
</coding>
</classifier>
<component>
<type>
<text value="is Major topic"/>
</type>
<classifier>
<coding>
<system value="https://ncithesaurus.nci.nih.gov/ncitbrowser"/>
<code value="C49487"/>
<display value="No"/>
</coding>
</classifier>
</component>
</component>
<component>
<type>
<text value="qualifier"/>
</type>
<classifier>
<coding>
<system value="https://meshb.nlm.nih.gov/"/>
<code value="Q000517"/>
<display value="prevention & control"/>
</coding>
</classifier>
<component>
<type>
<text value="is Major topic"/>
</type>
<classifier>
<coding>
<system value="https://ncithesaurus.nci.nih.gov/ncitbrowser"/>
<code value="C49487"/>
<display value="No"/>
</coding>
</classifier>
</component>
</component>
</content>
<content>
<informationType value="classifier"/>
<type>
<coding>
<system
value="http://hl7.org/fhir/cited-artifact-classification-type"/>
<code value="mesh-heading"/>
<display value="MeSH heading"/>
</coding>
<text value="components (if present) include qualifier codings"/>
</type>
<classifier>
<coding>
<system value="https://meshb.nlm.nih.gov/"/>
<code value="D006679"/>
<display value="HIV Seropositivity"/>
<userSelected value="false"/>
</coding>
</classifier>
<freeToShare value="true"/>
<component>
<type>
<text value="qualifier"/>
</type>
<classifier>
<text value="is Major topic"/>
</classifier>
</component>
<component>
<type>
<text value="qualifier"/>
</type>
<classifier>
<coding>
<system value="https://meshb.nlm.nih.gov/"/>
<code value="Q000188"/>
<display value="drug therapy"/>
</coding>
</classifier>
<component>
<type>
<text value="is Major topic"/>
</type>
<classifier>
<coding>
<system value="https://ncithesaurus.nci.nih.gov/ncitbrowser"/>
<code value="C49487"/>
<display value="No"/>
</coding>
</classifier>
</component>
</component>
</content>
<content>
<informationType value="classifier"/>
<type>
<coding>
<system
value="http://hl7.org/fhir/cited-artifact-classification-type"/>
<code value="mesh-heading"/>
<display value="MeSH heading"/>
</coding>
<text value="components (if present) include qualifier codings"/>
</type>
<classifier>
<coding>
<system value="https://meshb.nlm.nih.gov/"/>
<code value="D015497"/>
<display value="HIV-1"/>
<userSelected value="false"/>
</coding>
</classifier>
<freeToShare value="true"/>
<component>
<type>
<text value="qualifier"/>
</type>
<classifier>
<text value="is Major topic"/>
</classifier>
</component>
</content>
<content>
<informationType value="classifier"/>
<type>
<coding>
<system
value="http://hl7.org/fhir/cited-artifact-classification-type"/>
<code value="mesh-heading"/>
<display value="MeSH heading"/>
</coding>
<text value="components (if present) include qualifier codings"/>
</type>
<classifier>
<coding>
<system value="https://meshb.nlm.nih.gov/"/>
<code value="D006801"/>
<display value="Humans"/>
<userSelected value="false"/>
</coding>
</classifier>
<freeToShare value="true"/>
<component>
<type>
<text value="qualifier"/>
</type>
<classifier>
<text value="is not a major topic"/>
</classifier>
</component>
</content>
<content>
<informationType value="classifier"/>
<type>
<coding>
<system
value="http://hl7.org/fhir/cited-artifact-classification-type"/>
<code value="mesh-heading"/>
<display value="MeSH heading"/>
</coding>
<text value="components (if present) include qualifier codings"/>
</type>
<classifier>
<coding>
<system value="https://meshb.nlm.nih.gov/"/>
<code value="D007231"/>
<display value="Infant, Newborn"/>
<userSelected value="false"/>
</coding>
</classifier>
<freeToShare value="true"/>
<component>
<type>
<text value="qualifier"/>
</type>
<classifier>
<text value="is not a major topic"/>
</classifier>
</component>
</content>
<content>
<informationType value="classifier"/>
<type>
<coding>
<system
value="http://hl7.org/fhir/cited-artifact-classification-type"/>
<code value="mesh-heading"/>
<display value="MeSH heading"/>
</coding>
<text value="components (if present) include qualifier codings"/>
</type>
<classifier>
<coding>
<system value="https://meshb.nlm.nih.gov/"/>
<code value="D011247"/>
<display value="Pregnancy"/>
<userSelected value="false"/>
</coding>
</classifier>
<freeToShare value="true"/>
<component>
<type>
<text value="qualifier"/>
</type>
<classifier>
<text value="is not a major topic"/>
</classifier>
</component>
</content>
<content>
<informationType value="classifier"/>
<type>
<coding>
<system
value="http://hl7.org/fhir/cited-artifact-classification-type"/>
<code value="mesh-heading"/>
<display value="MeSH heading"/>
</coding>
<text value="components (if present) include qualifier codings"/>
</type>
<classifier>
<coding>
<system value="https://meshb.nlm.nih.gov/"/>
<code value="D011728"/>
<display value="Pyridones"/>
<userSelected value="false"/>
</coding>
</classifier>
<freeToShare value="true"/>
<component>
<type>
<text value="qualifier"/>
</type>
<classifier>
<text value="is not a major topic"/>
</classifier>
</component>
<component>
<type>
<text value="qualifier"/>
</type>
<classifier>
<coding>
<system value="https://meshb.nlm.nih.gov/"/>
<code value="Q000627"/>
<display value="therapeutic use"/>
</coding>
</classifier>
<component>
<type>
<text value="is Major topic"/>
</type>
<classifier>
<coding>
<system value="https://ncithesaurus.nci.nih.gov/ncitbrowser"/>
<code value="C49487"/>
<display value="No"/>
</coding>
</classifier>
</component>
</component>
</content>
</ArtifactAssessment>
</contained>
<url value="https://fevir.net/resources/Citation/153881"/>
<identifier>
<type>
<coding>
<system value="http://terminology.hl7.org/CodeSystem/v2-0203"/>
<code value="ACSN"/>
<display value="Accession ID"/>
</coding>
<text value="FEvIR Object Identifier"/>
</type>
<system value="https://fevir.net"/>
<value value="153881"/>
<assigner>
<display value="Computable Publishing LLC"/>
</assigner>
</identifier>
<identifier>
<system value="https://pubmed.ncbi.nlm.nih.gov"/>
<value value="35378077"/>
</identifier>
<identifier>
<system value="urn:ietf:rfc:3986"/>
<value value="urn:oid:2.16.840.1.113883.4.642.40.44.15.26"/>
</identifier>
<version value="2.0.0-ballot"/>
<title value="Delany-Moretlwe 2022 clinical trial"/>
<status value="active"/>
<date value="2024-12-19T14:29:51+00:00"/>
<publisher value="HL7 International / Clinical Decision Support"/>
<contact>
<name value="HL7 International / Clinical Decision Support"/>
<telecom>
<system value="url"/>
<value value="http://www.hl7.org/Special/committees/dss"/>
</telecom>
</contact>
<description
value="This Citation Resource is referenced in an example for the EBMonFHIR Implementation Guide."/>
<useContext>
<code>
<system value="http://hl7.org/fhir/citation-classification-type"/>
<code value="fevir-platform-use"/>
<display value="FEvIR Platform Use"/>
</code>
<valueCodeableConcept>
<coding>
<system value="http://hl7.org/fhir/citation-artifact-classifier"/>
<code value="project-specific"/>
<display value="Project Specific"/>
</coding>
</valueCodeableConcept>
</useContext>
<jurisdiction>
<coding>
<system value="http://unstats.un.org/unsd/methods/m49/m49.htm"/>
<code value="001"/>
<display value="World"/>
</coding>
</jurisdiction>
<copyright value="https://creativecommons.org/licenses/by-nc-sa/4.0/"/>
<approvalDate value="2022-05-10"/>
<lastReviewDate value="2023-03-17"/>
<author>
<name value="Brian S. Alper"/>
</author>
<author>
