{"resourceType":"EvidenceVariable","id":"example-outcome-death-or-major-injury","extension":[{"url":"http://hl7.org/fhir/StructureDefinition/structuredefinition-wg","valueCode":"cds"}],"url":"http://hl7.org/fhir/EvidenceVariable/example-outcome-death-or-major-injury","identifier":[{"type":{"text":"FEvIR Object Identifier"},"system":"urn:ietf:rfc:3986","value":"https://fevir.net/FOI/297743","assigner":{"display":"Computable Publishing LLC"}}],"title":"Outcome: Death or Major Traumatic Injury on Impact","shortTitle":"Death or Major Traumatic Injury on Impact","citeAs":"Outcome: Death or Major Traumatic Injury on Impact [Database Entry: FHIR EvidenceVariable Resource]. Contributors: Joanne Dehnbostel [Authors/Creators]. In: Fast Evidence Interoperability Resources (FEvIR) Platform, FOI 297743. Revised 2025-02-15. Available at: https://fevir.net/resources/EvidenceVariable/297743. Computable resource at: https://fevir.net/resources/EvidenceVariable/297743#json.","status":"active","author":[{"name":"Joanne Dehnbostel"}],"publisher":"HL7 International / Clinical Decision Support","contact":[{"telecom":[{"system":"url","value":"http://www.hl7.org/Special/committees/dss"}]}],"description":"Example of VariableDefinition for EBMonFHIR IG","useContext":[{"code":{"system":"https://fevir.net/resources/CodeSystem/179423","code":"evidence-communication","display":"Evidence Communication"},"valueCodeableConcept":{"coding":[{"system":"https://fevir.net/resources/CodeSystem/179423","code":"VariableDefinition","display":"VariableDefinition"}]}}],"copyright":"https://creativecommons.org/licenses/by-nc-sa/4.0/","actual":true,"definition":{"concept":{"coding":[{"system":"http://snomed.info/sct","code":"417746004","display":"Traumatic injury"}],"text":"Death or Major Traumatic Injury"}},"definitionModifier":[{"code":{"coding":[{"system":"http://snomed.info/ct","code":"246112005","display":"Severity"}]},"valueCodeableConcept":{"coding":[{"system":"http://snomed.info/sct","code":"371924009","display":"Moderate to severe"}],"text":"Major or Fatal (in the context of severity of traumatic injury)"}}],"timing":{"contextCode":{"text":"impact"},"offsetDuration":{"value":0},"text":"on impact"}}
{"resourceType":"EvidenceVariable","id":"example-dead-or-dependent-90day","text":{"status":"generated","div":"\u003cdiv xmlns\u003d\"http://www.w3.org/1999/xhtml\"\u003e\n      \n      \u003cp\u003e\n        \u0026quot;Dead or functionally dependent at 90 days\u0026quot; is an outcome used in expressing what an Evidence is about.\n      \u003c/p\u003e\n\t\n    \u003c/div\u003e"},"contained":[{"resourceType":"Group","id":"Definition-Group","title":"VariableDefinition: Alive and not functionally dependent at 90 days","type":"person","membership":"definitional","combinationMethod":"any-of","characteristic":[{"code":{"coding":[{"system":"http://snomed.info/sct","code":"260905004","display":"Condition"}]},"valueCodeableConcept":{"coding":[{"system":"http://snomed.info/sct","code":"419099009","display":"Dead (finding)"}]},"exclude":false,"description":"dead at 90 days","timing":[{"contextCode":{"coding":[{"system":"http://hl7.org/fhir/evidence-variable-event","code":"study-start","display":"Study Start"}]},"offsetDuration":{"value":90,"unit":"days","system":"http://unitsofmeasure.org","code":"d"}}]},{"code":{"coding":[{"system":"http://snomed.info/sct","code":"260905004","display":"Condition"}]},"valueCodeableConcept":{"coding":[{"system":"http://snomed.info/sct","code":"718705001","display":"Functionally dependent (finding)"}]},"exclude":false,"description":"functionally dependent at 90 days","timing":[{"contextCode":{"coding":[{"system":"http://hl7.org/fhir/evidence-variable-event","code":"study-start","display":"Study Start"}]},"offsetDuration":{"value":90,"unit":"days","system":"http://unitsofmeasure.org","code":"d"}}]}]}],"extension":[{"url":"http://hl7.org/fhir/StructureDefinition/structuredefinition-wg","valueCode":"cds"}],"name":"DeadOrFunctionallyDependentAt90Days","title":"Dead or functionally dependent at 90 days","status":"draft","publisher":"HL7 International / Clinical Decision Support","contact":[{"telecom":[{"system":"url","value":"http://www.hl7.org/Special/committees/dss"}]}],"description":"Dead or functionally dependent at 90 days","actual":false,"definition":{"reference":{"reference":"#Definition-Group"}}}
