Clinical Genomics Resource Incubator
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Clinical Genomics Resource Incubator, published by HL7 International / Clinical Genomics. This guide is not an authorized publication; it is the continuous build for version 0.1.0-ci-build built by the FHIR (HL7® FHIR® Standard) CI Build. This version is based on the current content of https://github.com/HL7/cg-incubator/ and changes regularly. See the Directory of published versions

Resource: Genomic Study - XML Resource

Page standards status: Draft Maturity Level: 1

XML representation of the GenomicStudy resource.

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<StructureDefinition xmlns="http://hl7.org/fhir">
  <id value="GenomicStudy"/>
  <meta>
    <lastUpdated value="2021-01-02T08:58:31.578+11:00"/>
  </meta>
  <language value="en"/>
  <text>
    <status value="extensions"/>
    <div xmlns="http://www.w3.org/1999/xhtml"><p class="res-header-id"><b>Generated Narrative: StructureDefinition GenomicStudy</b></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Last updated: 2021-01-02 08:58:31+1100</p></div><table border="0" cellpadding="0" cellspacing="0" style="border: 0px #F0F0F0 solid; font-size: 11px; font-family: verdana; vertical-align: top;"><tr style="border: 1px #F0F0F0 solid; font-size: 11px; font-family: verdana; vertical-align: top"><th style="vertical-align: top; text-align : var(--ig-left,left); background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px; padding-top: 3px; padding-bottom: 3px" class="hierarchy"><a href="https://build.fhir.org/ig/FHIR/ig-guidance/readingIgs.html#table-views" title="The logical name of the element">Name</a></th><th style="vertical-align: top; text-align : var(--ig-left,left); background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px; padding-top: 3px; padding-bottom: 3px" class="hierarchy"><a href="https://build.fhir.org/ig/FHIR/ig-guidance/readingIgs.html#table-views" title="Information about the use of the element">Flags</a></th><th style="vertical-align: top; text-align : var(--ig-left,left); background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px; padding-top: 3px; padding-bottom: 3px" class="hierarchy"><a href="https://build.fhir.org/ig/FHIR/ig-guidance/readingIgs.html#table-views" title="Minimum and Maximum # of times the element can appear in the instance">Card.</a></th><th style="vertical-align: top; text-align : var(--ig-left,left); background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px; padding-top: 3px; padding-bottom: 3px; width: 100px" class="hierarchy"><a href="https://build.fhir.org/ig/FHIR/ig-guidance/readingIgs.html#table-views" title="Reference to the type of the element">Type</a></th><th style="vertical-align: top; text-align : var(--ig-left,left); background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px; padding-top: 3px; padding-bottom: 3px" class="hierarchy"><a href="https://build.fhir.org/ig/FHIR/ig-guidance/readingIgs.html#table-views" title="Additional information about the element">Description &amp; Constraints</a><span style="float: right"><a href="https://build.fhir.org/ig/FHIR/ig-guidance/readingIgs.html#table-views" title="Legend for this format"><img src="data:image/png;base64,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" alt="doco" style="background-color: inherit"/></a></span></th></tr><tr style="border: 0px #F0F0F0 solid; padding:0px; vertical-align: top; background-color: white"><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px; white-space: nowrap; background-image: url(tbl_bck1.png)" class="hierarchy"><img src="tbl_spacer.png" alt="." style="background-color: inherit" class="hierarchy"/><img src="icon_resource.png" alt="." style="background-color: white; background-color: inherit" title="Resource" class="hierarchy"/> <a href="StructureDefinition-GenomicStudy-definitions.html#GenomicStudy" title="A GenomicStudy is a set of analyses performed to analyze and generate genomic data.">GenomicStudy</a><a name="GenomicStudy"> </a></td><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy"/><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy">0..*</td><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy"><a href="http://hl7.org/fhir/R5/domainresource.html">DomainResource</a></td><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy">Genomic Study<br/><br/>Elements defined in Ancestors:<a href="http://hl7.org/fhir/R5/resource.html" title="The logical id of the resource, as used in the URL for the resource. Once assigned, this value never changes.">id</a>, <a href="http://hl7.org/fhir/R5/resource.html" title="The metadata about the resource. This is content that is maintained by the infrastructure. Changes to the content might not always be associated with version changes to the resource.">meta</a>, <a href="http://hl7.org/fhir/R5/resource.html" title="A reference to a set of rules that were followed when the resource was constructed, and which must be understood when processing the content. Often, this is a reference to an implementation guide that defines the special rules along with other profiles etc.">implicitRules</a>, <a href="http://hl7.org/fhir/R5/resource.html" title="The base language in which the resource is written.">language</a>, <a href="http://hl7.org/fhir/R5/domainresource.html" title="A human-readable narrative that contains a summary of the resource and can be used to represent the content of the resource to a human. The narrative need not encode all the structured data, but is required to contain sufficient detail to make it &quot;clinically safe&quot; for a human to just read the narrative. Resource definitions may define what content should be represented in the narrative to ensure clinical safety.">text</a>, <a href="http://hl7.org/fhir/R5/domainresource.html" title="These resources do not have an independent existence apart from the resource that contains them - they cannot be identified independently, nor can they have their own independent transaction scope. This is allowed to be a Parameters resource if and only if it is referenced by a resource that provides context/meaning.">contained</a>, <a href="http://hl7.org/fhir/R5/domainresource.html" title="May be used to represent additional information that is not part of the basic definition of the resource. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.">extension</a>, <a href="http://hl7.org/fhir/R5/domainresource.html" title="May be used to represent additional information that is not part of the basic definition of the resource and that modifies the understanding of the element that contains it and/or the understanding of the containing element's descendants. Usually modifier elements provide negation or qualification. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer is allowed to define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Applications processing a resource are required to check for modifier extensions.

Modifier extensions SHALL NOT change the meaning of any elements on Resource or DomainResource (including cannot change the meaning of modifierExtension itself).">modifierExtension</a><br/></td></tr>
<tr style="border: 0px #F0F0F0 solid; padding:0px; vertical-align: top; background-color: #F7F7F7"><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px; white-space: nowrap; background-image: url(tbl_bck10.png)" class="hierarchy"><img src="tbl_spacer.png" alt="." style="background-color: inherit" class="hierarchy"/><img src="tbl_vjoin.png" alt="." style="background-color: inherit" class="hierarchy"/><img src="icon_datatype.gif" alt="." style="background-color: #F7F7F7; background-color: inherit" title="Data Type" class="hierarchy"/> <a href="StructureDefinition-GenomicStudy-definitions.html#GenomicStudy.identifier" title="Identifiers for this genomic study.">identifier</a><a name="GenomicStudy.identifier"> </a></td><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy"><span style="padding-left: 3px; padding-right: 3px; color: black; null" title="This element is included in summaries">Σ</span></td><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy">0..*</td><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy"><a href="http://hl7.org/fhir/R5/datatypes.html#Identifier">Identifier</a></td><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy">Identifiers for this genomic study<br/></td></tr>
<tr style="border: 0px #F0F0F0 solid; padding:0px; vertical-align: top; background-color: white"><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px; white-space: nowrap; background-image: url(tbl_bck10.png)" class="hierarchy"><img src="tbl_spacer.png" alt="." style="background-color: inherit" class="hierarchy"/><img src="tbl_vjoin.png" alt="." style="background-color: inherit" class="hierarchy"/><img src="icon_primitive.png" alt="." style="background-color: white; background-color: inherit" title="Primitive Data Type" class="hierarchy"/> <a href="StructureDefinition-GenomicStudy-definitions.html#GenomicStudy.status" title="The status of the genomic study.">status</a><a name="GenomicStudy.status"> </a></td><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy"><span style="padding-left: 3px; padding-right: 3px; color: black; null" title="This element is a modifier element">?!</span><span style="padding-left: 3px; padding-right: 3px; color: black; null" title="This element is included in summaries">Σ</span></td><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy">1..1</td><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy"><a href="http://hl7.org/fhir/R5/datatypes.html#code">code</a></td><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy">registered | available | cancelled | entered-in-error | unknown<br class="binding"/><span style="font-weight:bold" title="null" class="binding">Binding: </span><a href="ValueSet-genomicstudy-status.html" title="http://hl7.org/fhir/uv/cg-incubator/ValueSet/genomicstudy-status" class="binding">Genomic Study Status VS</a><span title="null" class="binding"> (</span><a href="http://hl7.org/fhir/R5/terminologies.html#required" title="To be conformant, the concept in this element SHALL be from the specified value set." class="binding">required</a><span title="null" class="binding">)</span><span title="null" class="binding">: </span><span title="null" class="binding">The status of the GenomicStudy.</span></td></tr>
<tr style="border: 0px #F0F0F0 solid; padding:0px; vertical-align: top; background-color: #F7F7F7"><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px; white-space: nowrap; background-image: url(tbl_bck10.png)" class="hierarchy"><img src="tbl_spacer.png" alt="." style="background-color: inherit" class="hierarchy"/><img src="tbl_vjoin.png" alt="." style="background-color: inherit" class="hierarchy"/><img src="icon_datatype.gif" alt="." style="background-color: #F7F7F7; background-color: inherit" title="Data Type" class="hierarchy"/> <a href="StructureDefinition-GenomicStudy-definitions.html#GenomicStudy.type" title="The type of the study, e.g., Familial variant segregation, Functional variation detection, or Gene expression profiling.">type</a><a name="GenomicStudy.type"> </a></td><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy"><span style="padding-left: 3px; padding-right: 3px; color: black; null" title="This element is included in summaries">Σ</span></td><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy">0..*</td><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy"><a href="http://hl7.org/fhir/R5/datatypes.html#CodeableConcept">CodeableConcept</a></td><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy">The type of the study (e.g., Familial variant segregation, Functional variation detection, or Gene expression profiling)<br class="binding"/><span style="font-weight:bold" title="null" class="binding">Binding: </span><a href="ValueSet-genomicstudy-type.html" title="http://hl7.org/fhir/uv/cg-incubator/ValueSet/genomicstudy-type" class="binding">Genomic Study Type VS</a><span title="null" class="binding"> (</span><a href="http://hl7.org/fhir/R5/terminologies.html#example" title="Instances are not expected or even encouraged to draw from the specified value set.  The value set merely provides examples of the types of concepts intended to be included." class="binding">example</a><span title="null" class="binding">)</span><span title="null" class="binding">: </span><span title="null" class="binding">The type relevant to GenomicStudy.</span><br/></td></tr>
<tr style="border: 0px #F0F0F0 solid; padding:0px; vertical-align: top; background-color: white"><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px; white-space: nowrap; background-image: url(tbl_bck10.png)" class="hierarchy"><img src="tbl_spacer.png" alt="." style="background-color: inherit" class="hierarchy"/><img src="tbl_vjoin.png" alt="." style="background-color: inherit" class="hierarchy"/><img src="icon_reference.png" alt="." style="background-color: white; background-color: inherit" title="Reference to another Resource" class="hierarchy"/> <a href="StructureDefinition-GenomicStudy-definitions.html#GenomicStudy.subject" title="The primary subject of the genomic study.">subject</a><a name="GenomicStudy.subject"> </a></td><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy"><span style="padding-left: 3px; padding-right: 3px; color: black; null" title="This element is included in summaries">Σ</span></td><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy">1..1</td><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy"><a href="http://hl7.org/fhir/R5/references.html">Reference</a>(<a href="http://hl7.org/fhir/R5/patient.html">Patient</a> | <a href="http://hl7.org/fhir/R5/group.html">Group</a> | <a href="http://hl7.org/fhir/R5/substance.html">Substance</a> | <a href="http://hl7.org/fhir/R5/biologicallyderivedproduct.html">BiologicallyDerivedProduct</a> | <a href="http://hl7.org/fhir/R5/nutritionproduct.html">NutritionProduct</a>)</td><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy">The primary subject of the genomic study</td></tr>
<tr style="border: 0px #F0F0F0 solid; padding:0px; vertical-align: top; background-color: #F7F7F7"><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px; white-space: nowrap; background-image: url(tbl_bck10.png)" class="hierarchy"><img src="tbl_spacer.png" alt="." style="background-color: inherit" class="hierarchy"/><img src="tbl_vjoin.png" alt="." style="background-color: inherit" class="hierarchy"/><img src="icon_reference.png" alt="." style="background-color: #F7F7F7; background-color: inherit" title="Reference to another Resource" class="hierarchy"/> <a href="StructureDefinition-GenomicStudy-definitions.html#GenomicStudy.encounter" title="The healthcare event with which this genomics study is associated.">encounter</a><a name="GenomicStudy.encounter"> </a></td><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy"><span style="padding-left: 3px; padding-right: 3px; color: black; null" title="This element is included in summaries">Σ</span></td><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy">0..1</td><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy"><a href="http://hl7.org/fhir/R5/references.html">Reference</a>(<a href="http://hl7.org/fhir/R5/encounter.html">Encounter</a>)</td><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy">The healthcare event with which this genomics study is associated</td></tr>
<tr style="border: 0px #F0F0F0 solid; padding:0px; vertical-align: top; background-color: white"><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px; white-space: nowrap; background-image: url(tbl_bck10.png)" class="hierarchy"><img src="tbl_spacer.png" alt="." style="background-color: inherit" class="hierarchy"/><img src="tbl_vjoin.png" alt="." style="background-color: inherit" class="hierarchy"/><img src="icon_primitive.png" alt="." style="background-color: white; background-color: inherit" title="Primitive Data Type" class="hierarchy"/> <a href="StructureDefinition-GenomicStudy-definitions.html#GenomicStudy.startDate" title="When the genomic study was started.">startDate</a><a name="GenomicStudy.startDate"> </a></td><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy"/><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy">0..1</td><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy"><a href="http://hl7.org/fhir/R5/datatypes.html#dateTime">dateTime</a></td><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy">When the genomic study was started</td></tr>
<tr style="border: 0px #F0F0F0 solid; padding:0px; vertical-align: top; background-color: #F7F7F7"><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px; white-space: nowrap; background-image: url(tbl_bck10.png)" class="hierarchy"><img src="tbl_spacer.png" alt="." style="background-color: inherit" class="hierarchy"/><img src="tbl_vjoin.png" alt="." style="background-color: inherit" class="hierarchy"/><img src="icon_reference.png" alt="." style="background-color: #F7F7F7; background-color: inherit" title="Reference to another Resource" class="hierarchy"/> <a href="StructureDefinition-GenomicStudy-definitions.html#GenomicStudy.basedOn" title="Event resources that the genomic study is based on.">basedOn</a><a name="GenomicStudy.basedOn"> </a></td><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy"/><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy">0..*</td><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy"><a href="http://hl7.org/fhir/R5/references.html">Reference</a>(<a href="http://hl7.org/fhir/R5/servicerequest.html">ServiceRequest</a> | <a href="http://hl7.org/fhir/R5/task.html">Task</a>)</td><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy">Event resources that the genomic study is based on<br/></td></tr>
<tr style="border: 0px #F0F0F0 solid; padding:0px; vertical-align: top; background-color: white"><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px; white-space: nowrap; background-image: url(tbl_bck10.png)" class="hierarchy"><img src="tbl_spacer.png" alt="." style="background-color: inherit" class="hierarchy"/><img src="tbl_vjoin.png" alt="." style="background-color: inherit" class="hierarchy"/><img src="icon_reference.png" alt="." style="background-color: white; background-color: inherit" title="Reference to another Resource" class="hierarchy"/> <a href="StructureDefinition-GenomicStudy-definitions.html#GenomicStudy.referrer" title="Healthcare professional who requested or referred the genomic study.">referrer</a><a name="GenomicStudy.referrer"> </a></td><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy"/><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy">0..1</td><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy"><a href="http://hl7.org/fhir/R5/references.html">Reference</a>(<a href="http://hl7.org/fhir/R5/practitioner.html">Practitioner</a> | <a href="http://hl7.org/fhir/R5/practitionerrole.html">PractitionerRole</a>)</td><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy">Healthcare professional who requested or referred the genomic study</td></tr>
<tr style="border: 0px #F0F0F0 solid; padding:0px; vertical-align: top; background-color: #F7F7F7"><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px; white-space: nowrap; background-image: url(tbl_bck10.png)" class="hierarchy"><img src="tbl_spacer.png" alt="." style="background-color: inherit" class="hierarchy"/><img src="tbl_vjoin.png" alt="." style="background-color: inherit" class="hierarchy"/><img src="icon_reference.png" alt="." style="background-color: #F7F7F7; background-color: inherit" title="Reference to another Resource" class="hierarchy"/> <a href="StructureDefinition-GenomicStudy-definitions.html#GenomicStudy.interpreter" title="Healthcare professionals who interpreted the genomic study.">interpreter</a><a name="GenomicStudy.interpreter"> </a></td><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy"/><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy">0..*</td><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy"><a href="http://hl7.org/fhir/R5/references.html">Reference</a>(<a href="http://hl7.org/fhir/R5/practitioner.html">Practitioner</a> | <a href="http://hl7.org/fhir/R5/practitionerrole.html">PractitionerRole</a>)</td><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy">Healthcare professionals who interpreted the genomic study<br/></td></tr>
<tr style="border: 0px #F0F0F0 solid; padding:0px; vertical-align: top; background-color: white"><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px; white-space: nowrap; background-image: url(tbl_bck10.png)" class="hierarchy"><img src="tbl_spacer.png" alt="." style="background-color: inherit" class="hierarchy"/><img src="tbl_vjoin.png" alt="." style="background-color: inherit" class="hierarchy"/><img src="icon_reference.png" alt="." style="background-color: white; background-color: inherit" title="Reference to another Resource" class="hierarchy"/> <a href="StructureDefinition-GenomicStudy-definitions.html#GenomicStudy.reason" title="Why the genomic study was performed.">reason</a><a name="GenomicStudy.reason"> </a></td><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy"/><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy">0..*</td><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy"><a href="http://hl7.org/fhir/R5/references.html">CodeableReference</a>(<a href="http://hl7.org/fhir/R5/condition.html">Condition</a> | <a href="http://hl7.org/fhir/R5/observation.html">Observation</a>)</td><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy">Why the genomic study was performed<br/></td></tr>
<tr style="border: 0px #F0F0F0 solid; padding:0px; vertical-align: top; background-color: #F7F7F7"><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px; white-space: nowrap; background-image: url(tbl_bck10.png)" class="hierarchy"><img src="tbl_spacer.png" alt="." style="background-color: inherit" class="hierarchy"/><img src="tbl_vjoin.png" alt="." style="background-color: inherit" class="hierarchy"/><img src="icon_primitive.png" alt="." style="background-color: #F7F7F7; background-color: inherit" title="Primitive Data Type" class="hierarchy"/> <a href="StructureDefinition-GenomicStudy-definitions.html#GenomicStudy.instantiatesCanonical" title="The defined protocol that describes the study.">instantiatesCanonical</a><a name="GenomicStudy.instantiatesCanonical"> </a></td><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy"/><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy">0..1</td><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy"><a href="http://hl7.org/fhir/R5/references.html">canonical</a>(<a href="http://hl7.org/fhir/R5/plandefinition.html">PlanDefinition</a>)</td><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy">The defined protocol that describes the study</td></tr>
<tr style="border: 0px #F0F0F0 solid; padding:0px; vertical-align: top; background-color: white"><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px; white-space: nowrap; background-image: url(tbl_bck10.png)" class="hierarchy"><img src="tbl_spacer.png" alt="." style="background-color: inherit" class="hierarchy"/><img src="tbl_vjoin.png" alt="." style="background-color: inherit" class="hierarchy"/><img src="icon_primitive.png" alt="." style="background-color: white; background-color: inherit" title="Primitive Data Type" class="hierarchy"/> <a href="StructureDefinition-GenomicStudy-definitions.html#GenomicStudy.instantiatesUri" title="The URL pointing to an externally maintained protocol that describes the study.">instantiatesUri</a><a name="GenomicStudy.instantiatesUri"> </a></td><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy"/><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy">0..1</td><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy"><a href="http://hl7.org/fhir/R5/datatypes.html#uri">uri</a></td><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy">The URL pointing to an externally maintained protocol that describes the study</td></tr>
<tr style="border: 0px #F0F0F0 solid; padding:0px; vertical-align: top; background-color: #F7F7F7"><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px; white-space: nowrap; background-image: url(tbl_bck10.png)" class="hierarchy"><img src="tbl_spacer.png" alt="." style="background-color: inherit" class="hierarchy"/><img src="tbl_vjoin.png" alt="." style="background-color: inherit" class="hierarchy"/><img src="icon_datatype.gif" alt="." style="background-color: #F7F7F7; background-color: inherit" title="Data Type" class="hierarchy"/> <a href="StructureDefinition-GenomicStudy-definitions.html#GenomicStudy.note" title="Comments related to the genomic study.">note</a><a name="GenomicStudy.note"> </a></td><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy"/><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy">0..*</td><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy"><a href="http://hl7.org/fhir/R5/datatypes.html#Annotation">Annotation</a></td><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy">Comments related to the genomic study<br/></td></tr>
<tr style="border: 0px #F0F0F0 solid; padding:0px; vertical-align: top; background-color: white"><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px; white-space: nowrap; background-image: url(tbl_bck10.png)" class="hierarchy"><img src="tbl_spacer.png" alt="." style="background-color: inherit" class="hierarchy"/><img src="tbl_vjoin.png" alt="." style="background-color: inherit" class="hierarchy"/><img src="icon_primitive.png" alt="." style="background-color: white; background-color: inherit" title="Primitive Data Type" class="hierarchy"/> <a href="StructureDefinition-GenomicStudy-definitions.html#GenomicStudy.description" title="Description of the genomic study.">description</a><a name="GenomicStudy.description"> </a></td><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy"/><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy">0..1</td><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy"><a href="http://hl7.org/fhir/R5/datatypes.html#markdown">markdown</a></td><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy">Description of the genomic study</td></tr>
