<status value="active"/><experimental value="true"/><date value="2026-06-30"/><publisher value="HL7 (FHIR Project)"/><contact><telecom><system value="url"/><value value="http://hl7.org/fhir"/></telecom><telecom><system value="email"/><value value="fhir@lists.hl7.org"/></telecom></contact><description value="A high-level summary of how a protein has been modified, e.g. PEGylation, lipidation, Fc fusion. Useful for categorising modified biologics without enumerating the detailed chemistry."/><jurisdiction><coding><system value="http://unstats.un.org/unsd/methods/m49/m49.htm"/><code value="001"/><display value="World"/></coding></jurisdiction><caseSensitive value="true"/><valueSet value="http://hl7.org/fhir/ValueSet/protein-modification-type"/><content value="complete"/><concept><code value="PEGylated"/><display value="PEGylated"/><definition value="Conjugated to one or more polyethylene glycol (PEG) chains for half-life extension. Examples: pegfilgrastim, peginterferon, certolizumab pegol."/></concept><concept><code value="lipidated"/><display value="Lipidated"/><definition value="Conjugated to a fatty acid chain (acylation) for half-life extension via albumin binding. Examples: semaglutide, liraglutide, insulin detemir, insulin degludec."/></concept><concept><code value="Fc-fused"/><display value="Fc fusion"/><definition value="Fused to an immunoglobulin Fc region for half-life extension and effector function. Examples: etanercept, abatacept, aflibercept, dulaglutide."/></concept><concept><code value="albumin-fused"/><display value="Albumin fusion"/><definition value="Fused to human serum albumin for half-life extension. Example: albiglutide."/></concept><concept><code value="drug-conjugated"/><display value="Drug-conjugated (ADC)"/><definition value="Conjugated to a small-molecule drug payload via a linker (antibody-drug conjugate). Examples: trastuzumab emtansine, brentuximab vedotin, gemtuzumab ozogamicin."/></concept><concept><code value="polysaccharide-conjugated"/><display value="Polysaccharide-conjugated"/><definition value="Conjugated to a polysaccharide antigen for vaccine immunogenicity. Examples: Hib, pneumococcal and meningococcal conjugate vaccines."/></concept><concept><code value="glycoengineered"/><display value="Glycoengineered"/><definition value="Glycan structure engineered (e.g. afucosylated) to alter biological activity. Examples: obinutuzumab, mogamulizumab (enhanced ADCC)."/></concept><concept><code value="amino-acid-substituted"/><display value="Amino acid substituted"/><definition value="Sequence carries one or more amino acid substitutions relative to a natural or parent protein. Examples: insulin analogs lispro, aspart, glargine."/></concept><concept><code value="truncated"/><display value="Truncated"/><definition value="Sequence is shortened relative to the parent protein."/></concept><concept><code value="biotinylated"/><display value="Biotinylated"/><definition value="Covalently labelled with biotin. Typical for research or diagnostic reagents."/></concept><concept><code value="fluorescent-labeled"/><display value="Fluorescent labelled"/><definition value="Covalently labelled with a fluorescent dye. Typical for imaging or flow-cytometry reagents."/></concept></CodeSystem>

Generated Narrative: CodeSystem protein-modification-type

This case-sensitive code system http://hl7.org/fhir/protein-modification-type defines the following codes:

Code	Display	Definition
PEGylated	PEGylated	Conjugated to one or more polyethylene glycol (PEG) chains for half-life extension. Examples: pegfilgrastim, peginterferon, certolizumab pegol.
lipidated	Lipidated	Conjugated to a fatty acid chain (acylation) for half-life extension via albumin binding. Examples: semaglutide, liraglutide, insulin detemir, insulin degludec.
Fc-fused	Fc fusion	Fused to an immunoglobulin Fc region for half-life extension and effector function. Examples: etanercept, abatacept, aflibercept, dulaglutide.
albumin-fused	Albumin fusion	Fused to human serum albumin for half-life extension. Example: albiglutide.
drug-conjugated	Drug-conjugated (ADC)	Conjugated to a small-molecule drug payload via a linker (antibody-drug conjugate). Examples: trastuzumab emtansine, brentuximab vedotin, gemtuzumab ozogamicin.
polysaccharide-conjugated	Polysaccharide-conjugated	Conjugated to a polysaccharide antigen for vaccine immunogenicity. Examples: Hib, pneumococcal and meningococcal conjugate vaccines.
glycoengineered	Glycoengineered	Glycan structure engineered (e.g. afucosylated) to alter biological activity. Examples: obinutuzumab, mogamulizumab (enhanced ADCC).
amino-acid-substituted	Amino acid substituted	Sequence carries one or more amino acid substitutions relative to a natural or parent protein. Examples: insulin analogs lispro, aspart, glargine.
truncated	Truncated	Sequence is shortened relative to the parent protein.
biotinylated	Biotinylated	Covalently labelled with biotin. Typical for research or diagnostic reagents.
fluorescent-labeled	Fluorescent labelled	Covalently labelled with a fluorescent dye. Typical for imaging or flow-cytometry reagents.