<name value="Computable Publishing®: MEDLINE-to-FEvIR Converter"/>
</author>
<classification>
<type>
<coding>
<system value="http://hl7.org/fhir/citation-classification-type"/>
<code value="citation-source"/>
<display value="Citation Source"/>
</coding>
</type>
<classifier>
<text value="MEDLINE"/>
</classifier>
</classification>
<classification>
<type>
<coding>
<system value="http://hl7.org/fhir/citation-classification-type"/>
<code value="medline-owner"/>
<display value="MEDLINE Citation Owner"/>
</coding>
</type>
<classifier>
<coding>
<system
value="https://www.nlm.nih.gov/bsd/licensee/elements_descriptions.html#owner_value"/>
<code value="NLM"/>
<display value="National Library of Medicine, Index Section"/>
<userSelected value="false"/>
</coding>
</classifier>
</classification>
<currentState>
<coding>
<system value="http://hl7.org/fhir/citation-status-type"/>
<code value="medline-medline"/>
<display value="Medline Citation Status of Medline"/>
</coding>
</currentState>
<currentState>
<coding>
<system value="http://hl7.org/fhir/citation-status-type"/>
<code value="pubmed-publication-status-ppublish"/>
<display value="PubMed PublicationStatus of ppublish"/>
</coding>
</currentState>
<statusDate>
<activity>
<coding>
<system value="http://hl7.org/fhir/citation-status-type"/>
<code value="pubmed-pubstatus-received"/>
<display value="PubMed Pubstatus of Received"/>
</coding>
</activity>
<period>
<end value="2022-02-27"/>
</period>
</statusDate>
<statusDate>
<activity>
<coding>
<system value="http://hl7.org/fhir/citation-status-type"/>
<code value="pubmed-pubstatus-revised"/>
<display value="PubMed Pubstatus of Revised"/>
</coding>
</activity>
<period>
<end value="2022-03-12"/>
</period>
</statusDate>
<statusDate>
<activity>
<coding>
<system value="http://hl7.org/fhir/citation-status-type"/>
<code value="pubmed-pubstatus-accepted"/>
<display value="PubMed Pubstatus of Accepted"/>
</coding>
</activity>
<period>
<end value="2022-03-14"/>
</period>
</statusDate>
<statusDate>
<activity>
<coding>
<system value="http://hl7.org/fhir/citation-status-type"/>
<code value="pubmed-pubstatus-pubmed"/>
<display value="PubMed Pubstatus of Pubmed"/>
</coding>
</activity>
<period>
<end value="2022-04-05T06:00:00.000Z"/>
</period>
</statusDate>
<statusDate>
<activity>
<coding>
<system value="http://hl7.org/fhir/citation-status-type"/>
<code value="pubmed-pubstatus-medline"/>
<display value="PubMed Pubstatus of Medline"/>
</coding>
</activity>
<period>
<end value="2022-05-11T06:00:00.000Z"/>
</period>
</statusDate>
<statusDate>
<activity>
<coding>
<system value="http://hl7.org/fhir/citation-status-type"/>
<code value="pubmed-pubstatus-entrez"/>
<display value="PubMed Pubstatus of Entrez"/>
</coding>
</activity>
<period>
<end value="2022-04-04T20:10:00.000Z"/>
</period>
</statusDate>
<citedArtifact>
<identifier>
<system value="https://pubmed.ncbi.nlm.nih.gov"/>
<value value="35378077"/>
</identifier>
<identifier>
<system value="https://www.ncbi.nlm.nih.gov/pmc/"/>
<value value="PMC9077443"/>
</identifier>
<identifier>
<system value="https://doi.org"/>
<value value="10.1016/S0140-6736(22)00538-4"/>
</identifier>
<identifier>
<type>
<coding>
<system value="http://terminology.hl7.org/CodeSystem/v2-0203"/>
<code value="ACSN"/>
<display value="Accession ID"/>
</coding>
<text value="pii"/>
</type>
<value value="S0140-6736(22)00538-4"/>
</identifier>
<relatedIdentifier>
<system value="https://clinicaltrials.gov"/>
<value value="NCT03164564"/>
<assigner>
<display value="ClinicalTrials.gov"/>
</assigner>
</relatedIdentifier>
<title>
<type>
<coding>
<system value="http://hl7.org/fhir/title-type"/>
<code value="primary"/>
<display value="Primary title"/>
</coding>
</type>
<language>
<coding>
<system value="urn:ietf:bcp:47"/>
<code value="en"/>
<display value="English"/>
</coding>
</language>
<text
value="Cabotegravir for the prevention of HIV-1 in women: results from HPTN 084, a phase 3, randomised clinical trial."/>
</title>
<abstract>
<text
value="**BACKGROUND:** Oral pre-exposure prophylaxis has been introduced in more than 70 countries, including many in sub-Saharan Africa, but women experience considerable barriers to daily pill-taking, such as stigma, judgement, and the fear of violence. Safe and effective long-acting agents for HIV prevention are needed for women. We aimed to evaluate the safety and efficacy of injectable cabotegravir compared with daily oral tenofovir diphosphate plus emtricitabine (TDF-FTC) for HIV prevention in HIV-uninfected women.
**METHODS:** HPTN 084 was a phase 3, randomised, double-blind, double-dummy, active-controlled, superiority trial in 20 clinical research sites in seven countries in sub-Saharan Africa. Participants were eligible for enrolment if they were assigned female sex at birth, were aged 18-45 years, reported at least two episodes of vaginal intercourse in the previous 30 days, were at risk of HIV infection based on an HIV risk score, and agreed to use a long-acting reversible contraceptive method. Participants were randomly assigned (1:1) to either active cabotegravir with TDF-FTC placebo (cabotegravir group) or active TDF-FTC with cabotegravir placebo (TDF-FTC group). Study staff and participants were masked to study group allocation, with the exception of the site pharmacist who was responsible for study product preparation. Participants were prescribed 5 weeks of daily oral product followed by intramuscular injections every 8 weeks after an initial 4-week interval load, alongside daily oral pills. Participants who discontinued injections were offered open-label daily TDF-FTC for 48 weeks. The primary endpoints of the study were incident HIV infection in the intention-to-treat population, and clinical and laboratory events that were grade 2 or higher in all women who had received at least one dose of study product. This study is registered with ClinicalTrials.gov, NCT03164564.
**FINDINGS:** From Nov 27, 2017, to Nov 4, 2020, we enrolled 3224 participants (1614 in the cabotegravir group and 1610 in the TDF-FTC group). Median age was 25 years (IQR 22-30); 1755 (54·7%) of 3209 had two or more partners in the preceding month. 40 incident infections were observed over 3898 person-years (HIV incidence 1·0% [95% CI 0·73-1·40]); four in the cabotegravir group (HIV incidence 0·2 cases per 100 person-years [0·06-0·52]) and 36 in the TDF-FTC group (1·85 cases per 100 person-years [1·3-2·57]; hazard ratio 0·12 [0·05-0·31]; p&lt;0·0001; risk difference -1·6% [-1·0% to -2·3%]. In a random subset of 405 TDF-FTC participants, 812 (42·1%) of 1929 plasma samples had tenofovir concentrations consistent with daily use. Injection coverage was 93% of the total number of person-years. Adverse event rates were similar across both groups, apart from injection site reactions, which were more frequent in the cabotegravir group than in the TDF-FTC group (577 [38·0%] of 1519 vs 162 [10·7%] of 1516]) but did not result in injection discontinuation. Confirmed pregnancy incidence was 1·3 per 100 person-years (0·9-1·7); no congenital birth anomalies were reported.
**INTERPRETATION:** Although both products for HIV prevention were generally safe, well tolerated, and effective, cabotegravir was superior to TDF-FTC in preventing HIV infection in women.
