{"caseSensitive":true,"concept":[{"code":"antisense","definition":"An antisense oligonucleotide (ASO) that binds to a complementary mRNA sequence to inhibit gene expression.","display":"Antisense oligonucleotide"},{"code":"sirna","definition":"A short double-stranded RNA that triggers degradation of a target mRNA through the RNA interference pathway.","display":"Small interfering RNA (siRNA)"},{"code":"mirna","definition":"A short non-coding RNA that regulates gene expression by base-pairing with target mRNAs.","display":"MicroRNA (miRNA)"},{"code":"aptamer","definition":"A short single-stranded oligonucleotide that binds a specific target through its three-dimensional structure.","display":"Aptamer"},{"code":"decoy","definition":"An oligonucleotide that mimics a regulatory binding site to sequester a transcription factor or other binding protein.","display":"Decoy oligonucleotide"},{"code":"ribozyme","definition":"A catalytic oligonucleotide capable of cleaving a target nucleic acid.","display":"Ribozyme / DNAzyme"},{"code":"gene-fragment","definition":"A fragment of a gene such as a promoter, enhancer, coding region or silencer.","display":"Gene fragment"}],"contact":[{"telecom":[{"system":"url","value":"http://hl7.org/fhir"},{"system":"email","value":"fhir@lists.hl7.org"}]}],"content":"complete","date":"2026-06-21","description":"The class of oligonucleotide, where relevant (e.g. antisense, siRNA, aptamer).","experimental":true,"extension":[{"url":"http://hl7.org/fhir/StructureDefinition/structuredefinition-wg","valueCode":"brr"},{"url":"http://hl7.org/fhir/StructureDefinition/structuredefinition-standards-status","valueCode":"informative"},{"url":"http://hl7.org/fhir/StructureDefinition/structuredefinition-fmm","valueInteger":1}],"id":"oligo-nucleotide-type","jurisdiction":[{"coding":[{"code":"001","display":"World","system":"http://unstats.un.org/unsd/methods/m49/m49.htm"}]}],"meta":{"lastUpdated":"2026-06-23T16:20:19.822+00:00"},"name":"OligoNucleotideTypeExample","publisher":"HL7 (FHIR Project)","resourceType":"CodeSystem","status":"active","text":{"div":"<div xmlns=\"http://www.w3.org/1999/xhtml\"><p class=\"res-header-id\"><b>Generated Narrative: CodeSystem oligo-nucleotide-type</b></p><a name=\"oligo-nucleotide-type\"> </a><a name=\"hcoligo-nucleotide-type\"> </a><p>This case-sensitive code system <code>http://hl7.org/fhir/oligo-nucleotide-type</code> defines the following codes:</p><table class=\"codes\"><tr><td style=\"white-space:nowrap\"><b>Code</b></td><td><b>Display</b></td><td><b>Definition</b></td></tr><tr><td style=\"white-space:nowrap\">antisense<a name=\"oligo-nucleotide-type-antisense\"> </a></td><td>Antisense oligonucleotide</td><td>An antisense oligonucleotide (ASO) that binds to a complementary mRNA sequence to inhibit gene expression.</td></tr><tr><td style=\"white-space:nowrap\">sirna<a name=\"oligo-nucleotide-type-sirna\"> </a></td><td>Small interfering RNA (siRNA)</td><td>A short double-stranded RNA that triggers degradation of a target mRNA through the RNA interference pathway.</td></tr><tr><td style=\"white-space:nowrap\">mirna<a name=\"oligo-nucleotide-type-mirna\"> </a></td><td>MicroRNA (miRNA)</td><td>A short non-coding RNA that regulates gene expression by base-pairing with target mRNAs.</td></tr><tr><td style=\"white-space:nowrap\">aptamer<a name=\"oligo-nucleotide-type-aptamer\"> </a></td><td>Aptamer</td><td>A short single-stranded oligonucleotide that binds a specific target through its three-dimensional structure.</td></tr><tr><td style=\"white-space:nowrap\">decoy<a name=\"oligo-nucleotide-type-decoy\"> </a></td><td>Decoy oligonucleotide</td><td>An oligonucleotide that mimics a regulatory binding site to sequester a transcription factor or other binding protein.</td></tr><tr><td style=\"white-space:nowrap\">ribozyme<a name=\"oligo-nucleotide-type-ribozyme\"> </a></td><td>Ribozyme / DNAzyme</td><td>A catalytic oligonucleotide capable of cleaving a target nucleic acid.</td></tr><tr><td style=\"white-space:nowrap\">gene-fragment<a name=\"oligo-nucleotide-type-gene-fragment\"> </a></td><td>Gene fragment</td><td>A fragment of a gene such as a promoter, enhancer, coding region or silencer.</td></tr></table></div>","status":"generated"},"title":"Oligonucleotide Type","url":"http://hl7.org/fhir/oligo-nucleotide-type","valueSet":"http://hl7.org/fhir/ValueSet/oligo-nucleotide-type","version":"6.0.0-ballot4"}