{"resourceType":"EvidenceVariable","id":"example-mRS0-2-at-90days","text":{"status":"generated","div":"\u003cdiv xmlns\u003d\"http://www.w3.org/1999/xhtml\"\u003e\n      \n      \u003cp\u003e\n        \u0026quot;mRS 0-2 at 90 days\u0026quot; is an outcome, defined by a CQL expression, used in expressing what an Evidence is about.\n      \u003c/p\u003e\n\t\n    \u003c/div\u003e"},"contained":[{"resourceType":"Group","id":"Definition-Group","title":"VariableDefinition: mRS 0-2 at 90 days","type":"person","membership":"definitional","characteristic":[{"code":{"coding":[{"system":"http://snomed.info/sct","code":"260905004","display":"Condition"}]},"valueExpression":{"description":"mRS 0-2","language":"text/cql-expression","expression":"[\"Observation\": code in \"75859-9|LOINC\"] mRS where mRS.value between 0 and 2"},"exclude":false,"description":"mRS 0-2 at 90 days","timing":[{"contextCode":{"coding":[{"system":"http://hl7.org/fhir/evidence-variable-event","code":"study-start","display":"Study Start"}]},"offsetDuration":{"value":90,"unit":"days","system":"http://unitsofmeasure.org","code":"d"}}]}]}],"extension":[{"url":"http://hl7.org/fhir/StructureDefinition/structuredefinition-wg","valueCode":"cds"}],"name":"ModifiedRankinScaleScore02At90DaysAfterTreatment","title":"Modified Rankin Scale score 0-2 at 90 days after treatment","status":"draft","publisher":"HL7 International / Clinical Decision Support","contact":[{"telecom":[{"system":"url","value":"http://www.hl7.org/Special/committees/dss"}]}],"description":"Modified Rankin Scale score 0-2 at 90 days after treatment","actual":true,"definition":{"reference":{"reference":"#Definition-Group"}}}
{"resourceType":"EvidenceVariable","id":"example-group-assignment","meta":{"versionId":"1","lastUpdated":"2024-12-17T19:40:19.291Z","profile":["http://hl7.org/fhir/uv/ebm/StructureDefinition/group-assignment"]},"extension":[{"url":"http://hl7.org/fhir/StructureDefinition/structuredefinition-wg","valueCode":"cds"}],"url":"http://hl7.org/fhir/EvidenceVariable/example-group-assignment","identifier":[{"type":{"text":"FEvIR Object Identifier"},"system":"urn:ietf:rfc:3986","value":"https://fevir.net/FOI/297490","assigner":{"display":"Computable Publishing LLC"}}],"title":"GroupAssignment: Jumping from aircraft with parachute vs. Jumping from aircraft with empty backpack","status":"active","author":[{"name":"Joanne Dehnbostel"}],"publisher":"HL7 International / Clinical Decision Support","contact":[{"telecom":[{"system":"url","value":"http://www.hl7.org/Special/committees/dss"}]}],"description":"This EvidenceVariable Resource (GroupAssignment Profile) describes a 2-group study (so handling\u003d\u0027dichotomous\u0027) and lists the 2 study arms in category.name elements. Because the definition of this EvidenceVariable Resource is fully expressed in the handling and category elements, the defintion.concept element uses a CodeableConcept for \u0027Defined in handling and category elements\u0027.","useContext":[{"code":{"system":"https://fevir.net/resources/CodeSystem/179423","code":"evidence-communication","display":"Evidence Communication"},"valueCodeableConcept":{"coding":[{"system":"https://fevir.net/resources/CodeSystem/179423","code":"GroupAssignment","display":"GroupAssignment"}]}}],"copyright":"https://creativecommons.org/licenses/by-nc-sa/4.0/","definition":{"concept":{"coding":[{"system":"https://fevir.net/resources/CodeSystem/179423","code":"defined-in-handling-and-category","display":"Defined in handling and category elements"}]}},"category":[{"name":"Jumping from aircraft with parachute","valueReference":{"reference":"Group/297486","type":"Group","display":"Jumping from aircraft with parachute"}},{"name":"Jumping from aircraft with empty backpack","valueReference":{"reference":"Group/297488","type":"Group","display":"Jumping from aircraft with empty backpack"}}]}
