{
  "resourceType" : "CodeSystem",
  "id" : "oligo-nucleotide-type",
  "meta" : {
    "lastUpdated" : "2026-06-23T16:20:19.822+00:00"
  },
  "text" : {
    "status" : "generated",
    "div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p class=\"res-header-id\"><b>Generated Narrative: CodeSystem oligo-nucleotide-type</b></p><a name=\"oligo-nucleotide-type\"> </a><a name=\"hcoligo-nucleotide-type\"> </a><p>This case-sensitive code system <code>http://hl7.org/fhir/oligo-nucleotide-type</code> defines the following codes:</p><table class=\"codes\"><tr><td style=\"white-space:nowrap\"><b>Code</b></td><td><b>Display</b></td><td><b>Definition</b></td></tr><tr><td style=\"white-space:nowrap\">antisense<a name=\"oligo-nucleotide-type-antisense\"> </a></td><td>Antisense oligonucleotide</td><td>An antisense oligonucleotide (ASO) that binds to a complementary mRNA sequence to inhibit gene expression.</td></tr><tr><td style=\"white-space:nowrap\">sirna<a name=\"oligo-nucleotide-type-sirna\"> </a></td><td>Small interfering RNA (siRNA)</td><td>A short double-stranded RNA that triggers degradation of a target mRNA through the RNA interference pathway.</td></tr><tr><td style=\"white-space:nowrap\">mirna<a name=\"oligo-nucleotide-type-mirna\"> </a></td><td>MicroRNA (miRNA)</td><td>A short non-coding RNA that regulates gene expression by base-pairing with target mRNAs.</td></tr><tr><td style=\"white-space:nowrap\">aptamer<a name=\"oligo-nucleotide-type-aptamer\"> </a></td><td>Aptamer</td><td>A short single-stranded oligonucleotide that binds a specific target through its three-dimensional structure.</td></tr><tr><td style=\"white-space:nowrap\">decoy<a name=\"oligo-nucleotide-type-decoy\"> </a></td><td>Decoy oligonucleotide</td><td>An oligonucleotide that mimics a regulatory binding site to sequester a transcription factor or other binding protein.</td></tr><tr><td style=\"white-space:nowrap\">ribozyme<a name=\"oligo-nucleotide-type-ribozyme\"> </a></td><td>Ribozyme / DNAzyme</td><td>A catalytic oligonucleotide capable of cleaving a target nucleic acid.</td></tr><tr><td style=\"white-space:nowrap\">gene-fragment<a name=\"oligo-nucleotide-type-gene-fragment\"> </a></td><td>Gene fragment</td><td>A fragment of a gene such as a promoter, enhancer, coding region or silencer.</td></tr></table></div>"
  },
  "extension" : [{
    "url" : "http://hl7.org/fhir/StructureDefinition/structuredefinition-wg",
    "valueCode" : "brr"
  },
  {
    "url" : "http://hl7.org/fhir/StructureDefinition/structuredefinition-standards-status",
    "valueCode" : "informative"
  },
  {
    "url" : "http://hl7.org/fhir/StructureDefinition/structuredefinition-fmm",
    "valueInteger" : 1
  }],
  "url" : "http://hl7.org/fhir/oligo-nucleotide-type",
  "version" : "6.0.0-ballot4",
  "name" : "OligoNucleotideTypeExample",
  "title" : "Oligonucleotide Type",
  "status" : "active",
  "experimental" : true,
  "date" : "2026-06-21",
  "publisher" : "HL7 (FHIR Project)",
  "contact" : [{
    "telecom" : [{
      "system" : "url",
      "value" : "http://hl7.org/fhir"
    },
    {
      "system" : "email",
      "value" : "fhir@lists.hl7.org"
    }]
  }],
  "description" : "The class of oligonucleotide, where relevant (e.g. antisense, siRNA, aptamer).",
  "jurisdiction" : [{
    "coding" : [{
      "system" : "http://unstats.un.org/unsd/methods/m49/m49.htm",
      "code" : "001",
      "display" : "World"
    }]
  }],
  "caseSensitive" : true,
  "valueSet" : "http://hl7.org/fhir/ValueSet/oligo-nucleotide-type",
  "content" : "complete",
  "concept" : [{
    "code" : "antisense",
    "display" : "Antisense oligonucleotide",
    "definition" : "An antisense oligonucleotide (ASO) that binds to a complementary mRNA sequence to inhibit gene expression."
  },
  {
    "code" : "sirna",
    "display" : "Small interfering RNA (siRNA)",
    "definition" : "A short double-stranded RNA that triggers degradation of a target mRNA through the RNA interference pathway."
  },
  {
    "code" : "mirna",
    "display" : "MicroRNA (miRNA)",
    "definition" : "A short non-coding RNA that regulates gene expression by base-pairing with target mRNAs."
  },
  {
    "code" : "aptamer",
    "display" : "Aptamer",
    "definition" : "A short single-stranded oligonucleotide that binds a specific target through its three-dimensional structure."
  },
  {
    "code" : "decoy",
    "display" : "Decoy oligonucleotide",
    "definition" : "An oligonucleotide that mimics a regulatory binding site to sequester a transcription factor or other binding protein."
  },
  {
    "code" : "ribozyme",
    "display" : "Ribozyme / DNAzyme",
    "definition" : "A catalytic oligonucleotide capable of cleaving a target nucleic acid."
  },
  {
    "code" : "gene-fragment",
    "display" : "Gene fragment",
    "definition" : "A fragment of a gene such as a promoter, enhancer, coding region or silencer."
  }]
}