Clinical Genomics Resource Incubator
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Clinical Genomics Resource Incubator, published by HL7 International / Clinical Genomics. This guide is not an authorized publication; it is the continuous build for version 0.1.0-ci-build built by the FHIR (HL7® FHIR® Standard) CI Build. This version is based on the current content of https://github.com/HL7/cg-incubator/ and changes regularly. See the Directory of published versions

: Nucleotide DNA Symbols

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<CodeSystem xmlns="http://hl7.org/fhir">
  <id value="nucleotide-dna"/>
  <meta>
    <lastUpdated value="2026-03-23T00:00:00Z"/>
    <profile
             value="http://hl7.org/fhir/StructureDefinition/shareablecodesystem"/>
  </meta>
  <language value="en"/>
  <text>
    <status value="generated"/>
    <div xmlns="http://www.w3.org/1999/xhtml"><p class="res-header-id"><b>Generated Narrative: CodeSystem nucleotide-dna</b></p><a name="nucleotide-dna"> </a><a name="hcnucleotide-dna"> </a><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Last updated: 2026-03-23 00:00:00+0000</p><p style="margin-bottom: 0px">Profile: <a href="http://hl7.org/fhir/R5/shareablecodesystem.html">Shareable CodeSystem</a></p></div><p>This case-sensitive code system <code>http://hl7.org/fhir/uv/cg-incubator/CodeSystem/nucleotide-dna</code> defines the following codes:</p><table class="codes"><tr><td style="white-space:nowrap"><b>Code</b></td><td><b>Display</b></td><td><b>Definition</b></td></tr><tr><td style="white-space:nowrap">G<a name="nucleotide-dna-G"> </a></td><td>Guanine</td><td>G</td></tr><tr><td style="white-space:nowrap">A<a name="nucleotide-dna-A"> </a></td><td>Adenine</td><td>A</td></tr><tr><td style="white-space:nowrap">T<a name="nucleotide-dna-T"> </a></td><td>Thymine</td><td>T</td></tr><tr><td style="white-space:nowrap">C<a name="nucleotide-dna-C"> </a></td><td>Cytosine</td><td>C</td></tr><tr><td style="white-space:nowrap">R<a name="nucleotide-dna-R"> </a></td><td>Purine</td><td>G or A</td></tr><tr><td style="white-space:nowrap">Y<a name="nucleotide-dna-Y"> </a></td><td>Pyrimidine</td><td>T or C</td></tr><tr><td style="white-space:nowrap">M<a name="nucleotide-dna-M"> </a></td><td>Amino</td><td>A or C</td></tr><tr><td style="white-space:nowrap">K<a name="nucleotide-dna-K"> </a></td><td>Keto</td><td>G or T</td></tr><tr><td style="white-space:nowrap">S<a name="nucleotide-dna-S"> </a></td><td>Strong interaction (3 H bonds)</td><td>G or C</td></tr><tr><td style="white-space:nowrap">W<a name="nucleotide-dna-W"> </a></td><td>Weak interaction (2 H bonds)</td><td>A or T</td></tr><tr><td style="white-space:nowrap">H<a name="nucleotide-dna-H"> </a></td><td>Not-G (H follows G in the alphabet)</td><td>A or C or T</td></tr><tr><td style="white-space:nowrap">B<a name="nucleotide-dna-B"> </a></td><td>Not-A (B follows A)</td><td>G or T or C</td></tr><tr><td style="white-space:nowrap">V<a name="nucleotide-dna-V"> </a></td><td>Not-T/Not-U (V follows U)</td><td>G or C or A</td></tr><tr><td style="white-space:nowrap">D<a name="nucleotide-dna-D"> </a></td><td>Not-C (D follows C)</td><td>G or A or T</td></tr><tr><td style="white-space:nowrap">N<a name="nucleotide-dna-N"> </a></td><td>Any nucleotide</td><td>G or A or T or C</td></tr></table></div>
  </text>
  <extension
             url="http://hl7.org/fhir/StructureDefinition/structuredefinition-wg">
    <valueCode value="cg"/>
  </extension>
  <extension
             url="http://hl7.org/fhir/StructureDefinition/structuredefinition-standards-status">
    <valueCode value="informative"/>
  </extension>
  <extension
             url="http://hl7.org/fhir/StructureDefinition/structuredefinition-fmm">
    <valueInteger value="0"/>
  </extension>
  <url value="http://hl7.org/fhir/uv/cg-incubator/CodeSystem/nucleotide-dna"/>
  <version value="0.1.0-ci-build"/>
  <name value="NucleotideDNA"/>
  <title value="Nucleotide DNA Symbols"/>
  <status value="draft"/>
  <experimental value="true"/>
  <date value="2026-03-23"/>
  <publisher value="HL7 International / Clinical Genomics"/>
  <contact>
    <name value="HL7 International / Clinical Genomics"/>
    <telecom>
      <system value="url"/>
      <value value="http://www.hl7.org/Special/committees/clingenomics"/>
    </telecom>
    <telecom>
      <system value="email"/>
      <value value="clingenomics@lists.hl7.org"/>
    </telecom>
  </contact>
  <description
               value="Single-letter symbols for DNA residues based on IUPAC nomenclature, including unambiguous, ambiguous, and N symbols."/>
  <jurisdiction>
    <coding>
      <system value="http://unstats.un.org/unsd/methods/m49/m49.htm"/>
      <code value="001"/>
      <display value="World"/>
    </coding>
  </jurisdiction>
  <caseSensitive value="true"/>
  <content value="complete"/>
  <concept>
    <code value="G"/>
    <display value="Guanine"/>
    <definition value="G"/>
  </concept>
  <concept>
    <code value="A"/>
    <display value="Adenine"/>
    <definition value="A"/>
  </concept>
  <concept>
    <code value="T"/>
    <display value="Thymine"/>
    <definition value="T"/>
  </concept>
  <concept>
    <code value="C"/>
    <display value="Cytosine"/>
    <definition value="C"/>
  </concept>
  <concept>
    <code value="R"/>
    <display value="Purine"/>
    <definition value="G or A"/>
  </concept>
  <concept>
    <code value="Y"/>
    <display value="Pyrimidine"/>
    <definition value="T or C"/>
  </concept>
  <concept>
    <code value="M"/>
    <display value="Amino"/>
    <definition value="A or C"/>
  </concept>
  <concept>
    <code value="K"/>
    <display value="Keto"/>
    <definition value="G or T"/>
  </concept>
  <concept>
    <code value="S"/>
    <display value="Strong interaction (3 H bonds)"/>
    <definition value="G or C"/>
  </concept>
  <concept>
    <code value="W"/>
    <display value="Weak interaction (2 H bonds)"/>
    <definition value="A or T"/>
  </concept>
  <concept>
    <code value="H"/>
    <display value="Not-G (H follows G in the alphabet)"/>
    <definition value="A or C or T"/>
  </concept>
  <concept>
    <code value="B"/>
    <display value="Not-A (B follows A)"/>
    <definition value="G or T or C"/>
  </concept>
  <concept>
    <code value="V"/>
    <display value="Not-T/Not-U (V follows U)"/>
    <definition value="G or C or A"/>
  </concept>
  <concept>
    <code value="D"/>
    <display value="Not-C (D follows C)"/>
    <definition value="G or A or T"/>
  </concept>
  <concept>
    <code value="N"/>
    <display value="Any nucleotide"/>
    <definition value="G or A or T or C"/>
  </concept>
</CodeSystem>