{
  "resourceType": "SubstanceDefinition",
  "id": "her2",
  "identifier": [
    {
      "system": "https://www.uniprot.org",
      "value": "P04626"
    }
  ],
  "status": {
    "coding": [
      {
        "system": "http://hl7.org/fhir/publication-status",
        "code": "active",
        "display": "Active"
      }
    ]
  },
  "classification": [
    {
      "coding": [
        {
          "system": "http://example.europa.eu/fhir/SubstanceType",
          "code": "protein",
          "display": "Protein"
        }
      ]
    }
  ],
  "domain": {
    "coding": [
      {
        "system": "http://example.europa.eu/fhir/Domain",
        "code": "human",
        "display": "Human use"
      }
    ]
  },
  "description": "Human HER2 (ErbB2, receptor tyrosine-protein kinase erbB-2). A transmembrane receptor of the EGFR family, frequently overexpressed in breast and gastric cancers. The molecular target of trastuzumab and other HER2-directed therapies.",
  "code": [
    {
      "code": {
        "coding": [
          {
            "system": "https://www.uniprot.org",
            "code": "P04626",
            "display": "ERBB2_HUMAN"
          }
        ]
      }
    }
  ],
  "name": [
    {
      "name": "Receptor tyrosine-protein kinase erbB-2",
      "preferred": true,
      "language": [
        {
          "coding": [
            {
              "system": "urn:ietf:bcp:47",
              "code": "en",
              "display": "English"
            }
          ]
        }
      ]
    },
    {
      "name": "HER2",
      "preferred": false
    },
    {
      "name": "ErbB-2",
      "preferred": false
    },
    {
      "name": "CD340",
      "preferred": false
    }
  ],
  "protein": {
    "sequenceType": {
      "coding": [
        {
          "system": "http://hl7.org/fhir/substance-sequence-type",
          "code": "complete",
          "display": "Complete"
        }
      ]
    },
    "numberOfSubunits": 1,
    "subunit": [
      {
        "subunit": 1,
        "length": 1255
      }
    ],
    "gene": [
      {
        "sequenceOrigin": {
          "coding": [
            {
              "system": "http://hl7.org/fhir/gene-sequence-origin",
              "code": "human",
              "display": "Human"
            }
          ]
        },
        "gene": {
          "concept": {
            "coding": [
              {
                "system": "http://www.genenames.org",
                "code": "ERBB2",
                "display": "Erb-B2 receptor tyrosine kinase 2"
              }
            ]
          }
        }
      }
    ]
  },
  "meta": {
    "tag": [
      {
        "system": "http://terminology.hl7.org/CodeSystem/v3-ActReason",
        "code": "HTEST",
        "display": "test health data"
      }
    ]
  }
}