**FUNDING:** National Institute of Allergy and Infectious Diseases, ViiV Healthcare, and the Bill &amp; Melinda Gates Foundation. Additional support was provided through the National Institute of Mental Health, the National Institute on Drug Abuse, and the Eunice Kennedy Shriver National Institute of Child Health and Human Development. ViiV Healthcare and Gilead Sciences provided pharmaceutical support."/>
<copyright
value="Copyright © 2022 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license. Published by Elsevier Ltd.. All rights reserved."/>
</abstract>
<relatesTo>
<type value="cites"/>
<citation
value="UNAIDS Confronting inequalities: lessons for pandemic responses from 40 years of AIDS. July 14, 2021. https://www.unaids.org/en/resources/documents/2021/2021-global-aids-update-slideset"/>
</relatesTo>
<relatesTo>
<type value="cites"/>
<citation
value="WHO . World Health Organization; Geneva: 2015. Policy brief: pre-exposure prophylaxis (PrEP): WHO expands recommendation on oral pre-exposure prophylaxis of HIV infection (PrEP)"/>
</relatesTo>
<relatesTo>
<type value="cites"/>
<classifier>
<coding>
<system value="http://hl7.org/fhir/citation-artifact-classifier"/>
<code value="D016428"/>
<display value="Journal Article"/>
</coding>
</classifier>
<citation
value="Celum CL, Delany-Moretlwe S, Baeten JM, et al. HIV pre-exposure prophylaxis for adolescent girls and young women in Africa: from efficacy trials to delivery. J Int AIDS Soc. 2019;22(suppl 4)"/>
<document>
<url value="https://pubmed.ncbi.nlm.nih.gov/31328444/"/>
</document>
<resourceReference>
<identifier>
<system value="https://pubmed.ncbi.nlm.nih.gov"/>
<value value="31328444"/>
<assigner>
<display value="NLM"/>
</assigner>
</identifier>
</resourceReference>
</relatesTo>
<relatesTo>
<type value="cites"/>
<classifier>
<coding>
<system value="http://hl7.org/fhir/citation-artifact-classifier"/>
<code value="D016428"/>
<display value="Journal Article"/>
</coding>
</classifier>
<citation
value="Velloza J, Khoza N, Scorgie F, et al. The influence of HIV-related stigma on PrEP disclosure and adherence among adolescent girls and young women in HPTN 082: a qualitative study. J Int AIDS Soc. 2020;23"/>
<document>
<url value="https://pubmed.ncbi.nlm.nih.gov/32144874/"/>
</document>
<resourceReference>
<identifier>
<system value="https://pubmed.ncbi.nlm.nih.gov"/>
<value value="32144874"/>
<assigner>
<display value="NLM"/>
</assigner>
</identifier>
</resourceReference>
</relatesTo>
<relatesTo>
<type value="cites"/>
<classifier>
<coding>
<system value="http://hl7.org/fhir/citation-artifact-classifier"/>
<code value="D016428"/>
<display value="Journal Article"/>
</coding>
</classifier>
<citation
value="Cottrell ML, Yang KH, Prince HM, et al. A translational pharmacology approach to predicting outcomes of preexposure prophylaxis against HIV in men and women using tenofovir disoproxil fumarate with or without emtricitabine. J Infect Dis. 2016;214:55–64."/>
<document>
<url value="https://pubmed.ncbi.nlm.nih.gov/26917574/"/>
</document>
<resourceReference>
<identifier>
<system value="https://pubmed.ncbi.nlm.nih.gov"/>
<value value="26917574"/>
<assigner>
<display value="NLM"/>
</assigner>
</identifier>
</resourceReference>
</relatesTo>
<relatesTo>
<type value="cites"/>
<classifier>
<coding>
<system value="http://hl7.org/fhir/citation-artifact-classifier"/>
<code value="D016428"/>
<display value="Journal Article"/>
</coding>
</classifier>
<citation
value="Andrews CD, Yueh YL, Spreen WR, et al. A long-acting integrase inhibitor protects female macaques from repeated high-dose intravaginal SHIV challenge. Sci Transl Med. 2015;7"/>
<document>
<url value="https://pubmed.ncbi.nlm.nih.gov/25589630/"/>
</document>
<resourceReference>
<identifier>
<system value="https://pubmed.ncbi.nlm.nih.gov"/>
<value value="25589630"/>
<assigner>
<display value="NLM"/>
</assigner>
</identifier>
</resourceReference>
</relatesTo>
<relatesTo>
<type value="cites"/>
<classifier>
<coding>
<system value="http://hl7.org/fhir/citation-artifact-classifier"/>
<code value="D016428"/>
<display value="Journal Article"/>
</coding>
</classifier>
<citation
value="Radzio J, Spreen W, Yueh YL, et al. The long-acting integrase inhibitor GSK744 protects macaques from repeated intravaginal SHIV challenge. Sci Transl Med. 2015;7"/>
<document>
<url value="https://pubmed.ncbi.nlm.nih.gov/25589631/"/>
</document>
<resourceReference>
<identifier>
<system value="https://pubmed.ncbi.nlm.nih.gov"/>
<value value="25589631"/>
<assigner>
<display value="NLM"/>
</assigner>
</identifier>
</resourceReference>
</relatesTo>
<relatesTo>
<type value="cites"/>
<classifier>
<coding>
<system value="http://hl7.org/fhir/citation-artifact-classifier"/>
<code value="D016428"/>
<display value="Journal Article"/>
</coding>
</classifier>
<citation
value="Markowitz M, Frank I, Grant RM, et al. Safety and tolerability of long-acting cabotegravir injections in HIV-uninfected men (ECLAIR): a multicentre, double-blind, randomised, placebo-controlled, phase 2a trial. Lancet HIV. 2017;4:e331–e340."/>
<document>
<url value="https://pubmed.ncbi.nlm.nih.gov/28546090/"/>
</document>
<resourceReference>
<identifier>
<system value="https://pubmed.ncbi.nlm.nih.gov"/>
<value value="28546090"/>
<assigner>
<display value="NLM"/>
</assigner>
</identifier>
</resourceReference>
</relatesTo>
<relatesTo>
<type value="cites"/>
<classifier>
<coding>
<system value="http://hl7.org/fhir/citation-artifact-classifier"/>
<code value="D016428"/>
<display value="Journal Article"/>
</coding>
</classifier>
<citation
value="Landovitz RJ, Li S, Grinsztejn B, et al. Safety, tolerability, and pharmacokinetics of long-acting injectable cabotegravir in low-risk HIV-uninfected individuals: HPTN 077, a phase 2a randomized controlled trial. PLoS Med. 2018;15"/>
<document>
<url value="https://pubmed.ncbi.nlm.nih.gov/30408115/"/>
</document>
<resourceReference>
<identifier>
<system value="https://pubmed.ncbi.nlm.nih.gov"/>
<value value="30408115"/>
<assigner>
<display value="NLM"/>
</assigner>
</identifier>
</resourceReference>
</relatesTo>
<relatesTo>
<type value="cites"/>
<classifier>
<coding>
<system value="http://hl7.org/fhir/citation-artifact-classifier"/>
<code value="D016428"/>
<display value="Journal Article"/>
</coding>
</classifier>
<citation
value="Landovitz RJ, Donnell D, Clement ME, et al. Cabotegravir for HIV prevention in cisgender men and transgender women. N Engl J Med. 2021;385:595–608."/>
<document>
<url value="https://pubmed.ncbi.nlm.nih.gov/34379922/"/>
</document>
<resourceReference>
<identifier>
<system value="https://pubmed.ncbi.nlm.nih.gov"/>
<value value="34379922"/>
<assigner>
<display value="NLM"/>
</assigner>
</identifier>
</resourceReference>
</relatesTo>
<relatesTo>
<type value="cites"/>
<classifier>
<coding>
<system value="http://hl7.org/fhir/citation-artifact-classifier"/>
<code value="D016428"/>
<display value="Journal Article"/>
</coding>
</classifier>
<citation