{"resourceType":"EvidenceVariable","id":"example-participant-flow","meta":{"versionId":"3","lastUpdated":"2025-03-10T13:18:16.608Z","profile":["http://hl7.org/fhir/uv/ebm/StructureDefinition/participant-flow-evidence-variable"]},"extension":[{"url":"http://hl7.org/fhir/StructureDefinition/structuredefinition-wg","valueCode":"cds"}],"url":"http://hl7.org/fhir/EvidenceVariable/example-participant-flow","identifier":[{"type":{"text":"FEvIR Object Identifier"},"system":"urn:ietf:rfc:3986","value":"https://fevir.net/FOI/346779","assigner":{"display":"Computable Publishing LLC"}}],"title":"PARACHUTE Trial Participants that declined randomization - Example EvidenceVariable","citeAs":"PARACHUTE Trial Participants that declined randomization - Example EvidenceVariable [Database Entry: FHIR EvidenceVariable Resource]. Contributors: Brian S. Alper, MD, MSPH [Authors/Creators]. In: Fast Evidence Interoperability Resources (FEvIR) Platform, FOI 346779. Revised 2025-03-10. Available at: https://fevir.net/resources/EvidenceVariable/346779. Computable resource at: https://fevir.net/resources/EvidenceVariable/346779#json.","status":"active","author":[{"name":"Brian S. Alper, MD, MSPH"}],"publisher":"HL7 International / Clinical Decision Support","contact":[{"telecom":[{"system":"url","value":"http://www.hl7.org/Special/committees/dss"}]}],"description":"Example variable definition for the ParticipantFlowEvidenceVariable Profile from the EBMonFHIR IG","useContext":[{"code":{"system":"https://fevir.net/resources/CodeSystem/179423","code":"evidence-communication","display":"Evidence Communication"},"valueCodeableConcept":{"coding":[{"system":"https://fevir.net/resources/CodeSystem/179423","code":"ParticipantFlowEvidenceVariable","display":"ParticipantFlowEvidenceVariable"}]}}],"copyright":"https://creativecommons.org/licenses/by-nc-sa/4.0/","actual":true,"definition":{"concept":{"text":"PARACHUTE Trial Participants that declined randomization"}}}
{"resourceType":"EvidenceVariable","id":"example-no-alteplase","text":{"status":"generated","div":"\u003cdiv xmlns\u003d\"http://www.w3.org/1999/xhtml\"\u003e\n      \n      \u003cp\u003e\n        \u0026quot;No alteplase\u0026quot; is an intended exposure concept that may be used in expressing what an Evidence is about.\n      \u003c/p\u003e\n\t\n    \u003c/div\u003e"},"contained":[{"resourceType":"Group","id":"Definition-Group","title":"VariableDefinition: No alteplase","membership":"conceptual","characteristic":[{"code":{"text":"Defined by CodeableConcept"},"valueCodeableConcept":{"coding":[{"system":"http://www.nlm.nih.gov/research/umls/rxnorm","code":"8410","display":"alteplase"}]},"exclude":true,"description":"No alteplase"}]}],"extension":[{"url":"http://hl7.org/fhir/StructureDefinition/structuredefinition-wg","valueCode":"cds"}],"name":"NoAlteplase","title":"No Alteplase","status":"draft","publisher":"HL7 International / Clinical Decision Support","contact":[{"telecom":[{"system":"url","value":"http://www.hl7.org/Special/committees/dss"}]}],"description":"no alteplase","actual":false,"definition":{"reference":{"reference":"#Definition-Group"}}}
