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    <p class="res-header-id"><b> Generated Narrative: Citation 179559</b> </p> <a name="179559"> </a> <a name="hc179559"> </a> <a name="179559-en-US"> </a> <div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border:
       1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">version: 5; Last updated: 2023-12-02 22:30:09+0000</p> <p style="margin-bottom: 0px">Profile: <a href="StructureDefinition-dataset-citation.html">DatasetCitation</a> </p> </div> <p> <b> url</b> : <a href="Citation-179559.html">Citation DatasetCitation: Extrachromosomal DNA Amplification Contributes to Small
           Cell Lung Cancer Heterogeneity and is Associated with Worse Outcomes</a> </p> <p> <b> identifier</b> : FEvIR Object Identifier/179559</p> <p> <b> version</b> : 1.0.0-ballot2</p> <p> <b> title</b> : DatasetCitation: Extrachromosomal DNA Amplification Contributes to Small Cell
         Lung Cancer Heterogeneity and is Associated with Worse Outcomes</p> <p> <b> status</b> : Active</p> <p> <b> date</b> : 2025-02-24 19:37:10+0000</p> <p> <b> publisher</b> : HL7 International / Clinical Decision Support</p> <p> <b> contact</b> : HL7 International / Clinical Decision Support: <a href="http://www.hl7.org/Special/committees/dss">http://www.hl7.org/Special/committees/dss</a> </p> <p> <b> description</b> : </p> <div> <p> This Citation Resource is referenced in an example for the EBMonFHIR Implementation
           Guide.</p> 
    </div> <p> <b> jurisdiction</b> : <span title="Codes:{http://unstats.un.org/unsd/methods/m49/m49.htm 001}">World</span> </p> <p> <b> copyright</b> : </p> <div> <p> https://creativecommons.org/licenses/by-nc-sa/4.0/</p> 
    </div> <p> <b> author</b> : Brian S. Alper: </p> <h3> Summaries</h3> <table class="grid"><tr> <td style="display: none">-</td> <td> <b> Style</b> </td> <td> <b> Text</b> </td> </tr> <tr> <td style="display: none">*</td> <td> <span title="Codes:{http://hl7.org/fhir/citation-summary-style comppub}">Computable Publishing</span> </td> <td> <div> <p> Extrachromosomal DNA Amplification Contributes to Small Cell Lung Cancer Heterogeneity
                 and is Associated with Worse Outcomes [Dataset]. Contributors:  Anish Thomas, 
                 Lorinc S. Pongor,  Rajesh Kumar,  Parth Desai [Authors]. In: database of Genotypes
                 and Phenotypes, Accession Number phs003190.v1.p1. Published October 16, 2023. Available
                 at: https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs003190.v1.p1.</p> 
    </div> </td> </tr> </table> <blockquote> <p> <b> citedArtifact</b> </p> <p> <b> identifier</b> : dbGaP Study Accession/phs003190.v1.p1</p> <h3> Titles</h3> <table class="grid"><tr> <td style="display: none">-</td> <td> <b> Type</b> </td> <td> <b> Language</b> </td> <td> <b> Text</b> </td> </tr> <tr> <td style="display: none">*</td> <td> <span title="Codes:{http://hl7.org/fhir/title-type primary}">Primary title</span> </td> <td> <span title="Codes:{urn:ietf:bcp:47 en}">English</span> </td> <td> <div> <p> Extrachromosomal DNA Amplification Contributes to Small Cell Lung Cancer Heterogeneity
                   and is Associated with Worse Outcomes</p> 
    </div> </td> </tr> </table> <h3> Abstracts</h3> <table class="grid"><tr> <td style="display: none">-</td> <td> <b> Type</b> </td> <td> <b> Language</b> </td> <td> <b> Text</b> </td> </tr> <tr> <td style="display: none">*</td> <td> <span title="Codes:{https://fevir.net/resources/CodeSystem/179423 description}">Study Description</span> </td> <td> <span title="Codes:{urn:ietf:bcp:47 en}">English</span> </td> <td> <div> <p> Small-cell lung cancer (SCLC) is a very aggressive neuroendocrine lung cancer often
                   associated with oncogenic MYC amplifications, which are known to drive SCLC heterogeneity
                   marked by neuroendocrine (NE) and non-neuroendocrine (non-NE) cell states. The
                   genetic mechanisms of MYC amplification and phenotypic plasticity between cell
                   states is not known. Using data from cell-lines and a few patient-derived samples
                   along with integrated whole-genome sequencing, long-range optical mapping, single-cell
                   DNA sequencing, and fluorescence in situ hybridization, we have attempted to successfully
                   characterize extrachromosomal DNA (ecDNA) as the primary source of MYC amplifications
                   and driver fusions in SCLC.</p> 
    <p> Study Design:
    Cross-Sectional
    Study Type:
    Observational
    Total number of consented subjects: 5</p> 
    </div> </td> </tr> </table> <blockquote> <p> <b> publicationForm</b> </p> <h3> PublishedIns</h3> <table class="grid"><tr> <td style="display: none">-</td> <td> <b> Type</b> </td> <td> <b> Identifier</b> </td> <td> <b> Title</b> </td> <td> <b> Publisher</b> </td> <td> <b> PublisherLocation</b> </td> </tr> <tr> <td style="display: none">*</td> <td> <span title="Codes:{http://hl7.org/fhir/published-in-type D019991}">Database</span> </td> <td> Abbreviation/dbGaP</td> <td> database of Genotypes and Phenotypes</td> <td> NLM</td> <td> Bethesda, MD, USA</td> </tr> </table> <p> <b> citedMedium</b> : <span title="Codes:{http://hl7.org/fhir/cited-medium internet}">Internet</span> </p> <p> <b> articleDate</b> : 2023-10-16</p> <p> <b> accessionNumber</b> : phs003190.v1.p1</p> <p> <b> pageCount</b> : Total number of consented subjects: 5</p> <p> <b> copyright</b> : </p> <div> <p> Data access provided by: dbGaP Authorized Access. For publicly available data (public
               ftp), Connect to the public download site. The site contains release notes and
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Cross-Sectional
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Observational
Total number of consented subjects: 5"/> 
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