{
  "resourceType": "MedicationRequest",
  "id": "medrx0317",
  "contained": [
    {
      "resourceType": "Medication",
      "id": "med0303",
      "code": {
        "coding": [
          {
            "system": "http://www.nlm.nih.gov/research/umls/rxnorm",
            "code": "1594660",
            "display": "alemtuzumab 10 MG/ML [Lemtrada]"
          }
        ]
      }
    }
  ],
  "identifier": [
    {
      "use": "official",
      "system": "http://www.bmc.nl/portal/prescriptions",
      "value": "12345689"
    }
  ],
  "status": "completed",
  "intent": "order",
  "medication": {
    "reference": {
      "reference": "#med0303"
    }
  },
  "subject": {
    "reference": "Patient/pat1",
    "display": "Donald Duck"
  },
  "authoredOn": "2015-01-15",
  "requester": {
    "reference": "Practitioner/f007",
    "display": "Patrick Pump"
  },
  "reason": [
    {
      "concept": {
        "coding": [
          {
            "system": "http://snomed.info/sct",
            "code": "92814006",
            "display": "Chronic lymphoid leukemia, disease (disorder)"
          }
        ]
      }
    }
  ],
  "dosageInstruction": {
    "renderedInstruction": "Rapid daily-dose escalation, until tolerated, from 3 mg/d, then 10 mg/d, to 30 mg IV over 120 min, 3 times per week on alternate days for up to 12 weeks.",
    "step": [
      {
        "component": [
          {
            "text": "Rapid daily-dose escalation, until tolerated, from 3 mg/d, and then 10 mg/d, to the recommended maintenance dose of 30 mg IV over 120 min, 3 times per wk on alternate days for up to 12 wk",
            "additionalInstruction": [
              {
                "text": "Rapidly increase dose until tolerated"
              },
              {
                "text": "Administer on alternate days"
              }
            ],
            "timing": {
              "repeat": {
                "duration": 12,
                "durationUnit": "wk",
                "frequency": 3,
                "period": 1,
                "periodUnit": "wk"
              }
            },
            "route": {
              "coding": [
                {
                  "system": "http://snomed.info/sct",
                  "code": "47625008",
                  "display": "Intravenous route"
                }
              ]
            },
            "method": {
              "coding": [
                {
                  "system": "http://snomed.info/sct",
                  "code": "422145002",
                  "display": "Inject - dosing instruction imperative (qualifier value)"
                }
              ]
            },
            "doseAndRate": [
              {
                "type": {
                  "coding": [
                    {
                      "system": "http://terminology.hl7.org/CodeSystem/dose-rate-type",
                      "code": "ordered",
                      "display": "Ordered"
                    }
                  ]
                },
                "doseQuantity": {
                  "value": 3,
                  "unit": "mg",
                  "system": "http://unitsofmeasure.org",
                  "code": "mg"
                }
              }
            ]
          }
        ]
      },
      {
        "component": [
          {
            "text": "Rapid daily-dose escalation, until tolerated, from 3 mg/d, and then 10 mg/d, to the recommended maintenance dose of 30 mg IV over 120 min, 3 times per wk on alternate days for up to 12 wk",
            "additionalInstruction": [
              {
                "text": "Rapidly increase dose until tolerated"
              },
              {
                "text": "Administer on alternate days"
              }
            ],
            "timing": {
              "repeat": {
                "duration": 12,
                "durationUnit": "wk",
                "frequency": 3,
                "period": 1,
                "periodUnit": "wk"
              }
            },
            "route": {
              "coding": [
                {
                  "system": "http://snomed.info/sct",
                  "code": "47625008",
                  "display": "Intravenous route"
                }
              ]
            },
            "method": {
              "coding": [
                {
                  "system": "http://snomed.info/sct",
                  "code": "422145002",
                  "display": "Inject - dosing instruction imperative (qualifier value)"
                }
              ]
            },
            "doseAndRate": [
              {
                "type": {
                  "coding": [
                    {
                      "system": "http://terminology.hl7.org/CodeSystem/dose-rate-type",
                      "code": "ordered",
                      "display": "Ordered"
                    }
                  ]
                },
                "doseQuantity": {
                  "value": 10,
                  "unit": "mg",
                  "system": "http://unitsofmeasure.org",
                  "code": "mg"
                }
              }
            ]
          }
        ]
      },
      {
        "component": [
          {
            "text": "Rapid daily-dose escalation, until tolerated, from 3 mg/d, and then 10 mg/d, to the recommended maintenance dose of 30 mg IV over 120 min, 3 times per wk on alternate days for up to 12 wk",
            "additionalInstruction": [
              {
                "text": "Rapidly increase dose until tolerated"
              },
              {
                "text": "Administer on alternate days"
              }
            ],
            "timing": {
              "repeat": {
                "duration": 12,
                "durationUnit": "wk",
                "frequency": 3,
                "period": 1,
                "periodUnit": "wk"
              }
            },
            "route": {
              "coding": [
                {
                  "system": "http://snomed.info/sct",
                  "code": "47625008",
                  "display": "Intravenous route"
                }
              ]
            },
            "method": {
              "coding": [
                {
                  "system": "http://snomed.info/sct",
                  "code": "422145002",
                  "display": "Inject - dosing instruction imperative (qualifier value)"
                }
              ]
            },
            "doseAndRate": [
              {
                "type": {
                  "coding": [
                    {
                      "system": "http://terminology.hl7.org/CodeSystem/dose-rate-type",
                      "code": "ordered",
                      "display": "Ordered"
                    }
                  ]
                },
                "doseQuantity": {
                  "value": 30,
                  "unit": "mg",
                  "system": "http://unitsofmeasure.org",
                  "code": "mg"
                }
              }
            ]
          }
        ]
      }
    ]
  },
  "meta": {
    "tag": [
      {
        "system": "http://terminology.hl7.org/CodeSystem/v3-ActReason",
        "code": "HTEST",
        "display": "test health data"
      }
    ]
  }
}