{
  "resourceType": "ActivityDefinition",
  "id": "example-alteplase-dosing",
  "text": {
    "status": "generated",
    "div": "\u003cdiv xmlns\u003d\"http://www.w3.org/1999/xhtml\"\u003e\n      \n      \u003cp\u003e\n        \u0026quot;Alteplase Dosing for Stroke\u0026quot; defines a dosing instruction referenced from an EvidenceVariable resource.\n      \u003c/p\u003e\n\t\n    \u003c/div\u003e"
  },
  "extension": [
    {
      "url": "http://hl7.org/fhir/StructureDefinition/structuredefinition-wg",
      "valueCode": "cds"
    }
  ],
  "url": "http://example.org/fhir/ActivityDefinition/example-alteplase-dosing",
  "identifier": [
    {
      "system": "urn:ietf:rfc:3986",
      "value": "urn:oid:2.16.840.1.113883.4.642.19.3"
    }
  ],
  "name": "AlteplaseDosingForStroke",
  "title": "Alteplase Dosing for Stroke",
  "status": "draft",
  "publisher": "HL7 International / Clinical Decision Support",
  "contact": [
    {
      "telecom": [
        {
          "system": "url",
          "value": "http://www.hl7.org/Special/committees/dss"
        }
      ]
    }
  ],
  "description": "Alteplase Dosing for Stroke",
  "kind": "MedicationRequest",
  "code": {
    "coding": [
      {
        "system": "http://www.nlm.nih.gov/research/umls/rxnorm",
        "code": "1155608",
        "display": "alteplase injectable product"
      }
    ]
  },
  "intent": "order",
  "dosageInstruction": {
    "renderedInstruction": "give 10% of dose over 1 minute, give remaining 90% of dose over 1 hour",
    "step": [
      {
        "component": [
          {
            "text": "give 10% of dose over 1 minute",
            "route": {
              "coding": [
                {
                  "system": "http://snomed.info/sct",
                  "code": "47625008",
                  "display": "Intravenous use"
                }
              ]
            },
            "doseAndRate": [
              {
                "type": {
                  "coding": [
                    {
                      "system": "http://terminology.hl7.org/CodeSystem/dose-rate-type",
                      "code": "calculated",
                      "display": "Calculated"
                    }
                  ]
                },
                "doseQuantity": {
                  "value": 0.9,
                  "system": "http://unitsofmeasure.org",
                  "code": "mg/kg"
                }
              }
            ],
            "safety": {
              "doseLimit": [
                {
                  "valueQuantity": {
                    "value": 90,
                    "system": "http://unitsofmeasure.org",
                    "code": "mg"
                  },
                  "scope": "administration"
                }
              ]
            }
          }
        ]
      },
      {
        "component": [
          {
            "text": "give remaining 90% of dose over 1 hour",
            "route": {
              "coding": [
                {
                  "system": "http://snomed.info/sct",
                  "code": "47625008",
                  "display": "Intravenous use"
                }
              ]
            },
            "doseAndRate": [
              {
                "type": {
                  "coding": [
                    {
                      "system": "http://terminology.hl7.org/CodeSystem/dose-rate-type",
                      "code": "calculated",
                      "display": "Calculated"
                    }
                  ]
                },
                "doseQuantity": {
                  "value": 0.9,
                  "system": "http://unitsofmeasure.org",
                  "code": "mg/kg"
                }
              }
            ],
            "safety": {
              "doseLimit": [
                {
                  "valueQuantity": {
                    "value": 90,
                    "system": "http://unitsofmeasure.org",
                    "code": "mg"
                  },
                  "scope": "administration"
                }
              ]
            }
          }
        ]
      }
    ]
  }
}