value="Balkus JE, Brown E, Palanee T, et al. An empiric HIV risk scoring tool to predict HIV-1 acquisition in African women. J Acquir Immune Defic Syndr. 2016;72:333–343."/>
<document>
<url value="https://pubmed.ncbi.nlm.nih.gov/26918545/"/>
</document>
<resourceReference>
<identifier>
<system value="https://pubmed.ncbi.nlm.nih.gov"/>
<value value="26918545"/>
<assigner>
<display value="NLM"/>
</assigner>
</identifier>
</resourceReference>
</relatesTo>
<relatesTo>
<type value="cites"/>
<classifier>
<coding>
<system value="http://hl7.org/fhir/citation-artifact-classifier"/>
<code value="D016428"/>
<display value="Journal Article"/>
</coding>
</classifier>
<citation
value="Eshleman SH, Fogel JM, Piwowar-Manning E, et al. Characterization of HIV infections in women who received injectable cabotegravir or tenofovir disoproxil fumarate/emtricitabine for HIV prevention: HPTN 084. J Infect Dis (in press)."/>
<document>
<url value="https://pubmed.ncbi.nlm.nih.gov/35301540/"/>
</document>
<resourceReference>
<identifier>
<system value="https://pubmed.ncbi.nlm.nih.gov"/>
<value value="35301540"/>
<assigner>
<display value="NLM"/>
</assigner>
</identifier>
</resourceReference>
</relatesTo>
<relatesTo>
<type value="cites"/>
<classifier>
<coding>
<system value="http://hl7.org/fhir/citation-artifact-classifier"/>
<code value="D016428"/>
<display value="Journal Article"/>
</coding>
</classifier>
<citation
value="Castillo-Mancilla JR, Zheng JH, Rower JE, et al. Tenofovir, emtricitabine, and tenofovir diphosphate in dried blood spots for determining recent and cumulative drug exposure. AIDS Res Hum Retroviruses. 2013;29:384–390."/>
<document>
<url value="https://pubmed.ncbi.nlm.nih.gov/22935078/"/>
</document>
<resourceReference>
<identifier>
<system value="https://pubmed.ncbi.nlm.nih.gov"/>
<value value="22935078"/>
<assigner>
<display value="NLM"/>
</assigner>
</identifier>
</resourceReference>
</relatesTo>
<relatesTo>
<type value="cites"/>
<classifier>
<coding>
<system value="http://hl7.org/fhir/citation-artifact-classifier"/>
<code value="D016428"/>
<display value="Journal Article"/>
</coding>
</classifier>
<citation
value="Anderson PL, Liu AY, Castillo-Mancilla JR, et al. Intracellular tenofovir-diphosphate and emtricitabine-triphosphate in dried blood spots following directly observed therapy. Antimicrob Agents Chemother. 2017;62:e01710–e01717."/>
<document>
<url value="https://pubmed.ncbi.nlm.nih.gov/29038282/"/>
</document>
<resourceReference>
<identifier>
<system value="https://pubmed.ncbi.nlm.nih.gov"/>
<value value="29038282"/>
<assigner>
<display value="NLM"/>
</assigner>
</identifier>
</resourceReference>
</relatesTo>
<relatesTo>
<type value="cites"/>
<classifier>
<coding>
<system value="http://hl7.org/fhir/citation-artifact-classifier"/>
<code value="D016428"/>
<display value="Journal Article"/>
</coding>
</classifier>
<citation
value="Hendrix CW, Andrade A, Bumpus NN, et al. Dose frequency ranging pharmacokinetic study of tenofovir-emtricitabine after directly observed dosing in healthy volunteers to establish adherence benchmarks (HPTN 066) AIDS Res Hum Retroviruses. 2016;32:32–43."/>
<document>
<url value="https://pubmed.ncbi.nlm.nih.gov/26414912/"/>
</document>
<resourceReference>
<identifier>
<system value="https://pubmed.ncbi.nlm.nih.gov"/>
<value value="26414912"/>
<assigner>
<display value="NLM"/>
</assigner>
</identifier>
</resourceReference>
</relatesTo>
<relatesTo>
<type value="cites"/>
<classifier>
<coding>
<system value="http://hl7.org/fhir/citation-artifact-classifier"/>
<code value="D016428"/>
<display value="Journal Article"/>
</coding>
</classifier>
<citation
value="Donnell D, Baeten JM, Bumpus NN, et al. HIV protective efficacy and correlates of tenofovir blood concentrations in a clinical trial of PrEP for HIV prevention. J Acquir Immune Defic Syndr. 2014;66:340–348."/>
<document>
<url value="https://pubmed.ncbi.nlm.nih.gov/24784763/"/>
</document>
<resourceReference>
<identifier>
<system value="https://pubmed.ncbi.nlm.nih.gov"/>
<value value="24784763"/>
<assigner>
<display value="NLM"/>
</assigner>
</identifier>
</resourceReference>
</relatesTo>
<relatesTo>
<type value="cites"/>
<classifier>
<coding>
<system value="http://hl7.org/fhir/citation-artifact-classifier"/>
<code value="D016428"/>
<display value="Journal Article"/>
</coding>
</classifier>
<citation
value="Marzinke MA, Grinsztejn B, Fogel JM, et al. Characterization of human immunodeficiency virus (HIV) infection in cisgender men and transgender women who have sex with men receiving injectable cabotegravir for HIV prevention: HPTN 083. J Infect Dis. 2021;224:1581–1592."/>
<document>
<url value="https://pubmed.ncbi.nlm.nih.gov/33740057/"/>
</document>
<resourceReference>
<identifier>
<system value="https://pubmed.ncbi.nlm.nih.gov"/>
<value value="33740057"/>
<assigner>
<display value="NLM"/>
</assigner>
</identifier>
</resourceReference>
</relatesTo>
<relatesTo>
<type value="cites"/>
<citation
value="US Department of Health and Human Services Division of AIDS (DAIDS) table for grading the severity of adult and pediatric adverse events, corrected version 2.1. July, 2017. https://rsc.niaid.nih.gov/sites/default/files/daidsgradingcorrectedv21.pdf"/>
</relatesTo>
<relatesTo>
<type value="cites"/>
<citation
value="Emerson SS, Fleming TR. Parameter estimation following group sequential hypothesis testing. Biometrika. 1990;77:875–892."/>
</relatesTo>
<relatesTo>
<type value="cites"/>
<classifier>
<coding>
<system value="http://hl7.org/fhir/citation-artifact-classifier"/>
<code value="D016428"/>
<display value="Journal Article"/>
</coding>
</classifier>
<citation
value="Corey L, Gilbert PB, Juraska M, et al. Two randomized trials of neutralizing antibodies to prevent HIV-1 acquisition. N Engl J Med. 2021;384:1003–1014."/>
<document>
<url value="https://pubmed.ncbi.nlm.nih.gov/33730454/"/>
</document>
<resourceReference>
<identifier>
<system value="https://pubmed.ncbi.nlm.nih.gov"/>
<value value="33730454"/>
<assigner>
<display value="NLM"/>
</assigner>
</identifier>
</resourceReference>
</relatesTo>
<relatesTo>
<type value="cites"/>
<classifier>
<coding>
<system value="http://hl7.org/fhir/citation-artifact-classifier"/>
<code value="D016428"/>
<display value="Journal Article"/>
</coding>
</classifier>
<citation
value="Gray GE, Bekker LG, Laher F, et al. Vaccine efficacy of ALVAC-HIV and bivalent subtype C gp120-MF59 in adults. N Engl J Med. 2021;384:1089–1100."/>
<document>
<url value="https://pubmed.ncbi.nlm.nih.gov/33761206/"/>
</document>
<resourceReference>
<identifier>
<system value="https://pubmed.ncbi.nlm.nih.gov"/>
<value value="33761206"/>
<assigner>
<display value="NLM"/>
</assigner>
</identifier>
</resourceReference>
</relatesTo>
<relatesTo>
<type value="cites"/>
<citation
value="Palanee-Phillips T, Baeten J, Heller K, et al. HIV incidence remains high in women in South Africa: data from the ECHO trial. 10th International AIDS Society Conference on HIV Science; July 21–24, 2019 (abstr LBPEC23)."/>
</relatesTo>
<relatesTo>
<type value="cites"/>
<classifier>
<coding>
