@prefix fhir: <http://hl7.org/fhir/> .
@prefix owl: <http://www.w3.org/2002/07/owl#> .
@prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

# - resource -------------------------------------------------------------------

<http://hl7.org/fhir/PlanDefinition/KDN5> a fhir:PlanDefinition ;
  fhir:nodeRole fhir:treeRoot ;
  fhir:id [ fhir:v "KDN5"] ; # 
  fhir:text [
     fhir:status [ fhir:v "additional" ] ;
     fhir:div [ fhir:v "<div xmlns=\"http://www.w3.org/1999/xhtml\">\n      <table style=\"width: 100%;\">\n           <tr>\n          <td>\n            <div style=\"width: 200px; height: 100px; vertical-align: top;\">National Comprehensive Cancer Network</div>\n          </td>\n          <td>\n            <h3>Chemotherapy Order Template</h3>\n            <h1>Kidney Cancer</h1>\n            <h2>Gemcitabine/CARBOplatin</h2>\n          </td>\n          <td style=\"text-align: right; vertical-align: top;\">KDN5</td>\n           </tr>\n      </table>\n      <table style=\"width: 100%; border-top: 1px solid; border-bottom: 1px solid;\">\n           <tr>\n          <td style=\"width: 33%; border-right: 1px solid; vertical-align: top\">\n            <h4>INDICATION:</h4>\n            <p>Metastatic or Relapsed – Collecting Duct/Medullary Subtypes</p>\n          </td>\n          <td style=\"width: 34%; border-right: 1px solid; vertical-align: top\">\n            <h4>REFERENCES:</h4>\n            <ol>\n              <li>\n                <a href=\"http://www.example.org/professionals/physician_gls/PDF/kidney.pdf\">NCCN Guidelines® for Kidney Cancer. V.3.2015.</a>\n              </li>\n              <li>\n                <a href=\"http://www.ncbi.nlm.nih.gov/pubmed?term=%22The+Journal+of+urology%22%5BJour%5D+AND+1698%5Bpage%5D+AND+2007%5Bpdat%5D+AND+Oudard+S%5Bauthor%5D\">Oudard S, et al. \n                  <em>J Urol</em>. 2007;177(5):1698-702.\n                </a>\n                <sup>\n                  <a href=\"http://www.example.org/OrderTemplates/PDF/appendix_E.pdf\">a</a>\n                </sup>\n              </li>\n            </ol>\n          </td>\n          <td style=\"width: 33%; vertical-align: top\">\n            <h4>NCCN SUPPORTIVE CARE:</h4>\n            <ol>\n              <li>\n                <i>Emetic Risk:</i>\n                <table>\n                  <tr>\n                    <td>Day 1</td>\n                    <td>Moderate</td>\n                  </tr>\n                  <tr>\n                    <td>Day 8</td>\n                    <td>Low</td>\n                  </tr>\n                </table>\n              </li>\n              <li>\n                <i>Fever Neutropenia Risk:</i>\n                <br/>\n                Refer to \n                <a href=\"http://www.example.org/professionals/physician_gls/PDF/myeloid_growth.pdf\">NCCN Guidelines for Myeloid Growth Factors. V.2.2014</a>\n              </li>\n            </ol>\n          </td>\n           </tr>\n      </table>\n      <h4>CHEMOTHERAPY REGIMEN</h4>\n      <p>\n           <i>21-day cycle for 6 cycles</i>\n      </p>\n      <ul>\n           <li>Gemcitabine 1250 mg/m\n          <sup>2</sup> IV over 30 minutes on Days 1 and 8\n          </li>\n           <li>CARBOplatin AUC 5 IV over 30 minutes on Day 1</li>\n      </ul>\n    </div>"^^rdf:XMLLiteral ]
  ] ; # 
  fhir:contained ( [
     a fhir:ActivityDefinition ;
     fhir:id [ fhir:v "1111" ] ;