<tr style="border: 0px #F0F0F0 solid; padding:0px; vertical-align: top; background-color: #F7F7F7"><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px; white-space: nowrap; background-image: url(tbl_bck01.png)" class="hierarchy"><img src="tbl_spacer.png" alt="." style="background-color: inherit" class="hierarchy"/><img src="tbl_vjoin_end.png" alt="." style="background-color: inherit" class="hierarchy"/><img src="icon_datatype.gif" alt="." style="background-color: #F7F7F7; background-color: inherit" title="Data Type" class="hierarchy"/> <a href="StructureDefinition-GenomicStudy-definitions.html#GenomicStudy.analysis" title="The details about a specific analysis that was performed in this GenomicStudy.">analysis</a><a name="GenomicStudy.analysis"> </a></td><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy"><a style="padding-left: 3px; padding-right: 3px; border: 1px maroon solid; font-weight: bold; color: #301212; background-color: #fdf4f4;; padding-left: 3px; padding-right: 3px; border: 1px maroon solid; font-weight: bold; color: #301212; background-color: #fdf4f4;" href="http://build.fhir.org/conformance-rules.html#constraints" title="This element has or is affected by constraints ( gs-regions-1, gs-regions-2 )">C</a></td><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy">0..*</td><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy"><a href="http://hl7.org/fhir/R5/types.html#BackboneElement">BackboneElement</a></td><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy">Genomic Analysis Event<br class="constraint"/><span title="null" class="constraint">Constraints: </span><span style="font-weight:bold" title="When genomicRegion.studied entries use coded concepts, every code in genomicRegion.called and genomicRegion.uncalled entries should also appear in genomicRegion.studied. This constraint cannot be evaluated when BED file references (DocumentReference) are used instead of coded concepts." class="constraint">gs-regions-1</span><span title="null" class="constraint">, </span><span style="font-weight:bold" title="If all studied genomicRegion entries use coded concepts (none use DocumentReference), then all called and uncalled genomicRegion entries must also use coded concepts and not DocumentReference. This ensures a consistent representation when the studied scope is fully expressed as coded identifiers. Note: this constraint is intentionally one-directional — when studied uses DocumentReference (e.g., a BED file), called and uncalled entries may legitimately use coded concepts to name specific genes, since enumerating a full BED file as coded genes is impractical." class="constraint">gs-regions-2</span><br/></td></tr>
<tr style="border: 0px #F0F0F0 solid; padding:0px; vertical-align: top; background-color: white"><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px; white-space: nowrap; background-image: url(tbl_bck010.png)" class="hierarchy"><img src="tbl_spacer.png" alt="." style="background-color: inherit" class="hierarchy"/><img src="tbl_blank.png" alt="." style="background-color: inherit" class="hierarchy"/><img src="tbl_vjoin.png" alt="." style="background-color: inherit" class="hierarchy"/><img src="icon_datatype.gif" alt="." style="background-color: white; background-color: inherit" title="Data Type" class="hierarchy"/> <a href="StructureDefinition-GenomicStudy-definitions.html#GenomicStudy.analysis.identifier" title="Identifiers for the analysis event.">identifier</a><a name="GenomicStudy.analysis.identifier"> </a></td><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy"><span style="padding-left: 3px; padding-right: 3px; color: black; null" title="This element is included in summaries">Σ</span></td><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy">0..*</td><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy"><a href="http://hl7.org/fhir/R5/datatypes.html#Identifier">Identifier</a></td><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy">Identifiers for the analysis event<br/></td></tr>
<tr style="border: 0px #F0F0F0 solid; padding:0px; vertical-align: top; background-color: #F7F7F7"><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px; white-space: nowrap; background-image: url(tbl_bck010.png)" class="hierarchy"><img src="tbl_spacer.png" alt="." style="background-color: inherit" class="hierarchy"/><img src="tbl_blank.png" alt="." style="background-color: inherit" class="hierarchy"/><img src="tbl_vjoin.png" alt="." style="background-color: inherit" class="hierarchy"/><img src="icon_datatype.gif" alt="." style="background-color: #F7F7F7; background-color: inherit" title="Data Type" class="hierarchy"/> <a href="StructureDefinition-GenomicStudy-definitions.html#GenomicStudy.analysis.methodType" title="Type of the methods used in the analysis, e.g., Fluorescence in situ hybridization (FISH), Karyotyping, or Microsatellite instability testing (MSI).">methodType</a><a name="GenomicStudy.analysis.methodType"> </a></td><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy"><span style="padding-left: 3px; padding-right: 3px; color: black; null" title="This element is included in summaries">Σ</span></td><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy">0..*</td><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy"><a href="http://hl7.org/fhir/R5/datatypes.html#CodeableConcept">CodeableConcept</a></td><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy">Type of the methods used in the analysis (e.g., FISH, Karyotyping, MSI)<br class="binding"/><span style="font-weight:bold" title="null" class="binding">Binding: </span><a href="ValueSet-genomicstudy-methodtype.html" title="http://hl7.org/fhir/uv/cg-incubator/ValueSet/genomicstudy-methodtype" class="binding">Genomic Study Method Type VS</a><span title="null" class="binding"> (</span><a href="http://hl7.org/fhir/R5/terminologies.html#preferred" title="Instances are encouraged to draw from the specified codes for interoperability purposes but are not required to do so to be considered conformant." class="binding">preferred</a><span title="null" class="binding">)</span><span title="null" class="binding">: </span><span title="null" class="binding">The method type of the GenomicStudy analysis.</span><br/></td></tr>
<tr style="border: 0px #F0F0F0 solid; padding:0px; vertical-align: top; background-color: white"><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px; white-space: nowrap; background-image: url(tbl_bck010.png)" class="hierarchy"><img src="tbl_spacer.png" alt="." style="background-color: inherit" class="hierarchy"/><img src="tbl_blank.png" alt="." style="background-color: inherit" class="hierarchy"/><img src="tbl_vjoin.png" alt="." style="background-color: inherit" class="hierarchy"/><img src="icon_datatype.gif" alt="." style="background-color: white; background-color: inherit" title="Data Type" class="hierarchy"/> <a href="StructureDefinition-GenomicStudy-definitions.html#GenomicStudy.analysis.changeType" title="Type of the genomic changes studied in the analysis, e.g., DNA, RNA, or amino acid change.">changeType</a><a name="GenomicStudy.analysis.changeType"> </a></td><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy"/><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy">0..*</td><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy"><a href="http://hl7.org/fhir/R5/datatypes.html#CodeableConcept">CodeableConcept</a></td><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy">Type of the genomic changes studied in the analysis (e.g., DNA, RNA, or AA change)<br class="binding"/><span style="font-weight:bold" title="null" class="binding">Binding: </span><a href="ValueSet-genomicstudy-changetype.html" title="http://hl7.org/fhir/uv/cg-incubator/ValueSet/genomicstudy-changetype" class="binding">Genomic Study Change Type VS</a><span title="null" class="binding"> (</span><a href="http://hl7.org/fhir/R5/terminologies.html#preferred" title="Instances are encouraged to draw from the specified codes for interoperability purposes but are not required to do so to be considered conformant." class="binding">preferred</a><span title="null" class="binding">)</span><span title="null" class="binding">: </span><span title="null" class="binding">The change type relevant to GenomicStudy analysis.</span><br/></td></tr>
<tr style="border: 0px #F0F0F0 solid; padding:0px; vertical-align: top; background-color: #F7F7F7"><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px; white-space: nowrap; background-image: url(tbl_bck010.png)" class="hierarchy"><img src="tbl_spacer.png" alt="." style="background-color: inherit" class="hierarchy"/><img src="tbl_blank.png" alt="." style="background-color: inherit" class="hierarchy"/><img src="tbl_vjoin.png" alt="." style="background-color: inherit" class="hierarchy"/><img src="icon_datatype.gif" alt="." style="background-color: #F7F7F7; background-color: inherit" title="Data Type" class="hierarchy"/> <a href="StructureDefinition-GenomicStudy-definitions.html#GenomicStudy.analysis.genomeBuild" title="The reference genome build that is used in this analysis.">genomeBuild</a><a name="GenomicStudy.analysis.genomeBuild"> </a></td><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy"/><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy">0..1</td><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy"><a href="http://hl7.org/fhir/R5/datatypes.html#CodeableConcept">CodeableConcept</a></td><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy">Genome build that is used in this analysis<br class="binding"/><span style="font-weight:bold" title="null" class="binding">Binding: </span><a href="https://loinc.org/LL1040-6/" class="binding">LOINC Answer List LL1040-6</a><span title="null" class="binding"> (</span><a href="http://hl7.org/fhir/R5/terminologies.html#extensible" title="To be conformant, the concept in this element SHALL be from the specified value set if any of the codes within the value set can apply to the concept being communicated.  If the value set does not cover the concept (based on human review), alternate codings (or, data type allowing, text) may be included instead." class="binding">extensible</a><span title="null" class="binding">)</span><span title="null" class="binding">: </span><span title="null" class="binding">Human reference sequence NCBI build ID</span></td></tr>
<tr style="border: 0px #F0F0F0 solid; padding:0px; vertical-align: top; background-color: white"><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px; white-space: nowrap; background-image: url(tbl_bck010.png)" class="hierarchy"><img src="tbl_spacer.png" alt="." style="background-color: inherit" class="hierarchy"/><img src="tbl_blank.png" alt="." style="background-color: inherit" class="hierarchy"/><img src="tbl_vjoin.png" alt="." style="background-color: inherit" class="hierarchy"/><img src="icon_datatype.gif" alt="." style="background-color: white; background-color: inherit" title="Data Type" class="hierarchy"/> <a href="StructureDefinition-GenomicStudy-definitions.html#GenomicStudy.analysis.genomicSourceClass" title="The genomic source class of the specimens used in the analysis, e.g., somatic or germline.">genomicSourceClass</a><a name="GenomicStudy.analysis.genomicSourceClass"> </a></td><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy"/><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy">0..1</td><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy"><a href="http://hl7.org/fhir/R5/datatypes.html#CodeableConcept">CodeableConcept</a></td><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy">The genomic source class of the specimens used in the analysis (e.g., somatic, germline)<br class="binding"/><span style="font-weight:bold" title="null" class="binding">Binding: </span><a href="https://loinc.org/LL378-1/" class="binding">LOINC Answer List LL378-1</a><span title="null" class="binding"> (</span><a href="http://hl7.org/fhir/R5/terminologies.html#extensible" title="To be conformant, the concept in this element SHALL be from the specified value set if any of the codes within the value set can apply to the concept being communicated.  If the value set does not cover the concept (based on human review), alternate codings (or, data type allowing, text) may be included instead." class="binding">extensible</a><span title="null" class="binding">)</span><span title="null" class="binding">: </span><span title="null" class="binding">The genomic source class (e.g., somatic, germline) of the specimens being analyzed.</span></td></tr>
<tr style="border: 0px #F0F0F0 solid; padding:0px; vertical-align: top; background-color: #F7F7F7"><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px; white-space: nowrap; background-image: url(tbl_bck010.png)" class="hierarchy"><img src="tbl_spacer.png" alt="." style="background-color: inherit" class="hierarchy"/><img src="tbl_blank.png" alt="." style="background-color: inherit" class="hierarchy"/><img src="tbl_vjoin.png" alt="." style="background-color: inherit" class="hierarchy"/><img src="icon_primitive.png" alt="." style="background-color: #F7F7F7; background-color: inherit" title="Primitive Data Type" class="hierarchy"/> <a href="StructureDefinition-GenomicStudy-definitions.html#GenomicStudy.analysis.instantiatesCanonical" title="The defined protocol that describes the analysis.">instantiatesCanonical</a><a name="GenomicStudy.analysis.instantiatesCanonical"> </a></td><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy"/><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy">0..1</td><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy"><a href="http://hl7.org/fhir/R5/references.html">canonical</a>(<a href="http://hl7.org/fhir/R5/plandefinition.html">PlanDefinition</a> | <a href="http://hl7.org/fhir/R5/activitydefinition.html">ActivityDefinition</a>)</td><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy">The defined protocol that describes the analysis</td></tr>
<tr style="border: 0px #F0F0F0 solid; padding:0px; vertical-align: top; background-color: white"><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px; white-space: nowrap; background-image: url(tbl_bck010.png)" class="hierarchy"><img src="tbl_spacer.png" alt="." style="background-color: inherit" class="hierarchy"/><img src="tbl_blank.png" alt="." style="background-color: inherit" class="hierarchy"/><img src="tbl_vjoin.png" alt="." style="background-color: inherit" class="hierarchy"/><img src="icon_primitive.png" alt="." style="background-color: white; background-color: inherit" title="Primitive Data Type" class="hierarchy"/> <a href="StructureDefinition-GenomicStudy-definitions.html#GenomicStudy.analysis.instantiatesUri" title="The URL pointing to an externally maintained protocol that describes the analysis.">instantiatesUri</a><a name="GenomicStudy.analysis.instantiatesUri"> </a></td><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy"/><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy">0..1</td><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy"><a href="http://hl7.org/fhir/R5/datatypes.html#uri">uri</a></td><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy">The URL pointing to an externally maintained protocol that describes the analysis</td></tr>
<tr style="border: 0px #F0F0F0 solid; padding:0px; vertical-align: top; background-color: #F7F7F7"><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px; white-space: nowrap; background-image: url(tbl_bck010.png)" class="hierarchy"><img src="tbl_spacer.png" alt="." style="background-color: inherit" class="hierarchy"/><img src="tbl_blank.png" alt="." style="background-color: inherit" class="hierarchy"/><img src="tbl_vjoin.png" alt="." style="background-color: inherit" class="hierarchy"/><img src="icon_primitive.png" alt="." style="background-color: #F7F7F7; background-color: inherit" title="Primitive Data Type" class="hierarchy"/> <a href="StructureDefinition-GenomicStudy-definitions.html#GenomicStudy.analysis.title" title="Name of the analysis event (human friendly).">title</a><a name="GenomicStudy.analysis.title"> </a></td><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy"><span style="padding-left: 3px; padding-right: 3px; color: black; null" title="This element is included in summaries">Σ</span></td><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy">0..1</td><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy"><a href="http://hl7.org/fhir/R5/datatypes.html#string">string</a></td><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy">Name of the analysis event (human friendly)</td></tr>
<tr style="border: 0px #F0F0F0 solid; padding:0px; vertical-align: top; background-color: white"><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px; white-space: nowrap; background-image: url(tbl_bck010.png)" class="hierarchy"><img src="tbl_spacer.png" alt="." style="background-color: inherit" class="hierarchy"/><img src="tbl_blank.png" alt="." style="background-color: inherit" class="hierarchy"/><img src="tbl_vjoin.png" alt="." style="background-color: inherit" class="hierarchy"/><img src="icon_reference.png" alt="." style="background-color: white; background-color: inherit" title="Reference to another Resource" class="hierarchy"/> <a href="StructureDefinition-GenomicStudy-definitions.html#GenomicStudy.analysis.focus" title="The focus of a genomic analysis when it is not the patient of record representing something or someone associated with the patient such as a spouse, parent, child, or sibling. For example, in trio testing, the GenomicStudy.subject would be the child (proband) and the GenomicStudy.analysis.focus of a specific analysis would be the parent.">focus</a><a name="GenomicStudy.analysis.focus"> </a></td><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy"><span style="padding-left: 3px; padding-right: 3px; color: black; null" title="This element is included in summaries">Σ</span></td><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy">0..*</td><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy"><a href="http://hl7.org/fhir/R5/references.html">Reference</a>(<a href="http://hl7.org/fhir/R5/resource.html">Resource</a>)</td><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy">What the genomic analysis is about, when it is not about the subject of record<br/></td></tr>
<tr style="border: 0px #F0F0F0 solid; padding:0px; vertical-align: top; background-color: #F7F7F7"><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px; white-space: nowrap; background-image: url(tbl_bck010.png)" class="hierarchy"><img src="tbl_spacer.png" alt="." style="background-color: inherit" class="hierarchy"/><img src="tbl_blank.png" alt="." style="background-color: inherit" class="hierarchy"/><img src="tbl_vjoin.png" alt="." style="background-color: inherit" class="hierarchy"/><img src="icon_reference.png" alt="." style="background-color: #F7F7F7; background-color: inherit" title="Reference to another Resource" class="hierarchy"/> <a href="StructureDefinition-GenomicStudy-definitions.html#GenomicStudy.analysis.specimen" title="The specimen used in the analysis event.">specimen</a><a name="GenomicStudy.analysis.specimen"> </a></td><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy"><span style="padding-left: 3px; padding-right: 3px; color: black; null" title="This element is included in summaries">Σ</span></td><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy">0..*</td><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy"><a href="http://hl7.org/fhir/R5/references.html">Reference</a>(<a href="http://hl7.org/fhir/R5/specimen.html">Specimen</a>)</td><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy">The specimen used in the analysis event<br/></td></tr>
<tr style="border: 0px #F0F0F0 solid; padding:0px; vertical-align: top; background-color: white"><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px; white-space: nowrap; background-image: url(tbl_bck010.png)" class="hierarchy"><img src="tbl_spacer.png" alt="." style="background-color: inherit" class="hierarchy"/><img src="tbl_blank.png" alt="." style="background-color: inherit" class="hierarchy"/><img src="tbl_vjoin.png" alt="." style="background-color: inherit" class="hierarchy"/><img src="icon_primitive.png" alt="." style="background-color: white; background-color: inherit" title="Primitive Data Type" class="hierarchy"/> <a href="StructureDefinition-GenomicStudy-definitions.html#GenomicStudy.analysis.date" title="The date of the analysis event.">date</a><a name="GenomicStudy.analysis.date"> </a></td><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy"/><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy">0..1</td><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy"><a href="http://hl7.org/fhir/R5/datatypes.html#dateTime">dateTime</a></td><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy">The date of the analysis event</td></tr>
<tr style="border: 0px #F0F0F0 solid; padding:0px; vertical-align: top; background-color: #F7F7F7"><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px; white-space: nowrap; background-image: url(tbl_bck010.png)" class="hierarchy"><img src="tbl_spacer.png" alt="." style="background-color: inherit" class="hierarchy"/><img src="tbl_blank.png" alt="." style="background-color: inherit" class="hierarchy"/><img src="tbl_vjoin.png" alt="." style="background-color: inherit" class="hierarchy"/><img src="icon_datatype.gif" alt="." style="background-color: #F7F7F7; background-color: inherit" title="Data Type" class="hierarchy"/> <a href="StructureDefinition-GenomicStudy-definitions.html#GenomicStudy.analysis.note" title="Any notes capture with the analysis event.">note</a><a name="GenomicStudy.analysis.note"> </a></td><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy"/><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy">0..*</td><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy"><a href="http://hl7.org/fhir/R5/datatypes.html#Annotation">Annotation</a></td><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy">Any notes capture with the analysis event<br/></td></tr>
<tr style="border: 0px #F0F0F0 solid; padding:0px; vertical-align: top; background-color: white"><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px; white-space: nowrap; background-image: url(tbl_bck011.png)" class="hierarchy"><img src="tbl_spacer.png" alt="." style="background-color: inherit" class="hierarchy"/><img src="tbl_blank.png" alt="." style="background-color: inherit" class="hierarchy"/><img src="tbl_vjoin.png" alt="." style="background-color: inherit" class="hierarchy"/><img src="icon_datatype.gif" alt="." style="background-color: white; background-color: inherit" title="Data Type" class="hierarchy"/> <a href="StructureDefinition-GenomicStudy-definitions.html#GenomicStudy.analysis.metrics" title="High-level quality metrics about the sequencing analysis that was performed.">metrics</a><a name="GenomicStudy.analysis.metrics"> </a></td><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy"/><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy">0..1</td><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy"><a href="http://hl7.org/fhir/R5/types.html#BackboneElement">BackboneElement</a></td><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy">Quality metrics for the analysis</td></tr>
<tr style="border: 0px #F0F0F0 solid; padding:0px; vertical-align: top; background-color: #F7F7F7"><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px; white-space: nowrap; background-image: url(tbl_bck0110.png)" class="hierarchy"><img src="tbl_spacer.png" alt="." style="background-color: inherit" class="hierarchy"/><img src="tbl_blank.png" alt="." style="background-color: inherit" class="hierarchy"/><img src="tbl_vline.png" alt="." style="background-color: inherit" class="hierarchy"/><img src="tbl_vjoin.png" alt="." style="background-color: inherit" class="hierarchy"/><img src="icon_datatype.gif" alt="." style="background-color: #F7F7F7; background-color: inherit" title="Data Type" class="hierarchy"/> <a href="StructureDefinition-GenomicStudy-definitions.html#GenomicStudy.analysis.metrics.readDepth" title="The average read depth (number of reads for a position) for the sequencing analysis.">readDepth</a><a name="GenomicStudy.analysis.metrics.readDepth"> </a></td><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy"/><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy">0..1</td><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy"><a href="http://hl7.org/fhir/R5/datatypes.html#SimpleQuantity" title="Quantity">SimpleQuantity</a></td><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy">Average read depth (e.g., 30x, 100x)</td></tr>
<tr style="border: 0px #F0F0F0 solid; padding:0px; vertical-align: top; background-color: white"><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px; white-space: nowrap; background-image: url(tbl_bck0110.png)" class="hierarchy"><img src="tbl_spacer.png" alt="." style="background-color: inherit" class="hierarchy"/><img src="tbl_blank.png" alt="." style="background-color: inherit" class="hierarchy"/><img src="tbl_vline.png" alt="." style="background-color: inherit" class="hierarchy"/><img src="tbl_vjoin.png" alt="." style="background-color: inherit" class="hierarchy"/><img src="icon_datatype.gif" alt="." style="background-color: white; background-color: inherit" title="Data Type" class="hierarchy"/> <a href="StructureDefinition-GenomicStudy-definitions.html#GenomicStudy.analysis.metrics.sequencingCoverage" title="The percentage of the studied regions that were sequenced.">sequencingCoverage</a><a name="GenomicStudy.analysis.metrics.sequencingCoverage"> </a></td><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy"/><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy">0..1</td><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy"><a href="http://hl7.org/fhir/R5/datatypes.html#SimpleQuantity" title="Quantity">SimpleQuantity</a></td><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy">Percentage of studied regions sequenced (e.g., 95%)</td></tr>
<tr style="border: 0px #F0F0F0 solid; padding:0px; vertical-align: top; background-color: #F7F7F7"><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px; white-space: nowrap; background-image: url(tbl_bck0100.png)" class="hierarchy"><img src="tbl_spacer.png" alt="." style="background-color: inherit" class="hierarchy"/><img src="tbl_blank.png" alt="." style="background-color: inherit" class="hierarchy"/><img src="tbl_vline.png" alt="." style="background-color: inherit" class="hierarchy"/><img src="tbl_vjoin_end.png" alt="." style="background-color: inherit" class="hierarchy"/><img src="icon_primitive.png" alt="." style="background-color: #F7F7F7; background-color: inherit" title="Primitive Data Type" class="hierarchy"/> <a href="StructureDefinition-GenomicStudy-definitions.html#GenomicStudy.analysis.metrics.description" title="Freetext description of the coverage and quality metrics for the sequencing analysis.">description</a><a name="GenomicStudy.analysis.metrics.description"> </a></td><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy"/><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy">0..1</td><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy"><a href="http://hl7.org/fhir/R5/datatypes.html#string">string</a></td><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy">Freetext coverage metrics description</td></tr>
<tr style="border: 0px #F0F0F0 solid; padding:0px; vertical-align: top; background-color: white"><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px; white-space: nowrap; background-image: url(tbl_bck010.png)" class="hierarchy"><img src="tbl_spacer.png" alt="." style="background-color: inherit" class="hierarchy"/><img src="tbl_blank.png" alt="." style="background-color: inherit" class="hierarchy"/><img src="tbl_vjoin.png" alt="." style="background-color: inherit" class="hierarchy"/><img src="icon_reference.png" alt="." style="background-color: white; background-color: inherit" title="Reference to another Resource" class="hierarchy"/> <a href="StructureDefinition-GenomicStudy-definitions.html#GenomicStudy.analysis.protocolPerformed" title="The protocol that was performed for the analysis event.">protocolPerformed</a><a name="GenomicStudy.analysis.protocolPerformed"> </a></td><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy"/><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy">0..1</td><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy"><a href="http://hl7.org/fhir/R5/references.html">Reference</a>(<a href="http://hl7.org/fhir/R5/procedure.html">Procedure</a> | <a href="http://hl7.org/fhir/R5/task.html">Task</a>)</td><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy">The protocol that was performed for the analysis event</td></tr>