<system value="http://hl7.org/fhir/citation-artifact-classifier"/>
<code value="D016428"/>
<display value="Journal Article"/>
</coding>
</classifier>
<citation
value="Pillay D, Stankevitz K, Lanham M, et al. Factors influencing uptake, continuation, and discontinuation of oral PrEP among clients at sex worker and MSM facilities in South Africa. PLoS One. 2020;15"/>
<document>
<url value="https://pubmed.ncbi.nlm.nih.gov/32352969/"/>
</document>
<resourceReference>
<identifier>
<system value="https://pubmed.ncbi.nlm.nih.gov"/>
<value value="32352969"/>
<assigner>
<display value="NLM"/>
</assigner>
</identifier>
</resourceReference>
</relatesTo>
<relatesTo>
<type value="cites"/>
<classifier>
<coding>
<system value="http://hl7.org/fhir/citation-artifact-classifier"/>
<code value="D016428"/>
<display value="Journal Article"/>
</coding>
</classifier>
<citation
value="Bärnighausen K, Geldsetzer P, Matse S, et al. Qualitative accounts of PrEP discontinuation from the general population in Eswatini. Cult Health Sex. 2021;23:1198–1214."/>
<document>
<url value="https://pubmed.ncbi.nlm.nih.gov/32633617/"/>
</document>
<resourceReference>
<identifier>
<system value="https://pubmed.ncbi.nlm.nih.gov"/>
<value value="32633617"/>
<assigner>
<display value="NLM"/>
</assigner>
</identifier>
</resourceReference>
</relatesTo>
<relatesTo>
<type value="cites"/>
<classifier>
<coding>
<system value="http://hl7.org/fhir/citation-artifact-classifier"/>
<code value="D016428"/>
<display value="Journal Article"/>
</coding>
</classifier>
<citation
value="Quaife M, Eakle R, Cabrera Escobar MA, et al. Divergent preferences for HIV prevention: a discrete choice experiment for multipurpose HIV prevention products in South Africa. Med Decis Making. 2018;38:120–133."/>
<document>
<url value="https://pubmed.ncbi.nlm.nih.gov/28863752/"/>
</document>
<resourceReference>
<identifier>
<system value="https://pubmed.ncbi.nlm.nih.gov"/>
<value value="28863752"/>
<assigner>
<display value="NLM"/>
</assigner>
</identifier>
</resourceReference>
</relatesTo>
<relatesTo>
<type value="cites"/>
<classifier>
<coding>
<system value="http://hl7.org/fhir/citation-artifact-classifier"/>
<code value="D016428"/>
<display value="Journal Article"/>
</coding>
</classifier>
<citation
value="Minnis AM, Browne EN, Boeri M, et al. Young women's stated preferences for biomedical HIV prevention: results of a discrete choice experiment in Kenya and South Africa. J Acquir Immune Defic Syndr. 2019;80:394–403."/>
<document>
<url value="https://pubmed.ncbi.nlm.nih.gov/30633040/"/>
</document>
<resourceReference>
<identifier>
<system value="https://pubmed.ncbi.nlm.nih.gov"/>
<value value="30633040"/>
<assigner>
<display value="NLM"/>
</assigner>
</identifier>
</resourceReference>
</relatesTo>
<relatesTo>
<type value="cites"/>
<classifier>
<coding>
<system value="http://hl7.org/fhir/citation-artifact-classifier"/>
<code value="D016428"/>
<display value="Journal Article"/>
</coding>
</classifier>
<citation
value="Laher F, Salami T, Hornschuh S, et al. Willingness to use HIV prevention methods among vaccine efficacy trial participants in Soweto, South Africa: discretion is important. BMC Public Health. 2020;20"/>
<document>
<url value="https://pubmed.ncbi.nlm.nih.gov/33160341/"/>
</document>
<resourceReference>
<identifier>
<system value="https://pubmed.ncbi.nlm.nih.gov"/>
<value value="33160341"/>
<assigner>
<display value="NLM"/>
</assigner>
</identifier>
</resourceReference>
</relatesTo>
<relatesTo>
<type value="cites"/>
<classifier>
<coding>
<system value="http://hl7.org/fhir/citation-artifact-classifier"/>
<code value="D016428"/>
<display value="Journal Article"/>
</coding>
</classifier>
<citation
value="Marrazzo JM, Ramjee G, Richardson BA, et al. Tenofovir-based preexposure prophylaxis for HIV infection among African women. N Engl J Med. 2015;372:509–518."/>
<document>
<url value="https://pubmed.ncbi.nlm.nih.gov/25651245/"/>
</document>
<resourceReference>
<identifier>
<system value="https://pubmed.ncbi.nlm.nih.gov"/>
<value value="25651245"/>
<assigner>
<display value="NLM"/>
</assigner>
</identifier>
</resourceReference>
</relatesTo>
<relatesTo>
<type value="cites"/>
<classifier>
<coding>
<system value="http://hl7.org/fhir/citation-artifact-classifier"/>
<code value="D016428"/>
<display value="Journal Article"/>
</coding>
</classifier>
<citation
value="Baeten JM, Brown ER, Hillier SL. Dapivirine vaginal ring for HIV-1 prevention. N Engl J Med. 2017;376:995–996."/>
<document>
<url value="https://pubmed.ncbi.nlm.nih.gov/28273023/"/>
</document>
<resourceReference>
<identifier>
<system value="https://pubmed.ncbi.nlm.nih.gov"/>
<value value="28273023"/>
<assigner>
<display value="NLM"/>
</assigner>
</identifier>
</resourceReference>
</relatesTo>
<relatesTo>
<type value="cites"/>
<classifier>
<coding>
<system value="http://hl7.org/fhir/citation-artifact-classifier"/>
<code value="D016428"/>
<display value="Journal Article"/>
</coding>
</classifier>
<citation
value="Venter WDF, Moorhouse M, Sokhela S, et al. Dolutegravir plus two different prodrugs of tenofovir to treat HIV. N Engl J Med. 2019;381:803–815."/>
<document>
<url value="https://pubmed.ncbi.nlm.nih.gov/31339677/"/>
</document>
<resourceReference>
<identifier>
<system value="https://pubmed.ncbi.nlm.nih.gov"/>
<value value="31339677"/>
<assigner>
<display value="NLM"/>
</assigner>
</identifier>
</resourceReference>
</relatesTo>
<relatesTo>
<type value="cites"/>
<classifier>
<coding>
<system value="http://hl7.org/fhir/citation-artifact-classifier"/>
<code value="D016428"/>
<display value="Journal Article"/>
</coding>
</classifier>
<citation
value="Landovitz RJ, Zangeneh SZ, Chau G, et al. Cabotegravir is not associated with weight gain in human immunodeficiency virus-uninfected individuals in HPTN 077. Clin Infect Dis. 2020;70:319–322."/>
<document>
<url value="https://pubmed.ncbi.nlm.nih.gov/31125395/"/>
</document>
<resourceReference>
<identifier>
<system value="https://pubmed.ncbi.nlm.nih.gov"/>
<value value="31125395"/>
<assigner>
<display value="NLM"/>
</assigner>
</identifier>
</resourceReference>
</relatesTo>
<relatesTo>
<type value="cites"/>
<citation
value="Eshleman S, Fogel JM, Halvas EK, et al. CAB-LA PrEP: early detection of HIV infection may reduce InSTI resistance risk. 29th Conference on Retroviruses and Opportunistic Infections; Feb 12–16, 2022 (abstr Oral-08)."/>
</relatesTo>
<relatesTo>
<type value="comment-in"/>
<classifier>
<coding>
<system value="https://meshb.nlm.nih.gov/"/>
<code value="D016420"/>
<display value="Comment"/>
<userSelected value="false"/>
</coding>
</classifier>
<citation value="Lancet. 2022 May 7;399(10337):1754-1755"/>
<document>
<url value="https://pubmed.ncbi.nlm.nih.gov/35378079/"/>
</document>
<resourceReference>
<identifier>
<system value="https://pubmed.ncbi.nlm.nih.gov"/>
<value value="35378079"/>
<assigner>
<display value="NLM"/>
</assigner>
</identifier>
</resourceReference>
</relatesTo>
<relatesTo>
<type value="correction-in"/>
<classifier>
<coding>
<system value="https://meshb.nlm.nih.gov/"/>