{"resourceType":"EvidenceVariable","id":"example-placebo","text":{"status":"generated","div":"\u003cdiv xmlns\u003d\"http://www.w3.org/1999/xhtml\"\u003e\n\t\t\n      \u003cp\u003e\n\t\t\tIn a study of response rates if placebo is given, \u0026quot;placcebo given\u0026quot; may be the variable for the exposure of interest.\n      \u003c/p\u003e\n\t\n    \u003c/div\u003e"},"extension":[{"url":"http://hl7.org/fhir/StructureDefinition/structuredefinition-wg","valueCode":"cds"}],"name":"Placebo","title":"Placebo","status":"draft","publisher":"HL7 International / Clinical Decision Support","contact":[{"telecom":[{"system":"url","value":"http://www.hl7.org/Special/committees/dss"}]}],"description":"Placebo","actual":true,"definition":{"concept":{"coding":[{"system":"http://snomed.info/sct","code":"182886004","display":"Placebo given (situation)"}]}}}
{"resourceType":"EvidenceVariable","id":"example-mRS3-6-at-90days","text":{"status":"generated","div":"\u003cdiv xmlns\u003d\"http://www.w3.org/1999/xhtml\"\u003e\n      \n      \u003cp\u003e\n        \u0026quot;mRS 3-6 at 90 days\u0026quot; is an outcome, defined by a CQL expression, used in expressing what an Evidence is about.\n      \u003c/p\u003e\n\t\n    \u003c/div\u003e"},"contained":[{"resourceType":"Group","id":"Definition-Group","title":"VariableDefinition: mRS 3-6 at 90 days","type":"person","membership":"definitional","characteristic":[{"code":{"coding":[{"system":"http://snomed.info/sct","code":"260905004","display":"Condition"}]},"valueExpression":{"description":"mRS 3-6","language":"text/cql","expression":"[\"Observation\": code in \"75859-9|LOINC\"] mRS where mRS.value between 3 and 6"},"exclude":false,"description":"mRS 3-6 at 90 days","timing":[{"contextCode":{"coding":[{"system":"http://hl7.org/fhir/evidence-variable-event","code":"study-start","display":"Study Start"}]},"offsetDuration":{"value":90,"unit":"days","system":"http://unitsofmeasure.org","code":"d"}}]}]}],"extension":[{"url":"http://hl7.org/fhir/StructureDefinition/structuredefinition-wg","valueCode":"cds"}],"name":"ModifiedRankinScaleScore36At90DaysAfterTreatment","title":"Modified Rankin Scale score 3-6 at 90 days after treatment","status":"draft","publisher":"HL7 International / Clinical Decision Support","contact":[{"telecom":[{"system":"url","value":"http://www.hl7.org/Special/committees/dss"}]}],"description":"Modified Rankin Scale score 3-6 at 90 days after treatment","actual":true,"definition":{"reference":{"reference":"#Definition-Group"}}}
{"resourceType":"EvidenceVariable","id":"example-fatal-ICH-in-7-days","text":{"status":"generated","div":"\u003cdiv xmlns\u003d\"http://www.w3.org/1999/xhtml\"\u003e\n      \n      \u003cp\u003e\n        \u0026quot;Fatal Intracranial Hemorrhage Within Seven Days\u0026quot; is an outcome used in expressing what an Evidence is about.\n      \u003c/p\u003e\n\t\n    \u003c/div\u003e"},"contained":[{"resourceType":"Group","id":"Cohort-Definition","title":"CohortDefinition: Fatal Intracranial Hemorrhage","membership":"conceptual","combinationMethod":"all-of","characteristic":[{"code":{"coding":[{"system":"http://snomed.info/sct","code":"260905004","display":"Condition"}]},"valueCodeableConcept":{"coding":[{"system":"http://snomed.info/sct","code":"1386000","display":"Intracranial hemorrhage (disorder)"}]},"exclude":false,"description":"intracranial hemorrhage"},{"code":{"text":"resulting in"},"valueCodeableConcept":{"coding":[{"system":"http://snomed.info/sct","code":"419620001","display":"Death (event)"}]},"exclude":false,"description":"resulting in death"}]},{"resourceType":"Group","id":"Definition-Group","title":"VariableDefinition: Fatal Intracranial Hemorrhage Within Seven Days","type":"person","membership":"definitional","characteristic":[{"code":{"coding":[{"system":"http://snomed.info/sct","code":"260905004","display":"Condition"}]},"valueReference":{"reference":"#Cohort-Definition"},"exclude":false,"description":"fatal intracranial hemorrhage within 7 days","timing":[{"contextCode":{"coding":[{"system":"http://hl7.org/fhir/evidence-variable-event","code":"study-start","display":"Study Start"}]},"offsetDuration":{"value":7,"unit":"days","system":"http://unitsofmeasure.org","code":"d"}}]}]}],"extension":[{"url":"http://hl7.org/fhir/StructureDefinition/structuredefinition-wg","valueCode":"cds"}],"name":"FatalIntracranialHemorrhageWithinSevenDays","title":"Fatal Intracranial Hemorrhage Within Seven Days","status":"draft","publisher":"HL7 International / Clinical Decision Support","contact":[{"telecom":[{"system":"url","value":"http://www.hl7.org/Special/committees/dss"}]}],"description":"Fatal Intracranial Hemorrhage Within Seven Days","actual":true,"definition":{"reference":{"reference":"#Definition-Group"}}}
