<status value="active"/> <experimental value="true"/> <date value="2026-06-21"/> <publisher value="HL7 (FHIR Project)"/> <contact> <telecom> <system value="url"/> <value value="http://hl7.org/fhir"/> </telecom> <telecom> <system value="email"/> <value value="fhir@lists.hl7.org"/> </telecom> </contact> <description value="The class of oligonucleotide, where relevant (e.g. antisense, siRNA, aptamer)."/> <jurisdiction> <coding> <system value="http://unstats.un.org/unsd/methods/m49/m49.htm"/> <code value="001"/> <display value="World"/> </coding> </jurisdiction> <caseSensitive value="true"/> <valueSet value="http://hl7.org/fhir/ValueSet/oligo-nucleotide-type"/> <content value="complete"/> <concept> <code value="antisense"/> <display value="Antisense oligonucleotide"/> <definition value="An antisense oligonucleotide (ASO) that binds to a complementary mRNA sequence to inhibit gene expression."/> </concept> <concept> <code value="sirna"/> <display value="Small interfering RNA (siRNA)"/> <definition value="A short double-stranded RNA that triggers degradation of a target mRNA through the RNA interference pathway."/> </concept> <concept> <code value="mirna"/> <display value="MicroRNA (miRNA)"/> <definition value="A short non-coding RNA that regulates gene expression by base-pairing with target mRNAs."/> </concept> <concept> <code value="aptamer"/> <display value="Aptamer"/> <definition value="A short single-stranded oligonucleotide that binds a specific target through its three-dimensional structure."/> </concept> <concept> <code value="decoy"/> <display value="Decoy oligonucleotide"/> <definition value="An oligonucleotide that mimics a regulatory binding site to sequester a transcription factor or other binding protein."/> </concept> <concept> <code value="ribozyme"/> <display value="Ribozyme / DNAzyme"/> <definition value="A catalytic oligonucleotide capable of cleaving a target nucleic acid."/> </concept> <concept> <code value="gene-fragment"/> <display value="Gene fragment"/> <definition value="A fragment of a gene such as a promoter, enhancer, coding region or silencer."/> </concept> </CodeSystem>

Generated Narrative: CodeSystem oligo-nucleotide-type

This case-sensitive code system http://hl7.org/fhir/oligo-nucleotide-type defines the following codes:

Code	Display	Definition
antisense	Antisense oligonucleotide	An antisense oligonucleotide (ASO) that binds to a complementary mRNA sequence to inhibit gene expression.
sirna	Small interfering RNA (siRNA)	A short double-stranded RNA that triggers degradation of a target mRNA through the RNA interference pathway.
mirna	MicroRNA (miRNA)	A short non-coding RNA that regulates gene expression by base-pairing with target mRNAs.
aptamer	Aptamer	A short single-stranded oligonucleotide that binds a specific target through its three-dimensional structure.
decoy	Decoy oligonucleotide	An oligonucleotide that mimics a regulatory binding site to sequester a transcription factor or other binding protein.
ribozyme	Ribozyme / DNAzyme	A catalytic oligonucleotide capable of cleaving a target nucleic acid.
gene-fragment	Gene fragment	A fragment of a gene such as a promoter, enhancer, coding region or silencer.