<ArtifactAssessment xmlns="http://hl7.org/fhir"><id value="example-certainty-rating"/><identifier><type><text value="FEvIR Object Identifier"/></type><system value="https://fevir.net"/><value value="27756"/><assigner><display value="Computable Publishing LLC"/></assigner></identifier><artifactReference><reference value="Evidence/example-stroke-alteplase-fatalICH"/><type value="Evidence"/><display value="Critically appraised summary of all-cause mortality in meta-analysis of RCTs of heparin for moderately ill patients with COVID-19"/></artifactReference><date value="2021-11-02T14:48:59.890Z"/><copyright value="https://creativecommons.org/licenses/by-nc-sa/4.0/"/><content><summary value="serious concerns with risk of bias, inconsistency, and imprecision"/><type><coding><system value="http://hl7.org/fhir/certainty-type"/><code value="Overall"/><display value="Overall certainty"/></coding></type><classifier><coding><system value="http://terminology.hl7.org/CodeSystem/certainty-rating"/><code value="very-low"/><display value="Very low quality"/></coding></classifier><author><display value="Brian S. Alper"/></author><freeToShare value="true"/><component><summary value="risk of bias in both included trials"/><type><coding><system value="http://terminology.hl7.org/CodeSystem/certainty-type"/><code value="RiskOfBias"/><display value="Risk of bias"/></coding></type><classifier><coding><system value="http://terminology.hl7.org/CodeSystem/certainty-rating"/><code value="serious-concern"/><display value="serious concern"/></coding></classifier><author><display value="Brian S. Alper"/></author></component><component><summary value="high degree of heterogeneity (I-squared 80.7%) with confidence intervals of 2 trial effect estimates barely overlapping"/><type><coding><system value="http://terminology.hl7.org/CodeSystem/certainty-type"/><code value="Inconsistency"/><display value="Inconsistency"/></coding></type><classifier><coding><system value="http://terminology.hl7.org/CodeSystem/certainty-rating"/><code value="serious-concern"/><display value="serious concern"/></coding></classifier><author><display value="Brian S. Alper"/></author></component><component><type><coding><system value="http://terminology.hl7.org/CodeSystem/certainty-type"/><code value="Indirectness"/><display value="Indirectness"/></coding></type><classifier><coding><system value="http://terminology.hl7.org/CodeSystem/certainty-rating"/><code value="no-concern"/><display value="no serious concern"/></coding></classifier><author><display value="Brian S. Alper"/></author></component><component><summary value="95% confidence interval includes both large effects and no effects"/><type><coding><system value="http://terminology.hl7.org/CodeSystem/certainty-type"/><code value="Imprecision"/><display value="Imprecision"/></coding></type><classifier><coding><system value="http://terminology.hl7.org/CodeSystem/certainty-rating"/><code value="serious-concern"/><display value="serious concern"/></coding></classifier><author><display value="Brian S. Alper"/></author></component><component><type><coding><system value="http://terminology.hl7.org/CodeSystem/certainty-type"/><code value="PublicationBias"/><display value="Publication bias"/></coding></type><classifier><coding><system value="http://terminology.hl7.org/CodeSystem/certainty-rating"/><code value="no-concern"/><display value="no serious concern"/></coding></classifier><author><display value="Brian S. Alper"/></author></component></content></ArtifactAssessment>