{"resourceType":"EvidenceVariable","id":"example-alteplase-for-stroke","text":{"status":"generated","div":"\u003cdiv xmlns\u003d\"http://www.w3.org/1999/xhtml\"\u003e\n      \n      \u003cp\u003e\n        \u0026quot;Alteplase for Stroke\u0026quot; is an exposure concept with a detailed dosing instruction that may be used in expressing what an Evidence is about.\n      \u003c/p\u003e\n\t\n    \u003c/div\u003e"},"contained":[{"resourceType":"Group","id":"Definition-Group","title":"VariableDefinition: Alteplase for Stroke","membership":"conceptual","characteristic":[{"code":{"text":"Defined by Reference"},"valueUri":"http://example.org/fhir/ActivityDefinition/example-alteplase-dosing","exclude":false,"description":"IV alteplase 0.9 mg/kg (maximum 90 mg) as 10% of dose over 1 minute and 90% over 1 hour"}]}],"extension":[{"url":"http://hl7.org/fhir/StructureDefinition/structuredefinition-wg","valueCode":"cds"}],"name":"AlteplaseForStroke","title":"Alteplase for Stroke","status":"draft","publisher":"HL7 International / Clinical Decision Support","contact":[{"telecom":[{"system":"url","value":"http://www.hl7.org/Special/committees/dss"}]}],"description":"Alteplase for Stroke","actual":false,"definition":{"reference":{"reference":"#Definition-Group"}}}
{"resourceType":"EvidenceVariable","id":"example-alive-independent-90day","text":{"status":"generated","div":"\u003cdiv xmlns\u003d\"http://www.w3.org/1999/xhtml\"\u003e\n      \n      \u003cp\u003e\n        \u0026quot;Alive and not functionally dependent at 90 days\u0026quot; is an outcome used in expressing what an Evidence is about.\n      \u003c/p\u003e\n\t\n    \u003c/div\u003e"},"contained":[{"resourceType":"Group","id":"Definition-Group","title":"VariableDefinition: Alive and not functionally dependent at 90 days","type":"person","membership":"definitional","combinationMethod":"all-of","characteristic":[{"code":{"coding":[{"system":"http://snomed.info/sct","code":"260905004","display":"Condition"}]},"valueCodeableConcept":{"coding":[{"system":"http://snomed.info/sct","code":"419099009","display":"Dead (finding)"}]},"exclude":true,"description":"alive at 90 days (excluding dead at 90 days)","timing":[{"contextCode":{"coding":[{"system":"http://hl7.org/fhir/evidence-variable-event","code":"study-start","display":"Study Start"}]},"offsetDuration":{"value":90,"unit":"days","system":"http://unitsofmeasure.org","code":"d"}}]},{"code":{"coding":[{"system":"http://snomed.info/sct","code":"260905004","display":"Condition"}]},"valueCodeableConcept":{"coding":[{"system":"http://snomed.info/sct","code":"718705001","display":"Functionally dependent (finding)"}]},"exclude":true,"description":"not functionally dependent at 90 days (excluding functionally dependent at 90 days)","timing":[{"contextCode":{"coding":[{"system":"http://hl7.org/fhir/evidence-variable-event","code":"study-start","display":"Study Start"}]},"offsetDuration":{"value":90,"unit":"days","system":"http://unitsofmeasure.org","code":"d"}}]}]}],"extension":[{"url":"http://hl7.org/fhir/StructureDefinition/structuredefinition-wg","valueCode":"cds"}],"name":"AliveAndNotFunctionallyDependentAt90Days","title":"Alive and not functionally dependent at 90 days","status":"draft","publisher":"HL7 International / Clinical Decision Support","contact":[{"telecom":[{"system":"url","value":"http://www.hl7.org/Special/committees/dss"}]}],"description":"Alive and not functionally dependent at 90 days","actual":false,"definition":{"reference":{"reference":"#Definition-Group"}}}