<code value="D016425"/>
<display value="Published Erratum"/>
<userSelected value="false"/>
</coding>
</classifier>
<citation value="Lancet. 2022 May 7;399(10337):1778"/>
<document>
<url value="https://pubmed.ncbi.nlm.nih.gov/35526551/"/>
</document>
<resourceReference>
<identifier>
<system value="https://pubmed.ncbi.nlm.nih.gov"/>
<value value="35526551"/>
<assigner>
<display value="NLM"/>
</assigner>
</identifier>
</resourceReference>
</relatesTo>
<relatesTo>
<type value="comment-in"/>
<classifier>
<coding>
<system value="https://meshb.nlm.nih.gov/"/>
<code value="D016420"/>
<display value="Comment"/>
<userSelected value="false"/>
</coding>
</classifier>
<citation value="Nat Med. 2022 Aug;28(8):1542-1543"/>
<document>
<url value="https://pubmed.ncbi.nlm.nih.gov/35869309/"/>
</document>
<resourceReference>
<identifier>
<system value="https://pubmed.ncbi.nlm.nih.gov"/>
<value value="35869309"/>
<assigner>
<display value="NLM"/>
</assigner>
</identifier>
</resourceReference>
</relatesTo>
<relatesTo>
<type value="comment-in"/>
<classifier>
<coding>
<system value="https://meshb.nlm.nih.gov/"/>
<code value="D016420"/>
<display value="Comment"/>
<userSelected value="false"/>
</coding>
</classifier>
<citation value="Nature. 2022 Aug;608(7923):460-461"/>
<document>
<url value="https://pubmed.ncbi.nlm.nih.gov/35931763/"/>
</document>
<resourceReference>
<identifier>
<system value="https://pubmed.ncbi.nlm.nih.gov"/>
<value value="35931763"/>
<assigner>
<display value="NLM"/>
</assigner>
</identifier>
</resourceReference>
</relatesTo>
<relatesTo>
<type value="comment-in"/>
<classifier>
<coding>
<system value="https://meshb.nlm.nih.gov/"/>
<code value="D016420"/>
<display value="Comment"/>
<userSelected value="false"/>
</coding>
</classifier>
<citation value="Nature. 2022 Aug;608(7922):239"/>
<document>
<url value="https://pubmed.ncbi.nlm.nih.gov/35945377/"/>
</document>
<resourceReference>
<identifier>
<system value="https://pubmed.ncbi.nlm.nih.gov"/>
<value value="35945377"/>
<assigner>
<display value="NLM"/>
</assigner>
</identifier>
</resourceReference>
</relatesTo>
<publicationForm>
<publishedIn>
<type>
<coding>
<system value="http://hl7.org/fhir/published-in-type"/>
<code value="D020492"/>
<display value="Periodical"/>
</coding>
</type>
<identifier>
<type>
<coding>
<system
value="https://www.nlm.nih.gov/bsd/licensee/elements_descriptions.html#issn"/>
<code value="Electronic"/>
<display value="Electronic"/>
</coding>
<text value="Electronic ISSN Type"/>
</type>
<system value="https://portal.issn.org"/>
<value value="1474-547X"/>
</identifier>
<identifier>
<type>
<coding>
<system value="http://terminology.hl7.org/CodeSystem/v2-0203"/>
<code value="XX"/>
<display value="Organization identifier"/>
</coding>
<text value="ISOAbbreviation"/>
</type>
<system
value="https://www.issn.org/services/online-services/access-to-the-ltwa/"/>
<value value="Lancet"/>
</identifier>
<identifier>
<type>
<coding>
<system value="http://terminology.hl7.org/CodeSystem/v2-0203"/>
<code value="XX"/>
<display value="Organization identifier"/>
</coding>
<text value="ISSN Linking"/>
</type>
<system
value="https://www.issn.org/understanding-the-issn/assignment-rules/the-issn-l-for-publications-on-multiple-media/"/>
<value value="0140-6736"/>
</identifier>
<identifier>
<type>
<coding>
<system value="http://terminology.hl7.org/CodeSystem/v2-0203"/>
<code value="XX"/>
<display value="Organization identifier"/>
</coding>
<text value="Medline Title Abbreviation"/>
</type>
<system
value="https://www.nlm.nih.gov/tsd/cataloging/contructitleabbre.html"/>
<value value="Lancet"/>
</identifier>
<identifier>
<type>
<coding>
<system value="http://terminology.hl7.org/CodeSystem/v2-0203"/>
<code value="XX"/>
<display value="Organization identifier"/>
</coding>
<text value="NLM Unique ID"/>
</type>
<system
value="https://locatorplus.gov/cgi-bin/Pwebrecon.cgi?DB=local"/>
<value value="2985213R"/>
</identifier>
<title value="Lancet (London, England)"/>
<publisherLocation value="England"/>
</publishedIn>
<citedMedium>
<coding>
<system value="http://hl7.org/fhir/cited-medium"/>
<code value="internet"/>
<display value="Internet"/>
</coding>
</citedMedium>
<volume value="399"/>
<issue value="10337"/>
<articleDate value="2022-05-07"/>
<publicationDateText value="2022-May-07"/>
<language>
<coding>
<system value="urn:ietf:bcp:47"/>
<code value="en"/>
<display value="English"/>
</coding>
</language>
<pageString value="1779-1789"/>
</publicationForm>
<publicationForm>
<citedMedium>
<coding>
<system value="http://hl7.org/fhir/cited-medium"/>
<code value="internet-without-issue"/>
<display value="Internet without issue"/>
</coding>
</citedMedium>
<articleDate value="2022-04-01"/>
</publicationForm>
<webLocation>
<classifier>
<coding>
<system value="http://hl7.org/fhir/artifact-url-classifier"/>
<code value="abstract"/>
<display value="Abstract"/>
</coding>
</classifier>
<url value="https://pubmed.ncbi.nlm.nih.gov/35378077/"/>
</webLocation>
<webLocation>
<classifier>
<coding>
<system value="http://hl7.org/fhir/artifact-url-classifier"/>
<code value="doi-based"/>
<display value="DOI Based"/>
</coding>
</classifier>
<url value="https://doi.org/10.1016/S0140-6736(22)00538-4"/>
</webLocation>
<classification>
<type>
<coding>
<system
value="http://hl7.org/fhir/cited-artifact-classification-type"/>
<code value="publishing-model"/>
<display value="Publishing Model"/>
<userSelected value="false"/>
</coding>
</type>
<classifier>
<coding>
<system value="http://hl7.org/fhir/citation-artifact-classifier"/>
<code value="Print-Electronic"/>
<display value="Print Electronic"/>
<userSelected value="false"/>
</coding>
</classifier>
</classification>
<classification>
<type>
<coding>
<system
value="http://hl7.org/fhir/cited-artifact-classification-type"/>
<code value="chemical"/>
<display value="Chemical"/>
<userSelected value="false"/>
</coding>
</type>
<classifier>
<coding>
<system value="https://meshb.nlm.nih.gov/"/>
<code value="D019380"/>
<display value="Anti-HIV Agents"/>
<userSelected value="false"/>
</coding>
</classifier>
<classifier>
<coding>
<system value="https://meshb.nlm.nih.gov/"/>
<code value="D054659"/>
<display value="Diketopiperazines"/>
<userSelected value="false"/>
</coding>
</classifier>
<classifier>
<coding>
<system value="https://meshb.nlm.nih.gov/"/>
<code value="D011728"/>
<display value="Pyridones"/>
<userSelected value="false"/>
</coding>
</classifier>
<classifier>
<coding>
<system
value="https://www.cas.org/support/documentation/chemical-substances"/>
<code value="G70B4ETF4S"/>
<userSelected value="false"/>
</coding>
<coding>
<system value="https://meshb.nlm.nih.gov/"/>
<code value="D000068679"/>
<display value="Emtricitabine"/>
<userSelected value="false"/>
</coding>
</classifier>
<classifier>
<coding>
<system
value="https://www.cas.org/support/documentation/chemical-substances"/>
<code value="HMH0132Z1Q"/>
<userSelected value="false"/>
</coding>
<coding>
<system value="https://meshb.nlm.nih.gov/"/>
<code value="C584914"/>
