@prefix fhir: <http://hl7.org/fhir/> .
@prefix owl: <http://www.w3.org/2002/07/owl#> .
@prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix sct: <http://snomed.info/id/> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

# - resource -------------------------------------------------------------------

<http://hl7.org/fhir/ActivityDefinition/example-alteplase-dosing> a fhir:ActivityDefinition ;
  fhir:nodeRole fhir:treeRoot ;
  fhir:id [ fhir:v "example-alteplase-dosing"] ; # 
  fhir:text [
     fhir:status [ fhir:v "generated" ] ;
     fhir:div [ fhir:v "<div xmlns=\"http://www.w3.org/1999/xhtml\">\n      \n      <p>\n        \"Alteplase Dosing for Stroke\" defines a dosing instruction referenced from an EvidenceVariable resource.\n      </p>\n	\n    </div>"^^rdf:XMLLiteral ]
  ] ; # 
  fhir:extension ( [
     fhir:url [
       fhir:v "http://hl7.org/fhir/StructureDefinition/structuredefinition-wg"^^xsd:anyURI ;
       fhir:l <http://hl7.org/fhir/StructureDefinition/structuredefinition-wg>
     ] ;
     fhir:value [
       a fhir:Code ;
       fhir:v "cds"
     ]
  ] ) ; # 
  fhir:url [
     fhir:v "http://example.org/fhir/ActivityDefinition/example-alteplase-dosing"^^xsd:anyURI ;
     fhir:l <http://example.org/fhir/ActivityDefinition/example-alteplase-dosing>
  ] ; # 
  fhir:identifier ( [
     fhir:system [
       fhir:v "urn:ietf:rfc:3986"^^xsd:anyURI ;
       fhir:l <urn:ietf:rfc:3986>
     ] ;
     fhir:value [ fhir:v "urn:oid:2.16.840.1.113883.4.642.19.3" ]
  ] ) ; # 
  fhir:name [ fhir:v "AlteplaseDosingForStroke"] ; # 
  fhir:title [ fhir:v "Alteplase Dosing for Stroke"] ; # 
  fhir:status [ fhir:v "draft"] ; # 
  fhir:publisher [ fhir:v "HL7 International / Clinical Decision Support"] ; # 
  fhir:contact ( [
     fhir:telecom ( [
       fhir:system [ fhir:v "url" ] ;
       fhir:value [ fhir:v "http://www.hl7.org/Special/committees/dss" ]
     ] )
  ] ) ; # 
  fhir:description [ fhir:v "Alteplase Dosing for Stroke"] ; # 
  fhir:kind [ fhir:v "MedicationRequest"] ; # 
  fhir:code [
     fhir:coding ( [
       fhir:system [
         fhir:v "http://www.nlm.nih.gov/research/umls/rxnorm"^^xsd:anyURI ;
         fhir:l <http://www.nlm.nih.gov/research/umls/rxnorm>
       ] ;
       fhir:code [ fhir:v "1155608" ] ;
       fhir:display [ fhir:v "alteplase injectable product" ]
     ] )
  ] ; # 
  fhir:intent [ fhir:v "order"] ; # 
  fhir:dosage ( [
     fhir:text [ fhir:v "give 10% of dose over 1 minute" ] ;
     fhir:route [
       fhir:coding ( [
         a sct:47625008 ;
         fhir:system [
           fhir:v "http://snomed.info/sct"^^xsd:anyURI ;
           fhir:l <http://snomed.info/sct>
         ] ;
         fhir:code [ fhir:v "47625008" ] ;
         fhir:display [ fhir:v "Intravenous use" ]
       ] )
     ] ;
     fhir:doseAndRate ( [
       fhir:type [
         fhir:coding ( [
           fhir:system [
             fhir:v "http://terminology.hl7.org/CodeSystem/dose-rate-type"^^xsd:anyURI ;
             fhir:l <http://terminology.hl7.org/CodeSystem/dose-rate-type>
           ] ;
           fhir:code [ fhir:v "calculated" ] ;
           fhir:display [ fhir:v "Calculated" ]
         ] )
       ] ;
       fhir:dose [
         a fhir:Quantity ;
         fhir:value [ fhir:v 0.9 ] ;
         fhir:system [
           fhir:v "http://unitsofmeasure.org"^^xsd:anyURI ;
           fhir:l <http://unitsofmeasure.org>
         ] ;
         fhir:code [ fhir:v "mg/kg" ]
       ]
     ] ) ;
     fhir:safety [
       fhir:doseLimit ( [
         fhir:value [
           a fhir:Quantity ;
           fhir:value [ fhir:v "90"^^xsd:decimal ] ;
           fhir:system [
             fhir:v "http://unitsofmeasure.org"^^xsd:anyURI ;
             fhir:l <http://unitsofmeasure.org>
           ] ;
           fhir:code [ fhir:v "mg" ]
         ] ;
         fhir:scope [ fhir:v "administration" ]
       ] )
     ]
  ] [
     fhir:text [ fhir:v "give remaining 90% of dose over 1 hour" ] ;
     fhir:route [
       fhir:coding ( [
         a sct:47625008 ;
         fhir:system [
           fhir:v "http://snomed.info/sct"^^xsd:anyURI ;
           fhir:l <http://snomed.info/sct>
         ] ;
         fhir:code [ fhir:v "47625008" ] ;
         fhir:display [ fhir:v "Intravenous use" ]
       ] )
     ] ;
     fhir:doseAndRate ( [
       fhir:type [
         fhir:coding ( [
           fhir:system [
             fhir:v "http://terminology.hl7.org/CodeSystem/dose-rate-type"^^xsd:anyURI ;
             fhir:l <http://terminology.hl7.org/CodeSystem/dose-rate-type>
           ] ;
           fhir:code [ fhir:v "calculated" ] ;
           fhir:display [ fhir:v "Calculated" ]
         ] )
       ] ;
       fhir:dose [
         a fhir:Quantity ;
         fhir:value [ fhir:v 0.9 ] ;
         fhir:system [
           fhir:v "http://unitsofmeasure.org"^^xsd:anyURI ;
           fhir:l <http://unitsofmeasure.org>
         ] ;
         fhir:code [ fhir:v "mg/kg" ]
       ]
     ] ) ;
     fhir:safety [
       fhir:doseLimit ( [
         fhir:value [
           a fhir:Quantity ;
           fhir:value [ fhir:v "90"^^xsd:decimal ] ;
           fhir:system [
             fhir:v "http://unitsofmeasure.org"^^xsd:anyURI ;
             fhir:l <http://unitsofmeasure.org>
           ] ;
           fhir:code [ fhir:v "mg" ]
         ] ;
         fhir:scope [ fhir:v "administration" ]
       ] )
     ]
  ] ) . # 

# -------------------------------------------------------------------------------------

