<status value="draft"/><publisher value="HL7 International / Clinical Decision Support"/><contact><telecom><system value="url"/><value value="http://www.hl7.org/Special/committees/dss"/></telecom></contact><description value="Alteplase Dosing for Stroke"/><kind value="MedicationRequest"/><code><coding><system value="http://www.nlm.nih.gov/research/umls/rxnorm"/><code value="1155608"/><display value="alteplase injectable product"/></coding></code><intent value="order"/><dosage><text value="give 10% of dose over 1 minute"/><route><coding><system value="http://snomed.info/sct"/><code value="47625008"/><display value="Intravenous use"/></coding></route><doseAndRate><type><coding><system value="http://terminology.hl7.org/CodeSystem/dose-rate-type"/><code value="calculated"/><display value="Calculated"/></coding></type><doseQuantity><value value="0.9"/><system value="http://unitsofmeasure.org"/><code value="mg/kg"/></doseQuantity></doseAndRate><safety><doseLimit><valueQuantity><value value="90"/><system value="http://unitsofmeasure.org"/><code value="mg"/></valueQuantity><scope value="administration"/></doseLimit></safety></dosage><dosage><text value="give remaining 90% of dose over 1 hour"/><route><coding><system value="http://snomed.info/sct"/><code value="47625008"/><display value="Intravenous use"/></coding></route><doseAndRate><type><coding><system value="http://terminology.hl7.org/CodeSystem/dose-rate-type"/><code value="calculated"/><display value="Calculated"/></coding></type><doseQuantity><value value="0.9"/><system value="http://unitsofmeasure.org"/><code value="mg/kg"/></doseQuantity></doseAndRate><safety><doseLimit><valueQuantity><value value="90"/><system value="http://unitsofmeasure.org"/><code value="mg"/></valueQuantity><scope value="administration"/></doseLimit></safety></dosage></ActivityDefinition>

"Alteplase Dosing for Stroke" defines a dosing instruction referenced from an EvidenceVariable resource.