<status value="active"/><experimental value="true"/><date value="2026-06-21"/><publisher value="HL7 (FHIR Project)"/><contact><telecom><system value="url"/><value value="http://hl7.org/fhir"/></telecom><telecom><system value="email"/><value value="fhir@lists.hl7.org"/></telecom></contact><description value="The class of oligonucleotide, where relevant (e.g. antisense, siRNA, aptamer)."/><jurisdiction><coding><system value="http://unstats.un.org/unsd/methods/m49/m49.htm"/><code value="001"/><display value="World"/></coding></jurisdiction><caseSensitive value="true"/><valueSet value="http://hl7.org/fhir/ValueSet/oligo-nucleotide-type"/><content value="complete"/><concept><code value="antisense"/><display value="Antisense oligonucleotide"/><definition value="An antisense oligonucleotide (ASO) that binds to a complementary mRNA sequence to inhibit gene expression."/></concept><concept><code value="sirna"/><display value="Small interfering RNA (siRNA)"/><definition value="A short double-stranded RNA that triggers degradation of a target mRNA through the RNA interference pathway."/></concept><concept><code value="mirna"/><display value="MicroRNA (miRNA)"/><definition value="A short non-coding RNA that regulates gene expression by base-pairing with target mRNAs."/></concept><concept><code value="aptamer"/><display value="Aptamer"/><definition value="A short single-stranded oligonucleotide that binds a specific target through its three-dimensional structure."/></concept><concept><code value="decoy"/><display value="Decoy oligonucleotide"/><definition value="An oligonucleotide that mimics a regulatory binding site to sequester a transcription factor or other binding protein."/></concept><concept><code value="ribozyme"/><display value="Ribozyme / DNAzyme"/><definition value="A catalytic oligonucleotide capable of cleaving a target nucleic acid."/></concept><concept><code value="gene-fragment"/><display value="Gene fragment"/><definition value="A fragment of a gene such as a promoter, enhancer, coding region or silencer."/></concept></CodeSystem>

Generated Narrative: CodeSystem oligo-nucleotide-type

This case-sensitive code system http://hl7.org/fhir/oligo-nucleotide-type defines the following codes:

Code	Display	Definition
antisense	Antisense oligonucleotide	An antisense oligonucleotide (ASO) that binds to a complementary mRNA sequence to inhibit gene expression.
sirna	Small interfering RNA (siRNA)	A short double-stranded RNA that triggers degradation of a target mRNA through the RNA interference pathway.
mirna	MicroRNA (miRNA)	A short non-coding RNA that regulates gene expression by base-pairing with target mRNAs.
aptamer	Aptamer	A short single-stranded oligonucleotide that binds a specific target through its three-dimensional structure.
decoy	Decoy oligonucleotide	An oligonucleotide that mimics a regulatory binding site to sequester a transcription factor or other binding protein.
ribozyme	Ribozyme / DNAzyme	A catalytic oligonucleotide capable of cleaving a target nucleic acid.
gene-fragment	Gene fragment	A fragment of a gene such as a promoter, enhancer, coding region or silencer.