<display value="cabotegravir"/>
<userSelected value="false"/>
</coding>
</classifier>
</classification>
<classification>
<type>
<coding>
<system
value="http://hl7.org/fhir/cited-artifact-classification-type"/>
<code value="mesh-heading"/>
<display value="MeSH Heading"/>
</coding>
</type>
<artifactAssessment>
<reference value="#meshHeading0"/>
<type value="ArtifactAssessment"/>
</artifactAssessment>
</classification>
<classification>
<type>
<coding>
<system
value="http://hl7.org/fhir/cited-artifact-classification-type"/>
<code value="publication-type"/>
<display value="Publication Type"/>
</coding>
</type>
<classifier>
<coding>
<system value="https://meshb.nlm.nih.gov/"/>
<code value="D017428"/>
<display value="Clinical Trial, Phase III"/>
<userSelected value="false"/>
</coding>
</classifier>
<classifier>
<coding>
<system value="https://meshb.nlm.nih.gov/"/>
<code value="D016428"/>
<display value="Journal Article"/>
<userSelected value="false"/>
</coding>
</classifier>
<classifier>
<coding>
<system value="https://meshb.nlm.nih.gov/"/>
<code value="D016449"/>
<display value="Randomized Controlled Trial"/>
<userSelected value="false"/>
</coding>
</classifier>
</classification>
<classification>
<type>
<coding>
<system
value="http://hl7.org/fhir/cited-artifact-classification-type"/>
<code value="knowledge-artifact-type"/>
<display value="Knowledge Artifact Type"/>
<userSelected value="false"/>
</coding>
</type>
<classifier>
<coding>
<system value="http://hl7.org/fhir/citation-artifact-classifier"/>
<code value="D016428"/>
<display value="Journal Article"/>
<userSelected value="false"/>
</coding>
</classifier>
<artifactAssessment>
<display value="Classifier added by Computable Publishing LLC"/>
</artifactAssessment>
</classification>
<classification>
<type>
<coding>
<system
value="http://hl7.org/fhir/cited-artifact-classification-type"/>
<code value="citation-subset"/>
<display value="Citation Subset"/>
<userSelected value="false"/>
</coding>
</type>
<classifier>
<coding>
<system
value="https://www.nlm.nih.gov/bsd/licensee/elements_descriptions.html#citationsubset"/>
<code value="IM"/>
<display value="IM"/>
<userSelected value="false"/>
</coding>
</classifier>
</classification>
<contributorship>
<complete value="true"/>
<entry>
<contributor>
<reference value="#author0"/>
<type value="Practitioner"/>
<display value="Delany-Moretlwe S"/>
</contributor>
<forenameInitials value="S"/>
<affiliation>
<display
value="Wits Reproductive Health and HIV Institute, University of the Witwatersrand, Johannesburg, South Africa. Electronic address: sdelany@wrhi.ac.za."/>
</affiliation>
</entry>
<entry>
<contributor>
<reference value="#author1"/>
<type value="Practitioner"/>
<display value="Hughes JP"/>
</contributor>
<forenameInitials value="JP"/>
<affiliation>
<display
value="Statistical Centre for HIV/AIDS Research and Prevention, Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA."/>
</affiliation>
</entry>
<entry>
<contributor>
<reference value="#author2"/>
<type value="Practitioner"/>
<display value="Bock P"/>
</contributor>
<forenameInitials value="P"/>
<affiliation>
<display
value="Desmond Tutu TB Centre, University of Stellenbosch, Stellenbosch, South Africa."/>
</affiliation>
</entry>
<entry>
<contributor>
<reference value="#author3"/>
<type value="Practitioner"/>
<display value="Ouma SG"/>
</contributor>
<forenameInitials value="SG"/>
<affiliation>
<display
value="Kisumu Clinical Research Site, Centre for Global Health Research, Kenya Medical Research Institute, Kisumu, Kenya."/>
</affiliation>
</entry>
<entry>
<contributor>
<reference value="#author4"/>
<type value="Practitioner"/>
<display value="Hunidzarira P"/>
</contributor>
<forenameInitials value="P"/>
<affiliation>
<display
value="Clinical Trials Research Centre, University of Zimbabwe, Harare, Zimbabwe."/>
</affiliation>
</entry>
<entry>
<contributor>
<reference value="#author5"/>
<type value="Practitioner"/>
<display value="Kalonji D"/>
</contributor>
<forenameInitials value="D"/>
<affiliation>
<display
value="HIV and other Infectious Diseases Research Unit, South African Medical Research Council, Durban, South Africa."/>
</affiliation>
</entry>
<entry>
<contributor>
<reference value="#author6"/>
<type value="Practitioner"/>
<display value="Kayange N"/>
</contributor>
<forenameInitials value="N"/>
<affiliation>
<display
value="Blantyre Clinical Research Site, College of Medicine, University of Malawi, Blantyre, Malawi."/>
</affiliation>
</entry>
<entry>
<contributor>
<reference value="#author7"/>
<type value="Practitioner"/>
<display value="Makhema J"/>
</contributor>
<forenameInitials value="J"/>
<affiliation>
<display
value="Botswana Harvard AIDS Institute Partnership (BHP), Gaborone, Botswana."/>
</affiliation>
</entry>
<entry>
<contributor>
<reference value="#author8"/>
<type value="Practitioner"/>
<display value="Mandima P"/>
</contributor>
<forenameInitials value="P"/>
<affiliation>
<display
value="Clinical Trials Research Centre, University of Zimbabwe, Harare, Zimbabwe."/>
</affiliation>
</entry>
<entry>
<contributor>
<reference value="#author9"/>
<type value="Practitioner"/>
<display value="Mathew C"/>
</contributor>
<forenameInitials value="C"/>
<affiliation>
<display
value="Wits Reproductive Health and HIV Institute, University of the Witwatersrand, Johannesburg, South Africa."/>
</affiliation>
</entry>
<entry>
<contributor>
<reference value="#author10"/>
<type value="Practitioner"/>
<display value="Spooner E"/>
</contributor>
<forenameInitials value="E"/>
<affiliation>
<display
value="HIV and other Infectious Diseases Research Unit, South African Medical Research Council, Durban, South Africa."/>
</affiliation>
</entry>
<entry>
<contributor>
<reference value="#author11"/>
<type value="Practitioner"/>
<display value="Mpendo J"/>
</contributor>
<forenameInitials value="J"/>
<affiliation>
<display
value="International AIDS Vaccine Initiative, Uganda Virus Research Institute, Entebbe, Uganda."/>
</affiliation>
</entry>
<entry>
<contributor>
<reference value="#author12"/>
<type value="Practitioner"/>
<display value="Mukwekwerere P"/>
</contributor>
<forenameInitials value="P"/>
<affiliation>
<display
value="Clinical Trials Research Centre, University of Zimbabwe, Harare, Zimbabwe."/>
</affiliation>
</entry>
<entry>
<contributor>
<reference value="#author13"/>
<type value="Practitioner"/>
<display value="Mgodi N"/>
</contributor>
<forenameInitials value="N"/>
<affiliation>
<display
value="Clinical Trials Research Centre, University of Zimbabwe, Harare, Zimbabwe."/>
</affiliation>
</entry>
<entry>
<contributor>
<reference value="#author14"/>
<type value="Practitioner"/>
<display value="Ntege PN"/>
</contributor>
<forenameInitials value="PN"/>
<affiliation>
<display
value="Baylor College of Medicine Children's Foundation Uganda, Kampala, Uganda."/>
</affiliation>
</entry>
<entry>
<contributor>
<reference value="#author15"/>
<type value="Practitioner"/>
<display value="Nair G"/>
</contributor>
<forenameInitials value="G"/>
<affiliation>
<display
