<status value="active"/> <experimental value="false"/> <date value="2026-09-14"/> <publisher value="Health Level Seven International"/> <contact> <telecom> <system value="url"/> <value value="http://hl7.org"/> </telecom> <telecom> <system value="email"/> <value value="hq@HL7.org"/> </telecom> </contact> <description value="Codes that describe the potential clinical impact of a detected issue."/> <copyright value="This material derives from the HL7 Terminology (THO). THO is copyright ©1989+ Health Level Seven International and is made available under the CC0 designation. For more licensing information see: https://terminology.hl7.org/license"/> <caseSensitive value="true"/> <valueSet value="http://terminology.hl7.org/ValueSet/detectedissue-clinical-impact"/> <content value="complete"/> <concept> <code value="increased-effect"/> <display value="Increased effect"/> <definition value="The clinical or pharmacologic effect is expected to be increased for one or more implicated therapies."/> </concept> <concept> <code value="decreased-effect"/> <display value="Decreased effect"/> <definition value="The clinical or pharmacologic effect is expected to be decreased for one or more implicated therapies."/> </concept> <concept> <code value="mixed-effect"/> <display value="Mixed effect"/> <definition value="Mixed or differing changes in clinical or pharmacologic effects are expected."/> </concept> <concept> <code value="adverse-reaction"/> <display value="Adverse reaction"/> <definition value="An adverse reaction is expected or its risk is increased."/> </concept> <concept> <code value="additive-adverse-effects"/> <display value="Additive adverse effects"/> <definition value="Adverse or undesirable effects are expected to be additive for one or more implicated therapies."/> </concept> <concept> <code value="avoid-concurrent-use"/> <display value="Avoid concurrent use when possible"/> <definition value="Concurrent use should generally be avoided because of the identified clinical risk."/> </concept> <concept> <code value="contraindicated-in-some-patients"/> <display value="Contraindicated in some patients"/> <definition value="Concurrent use is contraindicated for a subset of patients based on patient-specific clinical characteristics or circumstances."/> </concept> </CodeSystem>

Generated Narrative: CodeSystem detectedissue-clinical-impact

This case-sensitive code system http://terminology.hl7.org/CodeSystem/detectedissue-clinical-impact defines the following codes:

Code	Display	Definition
increased-effect	Increased effect	The clinical or pharmacologic effect is expected to be increased for one or more implicated therapies.
decreased-effect	Decreased effect	The clinical or pharmacologic effect is expected to be decreased for one or more implicated therapies.
mixed-effect	Mixed effect	Mixed or differing changes in clinical or pharmacologic effects are expected.
adverse-reaction	Adverse reaction	An adverse reaction is expected or its risk is increased.
additive-adverse-effects	Additive adverse effects	Adverse or undesirable effects are expected to be additive for one or more implicated therapies.
avoid-concurrent-use	Avoid concurrent use when possible	Concurrent use should generally be avoided because of the identified clinical risk.
contraindicated-in-some-patients	Contraindicated in some patients	Concurrent use is contraindicated for a subset of patients based on patient-specific clinical characteristics or circumstances.