<tr style="border: 0px #F0F0F0 solid; padding:0px; vertical-align: top; background-color: #F7F7F7"><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px; white-space: nowrap; background-image: url(tbl_bck011.png)" class="hierarchy"><img src="tbl_spacer.png" alt="." style="background-color: inherit" class="hierarchy"/><img src="tbl_blank.png" alt="." style="background-color: inherit" class="hierarchy"/><img src="tbl_vjoin.png" alt="." style="background-color: inherit" class="hierarchy"/><img src="icon_datatype.gif" alt="." style="background-color: #F7F7F7; background-color: inherit" title="Data Type" class="hierarchy"/> <a href="StructureDefinition-GenomicStudy-definitions.html#GenomicStudy.analysis.genomicRegion" title="A set of genomic regions associated with this analysis, classified by their relationship to the analysis outcome (studied, called, or uncalled). Each repetition represents one group of regions sharing the same type.">genomicRegion</a><a name="GenomicStudy.analysis.genomicRegion"> </a></td><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy"/><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy">0..*</td><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy"><a href="http://hl7.org/fhir/R5/types.html#BackboneElement">BackboneElement</a></td><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy">Genomic regions relevant to the analysis, grouped by type<br/></td></tr>
<tr style="border: 0px #F0F0F0 solid; padding:0px; vertical-align: top; background-color: white"><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px; white-space: nowrap; background-image: url(tbl_bck0110.png)" class="hierarchy"><img src="tbl_spacer.png" alt="." style="background-color: inherit" class="hierarchy"/><img src="tbl_blank.png" alt="." style="background-color: inherit" class="hierarchy"/><img src="tbl_vline.png" alt="." style="background-color: inherit" class="hierarchy"/><img src="tbl_vjoin.png" alt="." style="background-color: inherit" class="hierarchy"/><img src="icon_datatype.gif" alt="." style="background-color: white; background-color: inherit" title="Data Type" class="hierarchy"/> <a href="StructureDefinition-GenomicStudy-definitions.html#GenomicStudy.analysis.genomicRegion.type" title="The type of this region group, indicating the relationship of these regions to the analysis outcome.">type</a><a name="GenomicStudy.analysis.genomicRegion.type"> </a></td><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy"/><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy">1..1</td><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy"><a href="http://hl7.org/fhir/R5/datatypes.html#CodeableConcept">CodeableConcept</a></td><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy">studied | called | uncalled<br class="binding"/><span style="font-weight:bold" title="null" class="binding">Binding: </span><a href="ValueSet-genomicstudy-regiontype.html" title="http://hl7.org/fhir/uv/cg-incubator/ValueSet/genomicstudy-regiontype" class="binding">Genomic Study Region Type VS</a><span title="null" class="binding"> (</span><a href="http://hl7.org/fhir/R5/terminologies.html#extensible" title="To be conformant, the concept in this element SHALL be from the specified value set if any of the codes within the value set can apply to the concept being communicated.  If the value set does not cover the concept (based on human review), alternate codings (or, data type allowing, text) may be included instead." class="binding">extensible</a><span title="null" class="binding">)</span><span title="null" class="binding">: </span><span title="null" class="binding">The type of genomic region group. Use studied, called, or uncalled where applicable; other codes may be used for methodology-specific region classifications not covered by this value set.</span></td></tr>
<tr style="border: 0px #F0F0F0 solid; padding:0px; vertical-align: top; background-color: #F7F7F7"><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px; white-space: nowrap; background-image: url(tbl_bck0110.png)" class="hierarchy"><img src="tbl_spacer.png" alt="." style="background-color: inherit" class="hierarchy"/><img src="tbl_blank.png" alt="." style="background-color: inherit" class="hierarchy"/><img src="tbl_vline.png" alt="." style="background-color: inherit" class="hierarchy"/><img src="tbl_vjoin.png" alt="." style="background-color: inherit" class="hierarchy"/><img src="icon_reference.png" alt="." style="background-color: #F7F7F7; background-color: inherit" title="Reference to another Resource" class="hierarchy"/> <a href="StructureDefinition-GenomicStudy-definitions.html#GenomicStudy.analysis.genomicRegion.locus" title="The genomic regions belonging to this group. May be expressed as a coded list of HGNC gene symbols (using CodeableReference.concept) or as a reference to a BED file (using CodeableReference.reference to a DocumentReference).">locus</a><a name="GenomicStudy.analysis.genomicRegion.locus"> </a></td><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy"/><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy">0..*</td><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy"><a href="http://hl7.org/fhir/R5/references.html">CodeableReference</a>(<a href="http://hl7.org/fhir/R5/documentreference.html">DocumentReference</a>)</td><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy">Genomic regions in this group (coded genes or BED file)<br class="binding"/><span style="font-weight:bold" title="null" class="binding">Binding: </span><a href="ValueSet-hgnc-vs.html" title="http://hl7.org/fhir/uv/cg-incubator/ValueSet/hgnc-vs" class="binding">HUGO Gene Nomenclature Committee Gene Names (HGNC)</a><span title="null" class="binding"> (</span><a href="http://hl7.org/fhir/R5/terminologies.html#extensible" title="To be conformant, the concept in this element SHALL be from the specified value set if any of the codes within the value set can apply to the concept being communicated.  If the value set does not cover the concept (based on human review), alternate codings (or, data type allowing, text) may be included instead." class="binding">extensible</a><span title="null" class="binding">)</span><span title="null" class="binding">: </span><span title="null" class="binding">HGNC gene names for coded gene lists.</span><br/></td></tr>
<tr style="border: 0px #F0F0F0 solid; padding:0px; vertical-align: top; background-color: white"><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px; white-space: nowrap; background-image: url(tbl_bck0100.png)" class="hierarchy"><img src="tbl_spacer.png" alt="." style="background-color: inherit" class="hierarchy"/><img src="tbl_blank.png" alt="." style="background-color: inherit" class="hierarchy"/><img src="tbl_vline.png" alt="." style="background-color: inherit" class="hierarchy"/><img src="tbl_vjoin_end.png" alt="." style="background-color: inherit" class="hierarchy"/><img src="icon_primitive.png" alt="." style="background-color: white; background-color: inherit" title="Primitive Data Type" class="hierarchy"/> <a href="StructureDefinition-GenomicStudy-definitions.html#GenomicStudy.analysis.genomicRegion.description" title="Free-text notes providing additional context about this group of regions. Particularly useful for 'uncalled' entries to document the reason calls could not be produced (e.g., 'low coverage &lt;20x', 'poor mapping due to repetitive sequence', 'homopolymer region exceeding assay limit').">description</a><a name="GenomicStudy.analysis.genomicRegion.description"> </a></td><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy"/><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy">0..1</td><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy"><a href="http://hl7.org/fhir/R5/datatypes.html#string">string</a></td><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy">Additional details about this region group</td></tr>
<tr style="border: 0px #F0F0F0 solid; padding:0px; vertical-align: top; background-color: #F7F7F7"><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px; white-space: nowrap; background-image: url(tbl_bck011.png)" class="hierarchy"><img src="tbl_spacer.png" alt="." style="background-color: inherit" class="hierarchy"/><img src="tbl_blank.png" alt="." style="background-color: inherit" class="hierarchy"/><img src="tbl_vjoin.png" alt="." style="background-color: inherit" class="hierarchy"/><img src="icon_datatype.gif" alt="." style="background-color: #F7F7F7; background-color: inherit" title="Data Type" class="hierarchy"/> <a href="StructureDefinition-GenomicStudy-definitions.html#GenomicStudy.analysis.input" title="Inputs for the analysis event.">input</a><a name="GenomicStudy.analysis.input"> </a></td><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy"/><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy">0..*</td><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy"><a href="http://hl7.org/fhir/R5/types.html#BackboneElement">BackboneElement</a></td><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy">Inputs for the analysis event<br/></td></tr>
<tr style="border: 0px #F0F0F0 solid; padding:0px; vertical-align: top; background-color: white"><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px; white-space: nowrap; background-image: url(tbl_bck0110.png)" class="hierarchy"><img src="tbl_spacer.png" alt="." style="background-color: inherit" class="hierarchy"/><img src="tbl_blank.png" alt="." style="background-color: inherit" class="hierarchy"/><img src="tbl_vline.png" alt="." style="background-color: inherit" class="hierarchy"/><img src="tbl_vjoin.png" alt="." style="background-color: inherit" class="hierarchy"/><img src="icon_reference.png" alt="." style="background-color: white; background-color: inherit" title="Reference to another Resource" class="hierarchy"/> <a href="StructureDefinition-GenomicStudy-definitions.html#GenomicStudy.analysis.input.file" title="File containing input data.">file</a><a name="GenomicStudy.analysis.input.file"> </a></td><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy"><span style="padding-left: 3px; padding-right: 3px; color: black; null" title="This element is included in summaries">Σ</span></td><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy">0..1</td><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy"><a href="http://hl7.org/fhir/R5/references.html">Reference</a>(<a href="http://hl7.org/fhir/R5/documentreference.html">DocumentReference</a>)</td><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy">File containing input data</td></tr>
<tr style="border: 0px #F0F0F0 solid; padding:0px; vertical-align: top; background-color: #F7F7F7"><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px; white-space: nowrap; background-image: url(tbl_bck0110.png)" class="hierarchy"><img src="tbl_spacer.png" alt="." style="background-color: inherit" class="hierarchy"/><img src="tbl_blank.png" alt="." style="background-color: inherit" class="hierarchy"/><img src="tbl_vline.png" alt="." style="background-color: inherit" class="hierarchy"/><img src="tbl_vjoin.png" alt="." style="background-color: inherit" class="hierarchy"/><img src="icon_datatype.gif" alt="." style="background-color: #F7F7F7; background-color: inherit" title="Data Type" class="hierarchy"/> <a href="StructureDefinition-GenomicStudy-definitions.html#GenomicStudy.analysis.input.type" title="Type of input data, e.g., BAM, CRAM, or FASTA.">type</a><a name="GenomicStudy.analysis.input.type"> </a></td><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy"/><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy">0..1</td><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy"><a href="http://hl7.org/fhir/R5/datatypes.html#CodeableConcept">CodeableConcept</a></td><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy">Type of input data (e.g., BAM, CRAM, or FASTA)<br class="binding"/><span style="font-weight:bold" title="null" class="binding">Binding: </span><a href="ValueSet-genomicstudy-dataformat.html" title="http://hl7.org/fhir/uv/cg-incubator/ValueSet/genomicstudy-dataformat" class="binding">Genomic Study Data Format VS</a><span title="null" class="binding"> (</span><a href="http://hl7.org/fhir/R5/terminologies.html#example" title="Instances are not expected or even encouraged to draw from the specified value set.  The value set merely provides examples of the types of concepts intended to be included." class="binding">example</a><span title="null" class="binding">)</span><span title="null" class="binding">: </span><span title="null" class="binding">The data format of the data file.</span></td></tr>
<tr style="border: 0px #F0F0F0 solid; padding:0px; vertical-align: top; background-color: white"><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px; white-space: nowrap; background-image: url(tbl_bck0101.png)" class="hierarchy"><img src="tbl_spacer.png" alt="." style="background-color: inherit" class="hierarchy"/><img src="tbl_blank.png" alt="." style="background-color: inherit" class="hierarchy"/><img src="tbl_vline.png" alt="." style="background-color: inherit" class="hierarchy"/><img src="tbl_vjoin_end.png" alt="." style="background-color: inherit" class="hierarchy"/><img src="icon_choice.gif" alt="." style="background-color: white; background-color: inherit" title="Choice of Types" class="hierarchy"/> <a href="StructureDefinition-GenomicStudy-definitions.html#GenomicStudy.analysis.input.generatedBy[x]" title="The analysis event or other GenomicStudy that generated this input file.">generatedBy[x]</a><a name="GenomicStudy.analysis.input.generatedBy_x_"> </a></td><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy"/><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy">0..1</td><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy"/><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy">The analysis event or other GenomicStudy that generated this input file</td></tr>
<tr style="border: 0px #F0F0F0 solid; padding:0px; vertical-align: top; background-color: #F7F7F7"><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px; white-space: nowrap; background-image: url(tbl_bck01010.png)" class="hierarchy"><img src="tbl_spacer.png" alt="." style="background-color: inherit" class="hierarchy"/><img src="tbl_blank.png" alt="." style="background-color: inherit" class="hierarchy"/><img src="tbl_vline.png" alt="." style="background-color: inherit" class="hierarchy"/><img src="tbl_blank.png" alt="." style="background-color: inherit" class="hierarchy"/><img src="tbl_vjoin.png" alt="." style="background-color: inherit" class="hierarchy"/><img src="icon_datatype.gif" alt="." style="background-color: #F7F7F7; background-color: inherit" title="Data Type" class="hierarchy"/> <span title="Identifier Type: An identifier - identifies some entity uniquely and unambiguously. Typically this is used for business identifiers.">generatedByIdentifier</span></td><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy"/><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy"/><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy"><a href="http://hl7.org/fhir/R5/datatypes.html#Identifier">Identifier</a></td><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy"/></tr>
<tr style="border: 0px #F0F0F0 solid; padding:0px; vertical-align: top; background-color: white"><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px; white-space: nowrap; background-image: url(tbl_bck01000.png)" class="hierarchy"><img src="tbl_spacer.png" alt="." style="background-color: inherit" class="hierarchy"/><img src="tbl_blank.png" alt="." style="background-color: inherit" class="hierarchy"/><img src="tbl_vline.png" alt="." style="background-color: inherit" class="hierarchy"/><img src="tbl_blank.png" alt="." style="background-color: inherit" class="hierarchy"/><img src="tbl_vjoin_end.png" alt="." style="background-color: inherit" class="hierarchy"/><img src="icon_reference.png" alt="." style="background-color: white; background-color: inherit" title="Reference to another Resource" class="hierarchy"/> generatedByReference</td><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy"/><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy"/><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy"><a href="http://hl7.org/fhir/R5/references.html#Reference">Reference</a>(<a href="StructureDefinition-GenomicStudy.html">Genomic Study</a>)</td><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy"/></tr>
<tr style="border: 0px #F0F0F0 solid; padding:0px; vertical-align: top; background-color: #F7F7F7"><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px; white-space: nowrap; background-image: url(tbl_bck011.png)" class="hierarchy"><img src="tbl_spacer.png" alt="." style="background-color: inherit" class="hierarchy"/><img src="tbl_blank.png" alt="." style="background-color: inherit" class="hierarchy"/><img src="tbl_vjoin.png" alt="." style="background-color: inherit" class="hierarchy"/><img src="icon_datatype.gif" alt="." style="background-color: #F7F7F7; background-color: inherit" title="Data Type" class="hierarchy"/> <a href="StructureDefinition-GenomicStudy-definitions.html#GenomicStudy.analysis.output" title="Outputs for the analysis event.">output</a><a name="GenomicStudy.analysis.output"> </a></td><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy"/><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy">0..*</td><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy"><a href="http://hl7.org/fhir/R5/types.html#BackboneElement">BackboneElement</a></td><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy">Outputs for the analysis event<br/></td></tr>
<tr style="border: 0px #F0F0F0 solid; padding:0px; vertical-align: top; background-color: white"><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px; white-space: nowrap; background-image: url(tbl_bck0110.png)" class="hierarchy"><img src="tbl_spacer.png" alt="." style="background-color: inherit" class="hierarchy"/><img src="tbl_blank.png" alt="." style="background-color: inherit" class="hierarchy"/><img src="tbl_vline.png" alt="." style="background-color: inherit" class="hierarchy"/><img src="tbl_vjoin.png" alt="." style="background-color: inherit" class="hierarchy"/><img src="icon_reference.png" alt="." style="background-color: white; background-color: inherit" title="Reference to another Resource" class="hierarchy"/> <a href="StructureDefinition-GenomicStudy-definitions.html#GenomicStudy.analysis.output.file" title="File containing output data.">file</a><a name="GenomicStudy.analysis.output.file"> </a></td><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy"><span style="padding-left: 3px; padding-right: 3px; color: black; null" title="This element is included in summaries">Σ</span></td><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy">0..1</td><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy"><a href="http://hl7.org/fhir/R5/references.html">Reference</a>(<a href="http://hl7.org/fhir/R5/documentreference.html">DocumentReference</a>)</td><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy">File containing output data</td></tr>
<tr style="border: 0px #F0F0F0 solid; padding:0px; vertical-align: top; background-color: #F7F7F7"><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px; white-space: nowrap; background-image: url(tbl_bck0100.png)" class="hierarchy"><img src="tbl_spacer.png" alt="." style="background-color: inherit" class="hierarchy"/><img src="tbl_blank.png" alt="." style="background-color: inherit" class="hierarchy"/><img src="tbl_vline.png" alt="." style="background-color: inherit" class="hierarchy"/><img src="tbl_vjoin_end.png" alt="." style="background-color: inherit" class="hierarchy"/><img src="icon_datatype.gif" alt="." style="background-color: #F7F7F7; background-color: inherit" title="Data Type" class="hierarchy"/> <a href="StructureDefinition-GenomicStudy-definitions.html#GenomicStudy.analysis.output.type" title="Type of output data, e.g., VCF, MAF, or BAM.">type</a><a name="GenomicStudy.analysis.output.type"> </a></td><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy"><span style="padding-left: 3px; padding-right: 3px; color: black; null" title="This element is included in summaries">Σ</span></td><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy">0..1</td><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy"><a href="http://hl7.org/fhir/R5/datatypes.html#CodeableConcept">CodeableConcept</a></td><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy">Type of output data (e.g., VCF, MAF, or BAM)<br class="binding"/><span style="font-weight:bold" title="null" class="binding">Binding: </span><a href="ValueSet-genomicstudy-dataformat.html" title="http://hl7.org/fhir/uv/cg-incubator/ValueSet/genomicstudy-dataformat" class="binding">Genomic Study Data Format VS</a><span title="null" class="binding"> (</span><a href="http://hl7.org/fhir/R5/terminologies.html#example" title="Instances are not expected or even encouraged to draw from the specified value set.  The value set merely provides examples of the types of concepts intended to be included." class="binding">example</a><span title="null" class="binding">)</span><span title="null" class="binding">: </span><span title="null" class="binding">The data format of the data file.</span></td></tr>
<tr style="border: 0px #F0F0F0 solid; padding:0px; vertical-align: top; background-color: white"><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px; white-space: nowrap; background-image: url(tbl_bck011.png)" class="hierarchy"><img src="tbl_spacer.png" alt="." style="background-color: inherit" class="hierarchy"/><img src="tbl_blank.png" alt="." style="background-color: inherit" class="hierarchy"/><img src="tbl_vjoin.png" alt="." style="background-color: inherit" class="hierarchy"/><img src="icon_datatype.gif" alt="." style="background-color: white; background-color: inherit" title="Data Type" class="hierarchy"/> <a href="StructureDefinition-GenomicStudy-definitions.html#GenomicStudy.analysis.performer" title="Performer for the analysis event.">performer</a><a name="GenomicStudy.analysis.performer"> </a></td><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy"/><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy">0..*</td><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy"><a href="http://hl7.org/fhir/R5/types.html#BackboneElement">BackboneElement</a></td><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy">Performer for the analysis event<br/></td></tr>
<tr style="border: 0px #F0F0F0 solid; padding:0px; vertical-align: top; background-color: #F7F7F7"><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px; white-space: nowrap; background-image: url(tbl_bck0110.png)" class="hierarchy"><img src="tbl_spacer.png" alt="." style="background-color: inherit" class="hierarchy"/><img src="tbl_blank.png" alt="." style="background-color: inherit" class="hierarchy"/><img src="tbl_vline.png" alt="." style="background-color: inherit" class="hierarchy"/><img src="tbl_vjoin.png" alt="." style="background-color: inherit" class="hierarchy"/><img src="icon_reference.png" alt="." style="background-color: #F7F7F7; background-color: inherit" title="Reference to another Resource" class="hierarchy"/> <a href="StructureDefinition-GenomicStudy-definitions.html#GenomicStudy.analysis.performer.actor" title="The organization, healthcare professional, or others who participated in performing this analysis.">actor</a><a name="GenomicStudy.analysis.performer.actor"> </a></td><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy"/><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy">0..1</td><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy"><a href="http://hl7.org/fhir/R5/references.html">Reference</a>(<a href="http://hl7.org/fhir/R5/practitioner.html">Practitioner</a> | <a href="http://hl7.org/fhir/R5/practitionerrole.html">PractitionerRole</a> | <a href="http://hl7.org/fhir/R5/organization.html">Organization</a> | <a href="http://hl7.org/fhir/R5/device.html">Device</a>)</td><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy">The organization, healthcare professional, or others who participated in performing this analysis</td></tr>
<tr style="border: 0px #F0F0F0 solid; padding:0px; vertical-align: top; background-color: white"><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px; white-space: nowrap; background-image: url(tbl_bck0100.png)" class="hierarchy"><img src="tbl_spacer.png" alt="." style="background-color: inherit" class="hierarchy"/><img src="tbl_blank.png" alt="." style="background-color: inherit" class="hierarchy"/><img src="tbl_vline.png" alt="." style="background-color: inherit" class="hierarchy"/><img src="tbl_vjoin_end.png" alt="." style="background-color: inherit" class="hierarchy"/><img src="icon_datatype.gif" alt="." style="background-color: white; background-color: inherit" title="Data Type" class="hierarchy"/> <a href="StructureDefinition-GenomicStudy-definitions.html#GenomicStudy.analysis.performer.role" title="Role of the actor for this analysis.">role</a><a name="GenomicStudy.analysis.performer.role"> </a></td><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy"/><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy">0..1</td><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy"><a href="http://hl7.org/fhir/R5/datatypes.html#CodeableConcept">CodeableConcept</a></td><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy">Role of the actor for this analysis</td></tr>
<tr style="border: 0px #F0F0F0 solid; padding:0px; vertical-align: top; background-color: #F7F7F7"><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px; white-space: nowrap; background-image: url(tbl_bck001.png)" class="hierarchy"><img src="tbl_spacer.png" alt="." style="background-color: inherit" class="hierarchy"/><img src="tbl_blank.png" alt="." style="background-color: inherit" class="hierarchy"/><img src="tbl_vjoin_end.png" alt="." style="background-color: inherit" class="hierarchy"/><img src="icon_datatype.gif" alt="." style="background-color: #F7F7F7; background-color: inherit" title="Data Type" class="hierarchy"/> <a href="StructureDefinition-GenomicStudy-definitions.html#GenomicStudy.analysis.device" title="Devices used for the analysis (e.g., instruments, software), with settings and parameters.">device</a><a name="GenomicStudy.analysis.device"> </a></td><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy"/><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy">0..*</td><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy"><a href="http://hl7.org/fhir/R5/types.html#BackboneElement">BackboneElement</a></td><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy">Devices used for the analysis (e.g., instruments, software), with settings and parameters<br/></td></tr>
