Alteplase Dosing for Stroke to be used by an EvidenceVariable resource (id = "example-alteplase-dosing")

<?xml version="1.0" encoding="UTF-8"?>

<ActivityDefinition xmlns="http://hl7.org/fhir">
  <id value="example-alteplase-dosing"/> 
  <text> 
    <status value="generated"/> <div xmlns="http://www.w3.org/1999/xhtml">
      
      <p> 
        &quot;Alteplase Dosing for Stroke&quot; defines a dosing instruction referenced
         from an EvidenceVariable resource.
      </p> 
  
    </div> 
  </text> 
  <extension url="http://hl7.org/fhir/StructureDefinition/structuredefinition-wg">
    <valueCode value="cds"/> 
  </extension> 
  <url value="http://example.org/fhir/ActivityDefinition/example-alteplase-dosing"/> 
  <identifier> 
    <system value="urn:ietf:rfc:3986"/> 
    <value value="urn:oid:2.16.840.1.113883.4.642.19.3"/> 
  </identifier> 
  <name value="AlteplaseDosingForStroke"/> 
  <title value="Alteplase Dosing for Stroke"/> 
  <status value="draft"/> 
  <publisher value="HL7 International / Clinical Decision Support"/> 
  <contact> 
    <telecom> 
      <system value="url"/> 
      <value value="http://www.hl7.org/Special/committees/dss"/> 
    </telecom> 
  </contact> 
  <description value="Alteplase Dosing for Stroke"/> 
  <kind value="MedicationRequest"/> 
  <code> 
    <coding> 
      <system value="http://www.nlm.nih.gov/research/umls/rxnorm"/> 
      <code value="1155608"/> 
      <display value="alteplase injectable product"/> 
    </coding> 
  </code> 
  <intent value="order"/> 
  <dosageInstruction> 
    <renderedInstruction value="give 10% of dose over 1 minute, give remaining 90% of dose over 1 hour"/> 
    <step> 
      <component> 
        <text value="give 10% of dose over 1 minute"/> 
        <route> 
          <coding> 
            <system value="http://snomed.info/sct"/> 
            <code value="47625008"/> 
            <display value="Intravenous use"/> 
          </coding> 
        </route> 
        <doseAndRate> 
          <type> 
            <coding> 
              <system value="http://terminology.hl7.org/CodeSystem/dose-rate-type"/> 
              <code value="calculated"/> 
              <display value="Calculated"/> 
            </coding> 
          </type> 
          <doseQuantity> 
            <value value="0.9"/> 
            <system value="http://unitsofmeasure.org"/> 
            <code value="mg/kg"/> 
          </doseQuantity> 
        </doseAndRate> 
        <safety> 
          <doseLimit> 
            <valueQuantity> 
              <value value="90"/> 
              <system value="http://unitsofmeasure.org"/> 
              <code value="mg"/> 
            </valueQuantity> 
            <scope value="administration"/> 
          </doseLimit> 
        </safety> 
      </component> 
    </step> 
    <step> 
      <component> 
        <text value="give remaining 90% of dose over 1 hour"/> 
        <route> 
          <coding> 
            <system value="http://snomed.info/sct"/> 
            <code value="47625008"/> 
            <display value="Intravenous use"/> 
          </coding> 
        </route> 
        <doseAndRate> 
          <type> 
            <coding> 
              <system value="http://terminology.hl7.org/CodeSystem/dose-rate-type"/> 
              <code value="calculated"/> 
              <display value="Calculated"/> 
            </coding> 
          </type> 
          <doseQuantity> 
            <value value="0.9"/> 
            <system value="http://unitsofmeasure.org"/> 
            <code value="mg/kg"/> 
          </doseQuantity> 
        </doseAndRate> 
        <safety> 
          <doseLimit> 
            <valueQuantity> 
              <value value="90"/> 
              <system value="http://unitsofmeasure.org"/> 
              <code value="mg"/> 
            </valueQuantity> 
            <scope value="administration"/> 
          </doseLimit> 
        </safety> 
      </component> 
    </step> 
  </dosageInstruction> 
</ActivityDefinition>