{
  "resourceType": "CodeSystem",
  "id": "oligo-nucleotide-type",
  "meta": {
    "lastUpdated": "2026-07-03T14:29:03.795+00:00"
  },
  "text": {
    "status": "generated",
    "div": "\u003cdiv xmlns\u003d\"http://www.w3.org/1999/xhtml\"\u003e\u003cp class\u003d\"res-header-id\"\u003e\u003cb\u003eGenerated Narrative: CodeSystem oligo-nucleotide-type\u003c/b\u003e\u003c/p\u003e\u003ca name\u003d\"oligo-nucleotide-type\"\u003e \u003c/a\u003e\u003ca name\u003d\"hcoligo-nucleotide-type\"\u003e \u003c/a\u003e\u003cp\u003eThis case-sensitive code system \u003ccode\u003ehttp://hl7.org/fhir/oligo-nucleotide-type\u003c/code\u003e defines the following codes:\u003c/p\u003e\u003ctable class\u003d\"codes\"\u003e\u003ctr\u003e\u003ctd style\u003d\"white-space:nowrap\"\u003e\u003cb\u003eCode\u003c/b\u003e\u003c/td\u003e\u003ctd\u003e\u003cb\u003eDisplay\u003c/b\u003e\u003c/td\u003e\u003ctd\u003e\u003cb\u003eDefinition\u003c/b\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd style\u003d\"white-space:nowrap\"\u003eantisense\u003ca name\u003d\"oligo-nucleotide-type-antisense\"\u003e \u003c/a\u003e\u003c/td\u003e\u003ctd\u003eAntisense oligonucleotide\u003c/td\u003e\u003ctd\u003eAn antisense oligonucleotide (ASO) that binds to a complementary mRNA sequence to inhibit gene expression.\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd style\u003d\"white-space:nowrap\"\u003esirna\u003ca name\u003d\"oligo-nucleotide-type-sirna\"\u003e \u003c/a\u003e\u003c/td\u003e\u003ctd\u003eSmall interfering RNA (siRNA)\u003c/td\u003e\u003ctd\u003eA short double-stranded RNA that triggers degradation of a target mRNA through the RNA interference pathway.\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd style\u003d\"white-space:nowrap\"\u003emirna\u003ca name\u003d\"oligo-nucleotide-type-mirna\"\u003e \u003c/a\u003e\u003c/td\u003e\u003ctd\u003eMicroRNA (miRNA)\u003c/td\u003e\u003ctd\u003eA short non-coding RNA that regulates gene expression by base-pairing with target mRNAs.\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd style\u003d\"white-space:nowrap\"\u003eaptamer\u003ca name\u003d\"oligo-nucleotide-type-aptamer\"\u003e \u003c/a\u003e\u003c/td\u003e\u003ctd\u003eAptamer\u003c/td\u003e\u003ctd\u003eA short single-stranded oligonucleotide that binds a specific target through its three-dimensional structure.\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd style\u003d\"white-space:nowrap\"\u003edecoy\u003ca name\u003d\"oligo-nucleotide-type-decoy\"\u003e \u003c/a\u003e\u003c/td\u003e\u003ctd\u003eDecoy oligonucleotide\u003c/td\u003e\u003ctd\u003eAn oligonucleotide that mimics a regulatory binding site to sequester a transcription factor or other binding protein.\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd style\u003d\"white-space:nowrap\"\u003eribozyme\u003ca name\u003d\"oligo-nucleotide-type-ribozyme\"\u003e \u003c/a\u003e\u003c/td\u003e\u003ctd\u003eRibozyme / DNAzyme\u003c/td\u003e\u003ctd\u003eA catalytic oligonucleotide capable of cleaving a target nucleic acid.\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd style\u003d\"white-space:nowrap\"\u003egene-fragment\u003ca name\u003d\"oligo-nucleotide-type-gene-fragment\"\u003e \u003c/a\u003e\u003c/td\u003e\u003ctd\u003eGene fragment\u003c/td\u003e\u003ctd\u003eA fragment of a gene such as a promoter, enhancer, coding region or silencer.\u003c/td\u003e\u003c/tr\u003e\u003c/table\u003e\u003c/div\u003e"
  },
  "extension": [
    {
      "url": "http://hl7.org/fhir/StructureDefinition/structuredefinition-wg",
      "valueCode": "brr"
    },
    {
      "url": "http://hl7.org/fhir/StructureDefinition/structuredefinition-standards-status",
      "valueCode": "informative"
    },
    {
      "url": "http://hl7.org/fhir/StructureDefinition/structuredefinition-fmm",
      "valueInteger": 1
    }
  ],
  "url": "http://hl7.org/fhir/oligo-nucleotide-type",
  "version": "6.0.0-ballot4",
  "name": "OligoNucleotideTypeExample",
  "title": "Oligonucleotide Type",
  "status": "active",
  "experimental": true,
  "date": "2026-06-21",
  "publisher": "HL7 (FHIR Project)",
  "contact": [
    {
      "telecom": [
        {
          "system": "url",
          "value": "http://hl7.org/fhir"
        },
        {
          "system": "email",
          "value": "fhir@lists.hl7.org"
        }
      ]
    }
  ],
  "description": "The class of oligonucleotide, where relevant (e.g. antisense, siRNA, aptamer).",
  "jurisdiction": [
    {
      "coding": [
        {
          "system": "http://unstats.un.org/unsd/methods/m49/m49.htm",
          "code": "001",
          "display": "World"
        }
      ]
    }
  ],
  "caseSensitive": true,
  "valueSet": "http://hl7.org/fhir/ValueSet/oligo-nucleotide-type",
  "content": "complete",
  "concept": [
    {
      "code": "antisense",
      "display": "Antisense oligonucleotide",
      "definition": "An antisense oligonucleotide (ASO) that binds to a complementary mRNA sequence to inhibit gene expression."
    },
    {
      "code": "sirna",
      "display": "Small interfering RNA (siRNA)",
      "definition": "A short double-stranded RNA that triggers degradation of a target mRNA through the RNA interference pathway."
    },
    {
      "code": "mirna",
      "display": "MicroRNA (miRNA)",
      "definition": "A short non-coding RNA that regulates gene expression by base-pairing with target mRNAs."
    },
    {
      "code": "aptamer",
      "display": "Aptamer",
      "definition": "A short single-stranded oligonucleotide that binds a specific target through its three-dimensional structure."
    },
    {
      "code": "decoy",
      "display": "Decoy oligonucleotide",
      "definition": "An oligonucleotide that mimics a regulatory binding site to sequester a transcription factor or other binding protein."
    },
    {
      "code": "ribozyme",
      "display": "Ribozyme / DNAzyme",
      "definition": "A catalytic oligonucleotide capable of cleaving a target nucleic acid."
    },
    {
      "code": "gene-fragment",
      "display": "Gene fragment",
      "definition": "A fragment of a gene such as a promoter, enhancer, coding region or silencer."
    }
  ]
}