<tr style="border: 0px #F0F0F0 solid; padding:0px; vertical-align: top; background-color: white"><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px; white-space: nowrap; background-image: url(tbl_bck0010.png)" class="hierarchy"><img src="tbl_spacer.png" alt="." style="background-color: inherit" class="hierarchy"/><img src="tbl_blank.png" alt="." style="background-color: inherit" class="hierarchy"/><img src="tbl_blank.png" alt="." style="background-color: inherit" class="hierarchy"/><img src="tbl_vjoin.png" alt="." style="background-color: inherit" class="hierarchy"/><img src="icon_reference.png" alt="." style="background-color: white; background-color: inherit" title="Reference to another Resource" class="hierarchy"/> <a href="StructureDefinition-GenomicStudy-definitions.html#GenomicStudy.analysis.device.device" title="Device used for the analysis.">device</a><a name="GenomicStudy.analysis.device.device"> </a></td><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy"/><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy">0..1</td><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy"><a href="http://hl7.org/fhir/R5/references.html">Reference</a>(<a href="http://hl7.org/fhir/R5/device.html">Device</a>)</td><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy">Device used for the analysis</td></tr>
<tr style="border: 0px #F0F0F0 solid; padding:0px; vertical-align: top; background-color: #F7F7F7"><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px; white-space: nowrap; background-image: url(tbl_bck0000.png)" class="hierarchy"><img src="tbl_spacer.png" alt="." style="background-color: inherit" class="hierarchy"/><img src="tbl_blank.png" alt="." style="background-color: inherit" class="hierarchy"/><img src="tbl_blank.png" alt="." style="background-color: inherit" class="hierarchy"/><img src="tbl_vjoin_end.png" alt="." style="background-color: inherit" class="hierarchy"/><img src="icon_datatype.gif" alt="." style="background-color: #F7F7F7; background-color: inherit" title="Data Type" class="hierarchy"/> <a href="StructureDefinition-GenomicStudy-definitions.html#GenomicStudy.analysis.device.function" title="Specific function for the device used for the analysis.">function</a><a name="GenomicStudy.analysis.device.function"> </a></td><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy"/><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy">0..1</td><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy"><a href="http://hl7.org/fhir/R5/datatypes.html#CodeableConcept">CodeableConcept</a></td><td style="vertical-align: top; text-align : var(--ig-left,left); background-color: #F7F7F7; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px" class="hierarchy">Specific function for the device used for the analysis</td></tr>
<tr><td colspan="5" class="hierarchy"><br/><a href="https://build.fhir.org/ig/FHIR/ig-guidance/readingIgs.html#table-views" title="Legend for this format"><img src="data:image/png;base64,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" alt="doco" style="background-color: inherit"/> Documentation for this format</a></td></tr></table></div>
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  <url value="http://hl7.org/fhir/StructureDefinition/GenomicStudy"/>
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    <value value="urn:oid:2.16.840.1.113883.4.642.5.1109"/>
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  <title value="Genomic Study"/>
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  <date value="2021-01-02T08:58:31+11:00"/>
  <publisher value="HL7 International / Clinical Genomics"/>
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    <telecom>
      <system value="email"/>
      <value value="clingenomics@lists.hl7.org"/>
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        <severity value="error"/>
        <human
               value="If the resource is contained in another resource, it SHALL NOT contain nested Resources"/>
        <expression value="contained.contained.empty()"/>
        <source
                value="http://hl7.org/fhir/StructureDefinition/DomainResource"/>
      </constraint>
      <constraint>
        <key value="dom-3"/>
        <severity value="error"/>
        <human
               value="If the resource is contained in another resource, it SHALL be referred to from elsewhere in the resource or SHALL refer to the containing resource"/>
        <expression
                    value="contained.where((('#'+id.trace('id') in %resource.descendants().select(reference | as(uri))) or descendants().where(reference='#' | as(uri)='#').exists()).not()).trace('unmatched', id).empty()"/>
        <source
                value="http://hl7.org/fhir/StructureDefinition/DomainResource"/>
      </constraint>
      <constraint>
        <key value="dom-4"/>
        <severity value="error"/>
        <human
               value="If a resource is contained in another resource, it SHALL NOT have a meta.versionId or a meta.lastUpdated"/>
        <expression
                    value="contained.meta.versionId.empty() and contained.meta.lastUpdated.empty()"/>
        <source
                value="http://hl7.org/fhir/StructureDefinition/DomainResource"/>
      </constraint>
      <constraint>
        <key value="dom-5"/>
        <severity value="error"/>
        <human
               value="If a resource is contained in another resource, it SHALL NOT have a security label"/>
        <expression value="contained.meta.security.empty()"/>
        <source
                value="http://hl7.org/fhir/StructureDefinition/DomainResource"/>
      </constraint>
      <constraint>
        <extension
                   url="http://hl7.org/fhir/StructureDefinition/elementdefinition-bestpractice">
          <valueBoolean value="true"/>
        </extension>
        <extension
                   url="http://hl7.org/fhir/StructureDefinition/elementdefinition-bestpractice-explanation">
          <valueMarkdown
                         value="When a resource has no narrative, only systems that fully understand the data can display the resource to a human safely. Including a human readable representation in the resource makes for a much more robust eco-system and cheaper handling of resources by intermediary systems. Some ecosystems restrict distribution of resources to only those systems that do fully understand the resources, and as a consequence implementers may believe that the narrative is superfluous. However experience shows that such eco-systems often open up to new participants over time."/>
        </extension>
        <key value="dom-6"/>
        <severity value="warning"/>
        <human
               value="A resource should have narrative for robust management"/>
        <expression value="text.`div`.exists()"/>
        <source
                value="http://hl7.org/fhir/StructureDefinition/DomainResource"/>
      </constraint>
      <mustSupport value="false"/>
      <isModifier value="false"/>
      <isSummary value="false"/>
      <mapping>
        <identity value="workflow"/>
        <map value="Event"/>
      </mapping>
      <mapping>
        <identity value="w5"/>
        <map value="clinical.diagnostics"/>
      </mapping>
      <mapping>
        <identity value="rim"/>
        <map value="Entity. Role, or Act,Entity, Role, or Act"/>
      </mapping>
    </element>
    <element id="GenomicStudy.id">
      <path value="GenomicStudy.id"/>
      <short value="Logical id of this artifact"/>
      <definition
                  value="The logical id of the resource, as used in the URL for the resource. Once assigned, this value never changes."/>
      <comment
               value="Within the context of the FHIR RESTful interactions, the resource has an id except for cases like the create and conditional update. Otherwise, the use of the resouce id depends on the given use case."/>
      <min value="0"/>
      <max value="1"/>
      <base>
        <path value="Resource.id"/>
        <min value="0"/>
        <max value="1"/>
      </base>
      <type>
        <extension
                   url="http://hl7.org/fhir/StructureDefinition/structuredefinition-fhir-type">
          <valueUrl value="id"/>
        </extension>
        <code value="http://hl7.org/fhirpath/System.String"/>
      </type>
      <mustSupport value="false"/>
      <isModifier value="false"/>
      <isSummary value="true"/>
    </element>
    <element id="GenomicStudy.meta">
      <path value="GenomicStudy.meta"/>
      <short value="Metadata about the resource"/>
      <definition
                  value="The metadata about the resource. This is content that is maintained by the infrastructure. Changes to the content might not always be associated with version changes to the resource."/>
      <min value="0"/>
      <max value="1"/>
      <base>
        <path value="Resource.meta"/>
        <min value="0"/>
        <max value="1"/>
      </base>
      <type>
        <code value="Meta"/>
      </type>
      <constraint>
        <key value="ele-1"/>
        <severity value="error"/>
        <human value="All FHIR elements must have a @value or children"/>
        <expression
                    value="hasValue() or (children().count() &gt; id.count())"/>
        <source value="http://hl7.org/fhir/StructureDefinition/Element"/>
      </constraint>
      <mustSupport value="false"/>
      <isModifier value="false"/>
      <isSummary value="true"/>
    </element>
    <element id="GenomicStudy.implicitRules">
      <path value="GenomicStudy.implicitRules"/>
      <short value="A set of rules under which this content was created"/>
      <definition
                  value="A reference to a set of rules that were followed when the resource was constructed, and which must be understood when processing the content. Often, this is a reference to an implementation guide that defines the special rules along with other profiles etc."/>
      <comment
               value="Asserting this rule set restricts the content to be only understood by a limited set of trading partners. This inherently limits the usefulness of the data in the long term. However, the existing health eco-system is highly fractured, and not yet ready to define, collect, and exchange data in a generally computable sense. Wherever possible, implementers and/or specification writers should avoid using this element. Often, when used, the URL is a reference to an implementation guide that defines these special rules as part of its narrative along with other profiles, value sets, etc."/>
      <min value="0"/>
      <max value="1"/>
      <base>
        <path value="Resource.implicitRules"/>
        <min value="0"/>
        <max value="1"/>
      </base>
      <type>
        <code value="uri"/>
      </type>
      <constraint>
        <key value="ele-1"/>
        <severity value="error"/>
        <human value="All FHIR elements must have a @value or children"/>
        <expression
                    value="hasValue() or (children().count() &gt; id.count())"/>
        <source value="http://hl7.org/fhir/StructureDefinition/Element"/>
      </constraint>
      <mustSupport value="false"/>
      <isModifier value="true"/>
      <isModifierReason
                        value="This element is labeled as a modifier because the implicit rules may provide additional knowledge about the resource that modifies its meaning or interpretation"/>
      <isSummary value="true"/>
    </element>
    <element id="GenomicStudy.language">
      <path value="GenomicStudy.language"/>
      <short value="Language of the resource content"/>
      <definition
                  value="The base language in which the resource is written."/>
      <comment
               value="Language is provided to support indexing and accessibility (typically, services such as text to speech use the language tag). The html language tag in the narrative applies  to the narrative. The language tag on the resource may be used to specify the language of other presentations generated from the data in the resource. Not all the content has to be in the base language. The Resource.language should not be assumed to apply to the narrative automatically. If a language is specified, it should it also be specified on the div element in the html (see rules in HTML5 for information about the relationship between xml:lang and the html lang attribute)."/>
      <min value="0"/>
      <max value="1"/>
      <base>
        <path value="Resource.language"/>
        <min value="0"/>
        <max value="1"/>
      </base>
      <type>
        <code value="code"/>
      </type>
      <constraint>
        <key value="ele-1"/>
        <severity value="error"/>
        <human value="All FHIR elements must have a @value or children"/>
        <expression
                    value="hasValue() or (children().count() &gt; id.count())"/>
        <source value="http://hl7.org/fhir/StructureDefinition/Element"/>
      </constraint>
      <mustSupport value="false"/>
      <isModifier value="false"/>
      <isSummary value="false"/>
      <binding>
        <extension
                   url="http://hl7.org/fhir/StructureDefinition/elementdefinition-bindingName">
          <valueString value="Language"/>
        </extension>
        <strength value="required"/>
        <description value="IETF language tag for a human language"/>
        <valueSet
                  value="http://hl7.org/fhir/ValueSet/all-languages|6.0.0-ballot3"/>
        <additional>
          <purpose value="starter"/>
          <valueSet
                    value="http://hl7.org/fhir/ValueSet/languages|6.0.0-ballot3"/>
        </additional>
      </binding>
    </element>
    <element id="GenomicStudy.text">
      <path value="GenomicStudy.text"/>
      <short value="Text summary of the resource, for human interpretation"/>
      <definition
                  value="A human-readable narrative that contains a summary of the resource and can be used to represent the content of the resource to a human. The narrative need not encode all the structured data, but is required to contain sufficient detail to make it &quot;clinically safe&quot; for a human to just read the narrative. Resource definitions may define what content should be represented in the narrative to ensure clinical safety."/>
      <comment
               value="Contained resources do not have a narrative. Resources that are not contained SHOULD have a narrative. In some cases, a resource may only have text with little or no additional discrete data (as long as all minOccurs=1 elements are satisfied).  This may be necessary for data from legacy systems where information is captured as a &quot;text blob&quot; or where text is additionally entered raw or narrated and encoded information is added later."/>
      <alias value="narrative"/>
      <alias value="html"/>
      <alias value="xhtml"/>
      <alias value="display"/>
      <min value="0"/>
      <max value="1"/>
      <base>
        <path value="DomainResource.text"/>
        <min value="0"/>
        <max value="1"/>
      </base>
      <type>
        <code value="Narrative"/>
      </type>
      <condition value="dom-6"/>
      <constraint>
        <key value="ele-1"/>
        <severity value="error"/>
        <human value="All FHIR elements must have a @value or children"/>
        <expression
                    value="hasValue() or (children().count() &gt; id.count())"/>
        <source value="http://hl7.org/fhir/StructureDefinition/Element"/>
      </constraint>
      <mustSupport value="false"/>
      <isModifier value="false"/>
      <isSummary value="false"/>
      <mapping>
        <identity value="rim"/>
        <map value="Act.text?"/>
      </mapping>
    </element>
    <element id="GenomicStudy.contained">
      <path value="GenomicStudy.contained"/>
      <short value="Contained, inline Resources"/>
      <definition
                  value="These resources do not have an independent existence apart from the resource that contains them - they cannot be identified independently, nor can they have their own independent transaction scope. This is allowed to be a Parameters resource if and only if it is referenced by a resource that provides context/meaning."/>
      <comment
               value="This should never be done when the content can be identified properly, as once identification is lost, it is extremely difficult (and context dependent) to restore it again. Contained resources may have profiles and tags in their meta elements, but SHALL NOT have security labels. Contained resources may be a resource type defined in the FHIR specification, or an [additional resource](http://build.fhir.org/resource.html#additional)."/>
      <alias value="inline resources"/>
      <alias value="anonymous resources"/>
      <alias value="contained resources"/>
      <min value="0"/>
      <max value="*"/>
      <base>
        <path value="DomainResource.contained"/>
        <min value="0"/>
        <max value="*"/>
      </base>
      <type>
        <code value="Resource"/>
      </type>
      <condition value="dom-2"/>
      <condition value="dom-4"/>
      <condition value="dom-3"/>
      <condition value="dom-5"/>
      <mustSupport value="false"/>
      <isModifier value="false"/>
      <isSummary value="false"/>
      <mapping>
        <identity value="rim"/>
        <map value="N/A"/>
      </mapping>
    </element>
    <element id="GenomicStudy.extension">
      <path value="GenomicStudy.extension"/>
      <slicing>
        <discriminator>
          <type value="value"/>
          <path value="url"/>
        </discriminator>
        <description value="Extensions are always sliced by (at least) url"/>
        <rules value="open"/>
      </slicing>
      <short value="Additional content defined by implementations"/>
      <definition
                  value="May be used to represent additional information that is not part of the basic definition of the resource. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension."/>
      <comment
               value="There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions.  The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone."/>
      <alias value="extensions"/>
      <alias value="user content"/>
      <min value="0"/>
      <max value="*"/>
      <base>
        <path value="DomainResource.extension"/>
        <min value="0"/>
        <max value="*"/>
      </base>
      <type>
        <code value="Extension"/>
      </type>
      <constraint>
        <key value="ele-1"/>
        <severity value="error"/>
        <human value="All FHIR elements must have a @value or children"/>
        <expression
                    value="hasValue() or (children().count() &gt; id.count())"/>
        <source value="http://hl7.org/fhir/StructureDefinition/Element"/>
      </constraint>
      <mustSupport value="false"/>
      <isModifier value="false"/>
      <isSummary value="false"/>
      <mapping>
        <identity value="rim"/>
        <map value="N/A"/>
      </mapping>
    </element>
    <element id="GenomicStudy.modifierExtension">
      <path value="GenomicStudy.modifierExtension"/>
      <slicing>
        <discriminator>
          <type value="value"/>
          <path value="url"/>
        </discriminator>
        <description value="Extensions are always sliced by (at least) url"/>
        <rules value="open"/>
      </slicing>
      <short value="Extensions that cannot be ignored"/>
      <definition
                  value="May be used to represent additional information that is not part of the basic definition of the resource and that modifies the understanding of the element that contains it and/or the understanding of the containing element's descendants. Usually modifier elements provide negation or qualification. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer is allowed to define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Applications processing a resource are required to check for modifier extensions.

Modifier extensions SHALL NOT change the meaning of any elements on Resource or DomainResource (including cannot change the meaning of modifierExtension itself)."/>
      <comment
               value="There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions.  The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone."/>
      <requirements
                    value="Modifier extensions allow for extensions that *cannot* be safely ignored to be clearly distinguished from the vast majority of extensions which can be safely ignored.  This promotes interoperability by eliminating the need for implementers to prohibit the presence of extensions. For further information, see the [definition of modifier extensions](http://build.fhir.org/extensibility.html#modifierExtension)."/>
      <alias value="extensions"/>
      <alias value="user content"/>
      <min value="0"/>
      <max value="*"/>
      <base>
        <path value="DomainResource.modifierExtension"/>
        <min value="0"/>
        <max value="*"/>
      </base>
      <type>
        <code value="Extension"/>
      </type>
      <constraint>
        <key value="ele-1"/>
        <severity value="error"/>
        <human value="All FHIR elements must have a @value or children"/>
        <expression
                    value="hasValue() or (children().count() &gt; id.count())"/>
        <source value="http://hl7.org/fhir/StructureDefinition/Element"/>
      </constraint>
      <mustSupport value="false"/>
      <isModifier value="true"/>
      <isModifierReason
                        value="Modifier extensions are expected to modify the meaning or interpretation of the resource that contains them"/>
      <isSummary value="true"/>
      <mapping>
        <identity value="rim"/>
        <map value="N/A"/>
      </mapping>
    </element>
    <element id="GenomicStudy.identifier">
      <path value="GenomicStudy.identifier"/>
      <short value="Identifiers for this genomic study"/>
      <definition value="Identifiers for this genomic study."/>
      <min value="0"/>
      <max value="*"/>
      <base>
        <path value="GenomicStudy.identifier"/>
        <min value="0"/>
        <max value="*"/>
      </base>
      <type>
        <code value="Identifier"/>
      </type>
      <isSummary value="true"/>
    </element>
    <element id="GenomicStudy.status">
      <path value="GenomicStudy.status"/>
      <short
             value="registered | available | cancelled | entered-in-error | unknown"/>
      <definition value="The status of the genomic study."/>
      <min value="1"/>
      <max value="1"/>
      <base>
        <path value="GenomicStudy.status"/>
        <min value="1"/>
        <max value="1"/>
      </base>
      <type>
        <code value="code"/>
      </type>
      <isModifier value="true"/>
      <isModifierReason
                        value="This element is labeled as a modifier because it is a status element that contains status entered-in-error which means that the resource should not be treated as valid"/>
      <isSummary value="true"/>
      <binding>
        <extension
                   url="http://hl7.org/fhir/StructureDefinition/elementdefinition-bindingName">
          <valueString value="GenomicStudyStatus"/>
        </extension>
        <strength value="required"/>
        <description value="The status of the GenomicStudy."/>
        <valueSet
                  value="http://hl7.org/fhir/uv/cg-incubator/ValueSet/genomicstudy-status"/>
      </binding>
      <mapping>
        <identity value="workflow"/>
        <map value="Event.status"/>
      </mapping>
      <mapping>
        <identity value="w5"/>
        <map value="FiveWs.status"/>
      </mapping>
      <mapping>
        <identity value="v2"/>
        <map value="Varies by domain"/>
      </mapping>
      <mapping>
        <identity value="rim"/>
        <map value=".status"/>
      </mapping>
    </element>
    <element id="GenomicStudy.type">
      <path value="GenomicStudy.type"/>
      <short
             value="The type of the study (e.g., Familial variant segregation, Functional variation detection, or Gene expression profiling)"/>
      <definition
                  value="The type of the study, e.g., Familial variant segregation, Functional variation detection, or Gene expression profiling."/>
      <min value="0"/>
      <max value="*"/>
      <base>
        <path value="GenomicStudy.type"/>
        <min value="0"/>
        <max value="*"/>
      </base>
      <type>
        <code value="CodeableConcept"/>
      </type>
      <isSummary value="true"/>
      <binding>
        <extension
                   url="http://hl7.org/fhir/StructureDefinition/elementdefinition-bindingName">
          <valueString value="GenomicStudyType"/>
        </extension>
        <strength value="example"/>
        <description value="The type relevant to GenomicStudy."/>
        <valueSet
                  value="http://hl7.org/fhir/uv/cg-incubator/ValueSet/genomicstudy-type"/>
      </binding>
    </element>
    <element id="GenomicStudy.subject">
      <path value="GenomicStudy.subject"/>
      <short value="The primary subject of the genomic study"/>
      <definition value="The primary subject of the genomic study."/>
      <min value="1"/>
      <max value="1"/>
      <base>
        <path value="GenomicStudy.subject"/>
        <min value="1"/>
        <max value="1"/>
      </base>
      <type>
        <code value="Reference"/>
        <targetProfile
                       value="http://hl7.org/fhir/StructureDefinition/Patient"/>
        <targetProfile value="http://hl7.org/fhir/StructureDefinition/Group"/>
        <targetProfile
                       value="http://hl7.org/fhir/StructureDefinition/Substance"/>
        <targetProfile
                       value="http://hl7.org/fhir/StructureDefinition/BiologicallyDerivedProduct"/>
        <targetProfile
                       value="http://hl7.org/fhir/StructureDefinition/NutritionProduct"/>
      </type>
      <isSummary value="true"/>
    </element>
    <element id="GenomicStudy.encounter">
      <path value="GenomicStudy.encounter"/>
      <short
             value="The healthcare event with which this genomics study is associated"/>
      <definition
                  value="The healthcare event with which this genomics study is associated."/>
      <min value="0"/>
      <max value="1"/>
      <base>
        <path value="GenomicStudy.encounter"/>
        <min value="0"/>
        <max value="1"/>
      </base>
      <type>
        <code value="Reference"/>
        <targetProfile
                       value="http://hl7.org/fhir/StructureDefinition/Encounter"/>
      </type>
      <isSummary value="true"/>
    </element>
    <element id="GenomicStudy.startDate">
      <path value="GenomicStudy.startDate"/>
      <short value="When the genomic study was started"/>
      <definition value="When the genomic study was started."/>
      <min value="0"/>
      <max value="1"/>
      <base>
        <path value="GenomicStudy.startDate"/>
        <min value="0"/>
        <max value="1"/>
      </base>
      <type>
        <code value="dateTime"/>
      </type>
    </element>
    <element id="GenomicStudy.basedOn">
