{
  "resourceType": "SubstanceDefinition",
  "id": "trastuzumab",
  "identifier": [
    {
      "system": "http://example.europa.eu/fhir/SMSId",
      "value": "TRAS9123H"
    }
  ],
  "status": {
    "coding": [
      {
        "system": "http://hl7.org/fhir/publication-status",
        "code": "active",
        "display": "Active"
      }
    ]
  },
  "classification": [
    {
      "coding": [
        {
          "system": "http://example.europa.eu/fhir/SubstanceType",
          "code": "protein",
          "display": "Protein"
        }
      ]
    }
  ],
  "domain": {
    "coding": [
      {
        "system": "http://example.europa.eu/fhir/Domain",
        "code": "human",
        "display": "Human use"
      }
    ]
  },
  "description": "Trastuzumab — humanised IgG1 monoclonal antibody targeting the human epidermal growth factor receptor 2 (HER2/ErbB2). Variable regions derived from murine antibody 4D5, grafted onto human IgG1 framework. Produced in Chinese hamster ovary (CHO) cells.",
  "code": [
    {
      "code": {
        "coding": [
          {
            "system": "http://example.europa.eu/fhir/Substance",
            "code": "TRAS9123H"
          }
        ]
      }
    }
  ],
  "name": [
    {
      "name": "Trastuzumab",
      "preferred": true,
      "language": [
        {
          "coding": [
            {
              "system": "urn:ietf:bcp:47",
              "code": "en",
              "display": "English"
            }
          ]
        }
      ],
      "official": [
        {
          "authority": {
            "coding": [
              {
                "system": "http://hl7.org/fhir/substance-name-authority",
                "code": "INN",
                "display": "INN"
              }
            ]
          },
          "status": {
            "coding": [
              {
                "system": "http://hl7.org/fhir/publication-status",
                "code": "active",
                "display": "Active"
              }
            ]
          }
        }
      ]
    },
    {
      "name": "Herceptin",
      "preferred": false
    }
  ],
  "protein": {
    "sequenceType": {
      "coding": [
        {
          "system": "http://hl7.org/fhir/substance-sequence-type",
          "code": "complete",
          "display": "Complete"
        }
      ]
    },
    "numberOfSubunits": 2,
    "disulfideLinkage": [
      "HC22-HC96; HC144-HC200; HC222-LC214; HC228-HC228\u0027; HC231-HC231\u0027; HC265-HC325; HC371-HC429"
    ],
    "subunit": [
      {
        "subunit": 1,
        "sequence": "EVQLVESGGGLVQPGGSLRLSCAASGFNIKDTYIHWVRQAPGKGLEWVARIYPTNGYTRYADSVKGRFTISADTSKNTAYLQMNSLRAEDTAVYYCSRWGGDGFYAMDYWGQGTLVTVSS...",
        "length": 450,
        "nTerminalModification": {
          "concept": {
            "coding": [
              {
                "system": "http://example.europa.eu/fhir/Modification",
                "code": "pyroglutamate",
                "display": "Pyroglutamic acid (pE)"
              }
            ]
          }
        },
        "cTerminalModification": {
          "concept": {
            "coding": [
              {
                "system": "http://example.europa.eu/fhir/Modification",
                "code": "lysine-clipped",
                "display": "C-terminal lysine clipping"
              }
            ]
          }
        }
      },
      {
        "subunit": 2,
        "sequence": "DIQMTQSPSSLSASVGDRVTITCRASQDVNTAVAWYQQKPGKAPKLLIYSASFLYSGVPSRFSGSRSGTDFTLTISSLQPEDFATYYCQQHYTTPPTFGQGTKVEIK...",
        "length": 214
      }
    ],
    "gene": [
      {
        "sequenceOrigin": {
          "coding": [
            {
              "system": "http://hl7.org/fhir/gene-sequence-origin",
              "code": "humanised-mouse",
              "display": "Humanised mouse"
            }
          ]
        },
        "gene": {
          "concept": {
            "coding": [
              {
                "system": "http://www.genenames.org",
                "code": "IGHG1",
                "display": "Immunoglobulin heavy constant gamma 1"
              }
            ]
          }
        }
      }
    ]
  },
  "relationship": [
    {
      "substanceDefinitionReference": {
        "reference": "SubstanceDefinition/her2",
        "display": "Receptor tyrosine-protein kinase erbB-2 (HER2)"
      },
      "type": {
        "coding": [
          {
            "system": "http://hl7.org/fhir/substance-relationship-type",
            "code": "TherapeuticTarget",
            "display": "Therapeutic target"
          }
        ]
      },
      "interaction": {
        "coding": [
          {
            "system": "http://hl7.org/fhir/substance-interaction-type",
            "code": "binding",
            "display": "Binding"
          }
        ]
      },
      "measurementType": {
        "coding": [
          {
            "system": "http://hl7.org/fhir/substance-measurement-type",
            "code": "kd",
            "display": "Kd"
          }
        ]
      },
      "amountQuantity": {
        "value": 0.1,
        "unit": "nM",
        "system": "http://unitsofmeasure.org",
        "code": "nmol/L"
      }
    }
  ],
  "meta": {
    "tag": [
      {
        "system": "http://terminology.hl7.org/CodeSystem/v3-ActReason",
        "code": "HTEST",
        "display": "test health data"
      }
    ]
  }
}