{
  "resourceType": "SubstanceDefinition",
  "id": "ponatinib-hcl",
  "identifier": [
    {
      "system": "http://example.europa.eu/fhir/SMSId",
      "value": "PONA4321C"
    }
  ],
  "status": {
    "coding": [
      {
        "system": "http://hl7.org/fhir/publication-status",
        "code": "active",
        "display": "Active"
      }
    ]
  },
  "classification": [
    {
      "coding": [
        {
          "system": "http://example.europa.eu/fhir/SubstanceType",
          "code": "chemical",
          "display": "Chemical"
        }
      ]
    }
  ],
  "domain": {
    "coding": [
      {
        "system": "http://example.europa.eu/fhir/Domain",
        "code": "human",
        "display": "Human use"
      }
    ]
  },
  "description": "Ponatinib hydrochloride — a small-molecule tyrosine kinase inhibitor (TKI) used in the treatment of chronic myeloid leukemia (CML) and Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL). Hydrochloride salt of ponatinib.",
  "code": [
    {
      "code": {
        "coding": [
          {
            "system": "http://example.europa.eu/fhir/Substance",
            "code": "PONA4321C"
          }
        ]
      }
    }
  ],
  "name": [
    {
      "name": "Ponatinib Hydrochloride",
      "preferred": true,
      "language": [
        {
          "coding": [
            {
              "system": "urn:ietf:bcp:47",
              "code": "en",
              "display": "English"
            }
          ]
        }
      ],
      "official": [
        {
          "authority": {
            "coding": [
              {
                "system": "http://hl7.org/fhir/substance-name-authority",
                "code": "USAN",
                "display": "USAN"
              }
            ]
          },
          "status": {
            "coding": [
              {
                "system": "http://hl7.org/fhir/publication-status",
                "code": "active",
                "display": "Active"
              }
            ]
          }
        }
      ]
    }
  ],
  "molecularWeight": [
    {
      "type": {
        "coding": [
          {
            "system": "http://example.europa.eu/fhir/WeightType",
            "code": "exact",
            "display": "Exact"
          }
        ]
      },
      "amount": {
        "value": 569.04,
        "unit": "g/mol",
        "system": "http://unitsofmeasure.org",
        "code": "g/mol"
      }
    }
  ],
  "moiety": [
    {
      "role": {
        "coding": [
          {
            "system": "http://example.europa.eu/fhir/MoietyRole",
            "code": "active-moiety",
            "display": "Active moiety"
          }
        ]
      },
      "name": "Ponatinib",
      "molecularFormula": "C29H27F3N6O"
    },
    {
      "role": {
        "coding": [
          {
            "system": "http://example.europa.eu/fhir/MoietyRole",
            "code": "counter-ion",
            "display": "Counter-ion (salt)"
          }
        ]
      },
      "name": "Hydrochloride",
      "molecularFormula": "HCl"
    }
  ],
  "relationship": [
    {
      "substanceDefinitionCodeableConcept": {
        "coding": [
          {
            "system": "https://www.uniprot.org",
            "code": "A9UF07",
            "display": "BCR-ABL1 fusion kinase"
          }
        ]
      },
      "type": {
        "coding": [
          {
            "system": "http://hl7.org/fhir/substance-relationship-type",
            "code": "TherapeuticTarget",
            "display": "Therapeutic target"
          }
        ]
      },
      "interaction": {
        "coding": [
          {
            "system": "http://hl7.org/fhir/substance-interaction-type",
            "code": "inhibition",
            "display": "Inhibition"
          }
        ]
      },
      "measurementType": {
        "coding": [
          {
            "system": "http://hl7.org/fhir/substance-measurement-type",
            "code": "ic50",
            "display": "IC50"
          }
        ]
      },
      "amountQuantity": {
        "value": 0.37,
        "unit": "nM",
        "system": "http://unitsofmeasure.org",
        "code": "nmol/L"
      }
    }
  ],
  "meta": {
    "tag": [
      {
        "system": "http://terminology.hl7.org/CodeSystem/v3-ActReason",
        "code": "HTEST",
        "display": "test health data"
      }
    ]
  }
}