      <path value="GenomicStudy.basedOn"/>
      <short value="Event resources that the genomic study is based on"/>
      <definition
                  value="Event resources that the genomic study is based on."/>
      <min value="0"/>
      <max value="*"/>
      <base>
        <path value="GenomicStudy.basedOn"/>
        <min value="0"/>
        <max value="*"/>
      </base>
      <type>
        <code value="Reference"/>
        <targetProfile
                       value="http://hl7.org/fhir/StructureDefinition/ServiceRequest"/>
        <targetProfile value="http://hl7.org/fhir/StructureDefinition/Task"/>
      </type>
    </element>
    <element id="GenomicStudy.referrer">
      <path value="GenomicStudy.referrer"/>
      <short
             value="Healthcare professional who requested or referred the genomic study"/>
      <definition
                  value="Healthcare professional who requested or referred the genomic study."/>
      <min value="0"/>
      <max value="1"/>
      <base>
        <path value="GenomicStudy.referrer"/>
        <min value="0"/>
        <max value="1"/>
      </base>
      <type>
        <code value="Reference"/>
        <targetProfile
                       value="http://hl7.org/fhir/StructureDefinition/Practitioner"/>
        <targetProfile
                       value="http://hl7.org/fhir/StructureDefinition/PractitionerRole"/>
      </type>
    </element>
    <element id="GenomicStudy.interpreter">
      <path value="GenomicStudy.interpreter"/>
      <short
             value="Healthcare professionals who interpreted the genomic study"/>
      <definition
                  value="Healthcare professionals who interpreted the genomic study."/>
      <min value="0"/>
      <max value="*"/>
      <base>
        <path value="GenomicStudy.interpreter"/>
        <min value="0"/>
        <max value="*"/>
      </base>
      <type>
        <code value="Reference"/>
        <targetProfile
                       value="http://hl7.org/fhir/StructureDefinition/Practitioner"/>
        <targetProfile
                       value="http://hl7.org/fhir/StructureDefinition/PractitionerRole"/>
      </type>
    </element>
    <element id="GenomicStudy.reason">
      <path value="GenomicStudy.reason"/>
      <short value="Why the genomic study was performed"/>
      <definition value="Why the genomic study was performed."/>
      <min value="0"/>
      <max value="*"/>
      <base>
        <path value="GenomicStudy.reason"/>
        <min value="0"/>
        <max value="*"/>
      </base>
      <type>
        <code value="CodeableReference"/>
        <targetProfile
                       value="http://hl7.org/fhir/StructureDefinition/Condition"/>
        <targetProfile
                       value="http://hl7.org/fhir/StructureDefinition/Observation"/>
      </type>
    </element>
    <element id="GenomicStudy.instantiatesCanonical">
      <path value="GenomicStudy.instantiatesCanonical"/>
      <short value="The defined protocol that describes the study"/>
      <definition value="The defined protocol that describes the study."/>
      <min value="0"/>
      <max value="1"/>
      <base>
        <path value="GenomicStudy.instantiatesCanonical"/>
        <min value="0"/>
        <max value="1"/>
      </base>
      <type>
        <code value="canonical"/>
        <targetProfile
                       value="http://hl7.org/fhir/StructureDefinition/PlanDefinition"/>
      </type>
    </element>
    <element id="GenomicStudy.instantiatesUri">
      <path value="GenomicStudy.instantiatesUri"/>
      <short
             value="The URL pointing to an externally maintained protocol that describes the study"/>
      <definition
                  value="The URL pointing to an externally maintained protocol that describes the study."/>
      <min value="0"/>
      <max value="1"/>
      <base>
        <path value="GenomicStudy.instantiatesUri"/>
        <min value="0"/>
        <max value="1"/>
      </base>
      <type>
        <code value="uri"/>
      </type>
    </element>
    <element id="GenomicStudy.note">
      <path value="GenomicStudy.note"/>
      <short value="Comments related to the genomic study"/>
      <definition value="Comments related to the genomic study."/>
      <min value="0"/>
      <max value="*"/>
      <base>
        <path value="GenomicStudy.note"/>
        <min value="0"/>
        <max value="*"/>
      </base>
      <type>
        <code value="Annotation"/>
      </type>
    </element>
    <element id="GenomicStudy.description">
      <path value="GenomicStudy.description"/>
      <short value="Description of the genomic study"/>
      <definition value="Description of the genomic study."/>
      <min value="0"/>
      <max value="1"/>
      <base>
        <path value="GenomicStudy.description"/>
        <min value="0"/>
        <max value="1"/>
      </base>
      <type>
        <code value="markdown"/>
      </type>
    </element>
    <element id="GenomicStudy.analysis">
      <path value="GenomicStudy.analysis"/>
      <short value="Genomic Analysis Event"/>
      <definition
                  value="The details about a specific analysis that was performed in this GenomicStudy."/>
      <min value="0"/>
      <max value="*"/>
      <base>
        <path value="GenomicStudy.analysis"/>
        <min value="0"/>
        <max value="*"/>
      </base>
      <type>
        <code value="BackboneElement"/>
      </type>
      <constraint>
        <key value="gs-regions-1"/>
        <severity value="warning"/>
        <human
               value="When genomicRegion.studied entries use coded concepts, every code in genomicRegion.called and genomicRegion.uncalled entries should also appear in genomicRegion.studied. This constraint cannot be evaluated when BED file references (DocumentReference) are used instead of coded concepts."/>
        <expression
                    value="genomicRegion.where(type.coding.where(system = 'http://hl7.org/fhir/uv/cg-incubator/CodeSystem/genomicstudy-regiontype' and code = 'studied').exists()).locus.concept.exists() implies genomicRegion.where(type.coding.where(system = 'http://hl7.org/fhir/uv/cg-incubator/CodeSystem/genomicstudy-regiontype' and (code = 'called' or code = 'uncalled')).exists()).locus.concept.coding.where(system.exists()).all((system &amp; '|' &amp; code) in %context.genomicRegion.where(type.coding.where(system = 'http://hl7.org/fhir/uv/cg-incubator/CodeSystem/genomicstudy-regiontype' and code = 'studied').exists()).locus.concept.coding.select(system &amp; '|' &amp; code))"/>
      </constraint>
      <constraint>
        <key value="gs-regions-2"/>
        <severity value="error"/>
        <human
               value="If all studied genomicRegion entries use coded concepts (none use DocumentReference), then all called and uncalled genomicRegion entries must also use coded concepts and not DocumentReference. This ensures a consistent representation when the studied scope is fully expressed as coded identifiers. Note: this constraint is intentionally one-directional — when studied uses DocumentReference (e.g., a BED file), called and uncalled entries may legitimately use coded concepts to name specific genes, since enumerating a full BED file as coded genes is impractical."/>
        <expression
                    value="(genomicRegion.where(type.coding.where(system = 'http://hl7.org/fhir/uv/cg-incubator/CodeSystem/genomicstudy-regiontype' and code = 'studied').exists()).locus.reference.exists().not() and genomicRegion.where(type.coding.where(system = 'http://hl7.org/fhir/uv/cg-incubator/CodeSystem/genomicstudy-regiontype' and code = 'studied').exists()).locus.concept.exists()) implies genomicRegion.where(type.coding.where(system = 'http://hl7.org/fhir/uv/cg-incubator/CodeSystem/genomicstudy-regiontype' and (code = 'called' or code = 'uncalled')).exists()).locus.reference.exists().not()"/>
      </constraint>
      <constraint>
        <key value="ele-1"/>
        <severity value="error"/>
        <human
               value="All FHIR elements must have a @value or children or both"/>
        <expression
                    value="hasValue() or (children().count() &gt; id.count())"/>
        <source value="http://hl7.org/fhir/StructureDefinition/Element"/>
      </constraint>
    </element>
    <element id="GenomicStudy.analysis.id">
      <path value="GenomicStudy.analysis.id"/>
      <representation value="xmlAttr"/>
      <short value="Unique id for inter-element referencing"/>
      <definition
                  value="Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces."/>
      <min value="0"/>
      <max value="1"/>
      <base>
        <path value="Element.id"/>
        <min value="0"/>
        <max value="1"/>
      </base>
      <type>
        <extension
                   url="http://hl7.org/fhir/StructureDefinition/structuredefinition-fhir-type">
          <valueUrl value="id"/>
        </extension>
        <code value="http://hl7.org/fhirpath/System.String"/>
      </type>
      <condition value="ele-1"/>
      <isModifier value="false"/>
      <isSummary value="false"/>
      <mapping>
        <identity value="rim"/>
        <map value="n/a"/>
      </mapping>
    </element>
    <element id="GenomicStudy.analysis.extension">
      <path value="GenomicStudy.analysis.extension"/>
      <slicing>
        <discriminator>
          <type value="value"/>
          <path value="url"/>
        </discriminator>
        <description value="Extensions are always sliced by (at least) url"/>
        <rules value="open"/>
      </slicing>
      <short value="Additional content defined by implementations"/>
      <definition
                  value="May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension."/>
      <comment
               value="There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions.  The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone."/>
      <alias value="extensions"/>
      <alias value="user content"/>
      <min value="0"/>
      <max value="*"/>
      <base>
        <path value="Element.extension"/>
        <min value="0"/>
        <max value="*"/>
      </base>
      <type>
        <code value="Extension"/>
      </type>
      <constraint>
        <key value="ele-1"/>
        <severity value="error"/>
        <human value="All FHIR elements must have a @value or children"/>
        <expression
                    value="hasValue() or (children().count() &gt; id.count())"/>
        <source value="http://hl7.org/fhir/StructureDefinition/Element"/>
      </constraint>
      <isModifier value="false"/>
      <isSummary value="false"/>
      <mapping>
        <identity value="rim"/>
        <map value="n/a"/>
      </mapping>
    </element>
    <element id="GenomicStudy.analysis.modifierExtension">
      <path value="GenomicStudy.analysis.modifierExtension"/>
      <short value="Extensions that cannot be ignored even if unrecognized"/>
      <definition
                  value="May be used to represent additional information that is not part of the basic definition of the element and that modifies the understanding of the element in which it is contained and/or the understanding of the containing element's descendants. Usually modifier elements provide negation or qualification. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Applications processing a resource are required to check for modifier extensions.

Modifier extensions SHALL NOT change the meaning of any elements on Resource or DomainResource (including cannot change the meaning of modifierExtension itself)."/>
      <comment
               value="There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions.  The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone."/>
      <requirements
                    value="Modifier extensions allow for extensions that *cannot* be safely ignored to be clearly distinguished from the vast majority of extensions which can be safely ignored.  This promotes interoperability by eliminating the need for implementers to prohibit the presence of extensions. For further information, see the [definition of modifier extensions](http://build.fhir.org/extensibility.html#modifierExtension)."/>
      <alias value="extensions"/>
      <alias value="user content"/>
      <alias value="modifiers"/>
      <min value="0"/>
      <max value="*"/>
      <base>
        <path value="BackboneElement.modifierExtension"/>
        <min value="0"/>
        <max value="*"/>
      </base>
      <type>
        <code value="Extension"/>
      </type>
      <constraint>
        <key value="ele-1"/>
        <severity value="error"/>
        <human value="All FHIR elements must have a @value or children"/>
        <expression
                    value="hasValue() or (children().count() &gt; id.count())"/>
        <source value="http://hl7.org/fhir/StructureDefinition/Element"/>
      </constraint>
      <isModifier value="true"/>
      <isModifierReason
                        value="Modifier extensions are expected to modify the meaning or interpretation of the element that contains them"/>
      <isSummary value="true"/>
      <mapping>
        <identity value="rim"/>
        <map value="N/A"/>
      </mapping>
    </element>
    <element id="GenomicStudy.analysis.identifier">
      <path value="GenomicStudy.analysis.identifier"/>
      <short value="Identifiers for the analysis event"/>
      <definition value="Identifiers for the analysis event."/>
      <min value="0"/>
      <max value="*"/>
      <base>
        <path value="GenomicStudy.analysis.identifier"/>
        <min value="0"/>
        <max value="*"/>
      </base>
      <type>
        <code value="Identifier"/>
      </type>
      <isSummary value="true"/>
    </element>
    <element id="GenomicStudy.analysis.methodType">
      <path value="GenomicStudy.analysis.methodType"/>
      <short
             value="Type of the methods used in the analysis (e.g., FISH, Karyotyping, MSI)"/>
      <definition
                  value="Type of the methods used in the analysis, e.g., Fluorescence in situ hybridization (FISH), Karyotyping, or Microsatellite instability testing (MSI)."/>
      <min value="0"/>
      <max value="*"/>
      <base>
        <path value="GenomicStudy.analysis.methodType"/>
        <min value="0"/>
        <max value="*"/>
      </base>
      <type>
        <code value="CodeableConcept"/>
      </type>
      <isSummary value="true"/>
      <binding>
        <extension
                   url="http://hl7.org/fhir/StructureDefinition/elementdefinition-bindingName">
          <valueString value="GenomicStudyMethodType"/>
        </extension>
        <strength value="preferred"/>
        <description value="The method type of the GenomicStudy analysis."/>
        <valueSet
                  value="http://hl7.org/fhir/uv/cg-incubator/ValueSet/genomicstudy-methodtype"/>
      </binding>
    </element>
    <element id="GenomicStudy.analysis.changeType">
      <path value="GenomicStudy.analysis.changeType"/>
      <short
             value="Type of the genomic changes studied in the analysis (e.g., DNA, RNA, or AA change)"/>
      <definition
                  value="Type of the genomic changes studied in the analysis, e.g., DNA, RNA, or amino acid change."/>
      <min value="0"/>
      <max value="*"/>
      <base>
        <path value="GenomicStudy.analysis.changeType"/>
        <min value="0"/>
        <max value="*"/>
      </base>
      <type>
        <code value="CodeableConcept"/>
      </type>
      <binding>
        <extension
                   url="http://hl7.org/fhir/StructureDefinition/elementdefinition-bindingName">
          <valueString value="GenomicStudyChangeType"/>
        </extension>
        <strength value="preferred"/>
        <description
                     value="The change type relevant to GenomicStudy analysis."/>
        <valueSet
                  value="http://hl7.org/fhir/uv/cg-incubator/ValueSet/genomicstudy-changetype"/>
      </binding>
    </element>
    <element id="GenomicStudy.analysis.genomeBuild">
      <path value="GenomicStudy.analysis.genomeBuild"/>
      <short value="Genome build that is used in this analysis"/>
      <definition
                  value="The reference genome build that is used in this analysis."/>
      <min value="0"/>
      <max value="1"/>
      <base>
        <path value="GenomicStudy.analysis.genomeBuild"/>
        <min value="0"/>
        <max value="1"/>
      </base>
      <type>
        <code value="CodeableConcept"/>
      </type>
      <binding>
        <extension
                   url="http://hl7.org/fhir/StructureDefinition/elementdefinition-bindingName">
          <valueString value="HumanRefSeqNCBIBuildId"/>
        </extension>
        <extension
                   url="http://hl7.org/fhir/build/StructureDefinition/copyright">
          <valueString
                       value="Copyright © 2022 Regenstrief Institute, Inc. All Rights Reserved."/>
        </extension>
        <strength value="extensible"/>
        <description value="Human reference sequence NCBI build ID"/>
        <valueSet value="http://loinc.org/vs/LL1040-6"/>
      </binding>
    </element>
    <element id="GenomicStudy.analysis.genomicSourceClass">
      <path value="GenomicStudy.analysis.genomicSourceClass"/>
      <short
             value="The genomic source class of the specimens used in the analysis (e.g., somatic, germline)"/>
      <definition
                  value="The genomic source class of the specimens used in the analysis, e.g., somatic or germline."/>
      <min value="0"/>
      <max value="1"/>
      <base>
        <path value="GenomicStudy.analysis.genomicSourceClass"/>
        <min value="0"/>
        <max value="1"/>
      </base>
      <type>
        <code value="CodeableConcept"/>
      </type>
      <binding>
        <extension
                   url="http://hl7.org/fhir/StructureDefinition/elementdefinition-bindingName">
          <valueString value="GenomicStudyGenomicSourceClass"/>
        </extension>
        <extension
                   url="http://hl7.org/fhir/build/StructureDefinition/copyright">
          <valueString
                       value="Copyright © 2022 Regenstrief Institute, Inc. All Rights Reserved."/>
        </extension>
        <strength value="extensible"/>
        <description
                     value="The genomic source class (e.g., somatic, germline) of the specimens being analyzed."/>
        <valueSet value="http://loinc.org/vs/LL378-1"/>
      </binding>
    </element>
    <element id="GenomicStudy.analysis.instantiatesCanonical">
      <path value="GenomicStudy.analysis.instantiatesCanonical"/>
      <short value="The defined protocol that describes the analysis"/>
      <definition value="The defined protocol that describes the analysis."/>
      <min value="0"/>
      <max value="1"/>
      <base>
        <path value="GenomicStudy.analysis.instantiatesCanonical"/>
        <min value="0"/>
        <max value="1"/>
      </base>
      <type>
        <code value="canonical"/>
        <targetProfile
                       value="http://hl7.org/fhir/StructureDefinition/PlanDefinition"/>
        <targetProfile
                       value="http://hl7.org/fhir/StructureDefinition/ActivityDefinition"/>
      </type>
    </element>
    <element id="GenomicStudy.analysis.instantiatesUri">
      <path value="GenomicStudy.analysis.instantiatesUri"/>
      <short
             value="The URL pointing to an externally maintained protocol that describes the analysis"/>
      <definition
                  value="The URL pointing to an externally maintained protocol that describes the analysis."/>
      <min value="0"/>
      <max value="1"/>
      <base>
        <path value="GenomicStudy.analysis.instantiatesUri"/>
        <min value="0"/>
        <max value="1"/>
      </base>
      <type>
        <code value="uri"/>
      </type>
    </element>
    <element id="GenomicStudy.analysis.title">
      <path value="GenomicStudy.analysis.title"/>
      <short value="Name of the analysis event (human friendly)"/>
      <definition value="Name of the analysis event (human friendly)."/>
      <min value="0"/>
      <max value="1"/>
      <base>
        <path value="GenomicStudy.analysis.title"/>
        <min value="0"/>
        <max value="1"/>
      </base>
      <type>
        <code value="string"/>
      </type>
      <isSummary value="true"/>
    </element>
    <element id="GenomicStudy.analysis.focus">
      <path value="GenomicStudy.analysis.focus"/>
      <short
             value="What the genomic analysis is about, when it is not about the subject of record"/>
      <definition
                  value="The focus of a genomic analysis when it is not the patient of record representing something or someone associated with the patient such as a spouse, parent, child, or sibling. For example, in trio testing, the GenomicStudy.subject would be the child (proband) and the GenomicStudy.analysis.focus of a specific analysis would be the parent."/>
      <comment
               value="If the focus of the analysis is not known, the value of this field SHALL use the data absent extension."/>
      <min value="0"/>
      <max value="*"/>
      <base>
        <path value="GenomicStudy.analysis.focus"/>
        <min value="0"/>
        <max value="*"/>
      </base>
      <type>
        <code value="Reference"/>
        <targetProfile
                       value="http://hl7.org/fhir/StructureDefinition/Resource"/>
      </type>
      <isSummary value="true"/>
    </element>
    <element id="GenomicStudy.analysis.specimen">
      <path value="GenomicStudy.analysis.specimen"/>
      <short value="The specimen used in the analysis event"/>
      <definition value="The specimen used in the analysis event."/>
      <min value="0"/>
      <max value="*"/>
      <base>
        <path value="GenomicStudy.analysis.specimen"/>
        <min value="0"/>
        <max value="*"/>
      </base>
      <type>
        <code value="Reference"/>
        <targetProfile
                       value="http://hl7.org/fhir/StructureDefinition/Specimen"/>
      </type>
      <isSummary value="true"/>
    </element>
    <element id="GenomicStudy.analysis.date">
      <path value="GenomicStudy.analysis.date"/>
      <short value="The date of the analysis event"/>
      <definition value="The date of the analysis event."/>
      <min value="0"/>
      <max value="1"/>
      <base>
        <path value="GenomicStudy.analysis.date"/>
        <min value="0"/>
        <max value="1"/>
      </base>
      <type>
        <code value="dateTime"/>
      </type>
    </element>
    <element id="GenomicStudy.analysis.note">
      <path value="GenomicStudy.analysis.note"/>
      <short value="Any notes capture with the analysis event"/>
      <definition value="Any notes capture with the analysis event."/>
      <min value="0"/>
      <max value="*"/>
      <base>
        <path value="GenomicStudy.analysis.note"/>
        <min value="0"/>
        <max value="*"/>
      </base>
      <type>
        <code value="Annotation"/>
      </type>
    </element>
    <element id="GenomicStudy.analysis.metrics">
      <path value="GenomicStudy.analysis.metrics"/>
      <short value="Quality metrics for the analysis"/>
      <definition
                  value="High-level quality metrics about the sequencing analysis that was performed."/>
      <min value="0"/>
      <max value="1"/>
      <base>
        <path value="GenomicStudy.analysis.metrics"/>
        <min value="0"/>
        <max value="1"/>
      </base>
      <type>
        <code value="BackboneElement"/>
      </type>
      <constraint>
        <key value="ele-1"/>
        <severity value="error"/>
        <human
               value="All FHIR elements must have a @value or children or both"/>
        <expression
                    value="hasValue() or (children().count() &gt; id.count())"/>
        <source value="http://hl7.org/fhir/StructureDefinition/Element"/>
      </constraint>
    </element>
    <element id="GenomicStudy.analysis.metrics.id">
      <path value="GenomicStudy.analysis.metrics.id"/>
      <representation value="xmlAttr"/>
      <short value="Unique id for inter-element referencing"/>
      <definition
                  value="Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces."/>
      <min value="0"/>
      <max value="1"/>
      <base>
        <path value="Element.id"/>
        <min value="0"/>
        <max value="1"/>
      </base>
      <type>
        <extension
                   url="http://hl7.org/fhir/StructureDefinition/structuredefinition-fhir-type">
          <valueUrl value="id"/>
        </extension>
        <code value="http://hl7.org/fhirpath/System.String"/>
      </type>
      <condition value="ele-1"/>
      <isModifier value="false"/>
      <isSummary value="false"/>
      <mapping>
        <identity value="rim"/>
        <map value="n/a"/>
      </mapping>
    </element>
    <element id="GenomicStudy.analysis.metrics.extension">
      <path value="GenomicStudy.analysis.metrics.extension"/>
      <slicing>
        <discriminator>
          <type value="value"/>
          <path value="url"/>
        </discriminator>
        <description value="Extensions are always sliced by (at least) url"/>
        <rules value="open"/>
      </slicing>
      <short value="Additional content defined by implementations"/>
      <definition
                  value="May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension."/>
      <comment
               value="There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions.  The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone."/>
      <alias value="extensions"/>
      <alias value="user content"/>
      <min value="0"/>
      <max value="*"/>
      <base>
        <path value="Element.extension"/>
        <min value="0"/>
        <max value="*"/>
      </base>
      <type>
        <code value="Extension"/>
      </type>
      <constraint>
        <key value="ele-1"/>
        <severity value="error"/>
        <human value="All FHIR elements must have a @value or children"/>
        <expression
                    value="hasValue() or (children().count() &gt; id.count())"/>
        <source value="http://hl7.org/fhir/StructureDefinition/Element"/>
      </constraint>
      <isModifier value="false"/>
      <isSummary value="false"/>
      <mapping>
        <identity value="rim"/>
        <map value="n/a"/>
      </mapping>
    </element>
    <element id="GenomicStudy.analysis.metrics.modifierExtension">
      <path value="GenomicStudy.analysis.metrics.modifierExtension"/>
      <short value="Extensions that cannot be ignored even if unrecognized"/>
      <definition
                  value="May be used to represent additional information that is not part of the basic definition of the element and that modifies the understanding of the element in which it is contained and/or the understanding of the containing element's descendants. Usually modifier elements provide negation or qualification. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Applications processing a resource are required to check for modifier extensions.

