{
  "resourceType": "SubstanceDefinition",
  "id": "mipomersen",
  "identifier": [
    {
      "system": "http://example.europa.eu/fhir/SMSId",
      "value": "MIPO78654S"
    }
  ],
  "status": {
    "coding": [
      {
        "system": "http://hl7.org/fhir/publication-status",
        "code": "active"
      }
    ]
  },
  "classification": [
    {
      "coding": [
        {
          "system": "http://example.europa.eu/fhir/SubstanceType",
          "code": "nucleic-acid",
          "display": "Nucleic Acid"
        }
      ]
    }
  ],
  "domain": {
    "coding": [
      {
        "system": "http://example.europa.eu/fhir/Domain",
        "code": "human",
        "display": "Human use"
      }
    ]
  },
  "description": "Mipomersen sodium — a synthetic second-generation 2\u0027-methoxyethyl antisense oligonucleotide that inhibits the molecular target apolipoprotein B-100 (APOB-100). 20-mer phosphorothioate-linked sequence with 2\u0027-MOE wing chemistry.",
  "code": [
    {
      "code": {
        "coding": [
          {
            "system": "http://example.europa.eu/fhir/Substance",
            "code": "MIPO78654S"
          }
        ]
      }
    }
  ],
  "name": [
    {
      "name": "Mipomersen Sodium",
      "preferred": true,
      "language": [
        {
          "coding": [
            {
              "system": "urn:ietf:bcp:47",
              "code": "en",
              "display": "English"
            }
          ]
        }
      ],
      "official": [
        {
          "authority": {
            "coding": [
              {
                "system": "http://hl7.org/fhir/substance-name-authority",
                "code": "INN",
                "display": "INN"
              }
            ]
          },
          "status": {
            "coding": [
              {
                "system": "http://hl7.org/fhir/publication-status",
                "code": "active",
                "display": "Active"
              }
            ]
          }
        }
      ]
    }
  ],
  "nucleicAcid": {
    "sequenceType": {
      "coding": [
        {
          "system": "http://hl7.org/fhir/substance-sequence-type",
          "code": "complete",
          "display": "Complete"
        }
      ]
    },
    "numberOfSubunits": 1,
    "oligoNucleotideType": {
      "coding": [
        {
          "system": "http://hl7.org/fhir/oligo-nucleotide-type",
          "code": "antisense",
          "display": "Antisense oligonucleotide"
        }
      ]
    },
    "subunit": [
      {
        "subunit": 1,
        "sequence": "GCCUCAGTCTGCTTCGCACC",
        "length": 20,
        "fivePrime": {
          "coding": [
            {
              "system": "http://hl7.org/fhir/nucleotide-terminus",
              "code": "G",
              "display": "Guanosine"
            }
          ]
        },
        "threePrime": {
          "coding": [
            {
              "system": "http://hl7.org/fhir/nucleotide-terminus",
              "code": "C",
              "display": "Cytidine"
            }
          ]
        },
        "linkage": [
          {
            "substance": {
              "concept": {
                "coding": [
                  {
                    "system": "http://example.europa.eu/fhir/LinkageSubstance",
                    "code": "phosphorothioate",
                    "display": "Phosphorothioate linkage"
                  }
                ]
              }
            },
            "residueSite": "1-19"
          }
        ],
        "sugar": [
          {
            "substance": {
              "concept": {
                "coding": [
                  {
                    "system": "http://example.europa.eu/fhir/SugarSubstance",
                    "code": "2-MOE",
                    "display": "2\u0027-O-(2-methoxyethyl) ribose"
                  }
                ]
              }
            },
            "residueSite": "1-5,16-20"
          },
          {
            "substance": {
              "concept": {
                "coding": [
                  {
                    "system": "http://example.europa.eu/fhir/SugarSubstance",
                    "code": "deoxyribose",
                    "display": "2\u0027-deoxyribose"
                  }
                ]
              }
            },
            "residueSite": "6-15"
          }
        ]
      }
    ],
    "gene": [
      {
        "sequenceOrigin": {
          "coding": [
            {
              "system": "http://hl7.org/fhir/gene-sequence-origin",
              "code": "human",
              "display": "Human"
            }
          ]
        },
        "gene": {
          "concept": {
            "coding": [
              {
                "system": "http://www.genenames.org",
                "code": "APOB",
                "display": "apolipoprotein B"
              }
            ]
          }
        }
      }
    ]
  },
  "relationship": [
    {
      "substanceDefinitionCodeableConcept": {
        "coding": [
          {
            "system": "https://www.uniprot.org",
            "code": "P04114",
            "display": "apolipoprotein B-100"
          }
        ]
      },
      "type": {
        "coding": [
          {
            "system": "http://hl7.org/fhir/substance-relationship-type",
            "code": "TherapeuticTarget",
            "display": "Therapeutic target"
          }
        ]
      },
      "interaction": {
        "coding": [
          {
            "system": "http://hl7.org/fhir/substance-interaction-type",
            "code": "inhibition",
            "display": "Inhibition"
          }
        ]
      }
    }
  ],
  "meta": {
    "tag": [
      {
        "system": "http://terminology.hl7.org/CodeSystem/v3-ActReason",
        "code": "HTEST",
        "display": "test health data"
      }
    ]
  }
}