     fhir:status [ fhir:v "draft" ] ;
     fhir:product [
       a fhir:CodeableConcept ;
       fhir:coding ( [
         fhir:system [
           fhir:v "http://www.nlm.nih.gov/research/umls/rxnorm"^^xsd:anyURI ;
           fhir:l <http://www.nlm.nih.gov/research/umls/rxnorm>
         ] ;
         fhir:code [ fhir:v "12574" ] ;
         fhir:display [ fhir:v "gemcitabine" ]
       ] ) ;
       fhir:text [ fhir:v "gemcitabine" ]
     ] ;
     fhir:dosage ( [
       fhir:text [ fhir:v "1250 mg/m² IV over 30 minutes" ] ;
       fhir:timing [
         fhir:repeat [
           fhir:duration [ fhir:v "30"^^xsd:decimal ] ;
           fhir:durationUnit [ fhir:v "min" ]
         ]
       ] ;
       fhir:route [
         fhir:text [ fhir:v "IV" ]
       ] ;
       fhir:doseAndRate ( [
         fhir:type [
           fhir:coding ( [
             fhir:system [
               fhir:v "http://terminology.hl7.org/CodeSystem/dose-rate-type"^^xsd:anyURI ;
               fhir:l <http://terminology.hl7.org/CodeSystem/dose-rate-type>
             ] ;
             fhir:code [ fhir:v "ordered" ] ;
             fhir:display [ fhir:v "Ordered" ]
           ] )
         ] ;
         fhir:dose [
           a fhir:Quantity ;
           fhir:value [ fhir:v "1250"^^xsd:decimal ] ;
           fhir:unit [ fhir:v "mg/m²" ]
         ]
       ] )
     ] )
  ] [
     a fhir:ActivityDefinition ;
     fhir:id [ fhir:v "2222" ] ;
     fhir:status [ fhir:v "draft" ] ;
     fhir:product [
       a fhir:CodeableConcept ;
       fhir:coding ( [
         fhir:system [
           fhir:v "http://www.nlm.nih.gov/research/umls/rxnorm"^^xsd:anyURI ;
           fhir:l <http://www.nlm.nih.gov/research/umls/rxnorm>
         ] ;
         fhir:code [ fhir:v "40048" ] ;
         fhir:display [ fhir:v "Carboplatin" ]
       ] ) ;
       fhir:text [ fhir:v "CARBOplatin" ]
     ] ;
     fhir:dosage ( [
       fhir:text [ fhir:v "AUC 5 IV over 30 minutes" ] ;
       fhir:timing [
         fhir:repeat [
           fhir:duration [ fhir:v "30"^^xsd:decimal ] ;
           fhir:durationUnit [ fhir:v "min" ]
         ]
       ] ;
       fhir:route [
         fhir:text [ fhir:v "IV" ]
       ] ;
       fhir:doseAndRate ( [
         fhir:type [
           fhir:coding ( [
             fhir:system [
               fhir:v "http://terminology.hl7.org/CodeSystem/dose-rate-type"^^xsd:anyURI ;
               fhir:l <http://terminology.hl7.org/CodeSystem/dose-rate-type>
             ] ;
             fhir:code [ fhir:v "ordered" ] ;
             fhir:display [ fhir:v "Ordered" ]
           ] )
         ] ;
         fhir:dose [
           a fhir:Quantity ;
           fhir:extension ( [
             fhir:url [
               fhir:v "http://example.org/fhir/AUC-dose"^^xsd:anyURI ;
               fhir:l <http://example.org/fhir/AUC-dose>
             ] ;
             fhir:value [
               a fhir:Integer ;
               fhir:v 5
             ]
           ] )
         ]
       ] )
     ] )
  ] ) ; # 
  fhir:extension ( [
     fhir:url [
       fhir:v "http://hl7.org/fhir/StructureDefinition/structuredefinition-wg"^^xsd:anyURI ;
       fhir:l <http://hl7.org/fhir/StructureDefinition/structuredefinition-wg>
     ] ;
     fhir:value [
       a fhir:Code ;
       fhir:v "cds"
     ]
  ] ) ; # 
  fhir:identifier ( [
     fhir:system [
       fhir:v "http://example.org/ordertemplates"^^xsd:anyURI ;