Modifier extensions SHALL NOT change the meaning of any elements on Resource or DomainResource (including cannot change the meaning of modifierExtension itself)."/>
      <comment
               value="There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions.  The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone."/>
      <requirements
                    value="Modifier extensions allow for extensions that *cannot* be safely ignored to be clearly distinguished from the vast majority of extensions which can be safely ignored.  This promotes interoperability by eliminating the need for implementers to prohibit the presence of extensions. For further information, see the [definition of modifier extensions](http://build.fhir.org/extensibility.html#modifierExtension)."/>
      <alias value="extensions"/>
      <alias value="user content"/>
      <alias value="modifiers"/>
      <min value="0"/>
      <max value="*"/>
      <base>
        <path value="BackboneElement.modifierExtension"/>
        <min value="0"/>
        <max value="*"/>
      </base>
      <type>
        <code value="Extension"/>
      </type>
      <constraint>
        <key value="ele-1"/>
        <severity value="error"/>
        <human value="All FHIR elements must have a @value or children"/>
        <expression
                    value="hasValue() or (children().count() &gt; id.count())"/>
        <source value="http://hl7.org/fhir/StructureDefinition/Element"/>
      </constraint>
      <isModifier value="true"/>
      <isModifierReason
                        value="Modifier extensions are expected to modify the meaning or interpretation of the element that contains them"/>
      <isSummary value="true"/>
      <mapping>
        <identity value="rim"/>
        <map value="N/A"/>
      </mapping>
    </element>
    <element id="GenomicStudy.analysis.metrics.readDepth">
      <path value="GenomicStudy.analysis.metrics.readDepth"/>
      <short value="Average read depth (e.g., 30x, 100x)"/>
      <definition
                  value="The average read depth (number of reads for a position) for the sequencing analysis."/>
      <comment
               value="This value is typically represented with an 'x' after the number (30x). Share the quantity value only."/>
      <min value="0"/>
      <max value="1"/>
      <base>
        <path value="GenomicStudy.analysis.metrics.readDepth"/>
        <min value="0"/>
        <max value="1"/>
      </base>
      <type>
        <code value="Quantity"/>
        <profile
                 value="http://hl7.org/fhir/StructureDefinition/SimpleQuantity"/>
      </type>
    </element>
    <element id="GenomicStudy.analysis.metrics.sequencingCoverage">
      <path value="GenomicStudy.analysis.metrics.sequencingCoverage"/>
      <short value="Percentage of studied regions sequenced (e.g., 95%)"/>
      <definition
                  value="The percentage of the studied regions that were sequenced."/>
      <comment
               value="This value is typically represented with a '%' after the number (95%). Share the quantity value only."/>
      <min value="0"/>
      <max value="1"/>
      <base>
        <path value="GenomicStudy.analysis.metrics.sequencingCoverage"/>
        <min value="0"/>
        <max value="1"/>
      </base>
      <type>
        <code value="Quantity"/>
        <profile
                 value="http://hl7.org/fhir/StructureDefinition/SimpleQuantity"/>
      </type>
    </element>
    <element id="GenomicStudy.analysis.metrics.description">
      <path value="GenomicStudy.analysis.metrics.description"/>
      <short value="Freetext coverage metrics description"/>
      <definition
                  value="Freetext description of the coverage and quality metrics for the sequencing analysis."/>
      <min value="0"/>
      <max value="1"/>
      <base>
        <path value="GenomicStudy.analysis.metrics.description"/>
        <min value="0"/>
        <max value="1"/>
      </base>
      <type>
        <code value="string"/>
      </type>
    </element>
    <element id="GenomicStudy.analysis.protocolPerformed">
      <path value="GenomicStudy.analysis.protocolPerformed"/>
      <short value="The protocol that was performed for the analysis event"/>
      <definition
                  value="The protocol that was performed for the analysis event."/>
      <min value="0"/>
      <max value="1"/>
      <base>
        <path value="GenomicStudy.analysis.protocolPerformed"/>
        <min value="0"/>
        <max value="1"/>
      </base>
      <type>
        <code value="Reference"/>
        <targetProfile
                       value="http://hl7.org/fhir/StructureDefinition/Procedure"/>
        <targetProfile value="http://hl7.org/fhir/StructureDefinition/Task"/>
      </type>
    </element>
    <element id="GenomicStudy.analysis.genomicRegion">
      <path value="GenomicStudy.analysis.genomicRegion"/>
      <short
             value="Genomic regions relevant to the analysis, grouped by type"/>
      <definition
                  value="A set of genomic regions associated with this analysis, classified by their relationship to the analysis outcome (studied, called, or uncalled). Each repetition represents one group of regions sharing the same type."/>
      <comment
               value="Use one repetition per region type. For example, include one entry with type=studied for the full panel scope, one with type=called for regions with sufficient coverage to produce calls, and one with type=uncalled for regions where calls could not be produced. All three types may be present in a single analysis, or only a subset, as appropriate."/>
      <min value="0"/>
      <max value="*"/>
      <base>
        <path value="GenomicStudy.analysis.genomicRegion"/>
        <min value="0"/>
        <max value="*"/>
      </base>
      <type>
        <code value="BackboneElement"/>
      </type>
      <constraint>
        <key value="ele-1"/>
        <severity value="error"/>
        <human
               value="All FHIR elements must have a @value or children or both"/>
        <expression
                    value="hasValue() or (children().count() &gt; id.count())"/>
        <source value="http://hl7.org/fhir/StructureDefinition/Element"/>
      </constraint>
    </element>
    <element id="GenomicStudy.analysis.genomicRegion.id">
      <path value="GenomicStudy.analysis.genomicRegion.id"/>
      <representation value="xmlAttr"/>
      <short value="Unique id for inter-element referencing"/>
      <definition
                  value="Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces."/>
      <min value="0"/>
      <max value="1"/>
      <base>
        <path value="Element.id"/>
        <min value="0"/>
        <max value="1"/>
      </base>
      <type>
        <extension
                   url="http://hl7.org/fhir/StructureDefinition/structuredefinition-fhir-type">
          <valueUrl value="id"/>
        </extension>
        <code value="http://hl7.org/fhirpath/System.String"/>
      </type>
      <condition value="ele-1"/>
      <isModifier value="false"/>
      <isSummary value="false"/>
      <mapping>
        <identity value="rim"/>
        <map value="n/a"/>
      </mapping>
    </element>
    <element id="GenomicStudy.analysis.genomicRegion.extension">
      <path value="GenomicStudy.analysis.genomicRegion.extension"/>
      <slicing>
        <discriminator>
          <type value="value"/>
          <path value="url"/>
        </discriminator>
        <description value="Extensions are always sliced by (at least) url"/>
        <rules value="open"/>
      </slicing>
      <short value="Additional content defined by implementations"/>
      <definition
                  value="May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension."/>
      <comment
               value="There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions.  The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone."/>
      <alias value="extensions"/>
      <alias value="user content"/>
      <min value="0"/>
      <max value="*"/>
      <base>
        <path value="Element.extension"/>
        <min value="0"/>
        <max value="*"/>
      </base>
      <type>
        <code value="Extension"/>
      </type>
      <constraint>
        <key value="ele-1"/>
        <severity value="error"/>
        <human value="All FHIR elements must have a @value or children"/>
        <expression
                    value="hasValue() or (children().count() &gt; id.count())"/>
        <source value="http://hl7.org/fhir/StructureDefinition/Element"/>
      </constraint>
      <isModifier value="false"/>
      <isSummary value="false"/>
      <mapping>
        <identity value="rim"/>
        <map value="n/a"/>
      </mapping>
    </element>
    <element id="GenomicStudy.analysis.genomicRegion.modifierExtension">
      <path value="GenomicStudy.analysis.genomicRegion.modifierExtension"/>
      <short value="Extensions that cannot be ignored even if unrecognized"/>
      <definition
                  value="May be used to represent additional information that is not part of the basic definition of the element and that modifies the understanding of the element in which it is contained and/or the understanding of the containing element's descendants. Usually modifier elements provide negation or qualification. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Applications processing a resource are required to check for modifier extensions.

Modifier extensions SHALL NOT change the meaning of any elements on Resource or DomainResource (including cannot change the meaning of modifierExtension itself)."/>
      <comment
               value="There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions.  The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone."/>
      <requirements
                    value="Modifier extensions allow for extensions that *cannot* be safely ignored to be clearly distinguished from the vast majority of extensions which can be safely ignored.  This promotes interoperability by eliminating the need for implementers to prohibit the presence of extensions. For further information, see the [definition of modifier extensions](http://build.fhir.org/extensibility.html#modifierExtension)."/>
      <alias value="extensions"/>
      <alias value="user content"/>
      <alias value="modifiers"/>
      <min value="0"/>
      <max value="*"/>
      <base>
        <path value="BackboneElement.modifierExtension"/>
        <min value="0"/>
        <max value="*"/>
      </base>
      <type>
        <code value="Extension"/>
      </type>
      <constraint>
        <key value="ele-1"/>
        <severity value="error"/>
        <human value="All FHIR elements must have a @value or children"/>
        <expression
                    value="hasValue() or (children().count() &gt; id.count())"/>
        <source value="http://hl7.org/fhir/StructureDefinition/Element"/>
      </constraint>
      <isModifier value="true"/>
      <isModifierReason
                        value="Modifier extensions are expected to modify the meaning or interpretation of the element that contains them"/>
      <isSummary value="true"/>
      <mapping>
        <identity value="rim"/>
        <map value="N/A"/>
      </mapping>
    </element>
    <element id="GenomicStudy.analysis.genomicRegion.type">
      <path value="GenomicStudy.analysis.genomicRegion.type"/>
      <short value="studied | called | uncalled"/>
      <definition
                  value="The type of this region group, indicating the relationship of these regions to the analysis outcome."/>
      <comment
               value="Use 'studied' for the full intended scope of the analysis. Use 'called' for regions where sufficient coverage and data quality enabled variant calling. Use 'uncalled' for regions within the studied scope where calls could not be produced (e.g., due to low coverage or poor mapping quality). An 'uncalled' entry does not imply that a pathogenic variant is present or was missed; it indicates a technical limitation. Use genomicRegion.description to document the reason."/>
      <min value="1"/>
      <max value="1"/>
      <base>
        <path value="GenomicStudy.analysis.genomicRegion.type"/>
        <min value="1"/>
        <max value="1"/>
      </base>
      <type>
        <code value="CodeableConcept"/>
      </type>
      <binding>
        <extension
                   url="http://hl7.org/fhir/StructureDefinition/elementdefinition-bindingName">
          <valueString value="GenomicStudyRegionType"/>
        </extension>
        <strength value="extensible"/>
        <description
                     value="The type of genomic region group. Use studied, called, or uncalled where applicable; other codes may be used for methodology-specific region classifications not covered by this value set."/>
        <valueSet
                  value="http://hl7.org/fhir/uv/cg-incubator/ValueSet/genomicstudy-regiontype"/>
      </binding>
    </element>
    <element id="GenomicStudy.analysis.genomicRegion.locus">
      <path value="GenomicStudy.analysis.genomicRegion.locus"/>
      <short value="Genomic regions in this group (coded genes or BED file)"/>
      <definition
                  value="The genomic regions belonging to this group. May be expressed as a coded list of HGNC gene symbols (using CodeableReference.concept) or as a reference to a BED file (using CodeableReference.reference to a DocumentReference)."/>
      <comment
               value="For coded genes, use the HGNC gene symbol as display text and the HGNC gene ID as the code. If no HGNC code has been issued, use NCBI gene IDs. If region details beyond a coded gene list are needed (e.g., sub-gene coordinates), reference a BED file via DocumentReference. Multiple repetitions may be used to list individual genes or to combine a BED file reference with supplementary coded entries."/>
      <requirements
                    value="Expressed as a coded list of HGNC gene symbols or a reference to a BED file (DocumentReference)."/>
      <min value="0"/>
      <max value="*"/>
      <base>
        <path value="GenomicStudy.analysis.genomicRegion.locus"/>
        <min value="0"/>
        <max value="*"/>
      </base>
      <type>
        <code value="CodeableReference"/>
        <targetProfile
                       value="http://hl7.org/fhir/StructureDefinition/DocumentReference"/>
      </type>
      <binding>
        <extension
                   url="http://hl7.org/fhir/StructureDefinition/elementdefinition-bindingName">
          <valueString value="HGNCGeneNames"/>
        </extension>
        <strength value="extensible"/>
        <description value="HGNC gene names for coded gene lists."/>
        <valueSet
                  value="http://hl7.org/fhir/uv/cg-incubator/ValueSet/hgnc-vs"/>
      </binding>
    </element>
    <element id="GenomicStudy.analysis.genomicRegion.description">
      <path value="GenomicStudy.analysis.genomicRegion.description"/>
      <short value="Additional details about this region group"/>
      <definition
                  value="Free-text notes providing additional context about this group of regions. Particularly useful for 'uncalled' entries to document the reason calls could not be produced (e.g., 'low coverage &lt;20x', 'poor mapping due to repetitive sequence', 'homopolymer region exceeding assay limit')."/>
      <min value="0"/>
      <max value="1"/>
      <base>
        <path value="GenomicStudy.analysis.genomicRegion.description"/>
        <min value="0"/>
        <max value="1"/>
      </base>
      <type>
        <code value="string"/>
      </type>
    </element>
    <element id="GenomicStudy.analysis.input">
      <path value="GenomicStudy.analysis.input"/>
      <short value="Inputs for the analysis event"/>
      <definition value="Inputs for the analysis event."/>
      <min value="0"/>
      <max value="*"/>
      <base>
        <path value="GenomicStudy.analysis.input"/>
        <min value="0"/>
        <max value="*"/>
      </base>
      <type>
        <code value="BackboneElement"/>
      </type>
      <constraint>
        <key value="ele-1"/>
        <severity value="error"/>
        <human
               value="All FHIR elements must have a @value or children or both"/>
        <expression
                    value="hasValue() or (children().count() &gt; id.count())"/>
        <source value="http://hl7.org/fhir/StructureDefinition/Element"/>
      </constraint>
    </element>
    <element id="GenomicStudy.analysis.input.id">
      <path value="GenomicStudy.analysis.input.id"/>
      <representation value="xmlAttr"/>
      <short value="Unique id for inter-element referencing"/>
      <definition
                  value="Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces."/>
      <min value="0"/>
      <max value="1"/>
      <base>
        <path value="Element.id"/>
        <min value="0"/>
        <max value="1"/>
      </base>
      <type>
        <extension
                   url="http://hl7.org/fhir/StructureDefinition/structuredefinition-fhir-type">
          <valueUrl value="id"/>
        </extension>
        <code value="http://hl7.org/fhirpath/System.String"/>
      </type>
      <condition value="ele-1"/>
      <isModifier value="false"/>
      <isSummary value="false"/>
      <mapping>
        <identity value="rim"/>
        <map value="n/a"/>
      </mapping>
    </element>
    <element id="GenomicStudy.analysis.input.extension">
      <path value="GenomicStudy.analysis.input.extension"/>
      <slicing>
        <discriminator>
          <type value="value"/>
          <path value="url"/>
        </discriminator>
        <description value="Extensions are always sliced by (at least) url"/>
        <rules value="open"/>
      </slicing>
      <short value="Additional content defined by implementations"/>
      <definition
                  value="May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension."/>
      <comment
               value="There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions.  The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone."/>
      <alias value="extensions"/>
      <alias value="user content"/>
      <min value="0"/>
      <max value="*"/>
      <base>
        <path value="Element.extension"/>
        <min value="0"/>
        <max value="*"/>
      </base>
      <type>
        <code value="Extension"/>
      </type>
      <constraint>
        <key value="ele-1"/>
        <severity value="error"/>
        <human value="All FHIR elements must have a @value or children"/>
        <expression
                    value="hasValue() or (children().count() &gt; id.count())"/>
        <source value="http://hl7.org/fhir/StructureDefinition/Element"/>
      </constraint>
      <isModifier value="false"/>
      <isSummary value="false"/>
      <mapping>
        <identity value="rim"/>
        <map value="n/a"/>
      </mapping>
    </element>
    <element id="GenomicStudy.analysis.input.modifierExtension">
      <path value="GenomicStudy.analysis.input.modifierExtension"/>
      <short value="Extensions that cannot be ignored even if unrecognized"/>
      <definition
                  value="May be used to represent additional information that is not part of the basic definition of the element and that modifies the understanding of the element in which it is contained and/or the understanding of the containing element's descendants. Usually modifier elements provide negation or qualification. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Applications processing a resource are required to check for modifier extensions.

Modifier extensions SHALL NOT change the meaning of any elements on Resource or DomainResource (including cannot change the meaning of modifierExtension itself)."/>
      <comment
               value="There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions.  The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone."/>
      <requirements
                    value="Modifier extensions allow for extensions that *cannot* be safely ignored to be clearly distinguished from the vast majority of extensions which can be safely ignored.  This promotes interoperability by eliminating the need for implementers to prohibit the presence of extensions. For further information, see the [definition of modifier extensions](http://build.fhir.org/extensibility.html#modifierExtension)."/>
      <alias value="extensions"/>
      <alias value="user content"/>
      <alias value="modifiers"/>
      <min value="0"/>
      <max value="*"/>
      <base>
        <path value="BackboneElement.modifierExtension"/>
        <min value="0"/>
        <max value="*"/>
      </base>
      <type>
        <code value="Extension"/>
      </type>
      <constraint>
        <key value="ele-1"/>
        <severity value="error"/>
        <human value="All FHIR elements must have a @value or children"/>
        <expression
                    value="hasValue() or (children().count() &gt; id.count())"/>
        <source value="http://hl7.org/fhir/StructureDefinition/Element"/>
      </constraint>
      <isModifier value="true"/>
      <isModifierReason
                        value="Modifier extensions are expected to modify the meaning or interpretation of the element that contains them"/>
      <isSummary value="true"/>
      <mapping>
        <identity value="rim"/>
        <map value="N/A"/>
      </mapping>
    </element>
    <element id="GenomicStudy.analysis.input.file">
      <path value="GenomicStudy.analysis.input.file"/>
      <short value="File containing input data"/>
      <definition value="File containing input data."/>
      <min value="0"/>
      <max value="1"/>
      <base>
        <path value="GenomicStudy.analysis.input.file"/>
        <min value="0"/>
        <max value="1"/>
      </base>
      <type>
        <code value="Reference"/>
        <targetProfile
                       value="http://hl7.org/fhir/StructureDefinition/DocumentReference"/>
      </type>
      <isSummary value="true"/>
    </element>
    <element id="GenomicStudy.analysis.input.type">
      <path value="GenomicStudy.analysis.input.type"/>
      <short value="Type of input data (e.g., BAM, CRAM, or FASTA)"/>
      <definition value="Type of input data, e.g., BAM, CRAM, or FASTA."/>
      <min value="0"/>
      <max value="1"/>
      <base>
        <path value="GenomicStudy.analysis.input.type"/>
        <min value="0"/>
        <max value="1"/>
      </base>
      <type>
        <code value="CodeableConcept"/>
      </type>
      <binding>
        <extension
                   url="http://hl7.org/fhir/StructureDefinition/elementdefinition-bindingName">
          <valueString value="GenomicStudyDataFormat"/>
        </extension>
        <strength value="example"/>
        <description value="The data format of the data file."/>
        <valueSet
                  value="http://hl7.org/fhir/uv/cg-incubator/ValueSet/genomicstudy-dataformat"/>
      </binding>
    </element>
    <element id="GenomicStudy.analysis.input.generatedBy[x]">
      <path value="GenomicStudy.analysis.input.generatedBy[x]"/>
      <short
             value="The analysis event or other GenomicStudy that generated this input file"/>
      <definition
                  value="The analysis event or other GenomicStudy that generated this input file."/>
      <min value="0"/>
      <max value="1"/>
      <base>
        <path value="GenomicStudy.analysis.input.generatedBy[x]"/>
        <min value="0"/>
        <max value="1"/>
      </base>
      <type>
        <code value="Identifier"/>
      </type>
      <type>
        <code value="Reference"/>
        <targetProfile
                       value="http://hl7.org/fhir/StructureDefinition/GenomicStudy|0.1.0-ci-build"/>
      </type>
    </element>
    <element id="GenomicStudy.analysis.output">
      <path value="GenomicStudy.analysis.output"/>
      <short value="Outputs for the analysis event"/>
      <definition value="Outputs for the analysis event."/>
      <min value="0"/>
      <max value="*"/>
      <base>
        <path value="GenomicStudy.analysis.output"/>
        <min value="0"/>
        <max value="*"/>
      </base>
      <type>
        <code value="BackboneElement"/>
      </type>
      <constraint>
        <key value="ele-1"/>
        <severity value="error"/>
        <human
               value="All FHIR elements must have a @value or children or both"/>
        <expression
                    value="hasValue() or (children().count() &gt; id.count())"/>
        <source value="http://hl7.org/fhir/StructureDefinition/Element"/>
      </constraint>
    </element>
    <element id="GenomicStudy.analysis.output.id">
      <path value="GenomicStudy.analysis.output.id"/>
      <representation value="xmlAttr"/>
      <short value="Unique id for inter-element referencing"/>
      <definition
                  value="Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces."/>
      <min value="0"/>
      <max value="1"/>
      <base>
        <path value="Element.id"/>
        <min value="0"/>
        <max value="1"/>
      </base>
      <type>
        <extension
                   url="http://hl7.org/fhir/StructureDefinition/structuredefinition-fhir-type">
          <valueUrl value="id"/>
        </extension>
        <code value="http://hl7.org/fhirpath/System.String"/>
      </type>
      <condition value="ele-1"/>
      <isModifier value="false"/>
      <isSummary value="false"/>
      <mapping>
        <identity value="rim"/>
        <map value="n/a"/>
      </mapping>
    </element>
    <element id="GenomicStudy.analysis.output.extension">
      <path value="GenomicStudy.analysis.output.extension"/>
      <slicing>
        <discriminator>
          <type value="value"/>
          <path value="url"/>
        </discriminator>
        <description value="Extensions are always sliced by (at least) url"/>
        <rules value="open"/>
      </slicing>
      <short value="Additional content defined by implementations"/>
      <definition
                  value="May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension."/>
      <comment
               value="There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions.  The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone."/>
      <alias value="extensions"/>
      <alias value="user content"/>
      <min value="0"/>
      <max value="*"/>
      <base>
        <path value="Element.extension"/>
        <min value="0"/>
        <max value="*"/>
      </base>
      <type>
        <code value="Extension"/>
      </type>
      <constraint>
        <key value="ele-1"/>
        <severity value="error"/>
        <human value="All FHIR elements must have a @value or children"/>
        <expression
                    value="hasValue() or (children().count() &gt; id.count())"/>
        <source value="http://hl7.org/fhir/StructureDefinition/Element"/>
      </constraint>
      <isModifier value="false"/>
      <isSummary value="false"/>
      <mapping>
        <identity value="rim"/>
        <map value="n/a"/>
      </mapping>
    </element>
    <element id="GenomicStudy.analysis.output.modifierExtension">
      <path value="GenomicStudy.analysis.output.modifierExtension"/>
      <short value="Extensions that cannot be ignored even if unrecognized"/>
      <definition
                  value="May be used to represent additional information that is not part of the basic definition of the element and that modifies the understanding of the element in which it is contained and/or the understanding of the containing element's descendants. Usually modifier elements provide negation or qualification. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Applications processing a resource are required to check for modifier extensions.

