| Lvl | Code | Display | Definition | Not Selectable | Status | Not Selectable | Status |
| 1 | _ActSubstanceAdminSubstitutionCode | ActSubstanceAdminSubstitutionCode | Substitution occurred or is permitted with another product that may potentially have different ingredients, but having the same biological and therapeutic effects.
| true, true | active, active | true, true | active, active |
| 2 | E | equivalent | Substitution occurred or is permitted with another bioequivalent and therapeutically equivalent product.
| | active | | active |
| 3 | EC | equivalent composition | Substitution occurred or is permitted with another product that is a:
- pharmaceutical alternative containing the same active ingredient but is formulated with different salt, ester
- pharmaceutical equivalent that has the same active ingredient, strength, dosage form and route of administration
Examples:
- Pharmaceutical alternative: Erythromycin Ethylsuccinate for Erythromycin Stearate
- Pharmaceutical equivalent: Lisonpril for Zestril
| | active | | active |
| 4 | BC | brand composition | Substitution occurred or is permitted between equivalent Brands but not Generics
Examples:
- Zestril for Prinivil
- Coumadin for Jantoven
| | active | | active |
| 4 | G | generic composition | Substitution occurred or is permitted between equivalent Generics but not Brands
Examples:
- Lisnopril (Lupin Corp) for Lisnopril (Wockhardt Corp)
| | active | | active |
| 3 | TE | therapeutic alternative | Substitution occurred or is permitted with another product having the same therapeutic objective and safety profile.
Examples:
| | active | | active |
| 4 | TB | therapeutic brand | Substitution occurred or is permitted between therapeutically equivalent Brands but not Generics
Examples:
| | active | | active |
| 4 | TG | therapeutic generic | Substitution occurred or is permitted between therapeutically equivalent Generics but not Brands
Examples:
- Ranitidine for cimetidine
| | active | | active |
| 2 | F | formulary | This substitution was performed or is permitted based on formulary guidelines.
| | active | | active |
| 2 | N | none | No substitution occurred or is permitted.
| | active | | active |
| 2 | E | equivalent | Substitution occurred or is permitted with another bioequivalent and therapeutically equivalent product.
| | active, active | | active, active |
| 3 | EC | equivalent composition | Substitution occurred or is permitted with another product that is a:
- pharmaceutical alternative containing the same active ingredient but is formulated with different salt, ester
- pharmaceutical equivalent that has the same active ingredient, strength, dosage form and route of administration
Examples:
- Pharmaceutical alternative: Erythromycin Ethylsuccinate for Erythromycin Stearate
- Pharmaceutical equivalent: Lisonpril for Zestril
| | active | | active |
| 4 | BC | brand composition | Substitution occurred or is permitted between equivalent Brands but not Generics
Examples:
- Zestril for Prinivil
- Coumadin for Jantoven
| | active | | active |
| 4 | G | generic composition | Substitution occurred or is permitted between equivalent Generics but not Brands
Examples:
- Lisnopril (Lupin Corp) for Lisnopril (Wockhardt Corp)
| | active | | active |
| 3 | TE | therapeutic alternative | Substitution occurred or is permitted with another product having the same therapeutic objective and safety profile.
Examples:
| | active | | active |
| 4 | TB | therapeutic brand | Substitution occurred or is permitted between therapeutically equivalent Brands but not Generics
Examples:
| | active | | active |
| 4 | TG | therapeutic generic | Substitution occurred or is permitted between therapeutically equivalent Generics but not Brands
Examples:
- Ranitidine for cimetidine
| | active | | active |
| 3 | EC | equivalent composition | Substitution occurred or is permitted with another product that is a:
- pharmaceutical alternative containing the same active ingredient but is formulated with different salt, ester
- pharmaceutical equivalent that has the same active ingredient, strength, dosage form and route of administration
Examples:
- Pharmaceutical alternative: Erythromycin Ethylsuccinate for Erythromycin Stearate
- Pharmaceutical equivalent: Lisonpril for Zestril
| | active, active | | active, active |
| 4 | BC | brand composition | Substitution occurred or is permitted between equivalent Brands but not Generics
Examples:
- Zestril for Prinivil
- Coumadin for Jantoven
| | active | | active |
| 4 | G | generic composition | Substitution occurred or is permitted between equivalent Generics but not Brands
Examples:
- Lisnopril (Lupin Corp) for Lisnopril (Wockhardt Corp)
| | active | | active |
| 4 | BC | brand composition | Substitution occurred or is permitted between equivalent Brands but not Generics
Examples:
- Zestril for Prinivil
- Coumadin for Jantoven
| | active, active | | active, active |
| 4 | G | generic composition | Substitution occurred or is permitted between equivalent Generics but not Brands
Examples:
- Lisnopril (Lupin Corp) for Lisnopril (Wockhardt Corp)
| | active, active | | active, active |
| 3 | TE | therapeutic alternative | Substitution occurred or is permitted with another product having the same therapeutic objective and safety profile.
Examples:
| | active, active | | active, active |
| 4 | TB | therapeutic brand | Substitution occurred or is permitted between therapeutically equivalent Brands but not Generics
Examples:
| | active | | active |
| 4 | TG | therapeutic generic | Substitution occurred or is permitted between therapeutically equivalent Generics but not Brands
Examples:
- Ranitidine for cimetidine
| | active | | active |
| 4 | TB | therapeutic brand | Substitution occurred or is permitted between therapeutically equivalent Brands but not Generics
Examples:
| | active, active | | active, active |
| 4 | TG | therapeutic generic | Substitution occurred or is permitted between therapeutically equivalent Generics but not Brands
Examples:
- Ranitidine for cimetidine
| | active, active | | active, active |
| 2 | F | formulary | This substitution was performed or is permitted based on formulary guidelines.
| | active, active | | active, active |
| 2 | N | none | No substitution occurred or is permitted.
| | active, active | | active, active |