       fhir:l <http://example.org/ordertemplates>
     ] ;
     fhir:value [ fhir:v "KDN5" ]
  ] [
     fhir:system [
       fhir:v "urn:ietf:rfc:3986"^^xsd:anyURI ;
       fhir:l <urn:ietf:rfc:3986>
     ] ;
     fhir:value [ fhir:v "urn:oid:2.16.840.1.113883.4.642.11.21" ]
  ] ) ; # 
  fhir:version [ fhir:v "1"] ; # 
  fhir:name [ fhir:v "GemcitabineCARBOplatin"] ; # 
  fhir:title [ fhir:v "Gemcitabine/CARBOplatin"] ; # 
  fhir:type [
     fhir:text [ fhir:v "Chemotherapy Order Template" ]
  ] ; # 
  fhir:status [ fhir:v "draft"] ; # 
  fhir:experimental [ fhir:v true] ; # 
  fhir:publisher [ fhir:v "HL7 International / Clinical Decision Support"] ; # 
  fhir:contact ( [
     fhir:telecom ( [
       fhir:system [ fhir:v "url" ] ;
       fhir:value [ fhir:v "http://www.hl7.org/Special/committees/dss" ]
     ] )
  ] ) ; # 
  fhir:description [ fhir:v "Gemcitabine/CARBOplatin"] ; # 
  fhir:useContext ( [
     fhir:code [
       fhir:system [
         fhir:v "http://example.org/fhir/CodeSystem/indications"^^xsd:anyURI ;
         fhir:l <http://example.org/fhir/CodeSystem/indications>
       ] ;
       fhir:code [ fhir:v "treamentSetting-or-diseaseStatus" ]
     ] ;
     fhir:value [
       a fhir:CodeableConcept ;
       fhir:text [ fhir:v "Metastatic" ]
     ]
  ] [
     fhir:code [
       fhir:system [
         fhir:v "http://example.org/fhir/CodeSystem/indications"^^xsd:anyURI ;
         fhir:l <http://example.org/fhir/CodeSystem/indications>
       ] ;
       fhir:code [ fhir:v "disease-or-histology" ]
     ] ;
     fhir:value [
       a fhir:CodeableConcept ;
       fhir:text [ fhir:v "Collecting Duct/Medullary Subtypes" ]
     ]
  ] [
     fhir:code [
       fhir:system [
         fhir:v "http://terminology.hl7.org/CodeSystem/usage-context-type"^^xsd:anyURI ;
         fhir:l <http://terminology.hl7.org/CodeSystem/usage-context-type>
       ] ;
       fhir:code [ fhir:v "focus" ]
     ] ;
     fhir:value [
       a fhir:CodeableConcept ;
       fhir:text [ fhir:v "Kidney Cancer" ]
     ]
  ] [
     fhir:code [
       fhir:system [
         fhir:v "http://example.org/fhir/CodeSystem/indications"^^xsd:anyURI ;
         fhir:l <http://example.org/fhir/CodeSystem/indications>
       ] ;
       fhir:code [ fhir:v "treatmentSetting-or-diseaseStatus" ]
     ] ;
     fhir:value [
       a fhir:CodeableConcept ;
       fhir:text [ fhir:v "Relapsed" ]
     ]
  ] [
     fhir:code [
       fhir:system [
         fhir:v "http://example.org/fhir/CodeSystem/indications"^^xsd:anyURI ;
         fhir:l <http://example.org/fhir/CodeSystem/indications>
       ] ;
       fhir:code [ fhir:v "disease-or-histology" ]
     ] ;
     fhir:value [
       a fhir:CodeableConcept ;
       fhir:text [ fhir:v "Collecting Duct/Medullary Subtypes" ]
     ]
  ] [
     fhir:code [
       fhir:system [
         fhir:v "http://terminology.hl7.org/CodeSystem/usage-context-type"^^xsd:anyURI ;
         fhir:l <http://terminology.hl7.org/CodeSystem/usage-context-type>
       ] ;
       fhir:code [ fhir:v "focus" ]
     ] ;
     fhir:value [
       a fhir:CodeableConcept ;
       fhir:text [ fhir:v "Kidney Cancer – Collecting Duct/Medullary Subtypes - Metastatic" ]
     ]
  ] ) ; # 
  fhir:copyright [ fhir:v "All rights reserved."] ; # 
  fhir:approvalDate [ fhir:v "2016-07-27"^^xsd:date] ; # 
  fhir:lastReviewDate [ fhir:v "2016-07-27"^^xsd:date] ; # 