Modifier extensions SHALL NOT change the meaning of any elements on Resource or DomainResource (including cannot change the meaning of modifierExtension itself)."/>
      <comment
               value="There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions.  The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone."/>
      <requirements
                    value="Modifier extensions allow for extensions that *cannot* be safely ignored to be clearly distinguished from the vast majority of extensions which can be safely ignored.  This promotes interoperability by eliminating the need for implementers to prohibit the presence of extensions. For further information, see the [definition of modifier extensions](http://build.fhir.org/extensibility.html#modifierExtension)."/>
      <alias value="extensions"/>
      <alias value="user content"/>
      <alias value="modifiers"/>
      <min value="0"/>
      <max value="*"/>
      <base>
        <path value="BackboneElement.modifierExtension"/>
        <min value="0"/>
        <max value="*"/>
      </base>
      <type>
        <code value="Extension"/>
      </type>
      <constraint>
        <key value="ele-1"/>
        <severity value="error"/>
        <human value="All FHIR elements must have a @value or children"/>
        <expression
                    value="hasValue() or (children().count() &gt; id.count())"/>
        <source value="http://hl7.org/fhir/StructureDefinition/Element"/>
      </constraint>
      <isModifier value="true"/>
      <isModifierReason
                        value="Modifier extensions are expected to modify the meaning or interpretation of the element that contains them"/>
      <isSummary value="true"/>
      <mapping>
        <identity value="rim"/>
        <map value="N/A"/>
      </mapping>
    </element>
    <element id="GenomicStudy.analysis.output.file">
      <path value="GenomicStudy.analysis.output.file"/>
      <short value="File containing output data"/>
      <definition value="File containing output data."/>
      <min value="0"/>
      <max value="1"/>
      <base>
        <path value="GenomicStudy.analysis.output.file"/>
        <min value="0"/>
        <max value="1"/>
      </base>
      <type>
        <code value="Reference"/>
        <targetProfile
                       value="http://hl7.org/fhir/StructureDefinition/DocumentReference"/>
      </type>
      <isSummary value="true"/>
    </element>
    <element id="GenomicStudy.analysis.output.type">
      <path value="GenomicStudy.analysis.output.type"/>
      <short value="Type of output data (e.g., VCF, MAF, or BAM)"/>
      <definition value="Type of output data, e.g., VCF, MAF, or BAM."/>
      <min value="0"/>
      <max value="1"/>
      <base>
        <path value="GenomicStudy.analysis.output.type"/>
        <min value="0"/>
        <max value="1"/>
      </base>
      <type>
        <code value="CodeableConcept"/>
      </type>
      <isSummary value="true"/>
      <binding>
        <extension
                   url="http://hl7.org/fhir/StructureDefinition/elementdefinition-bindingName">
          <valueString value="GenomicStudyDataFormat"/>
        </extension>
        <strength value="example"/>
        <description value="The data format of the data file."/>
        <valueSet
                  value="http://hl7.org/fhir/uv/cg-incubator/ValueSet/genomicstudy-dataformat"/>
      </binding>
    </element>
    <element id="GenomicStudy.analysis.performer">
      <path value="GenomicStudy.analysis.performer"/>
      <short value="Performer for the analysis event"/>
      <definition value="Performer for the analysis event."/>
      <min value="0"/>
      <max value="*"/>
      <base>
        <path value="GenomicStudy.analysis.performer"/>
        <min value="0"/>
        <max value="*"/>
      </base>
      <type>
        <code value="BackboneElement"/>
      </type>
      <constraint>
        <key value="ele-1"/>
        <severity value="error"/>
        <human
               value="All FHIR elements must have a @value or children or both"/>
        <expression
                    value="hasValue() or (children().count() &gt; id.count())"/>
        <source value="http://hl7.org/fhir/StructureDefinition/Element"/>
      </constraint>
    </element>
    <element id="GenomicStudy.analysis.performer.id">
      <path value="GenomicStudy.analysis.performer.id"/>
      <representation value="xmlAttr"/>
      <short value="Unique id for inter-element referencing"/>
      <definition
                  value="Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces."/>
      <min value="0"/>
      <max value="1"/>
      <base>
        <path value="Element.id"/>
        <min value="0"/>
        <max value="1"/>
      </base>
      <type>
        <extension
                   url="http://hl7.org/fhir/StructureDefinition/structuredefinition-fhir-type">
          <valueUrl value="id"/>
        </extension>
        <code value="http://hl7.org/fhirpath/System.String"/>
      </type>
      <condition value="ele-1"/>
      <isModifier value="false"/>
      <isSummary value="false"/>
      <mapping>
        <identity value="rim"/>
        <map value="n/a"/>
      </mapping>
    </element>
    <element id="GenomicStudy.analysis.performer.extension">
      <path value="GenomicStudy.analysis.performer.extension"/>
      <slicing>
        <discriminator>
          <type value="value"/>
          <path value="url"/>
        </discriminator>
        <description value="Extensions are always sliced by (at least) url"/>
        <rules value="open"/>
      </slicing>
      <short value="Additional content defined by implementations"/>
      <definition
                  value="May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension."/>
      <comment
               value="There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions.  The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone."/>
      <alias value="extensions"/>
      <alias value="user content"/>
      <min value="0"/>
      <max value="*"/>
      <base>
        <path value="Element.extension"/>
        <min value="0"/>
        <max value="*"/>
      </base>
      <type>
        <code value="Extension"/>
      </type>
      <constraint>
        <key value="ele-1"/>
        <severity value="error"/>
        <human value="All FHIR elements must have a @value or children"/>
        <expression
                    value="hasValue() or (children().count() &gt; id.count())"/>
        <source value="http://hl7.org/fhir/StructureDefinition/Element"/>
      </constraint>
      <isModifier value="false"/>
      <isSummary value="false"/>
      <mapping>
        <identity value="rim"/>
        <map value="n/a"/>
      </mapping>
    </element>
    <element id="GenomicStudy.analysis.performer.modifierExtension">
      <path value="GenomicStudy.analysis.performer.modifierExtension"/>
      <short value="Extensions that cannot be ignored even if unrecognized"/>
      <definition
                  value="May be used to represent additional information that is not part of the basic definition of the element and that modifies the understanding of the element in which it is contained and/or the understanding of the containing element's descendants. Usually modifier elements provide negation or qualification. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Applications processing a resource are required to check for modifier extensions.

Modifier extensions SHALL NOT change the meaning of any elements on Resource or DomainResource (including cannot change the meaning of modifierExtension itself)."/>
      <comment
               value="There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions.  The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone."/>
      <requirements
                    value="Modifier extensions allow for extensions that *cannot* be safely ignored to be clearly distinguished from the vast majority of extensions which can be safely ignored.  This promotes interoperability by eliminating the need for implementers to prohibit the presence of extensions. For further information, see the [definition of modifier extensions](http://build.fhir.org/extensibility.html#modifierExtension)."/>
      <alias value="extensions"/>
      <alias value="user content"/>
      <alias value="modifiers"/>
      <min value="0"/>
      <max value="*"/>
      <base>
        <path value="BackboneElement.modifierExtension"/>
        <min value="0"/>
        <max value="*"/>
      </base>
      <type>
        <code value="Extension"/>
      </type>
      <constraint>
        <key value="ele-1"/>
        <severity value="error"/>
        <human value="All FHIR elements must have a @value or children"/>
        <expression
                    value="hasValue() or (children().count() &gt; id.count())"/>
        <source value="http://hl7.org/fhir/StructureDefinition/Element"/>
      </constraint>
      <isModifier value="true"/>
      <isModifierReason
                        value="Modifier extensions are expected to modify the meaning or interpretation of the element that contains them"/>
      <isSummary value="true"/>
      <mapping>
        <identity value="rim"/>
        <map value="N/A"/>
      </mapping>
    </element>
    <element id="GenomicStudy.analysis.performer.actor">
      <path value="GenomicStudy.analysis.performer.actor"/>
      <short
             value="The organization, healthcare professional, or others who participated in performing this analysis"/>
      <definition
                  value="The organization, healthcare professional, or others who participated in performing this analysis."/>
      <min value="0"/>
      <max value="1"/>
      <base>
        <path value="GenomicStudy.analysis.performer.actor"/>
        <min value="0"/>
        <max value="1"/>
      </base>
      <type>
        <code value="Reference"/>
        <targetProfile
                       value="http://hl7.org/fhir/StructureDefinition/Practitioner"/>
        <targetProfile
                       value="http://hl7.org/fhir/StructureDefinition/PractitionerRole"/>
        <targetProfile
                       value="http://hl7.org/fhir/StructureDefinition/Organization"/>
        <targetProfile
                       value="http://hl7.org/fhir/StructureDefinition/Device"/>
      </type>
    </element>
    <element id="GenomicStudy.analysis.performer.role">
      <path value="GenomicStudy.analysis.performer.role"/>
      <short value="Role of the actor for this analysis"/>
      <definition value="Role of the actor for this analysis."/>
      <min value="0"/>
      <max value="1"/>
      <base>
        <path value="GenomicStudy.analysis.performer.role"/>
        <min value="0"/>
        <max value="1"/>
      </base>
      <type>
        <code value="CodeableConcept"/>
      </type>
    </element>
    <element id="GenomicStudy.analysis.device">
      <path value="GenomicStudy.analysis.device"/>
      <short
             value="Devices used for the analysis (e.g., instruments, software), with settings and parameters"/>
      <definition
                  value="Devices used for the analysis (e.g., instruments, software), with settings and parameters."/>
      <min value="0"/>
      <max value="*"/>
      <base>
        <path value="GenomicStudy.analysis.device"/>
        <min value="0"/>
        <max value="*"/>
      </base>
      <type>
        <code value="BackboneElement"/>
      </type>
      <constraint>
        <key value="ele-1"/>
        <severity value="error"/>
        <human
               value="All FHIR elements must have a @value or children or both"/>
        <expression
                    value="hasValue() or (children().count() &gt; id.count())"/>
        <source value="http://hl7.org/fhir/StructureDefinition/Element"/>
      </constraint>
    </element>
    <element id="GenomicStudy.analysis.device.id">
      <path value="GenomicStudy.analysis.device.id"/>
      <representation value="xmlAttr"/>
      <short value="Unique id for inter-element referencing"/>
      <definition
                  value="Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces."/>
      <min value="0"/>
      <max value="1"/>
      <base>
        <path value="Element.id"/>
        <min value="0"/>
        <max value="1"/>
      </base>
      <type>
        <extension
                   url="http://hl7.org/fhir/StructureDefinition/structuredefinition-fhir-type">
          <valueUrl value="id"/>
        </extension>
        <code value="http://hl7.org/fhirpath/System.String"/>
      </type>
      <condition value="ele-1"/>
      <isModifier value="false"/>
      <isSummary value="false"/>
      <mapping>
        <identity value="rim"/>
        <map value="n/a"/>
      </mapping>
    </element>
    <element id="GenomicStudy.analysis.device.extension">
      <path value="GenomicStudy.analysis.device.extension"/>
      <slicing>
        <discriminator>
          <type value="value"/>
          <path value="url"/>
        </discriminator>
        <description value="Extensions are always sliced by (at least) url"/>
        <rules value="open"/>
      </slicing>
      <short value="Additional content defined by implementations"/>
      <definition
                  value="May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension."/>
      <comment
               value="There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions.  The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone."/>
      <alias value="extensions"/>
      <alias value="user content"/>
      <min value="0"/>
      <max value="*"/>
      <base>
        <path value="Element.extension"/>
        <min value="0"/>
        <max value="*"/>
      </base>
      <type>
        <code value="Extension"/>
      </type>
      <constraint>
        <key value="ele-1"/>
        <severity value="error"/>
        <human value="All FHIR elements must have a @value or children"/>
        <expression
                    value="hasValue() or (children().count() &gt; id.count())"/>
        <source value="http://hl7.org/fhir/StructureDefinition/Element"/>
      </constraint>
      <isModifier value="false"/>
      <isSummary value="false"/>
      <mapping>
        <identity value="rim"/>
        <map value="n/a"/>
      </mapping>
    </element>
    <element id="GenomicStudy.analysis.device.modifierExtension">
      <path value="GenomicStudy.analysis.device.modifierExtension"/>
      <short value="Extensions that cannot be ignored even if unrecognized"/>
      <definition
                  value="May be used to represent additional information that is not part of the basic definition of the element and that modifies the understanding of the element in which it is contained and/or the understanding of the containing element's descendants. Usually modifier elements provide negation or qualification. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Applications processing a resource are required to check for modifier extensions.

Modifier extensions SHALL NOT change the meaning of any elements on Resource or DomainResource (including cannot change the meaning of modifierExtension itself)."/>
      <comment
               value="There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions.  The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone."/>
      <requirements
                    value="Modifier extensions allow for extensions that *cannot* be safely ignored to be clearly distinguished from the vast majority of extensions which can be safely ignored.  This promotes interoperability by eliminating the need for implementers to prohibit the presence of extensions. For further information, see the [definition of modifier extensions](http://build.fhir.org/extensibility.html#modifierExtension)."/>
      <alias value="extensions"/>
      <alias value="user content"/>
      <alias value="modifiers"/>
      <min value="0"/>
      <max value="*"/>
      <base>
        <path value="BackboneElement.modifierExtension"/>
        <min value="0"/>
        <max value="*"/>
      </base>
      <type>
        <code value="Extension"/>
      </type>
      <constraint>
        <key value="ele-1"/>
        <severity value="error"/>
        <human value="All FHIR elements must have a @value or children"/>
        <expression
                    value="hasValue() or (children().count() &gt; id.count())"/>
        <source value="http://hl7.org/fhir/StructureDefinition/Element"/>
      </constraint>
      <isModifier value="true"/>
      <isModifierReason
                        value="Modifier extensions are expected to modify the meaning or interpretation of the element that contains them"/>
      <isSummary value="true"/>
      <mapping>
        <identity value="rim"/>
        <map value="N/A"/>
      </mapping>
    </element>
    <element id="GenomicStudy.analysis.device.device">
      <path value="GenomicStudy.analysis.device.device"/>
      <short value="Device used for the analysis"/>
      <definition value="Device used for the analysis."/>
      <min value="0"/>
      <max value="1"/>
      <base>
        <path value="GenomicStudy.analysis.device.device"/>
        <min value="0"/>
        <max value="1"/>
      </base>
      <type>
        <code value="Reference"/>
        <targetProfile
                       value="http://hl7.org/fhir/StructureDefinition/Device"/>
      </type>
    </element>
    <element id="GenomicStudy.analysis.device.function">
      <path value="GenomicStudy.analysis.device.function"/>
      <short value="Specific function for the device used for the analysis"/>
      <definition
                  value="Specific function for the device used for the analysis."/>
      <min value="0"/>
      <max value="1"/>
      <base>
        <path value="GenomicStudy.analysis.device.function"/>
        <min value="0"/>
        <max value="1"/>
      </base>
      <type>
        <code value="CodeableConcept"/>
      </type>
    </element>
  </snapshot>
  <differential>
    <element id="GenomicStudy">
      <extension url="http://hl7.org/fhir/build/StructureDefinition/svg">
        <valueCode value="0,0"/>
      </extension>
      <path value="GenomicStudy"/>
      <short value="Genomic Study"/>
      <definition
                  value="A GenomicStudy is a set of analyses performed to analyze and generate genomic data."/>
      <min value="0"/>
      <max value="*"/>
      <mapping>
        <identity value="workflow"/>
        <map value="Event"/>
      </mapping>
      <mapping>
        <identity value="w5"/>
        <map value="clinical.diagnostics"/>
      </mapping>
    </element>
    <element id="GenomicStudy.identifier">
      <path value="GenomicStudy.identifier"/>
      <short value="Identifiers for this genomic study"/>
      <definition value="Identifiers for this genomic study."/>
      <min value="0"/>
      <max value="*"/>
      <type>
        <code value="Identifier"/>
      </type>
      <isSummary value="true"/>
    </element>
    <element id="GenomicStudy.status">
      <path value="GenomicStudy.status"/>
      <short
             value="registered | available | cancelled | entered-in-error | unknown"/>
      <definition value="The status of the genomic study."/>
      <min value="1"/>
      <max value="1"/>
      <type>
        <code value="code"/>
      </type>
      <isModifier value="true"/>
      <isModifierReason
                        value="This element is labeled as a modifier because it is a status element that contains status entered-in-error which means that the resource should not be treated as valid"/>
      <isSummary value="true"/>
      <binding>
        <extension
                   url="http://hl7.org/fhir/StructureDefinition/elementdefinition-bindingName">
          <valueString value="GenomicStudyStatus"/>
        </extension>
        <strength value="required"/>
        <description value="The status of the GenomicStudy."/>
        <valueSet
                  value="http://hl7.org/fhir/uv/cg-incubator/ValueSet/genomicstudy-status"/>
      </binding>
      <mapping>
        <identity value="workflow"/>
        <map value="Event.status"/>
      </mapping>
      <mapping>
        <identity value="w5"/>
        <map value="FiveWs.status"/>
      </mapping>
      <mapping>
        <identity value="v2"/>
        <map value="Varies by domain"/>
      </mapping>
      <mapping>
        <identity value="rim"/>
        <map value=".status"/>
      </mapping>
    </element>
    <element id="GenomicStudy.type">
      <path value="GenomicStudy.type"/>
      <short
             value="The type of the study (e.g., Familial variant segregation, Functional variation detection, or Gene expression profiling)"/>
      <definition
                  value="The type of the study, e.g., Familial variant segregation, Functional variation detection, or Gene expression profiling."/>
      <min value="0"/>
      <max value="*"/>
      <type>
        <code value="CodeableConcept"/>
      </type>
      <isSummary value="true"/>
      <binding>
        <extension
                   url="http://hl7.org/fhir/StructureDefinition/elementdefinition-bindingName">
          <valueString value="GenomicStudyType"/>
        </extension>
        <strength value="example"/>
        <description value="The type relevant to GenomicStudy."/>
        <valueSet
                  value="http://hl7.org/fhir/uv/cg-incubator/ValueSet/genomicstudy-type"/>
      </binding>
    </element>
    <element id="GenomicStudy.subject">
      <path value="GenomicStudy.subject"/>
      <short value="The primary subject of the genomic study"/>
      <definition value="The primary subject of the genomic study."/>
      <min value="1"/>
      <max value="1"/>
      <type>
        <code value="Reference"/>
        <targetProfile
                       value="http://hl7.org/fhir/StructureDefinition/Patient"/>
        <targetProfile value="http://hl7.org/fhir/StructureDefinition/Group"/>
        <targetProfile
                       value="http://hl7.org/fhir/StructureDefinition/Substance"/>
        <targetProfile
                       value="http://hl7.org/fhir/StructureDefinition/BiologicallyDerivedProduct"/>
        <targetProfile
                       value="http://hl7.org/fhir/StructureDefinition/NutritionProduct"/>
      </type>
      <isSummary value="true"/>
    </element>
    <element id="GenomicStudy.encounter">
      <path value="GenomicStudy.encounter"/>
      <short
             value="The healthcare event with which this genomics study is associated"/>
      <definition
                  value="The healthcare event with which this genomics study is associated."/>
      <min value="0"/>
      <max value="1"/>
      <type>
        <code value="Reference"/>
        <targetProfile
                       value="http://hl7.org/fhir/StructureDefinition/Encounter"/>
      </type>
      <isSummary value="true"/>
    </element>
    <element id="GenomicStudy.startDate">
      <path value="GenomicStudy.startDate"/>
      <short value="When the genomic study was started"/>
      <definition value="When the genomic study was started."/>
      <min value="0"/>
      <max value="1"/>
      <type>
        <code value="dateTime"/>
      </type>
    </element>
    <element id="GenomicStudy.basedOn">
      <path value="GenomicStudy.basedOn"/>
      <short value="Event resources that the genomic study is based on"/>
      <definition
                  value="Event resources that the genomic study is based on."/>
      <min value="0"/>
      <max value="*"/>
      <type>
        <code value="Reference"/>
        <targetProfile
                       value="http://hl7.org/fhir/StructureDefinition/ServiceRequest"/>
        <targetProfile value="http://hl7.org/fhir/StructureDefinition/Task"/>
      </type>
    </element>
    <element id="GenomicStudy.referrer">
      <path value="GenomicStudy.referrer"/>
      <short
             value="Healthcare professional who requested or referred the genomic study"/>
      <definition
                  value="Healthcare professional who requested or referred the genomic study."/>
      <min value="0"/>
      <max value="1"/>
      <type>
        <code value="Reference"/>
        <targetProfile
                       value="http://hl7.org/fhir/StructureDefinition/Practitioner"/>
        <targetProfile
                       value="http://hl7.org/fhir/StructureDefinition/PractitionerRole"/>
      </type>
    </element>
    <element id="GenomicStudy.interpreter">
      <path value="GenomicStudy.interpreter"/>
      <short
             value="Healthcare professionals who interpreted the genomic study"/>
      <definition
                  value="Healthcare professionals who interpreted the genomic study."/>
      <min value="0"/>
      <max value="*"/>
      <type>
        <code value="Reference"/>
        <targetProfile
                       value="http://hl7.org/fhir/StructureDefinition/Practitioner"/>
        <targetProfile
                       value="http://hl7.org/fhir/StructureDefinition/PractitionerRole"/>
      </type>
    </element>
    <element id="GenomicStudy.reason">
      <path value="GenomicStudy.reason"/>
      <short value="Why the genomic study was performed"/>
      <definition value="Why the genomic study was performed."/>
      <min value="0"/>
      <max value="*"/>
      <type>
        <code value="CodeableReference"/>
        <targetProfile
                       value="http://hl7.org/fhir/StructureDefinition/Condition"/>
        <targetProfile
                       value="http://hl7.org/fhir/StructureDefinition/Observation"/>
      </type>
    </element>
    <element id="GenomicStudy.instantiatesCanonical">
      <path value="GenomicStudy.instantiatesCanonical"/>
      <short value="The defined protocol that describes the study"/>
      <definition value="The defined protocol that describes the study."/>
      <min value="0"/>
      <max value="1"/>
      <type>
        <code value="canonical"/>
        <targetProfile
                       value="http://hl7.org/fhir/StructureDefinition/PlanDefinition"/>
      </type>
    </element>
    <element id="GenomicStudy.instantiatesUri">
      <path value="GenomicStudy.instantiatesUri"/>
      <short
             value="The URL pointing to an externally maintained protocol that describes the study"/>
      <definition
                  value="The URL pointing to an externally maintained protocol that describes the study."/>
      <min value="0"/>
      <max value="1"/>
      <type>
        <code value="uri"/>
      </type>