value="Desmond Tutu Health Foundation, University of Cape Town, Cape Town, South Africa."/>
</affiliation>
</entry>
<entry>
<contributor>
<reference value="#author16"/>
<type value="Practitioner"/>
<display value="Nakabiito C"/>
</contributor>
<forenameInitials value="C"/>
<affiliation>
<display
value="Makerere University-Johns Hopkins University Research Collaboration, Kampala, Uganda."/>
</affiliation>
</entry>
<entry>
<contributor>
<reference value="#author17"/>
<type value="Practitioner"/>
<display value="Nuwagaba-Biribonwoha H"/>
</contributor>
<forenameInitials value="H"/>
<affiliation>
<display
value="Eswatini Prevention Center, International Center for AIDS Care and Treatment Program at Columbia University Mailman School of Public Health, New York, NY, USA."/>
</affiliation>
</entry>
<entry>
<contributor>
<reference value="#author18"/>
<type value="Practitioner"/>
<display value="Panchia R"/>
</contributor>
<forenameInitials value="R"/>
<affiliation>
<display
value="Perinatal HIV Research Unit, University of the Witwatersrand, Johannesburg, South Africa."/>
</affiliation>
</entry>
<entry>
<contributor>
<reference value="#author19"/>
<type value="Practitioner"/>
<display value="Singh N"/>
</contributor>
<forenameInitials value="N"/>
<affiliation>
<display
value="HIV and other Infectious Diseases Research Unit, South African Medical Research Council, Durban, South Africa."/>
</affiliation>
</entry>
<entry>
<contributor>
<reference value="#author20"/>
<type value="Practitioner"/>
<display value="Siziba B"/>
</contributor>
<forenameInitials value="B"/>
<affiliation>
<display
value="Clinical Trials Research Centre, University of Zimbabwe, Harare, Zimbabwe."/>
</affiliation>
</entry>
<entry>
<contributor>
<reference value="#author21"/>
<type value="Practitioner"/>
<display value="Farrior J"/>
</contributor>
<forenameInitials value="J"/>
<affiliation>
<display value="FHI 360, Durham, NC, USA."/>
</affiliation>
</entry>
<entry>
<contributor>
<reference value="#author22"/>
<type value="Practitioner"/>
<display value="Rose S"/>
</contributor>
<forenameInitials value="S"/>
<affiliation>
<display value="FHI 360, Durham, NC, USA."/>
</affiliation>
</entry>
<entry>
<contributor>
<reference value="#author23"/>
<type value="Practitioner"/>
<display value="Anderson PL"/>
</contributor>
<forenameInitials value="PL"/>
<affiliation>
<display
value="Anschutz Medical Campus, University of Colorado, Aurora, CO, USA."/>
</affiliation>
</entry>
<entry>
<contributor>
<reference value="#author24"/>
<type value="Practitioner"/>
<display value="Eshleman SH"/>
</contributor>
<forenameInitials value="SH"/>
<affiliation>
<display
value="Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA."/>
</affiliation>
</entry>
<entry>
<contributor>
<reference value="#author25"/>
<type value="Practitioner"/>
<display value="Marzinke MA"/>
</contributor>
<forenameInitials value="MA"/>
<affiliation>
<display
value="Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA."/>
</affiliation>
</entry>
<entry>
<contributor>
<reference value="#author26"/>
<type value="Practitioner"/>
<display value="Hendrix CW"/>
</contributor>
<forenameInitials value="CW"/>
<affiliation>
<display
value="Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA."/>
</affiliation>
</entry>
<entry>
<contributor>
<reference value="#author27"/>
<type value="Practitioner"/>
<display value="Beigel-Orme S"/>
</contributor>
<forenameInitials value="S"/>
<affiliation>
<display
value="Statistical Centre for HIV/AIDS Research and Prevention, Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA."/>
</affiliation>
</entry>
<entry>
<contributor>
<reference value="#author28"/>
<type value="Practitioner"/>
<display value="Hosek S"/>
</contributor>
<forenameInitials value="S"/>
<affiliation>
<display
value="Department of Psychiatry, Stroger Hospital of Cook County, Chicago, IL, USA."/>
</affiliation>
</entry>
<entry>
<contributor>
<reference value="#author29"/>
<type value="Practitioner"/>
<display value="Tolley E"/>
</contributor>
<forenameInitials value="E"/>
<affiliation>
<display value="FHI 360, Durham, NC, USA."/>
</affiliation>
</entry>
<entry>
<contributor>
<reference value="#author30"/>
<type value="Practitioner"/>
<display value="Sista N"/>
</contributor>
<forenameInitials value="N"/>
<affiliation>
<display value="FHI 360, Durham, NC, USA."/>
</affiliation>
</entry>
<entry>
<contributor>
<reference value="#author31"/>
<type value="Practitioner"/>
<display value="Adeyeye A"/>
</contributor>
<forenameInitials value="A"/>
<affiliation>
<display
value="Division of AIDS, National Institute of Allergy and Infectious Diseases, Rockville, MD, USA."/>
</affiliation>
</entry>
<entry>
<contributor>
<reference value="#author32"/>
<type value="Practitioner"/>
<display value="Rooney JF"/>
</contributor>
<forenameInitials value="JF"/>
<affiliation>
<display value="Gilead Sciences, Foster City, CA, USA."/>
</affiliation>
</entry>
<entry>
<contributor>
<reference value="#author33"/>
<type value="Practitioner"/>
<display value="Rinehart A"/>
</contributor>
<forenameInitials value="A"/>
<affiliation>
<display value="ViiV Healthcare, Durham, NC, USA."/>
</affiliation>
</entry>
<entry>
<contributor>
<reference value="#author34"/>
<type value="Practitioner"/>
<display value="Spreen WR"/>
</contributor>
<forenameInitials value="WR"/>
<affiliation>
<display value="ViiV Healthcare, Durham, NC, USA."/>
</affiliation>
</entry>
<entry>
<contributor>
<reference value="#author35"/>
<type value="Practitioner"/>
<display value="Smith K"/>
</contributor>
<forenameInitials value="K"/>
<affiliation>
<display value="ViiV Healthcare, Durham, NC, USA."/>
</affiliation>
</entry>
<entry>
<contributor>
<reference value="#author36"/>
<type value="Practitioner"/>
<display value="Hanscom B"/>
</contributor>
<forenameInitials value="B"/>
<affiliation>
<display
value="Statistical Centre for HIV/AIDS Research and Prevention, Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA."/>
</affiliation>
</entry>
<entry>
<contributor>
<reference value="#author37"/>
<type value="Practitioner"/>
<display value="Cohen MS"/>
</contributor>
<forenameInitials value="MS"/>
<affiliation>
<display
value="University of North Carolina (UNC) at Chapel Hill, Chapel Hill, NC, USA."/>
</affiliation>
</entry>
<entry>
<contributor>
<reference value="#author38"/>
<type value="Practitioner"/>
<display value="Hosseinipour MC"/>
</contributor>
<forenameInitials value="MC"/>
<affiliation>
<display
value="University of North Carolina (UNC) at Chapel Hill, Chapel Hill, NC, USA; UNC Project-Malawi, Lilongwe, Malawi."/>
</affiliation>
</entry>
<entry>
<contributor>
<reference value="#author39"/>
<type value="Organization"/>
<display value="HPTN 084 study group"/>
</contributor>
</entry>
</contributorship>
</citedArtifact>
</Citation>
IG © 2024+ HL7 International / Clinical Decision Support. Package hl7.fhir.uv.ebm#2.0.0-ballot based on FHIR 6.0.0-ballot2. Generated 2024-12-19
Links: Table of Contents |
QA Report
| Version History |
|
Propose a change