Protein substance: HER2 (ErbB2) — the target protein referenced by Trastuzumab (id = "her2")

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<!--  Example: Human HER2/ErbB2 — the target protein of Trastuzumab.
     This example demonstrates a target substance that can be referenced
     by another SubstanceDefinition's .relationship.substanceDefinition.  --><SubstanceDefinition xmlns="http://hl7.org/fhir">
  <id value="her2"/> 
  <identifier> 
    <system value="https://www.uniprot.org"/> 
    <value value="P04626"/> 
  </identifier> 
  <status> 
    <coding> 
      <system value="http://hl7.org/fhir/publication-status"/> 
      <code value="active"/> 
      <display value="Active"/> 
    </coding> 
  </status> 
  <classification> 
    <coding> 
      <system value="http://example.europa.eu/fhir/SubstanceType"/> 
      <code value="protein"/> 
      <display value="Protein"/> 
    </coding> 
  </classification> 
  <domain> 
    <coding> 
      <system value="http://example.europa.eu/fhir/Domain"/> 
      <code value="human"/> 
      <display value="Human use"/> 
    </coding> 
  </domain> 
  <description value="Human HER2 (ErbB2, receptor tyrosine-protein kinase erbB-2). A transmembrane receptor
   of the EGFR family, frequently overexpressed in breast and gastric cancers. The
   molecular target of trastuzumab and other HER2-directed therapies."/> 
  <code> 
    <code> 
      <coding> 
        <system value="https://www.uniprot.org"/> 
        <code value="P04626"/> 
        <display value="ERBB2_HUMAN"/> 
      </coding> 
    </code> 
  </code> 
  <name> 
    <name value="Receptor tyrosine-protein kinase erbB-2"/> 
    <preferred value="true"/> 
    <language> 
      <coding> 
        <system value="urn:ietf:bcp:47"/> 
        <code value="en"/> 
        <display value="English"/> 
      </coding> 
    </language> 
  </name> 
  <name> 
    <name value="HER2"/> 
    <preferred value="false"/> 
  </name> 
  <name> 
    <name value="ErbB-2"/> 
    <preferred value="false"/> 
  </name> 
  <name> 
    <name value="CD340"/> 
    <preferred value="false"/> 
  </name> 
  <protein> 
    <sequenceType> 
      <coding> 
        <system value="http://hl7.org/fhir/substance-sequence-type"/> 
        <code value="complete"/> 
        <display value="Complete"/> 
      </coding> 
    </sequenceType> 
    <numberOfSubunits value="1"/> 
    <subunit> 
      <subunit value="1"/> 
      <length value="1255"/> 
    </subunit> 
    <gene> 
      <sequenceOrigin> 
        <coding> 
          <system value="http://hl7.org/fhir/gene-sequence-origin"/> 
          <code value="human"/> 
          <display value="Human"/> 
        </coding> 
      </sequenceOrigin> 
      <gene> 
        <concept> 
          <coding> 
            <system value="http://www.genenames.org"/> 
            <code value="ERBB2"/> 
            <display value="Erb-B2 receptor tyrosine kinase 2"/> 
          </coding> 
        </concept> 
      </gene> 
    </gene> 
  </protein> 
</SubstanceDefinition>