    </element>
    <element id="GenomicStudy.note">
      <path value="GenomicStudy.note"/>
      <short value="Comments related to the genomic study"/>
      <definition value="Comments related to the genomic study."/>
      <min value="0"/>
      <max value="*"/>
      <type>
        <code value="Annotation"/>
      </type>
    </element>
    <element id="GenomicStudy.description">
      <path value="GenomicStudy.description"/>
      <short value="Description of the genomic study"/>
      <definition value="Description of the genomic study."/>
      <min value="0"/>
      <max value="1"/>
      <type>
        <code value="markdown"/>
      </type>
    </element>
    <element id="GenomicStudy.analysis">
      <path value="GenomicStudy.analysis"/>
      <short value="Genomic Analysis Event"/>
      <definition
                  value="The details about a specific analysis that was performed in this GenomicStudy."/>
      <min value="0"/>
      <max value="*"/>
      <type>
        <code value="BackboneElement"/>
      </type>
      <constraint>
        <key value="gs-regions-1"/>
        <severity value="warning"/>
        <human
               value="When genomicRegion.studied entries use coded concepts, every code in genomicRegion.called and genomicRegion.uncalled entries should also appear in genomicRegion.studied. This constraint cannot be evaluated when BED file references (DocumentReference) are used instead of coded concepts."/>
        <expression
                    value="genomicRegion.where(type.coding.where(system = 'http://hl7.org/fhir/uv/cg-incubator/CodeSystem/genomicstudy-regiontype' and code = 'studied').exists()).locus.concept.exists() implies genomicRegion.where(type.coding.where(system = 'http://hl7.org/fhir/uv/cg-incubator/CodeSystem/genomicstudy-regiontype' and (code = 'called' or code = 'uncalled')).exists()).locus.concept.coding.where(system.exists()).all((system &amp; '|' &amp; code) in %context.genomicRegion.where(type.coding.where(system = 'http://hl7.org/fhir/uv/cg-incubator/CodeSystem/genomicstudy-regiontype' and code = 'studied').exists()).locus.concept.coding.select(system &amp; '|' &amp; code))"/>
      </constraint>
      <constraint>
        <key value="gs-regions-2"/>
        <severity value="error"/>
        <human
               value="If all studied genomicRegion entries use coded concepts (none use DocumentReference), then all called and uncalled genomicRegion entries must also use coded concepts and not DocumentReference. This ensures a consistent representation when the studied scope is fully expressed as coded identifiers. Note: this constraint is intentionally one-directional — when studied uses DocumentReference (e.g., a BED file), called and uncalled entries may legitimately use coded concepts to name specific genes, since enumerating a full BED file as coded genes is impractical."/>
        <expression
                    value="(genomicRegion.where(type.coding.where(system = 'http://hl7.org/fhir/uv/cg-incubator/CodeSystem/genomicstudy-regiontype' and code = 'studied').exists()).locus.reference.exists().not() and genomicRegion.where(type.coding.where(system = 'http://hl7.org/fhir/uv/cg-incubator/CodeSystem/genomicstudy-regiontype' and code = 'studied').exists()).locus.concept.exists()) implies genomicRegion.where(type.coding.where(system = 'http://hl7.org/fhir/uv/cg-incubator/CodeSystem/genomicstudy-regiontype' and (code = 'called' or code = 'uncalled')).exists()).locus.reference.exists().not()"/>
      </constraint>
    </element>
    <element id="GenomicStudy.analysis.identifier">
      <path value="GenomicStudy.analysis.identifier"/>
      <short value="Identifiers for the analysis event"/>
      <definition value="Identifiers for the analysis event."/>
      <min value="0"/>
      <max value="*"/>
      <type>
        <code value="Identifier"/>
      </type>
      <isSummary value="true"/>
    </element>
    <element id="GenomicStudy.analysis.methodType">
      <path value="GenomicStudy.analysis.methodType"/>
      <short
             value="Type of the methods used in the analysis (e.g., FISH, Karyotyping, MSI)"/>
      <definition
                  value="Type of the methods used in the analysis, e.g., Fluorescence in situ hybridization (FISH), Karyotyping, or Microsatellite instability testing (MSI)."/>
      <min value="0"/>
      <max value="*"/>
      <type>
        <code value="CodeableConcept"/>
      </type>
      <isSummary value="true"/>
      <binding>
        <extension
                   url="http://hl7.org/fhir/StructureDefinition/elementdefinition-bindingName">
          <valueString value="GenomicStudyMethodType"/>
        </extension>
        <strength value="preferred"/>
        <description value="The method type of the GenomicStudy analysis."/>
        <valueSet
                  value="http://hl7.org/fhir/uv/cg-incubator/ValueSet/genomicstudy-methodtype"/>
      </binding>
    </element>
    <element id="GenomicStudy.analysis.changeType">
      <path value="GenomicStudy.analysis.changeType"/>
      <short
             value="Type of the genomic changes studied in the analysis (e.g., DNA, RNA, or AA change)"/>
      <definition
                  value="Type of the genomic changes studied in the analysis, e.g., DNA, RNA, or amino acid change."/>
      <min value="0"/>
      <max value="*"/>
      <type>
        <code value="CodeableConcept"/>
      </type>
      <binding>
        <extension
                   url="http://hl7.org/fhir/StructureDefinition/elementdefinition-bindingName">
          <valueString value="GenomicStudyChangeType"/>
        </extension>
        <strength value="preferred"/>
        <description
                     value="The change type relevant to GenomicStudy analysis."/>
        <valueSet
                  value="http://hl7.org/fhir/uv/cg-incubator/ValueSet/genomicstudy-changetype"/>
      </binding>
    </element>
    <element id="GenomicStudy.analysis.genomeBuild">
      <path value="GenomicStudy.analysis.genomeBuild"/>
      <short value="Genome build that is used in this analysis"/>
      <definition
                  value="The reference genome build that is used in this analysis."/>
      <min value="0"/>
      <max value="1"/>
      <type>
        <code value="CodeableConcept"/>
      </type>
      <binding>
        <extension
                   url="http://hl7.org/fhir/StructureDefinition/elementdefinition-bindingName">
          <valueString value="HumanRefSeqNCBIBuildId"/>
        </extension>
        <extension
                   url="http://hl7.org/fhir/build/StructureDefinition/copyright">
          <valueString
                       value="Copyright © 2022 Regenstrief Institute, Inc. All Rights Reserved."/>
        </extension>
        <strength value="extensible"/>
        <description value="Human reference sequence NCBI build ID"/>
        <valueSet value="http://loinc.org/vs/LL1040-6"/>
      </binding>
    </element>
    <element id="GenomicStudy.analysis.genomicSourceClass">
      <path value="GenomicStudy.analysis.genomicSourceClass"/>
      <short
             value="The genomic source class of the specimens used in the analysis (e.g., somatic, germline)"/>
      <definition
                  value="The genomic source class of the specimens used in the analysis, e.g., somatic or germline."/>
      <min value="0"/>
      <max value="1"/>
      <type>
        <code value="CodeableConcept"/>
      </type>
      <binding>
        <extension
                   url="http://hl7.org/fhir/StructureDefinition/elementdefinition-bindingName">
          <valueString value="GenomicStudyGenomicSourceClass"/>
        </extension>
        <extension
                   url="http://hl7.org/fhir/build/StructureDefinition/copyright">
          <valueString
                       value="Copyright © 2022 Regenstrief Institute, Inc. All Rights Reserved."/>
        </extension>
        <strength value="extensible"/>
        <description
                     value="The genomic source class (e.g., somatic, germline) of the specimens being analyzed."/>
        <valueSet value="http://loinc.org/vs/LL378-1"/>
      </binding>
    </element>
    <element id="GenomicStudy.analysis.instantiatesCanonical">
      <path value="GenomicStudy.analysis.instantiatesCanonical"/>
      <short value="The defined protocol that describes the analysis"/>
      <definition value="The defined protocol that describes the analysis."/>
      <min value="0"/>
      <max value="1"/>
      <type>
        <code value="canonical"/>
        <targetProfile
                       value="http://hl7.org/fhir/StructureDefinition/PlanDefinition"/>
        <targetProfile
                       value="http://hl7.org/fhir/StructureDefinition/ActivityDefinition"/>
      </type>
    </element>
    <element id="GenomicStudy.analysis.instantiatesUri">
      <path value="GenomicStudy.analysis.instantiatesUri"/>
      <short
             value="The URL pointing to an externally maintained protocol that describes the analysis"/>
      <definition
                  value="The URL pointing to an externally maintained protocol that describes the analysis."/>
      <min value="0"/>
      <max value="1"/>
      <type>
        <code value="uri"/>
      </type>
    </element>
    <element id="GenomicStudy.analysis.title">
      <path value="GenomicStudy.analysis.title"/>
      <short value="Name of the analysis event (human friendly)"/>
      <definition value="Name of the analysis event (human friendly)."/>
      <min value="0"/>
      <max value="1"/>
      <type>
        <code value="string"/>
      </type>
      <isSummary value="true"/>
    </element>
    <element id="GenomicStudy.analysis.focus">
      <path value="GenomicStudy.analysis.focus"/>
      <short
             value="What the genomic analysis is about, when it is not about the subject of record"/>
      <definition
                  value="The focus of a genomic analysis when it is not the patient of record representing something or someone associated with the patient such as a spouse, parent, child, or sibling. For example, in trio testing, the GenomicStudy.subject would be the child (proband) and the GenomicStudy.analysis.focus of a specific analysis would be the parent."/>
      <comment
               value="If the focus of the analysis is not known, the value of this field SHALL use the data absent extension."/>
      <min value="0"/>
      <max value="*"/>
      <type>
        <code value="Reference"/>
        <targetProfile
                       value="http://hl7.org/fhir/StructureDefinition/Resource"/>
      </type>
      <isSummary value="true"/>
    </element>
    <element id="GenomicStudy.analysis.specimen">
      <path value="GenomicStudy.analysis.specimen"/>
      <short value="The specimen used in the analysis event"/>
      <definition value="The specimen used in the analysis event."/>
      <min value="0"/>
      <max value="*"/>
      <type>
        <code value="Reference"/>
        <targetProfile
                       value="http://hl7.org/fhir/StructureDefinition/Specimen"/>
      </type>
      <isSummary value="true"/>
    </element>
    <element id="GenomicStudy.analysis.date">
      <path value="GenomicStudy.analysis.date"/>
      <short value="The date of the analysis event"/>
      <definition value="The date of the analysis event."/>
      <min value="0"/>
      <max value="1"/>
      <type>
        <code value="dateTime"/>
      </type>
    </element>
    <element id="GenomicStudy.analysis.note">
      <path value="GenomicStudy.analysis.note"/>
      <short value="Any notes capture with the analysis event"/>
      <definition value="Any notes capture with the analysis event."/>
      <min value="0"/>
      <max value="*"/>
      <type>
        <code value="Annotation"/>
      </type>
    </element>
    <element id="GenomicStudy.analysis.metrics">
      <path value="GenomicStudy.analysis.metrics"/>
      <short value="Quality metrics for the analysis"/>
      <definition
                  value="High-level quality metrics about the sequencing analysis that was performed."/>
      <min value="0"/>
      <max value="1"/>
      <type>
        <code value="BackboneElement"/>
      </type>
    </element>
    <element id="GenomicStudy.analysis.metrics.readDepth">
      <path value="GenomicStudy.analysis.metrics.readDepth"/>
      <short value="Average read depth (e.g., 30x, 100x)"/>
      <definition
                  value="The average read depth (number of reads for a position) for the sequencing analysis."/>
      <comment
               value="This value is typically represented with an 'x' after the number (30x). Share the quantity value only."/>
      <min value="0"/>
      <max value="1"/>
      <type>
        <code value="Quantity"/>
        <profile
                 value="http://hl7.org/fhir/StructureDefinition/SimpleQuantity"/>
      </type>
    </element>
    <element id="GenomicStudy.analysis.metrics.sequencingCoverage">
      <path value="GenomicStudy.analysis.metrics.sequencingCoverage"/>
      <short value="Percentage of studied regions sequenced (e.g., 95%)"/>
      <definition
                  value="The percentage of the studied regions that were sequenced."/>
      <comment
               value="This value is typically represented with a '%' after the number (95%). Share the quantity value only."/>
      <min value="0"/>
      <max value="1"/>
      <type>
        <code value="Quantity"/>
        <profile
                 value="http://hl7.org/fhir/StructureDefinition/SimpleQuantity"/>
      </type>
    </element>
    <element id="GenomicStudy.analysis.metrics.description">
      <path value="GenomicStudy.analysis.metrics.description"/>
      <short value="Freetext coverage metrics description"/>
      <definition
                  value="Freetext description of the coverage and quality metrics for the sequencing analysis."/>
      <min value="0"/>
      <max value="1"/>
      <type>
        <code value="string"/>
      </type>
    </element>
    <element id="GenomicStudy.analysis.protocolPerformed">
      <path value="GenomicStudy.analysis.protocolPerformed"/>
      <short value="The protocol that was performed for the analysis event"/>
      <definition
                  value="The protocol that was performed for the analysis event."/>
      <min value="0"/>
      <max value="1"/>
      <type>
        <code value="Reference"/>
        <targetProfile
                       value="http://hl7.org/fhir/StructureDefinition/Procedure"/>
        <targetProfile value="http://hl7.org/fhir/StructureDefinition/Task"/>
      </type>
    </element>
    <element id="GenomicStudy.analysis.genomicRegion">
      <path value="GenomicStudy.analysis.genomicRegion"/>
      <short
             value="Genomic regions relevant to the analysis, grouped by type"/>
      <definition
                  value="A set of genomic regions associated with this analysis, classified by their relationship to the analysis outcome (studied, called, or uncalled). Each repetition represents one group of regions sharing the same type."/>
      <comment
               value="Use one repetition per region type. For example, include one entry with type=studied for the full panel scope, one with type=called for regions with sufficient coverage to produce calls, and one with type=uncalled for regions where calls could not be produced. All three types may be present in a single analysis, or only a subset, as appropriate."/>
      <min value="0"/>
      <max value="*"/>
      <type>
        <code value="BackboneElement"/>
      </type>
    </element>
    <element id="GenomicStudy.analysis.genomicRegion.type">
      <path value="GenomicStudy.analysis.genomicRegion.type"/>
      <short value="studied | called | uncalled"/>
      <definition
                  value="The type of this region group, indicating the relationship of these regions to the analysis outcome."/>
      <comment
               value="Use 'studied' for the full intended scope of the analysis. Use 'called' for regions where sufficient coverage and data quality enabled variant calling. Use 'uncalled' for regions within the studied scope where calls could not be produced (e.g., due to low coverage or poor mapping quality). An 'uncalled' entry does not imply that a pathogenic variant is present or was missed; it indicates a technical limitation. Use genomicRegion.description to document the reason."/>
      <min value="1"/>
      <max value="1"/>
      <type>
        <code value="CodeableConcept"/>
      </type>
      <binding>
        <extension
                   url="http://hl7.org/fhir/StructureDefinition/elementdefinition-bindingName">
          <valueString value="GenomicStudyRegionType"/>
        </extension>
        <strength value="extensible"/>
        <description
                     value="The type of genomic region group. Use studied, called, or uncalled where applicable; other codes may be used for methodology-specific region classifications not covered by this value set."/>
        <valueSet
                  value="http://hl7.org/fhir/uv/cg-incubator/ValueSet/genomicstudy-regiontype"/>
      </binding>
    </element>
    <element id="GenomicStudy.analysis.genomicRegion.locus">
      <path value="GenomicStudy.analysis.genomicRegion.locus"/>
      <short value="Genomic regions in this group (coded genes or BED file)"/>
      <definition
                  value="The genomic regions belonging to this group. May be expressed as a coded list of HGNC gene symbols (using CodeableReference.concept) or as a reference to a BED file (using CodeableReference.reference to a DocumentReference)."/>
      <comment
               value="For coded genes, use the HGNC gene symbol as display text and the HGNC gene ID as the code. If no HGNC code has been issued, use NCBI gene IDs. If region details beyond a coded gene list are needed (e.g., sub-gene coordinates), reference a BED file via DocumentReference. Multiple repetitions may be used to list individual genes or to combine a BED file reference with supplementary coded entries."/>
      <requirements
                    value="Expressed as a coded list of HGNC gene symbols or a reference to a BED file (DocumentReference)."/>
      <min value="0"/>
      <max value="*"/>
      <type>
        <code value="CodeableReference"/>
        <targetProfile
                       value="http://hl7.org/fhir/StructureDefinition/DocumentReference"/>
      </type>
      <binding>
        <extension
                   url="http://hl7.org/fhir/StructureDefinition/elementdefinition-bindingName">
          <valueString value="HGNCGeneNames"/>
        </extension>
        <strength value="extensible"/>
        <description value="HGNC gene names for coded gene lists."/>
        <valueSet
                  value="http://hl7.org/fhir/uv/cg-incubator/ValueSet/hgnc-vs"/>
      </binding>
    </element>
    <element id="GenomicStudy.analysis.genomicRegion.description">
      <path value="GenomicStudy.analysis.genomicRegion.description"/>
      <short value="Additional details about this region group"/>
      <definition
                  value="Free-text notes providing additional context about this group of regions. Particularly useful for 'uncalled' entries to document the reason calls could not be produced (e.g., 'low coverage &lt;20x', 'poor mapping due to repetitive sequence', 'homopolymer region exceeding assay limit')."/>
      <min value="0"/>
      <max value="1"/>
      <type>
        <code value="string"/>
      </type>
    </element>
    <element id="GenomicStudy.analysis.input">
      <path value="GenomicStudy.analysis.input"/>
      <short value="Inputs for the analysis event"/>
      <definition value="Inputs for the analysis event."/>
      <min value="0"/>
      <max value="*"/>
      <type>
        <code value="BackboneElement"/>
      </type>
    </element>
    <element id="GenomicStudy.analysis.input.file">
      <path value="GenomicStudy.analysis.input.file"/>
      <short value="File containing input data"/>
      <definition value="File containing input data."/>
      <min value="0"/>
      <max value="1"/>
      <type>
        <code value="Reference"/>
        <targetProfile
                       value="http://hl7.org/fhir/StructureDefinition/DocumentReference"/>
      </type>
      <isSummary value="true"/>
    </element>
    <element id="GenomicStudy.analysis.input.type">
      <path value="GenomicStudy.analysis.input.type"/>
      <short value="Type of input data (e.g., BAM, CRAM, or FASTA)"/>
      <definition value="Type of input data, e.g., BAM, CRAM, or FASTA."/>
      <min value="0"/>
      <max value="1"/>
      <type>
        <code value="CodeableConcept"/>
      </type>
      <binding>
        <extension
                   url="http://hl7.org/fhir/StructureDefinition/elementdefinition-bindingName">
          <valueString value="GenomicStudyDataFormat"/>
        </extension>
        <strength value="example"/>
        <description value="The data format of the data file."/>
        <valueSet
                  value="http://hl7.org/fhir/uv/cg-incubator/ValueSet/genomicstudy-dataformat"/>
      </binding>
    </element>
    <element id="GenomicStudy.analysis.input.generatedBy[x]">
      <path value="GenomicStudy.analysis.input.generatedBy[x]"/>
      <short
             value="The analysis event or other GenomicStudy that generated this input file"/>
      <definition
                  value="The analysis event or other GenomicStudy that generated this input file."/>
      <min value="0"/>
      <max value="1"/>
      <type>
        <code value="Identifier"/>
      </type>
      <type>
        <code value="Reference"/>
        <targetProfile
                       value="http://hl7.org/fhir/StructureDefinition/GenomicStudy|0.1.0-ci-build"/>
      </type>
    </element>
    <element id="GenomicStudy.analysis.output">
      <path value="GenomicStudy.analysis.output"/>
      <short value="Outputs for the analysis event"/>
      <definition value="Outputs for the analysis event."/>
      <min value="0"/>
      <max value="*"/>
      <type>
        <code value="BackboneElement"/>
      </type>
    </element>
    <element id="GenomicStudy.analysis.output.file">
      <path value="GenomicStudy.analysis.output.file"/>
      <short value="File containing output data"/>
      <definition value="File containing output data."/>
      <min value="0"/>
      <max value="1"/>
      <type>
        <code value="Reference"/>
        <targetProfile
                       value="http://hl7.org/fhir/StructureDefinition/DocumentReference"/>
      </type>
      <isSummary value="true"/>
    </element>
    <element id="GenomicStudy.analysis.output.type">
      <path value="GenomicStudy.analysis.output.type"/>
      <short value="Type of output data (e.g., VCF, MAF, or BAM)"/>
      <definition value="Type of output data, e.g., VCF, MAF, or BAM."/>
      <min value="0"/>
      <max value="1"/>
      <type>
        <code value="CodeableConcept"/>
      </type>
      <isSummary value="true"/>
      <binding>
        <extension
                   url="http://hl7.org/fhir/StructureDefinition/elementdefinition-bindingName">
          <valueString value="GenomicStudyDataFormat"/>
        </extension>
        <strength value="example"/>
        <description value="The data format of the data file."/>
        <valueSet
                  value="http://hl7.org/fhir/uv/cg-incubator/ValueSet/genomicstudy-dataformat"/>
      </binding>
    </element>
    <element id="GenomicStudy.analysis.performer">
      <path value="GenomicStudy.analysis.performer"/>
      <short value="Performer for the analysis event"/>
      <definition value="Performer for the analysis event."/>
      <min value="0"/>
      <max value="*"/>
      <type>
        <code value="BackboneElement"/>
      </type>
    </element>
    <element id="GenomicStudy.analysis.performer.actor">
      <path value="GenomicStudy.analysis.performer.actor"/>
      <short
             value="The organization, healthcare professional, or others who participated in performing this analysis"/>
      <definition
                  value="The organization, healthcare professional, or others who participated in performing this analysis."/>
      <min value="0"/>
      <max value="1"/>
      <type>
        <code value="Reference"/>
        <targetProfile
                       value="http://hl7.org/fhir/StructureDefinition/Practitioner"/>
        <targetProfile
                       value="http://hl7.org/fhir/StructureDefinition/PractitionerRole"/>
        <targetProfile
                       value="http://hl7.org/fhir/StructureDefinition/Organization"/>
        <targetProfile
                       value="http://hl7.org/fhir/StructureDefinition/Device"/>
      </type>
    </element>
    <element id="GenomicStudy.analysis.performer.role">
      <path value="GenomicStudy.analysis.performer.role"/>
      <short value="Role of the actor for this analysis"/>
      <definition value="Role of the actor for this analysis."/>
      <min value="0"/>
      <max value="1"/>
      <type>
        <code value="CodeableConcept"/>
      </type>
    </element>
    <element id="GenomicStudy.analysis.device">
      <path value="GenomicStudy.analysis.device"/>
      <short
             value="Devices used for the analysis (e.g., instruments, software), with settings and parameters"/>
      <definition
                  value="Devices used for the analysis (e.g., instruments, software), with settings and parameters."/>
      <min value="0"/>
      <max value="*"/>
      <type>
        <code value="BackboneElement"/>
      </type>
    </element>
    <element id="GenomicStudy.analysis.device.device">
      <path value="GenomicStudy.analysis.device.device"/>
      <short value="Device used for the analysis"/>
      <definition value="Device used for the analysis."/>
      <min value="0"/>
      <max value="1"/>
      <type>
        <code value="Reference"/>
        <targetProfile
                       value="http://hl7.org/fhir/StructureDefinition/Device"/>
      </type>
    </element>
    <element id="GenomicStudy.analysis.device.function">
      <path value="GenomicStudy.analysis.device.function"/>
      <short value="Specific function for the device used for the analysis"/>
      <definition
                  value="Specific function for the device used for the analysis."/>
      <min value="0"/>
      <max value="1"/>
      <type>
        <code value="CodeableConcept"/>
      </type>
    </element>
  </differential>
</StructureDefinition>