Generated Narrative: CodeSystem substance-glycosylation-type

This case-sensitive code system http://hl7.org/fhir/substance-glycosylation-type defines the following codes:

Code	Display	Definition
human	Human	Glycosylation pattern from human cell lines (e.g. HEK293, PER.C6). No non-human glycan epitopes.
mammalian	Mammalian (non-human)	Glycosylation pattern from non-human mammalian cell lines such as CHO, BHK or NS0. The most common pattern for therapeutic monoclonal antibodies.
old-world-monkey	Old World Monkey	Glycosylation pattern from old world monkey cell lines such as Vero or COS. Often used for vaccine production.
mouse	Murine	Glycosylation pattern from murine cell lines such as NS0 or SP2/0 hybridoma. Carries the alpha-1,3-galactose epitope which can be immunogenic in humans.
mammalian-afucosylated	Mammalian, afucosylated	Glycosylation pattern from engineered mammalian cell lines lacking fucosyltransferase (e.g. Potelligent), producing antibodies with enhanced ADCC activity.
avian	Avian	Glycosylation pattern from egg-derived or avian cell line production. Common for influenza vaccines.
insect	Insect cell	Glycosylation pattern from insect cell expression systems such as baculovirus/Sf9. Used for some recombinant proteins and vaccines.
yeast	Yeast	Native yeast glycosylation pattern (e.g. Saccharomyces cerevisiae). Examples include insulin and hepatitis B surface antigen.
yeast-humanised	Yeast, humanised	Glycosylation pattern from glyco-engineered yeast (e.g. Pichia pastoris GlycoFi systems) that produces human-like glycan structures.
plant	Plant	Glycosylation pattern from plant or plant cell culture production (e.g. taliglucerase alfa from carrot cells).
bacterial	Bacterial	Bacterial expression (typically E. coli). Generally unglycosylated; included for completeness when the substance has been characterised as such.