Evidence Based Medicine on FHIR Implementation Guide, published by HL7 International / Clinical Decision Support. This guide is not an authorized publication; it is the continuous build for version 2.0.0-ballot built by the FHIR (HL7® FHIR® Standard) CI Build. This version is based on the current content of https://github.com/HL7/ebm/ and changes regularly. See the Directory of published versions
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<div xmlns="http://www.w3.org/1999/xhtml"><p class="res-header-id"><b>Generated Narrative: ArtifactAssessment 179693</b></p><a name="179693"> </a><a name="hc179693"> </a><a name="179693-en-US"> </a><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">version: 7; Last updated: 2024-12-12 13:06:16+0000</p><p style="margin-bottom: 0px">Profile: <a href="StructureDefinition-certainty-of-evidence.html">CertaintyOfEvidence</a></p></div><p><b>Artifact URL</b>: <a href="https://fevir.net/resources/ArtifactAssessment/179693">https://fevir.net/resources/ArtifactAssessment/179693</a></p><p><b>Artifact Description</b>: </p><div><p>This example of a CertaintyOfEvidence Profile shows a recursive pattern of component elements with type/classifier paired values for different aspects of rating the certainty of evidence.</p>
</div><p><b>identifier</b>: FEvIR Object Identifier/https://fevir.net/FOI/179693</p><p><b>title</b>: Certainty of Evidence Rating of 14-day mortality remdesivir vs placebo meta-analysis (ACTT-1, Wang et al, WHO SOLIDARITY)</p><p><b>artifact</b>: <a href="Evidence-55.html">14-day mortality remdesivir vs placebo meta-analysis (ACTT-1, Wang et al, WHO SOLIDARITY)</a></p><blockquote><p><b>content</b></p><p><b>summary</b>: </p><div><p>Low certainty due to inconsistency and risk of bias</p>
</div><p><b>type</b>: <span title="Codes:{http://hl7.org/fhir/certainty-type Overall}">Overall certainty</span></p><p><b>classifier</b>: <span title="Codes:{http://hl7.org/fhir/certainty-rating low}">Low quality</span></p><blockquote><p><b>component</b></p><p><b>type</b>: <span title="Codes:{http://hl7.org/fhir/certainty-type PublicationBias}">Publication bias</span></p><p><b>classifier</b>: <span title="Codes:{http://hl7.org/fhir/certainty-rating no-concern}">no serious concern</span></p></blockquote><blockquote><p><b>component</b></p><p><b>summary</b>: </p><div><p>There is a high degree of heterogeneity (I-squared = 73%). There is also inconsistency in findings between the fixed-effect and random-effects statistical models.</p>
</div><p><b>type</b>: <span title="Codes:{http://hl7.org/fhir/certainty-type Inconsistency}">Inconsistency</span></p><p><b>classifier</b>: <span title="Codes:{http://hl7.org/fhir/certainty-rating serious-concern}">serious concern</span></p></blockquote><blockquote><p><b>component</b></p><p><b>summary</b>: </p><div><p>Although the random-effects analysis finds an estimate without statistical significance, this imprecision is explained by the inconsistency (heterogeneity) and thus not further downrated in certainty assessment.</p>
</div><p><b>type</b>: <span title="Codes:{http://hl7.org/fhir/certainty-type Imprecision}">Imprecision</span></p><p><b>classifier</b>: <span title="Codes:{http://hl7.org/fhir/certainty-rating no-concern}">no serious concern</span></p></blockquote><blockquote><p><b>component</b></p><p><b>type</b>: <span title="Codes:{http://hl7.org/fhir/certainty-type Indirectness}">Indirectness</span></p><p><b>classifier</b>: <span title="Codes:{http://hl7.org/fhir/certainty-rating no-concern}">no serious concern</span></p></blockquote><blockquote><p><b>component</b></p><p><b>type</b>: <span title="Codes:{http://hl7.org/fhir/certainty-type RiskOfBias}">Risk of bias</span></p><p><b>classifier</b>: <span title="Codes:{http://hl7.org/fhir/certainty-rating serious-concern}">serious concern</span></p><h3>Components</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Summary</b></td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style="display: none">*</td><td><div><p>No blinding (no placebo control) in the largest trial</p>
</div></td><td><span title="Codes:{https://fevir.net/resources/CodeSystem/181513 SEVCO:00035}">Lack of blinding</span></td><td><span title="Codes:{http://hl7.org/fhir/certainty-rating present}">present</span></td></tr></table></blockquote></blockquote></div>
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