  fhir:author ( [
     fhir:name [ fhir:v "Lee Surprenant" ]
  ] ) ; # 
  fhir:relatedArtifact ( [
     fhir:type [ fhir:v "derived-from" ] ;
     fhir:display [ fhir:v "NCCN Guidelines for Kidney Cancer. V.2.2016" ] ;
     fhir:document [
       fhir:url [
         fhir:v "http://www.example.org/professionals/physician_gls/PDF/kidney.pdf"^^xsd:anyURI ;
         fhir:l <http://www.example.org/professionals/physician_gls/PDF/kidney.pdf>
       ]
     ]
  ] [
     fhir:type [
       fhir:v "citation" ;
       fhir:extension ( [
         fhir:url [
           fhir:v "http://example.org/fhir/regimenReferenceType"^^xsd:anyURI ;
           fhir:l <http://example.org/fhir/regimenReferenceType>
         ] ;
         fhir:value [
           a fhir:Code ;
           fhir:v "a"
         ]
       ] )
     ] ;
     fhir:citation [ fhir:v "Oudard S, et al. J Urol. 2007;177(5):1698-702" ] ;
     fhir:document [
       fhir:url [
         fhir:v "http://www.ncbi.nlm.nih.gov/pubmed/17437788"^^xsd:anyURI ;
         fhir:l <http://www.ncbi.nlm.nih.gov/pubmed/17437788>
       ]
     ]
  ] ) ; # 
  fhir:action ( [
     fhir:selectionBehavior [ fhir:v "exactly-one" ] ;
     fhir:action ( [
       fhir:selectionBehavior [ fhir:v "all" ] ;
       fhir:action ( [
         fhir:groupingBehavior [ fhir:v "sentence-group" ] ;
         fhir:selectionBehavior [ fhir:v "exactly-one" ] ;
         fhir:action ( [
           fhir:id [ fhir:v "cycle-definition-1" ] ;
           fhir:textEquivalent [ fhir:v "21-day cycle for 6 cycles" ] ;
           fhir:timing [
             a fhir:Timing ;
             fhir:repeat [
               fhir:count [ fhir:v "6"^^xsd:positiveInteger ] ;
               fhir:duration [ fhir:v "21"^^xsd:decimal ] ;
               fhir:durationUnit [ fhir:v "d" ]
             ]
           ] ;
           fhir:action ( [
             fhir:id [ fhir:v "action-1" ] ;
             fhir:extension ( [
               fhir:url [
                 fhir:v "http://hl7.org/fhir/StructureDefinition/timing-daysOfCycle"^^xsd:anyURI ;
                 fhir:l <http://hl7.org/fhir/StructureDefinition/timing-daysOfCycle>
               ] ;
               fhir:extension ( [
                 fhir:url [
                   fhir:v "day"^^xsd:anyURI ;
                   fhir:l fhir:day
                 ] ;
                 fhir:value [
                   a fhir:Integer ;
                   fhir:v 1
                 ]
               ] [
                 fhir:url [
                   fhir:v "day"^^xsd:anyURI ;
                   fhir:l fhir:day
                 ] ;
                 fhir:value [
                   a fhir:Integer ;
                   fhir:v 8
                 ]
               ] )
             ] ) ;
             fhir:textEquivalent [ fhir:v "Gemcitabine 1250 mg/m² IV over 30 minutes on days 1 and 8" ] ;
             fhir:definition [
               a fhir:Canonical ;
               fhir:v "#1111"^^xsd:anyURI ;
               fhir:l <#1111>
             ]
           ] [
             fhir:id [ fhir:v "action-2" ] ;
             fhir:extension ( [
               fhir:url [
                 fhir:v "http://hl7.org/fhir/StructureDefinition/timing-daysOfCycle"^^xsd:anyURI ;
                 fhir:l <http://hl7.org/fhir/StructureDefinition/timing-daysOfCycle>
               ] ;
               fhir:extension ( [
                 fhir:url [
                   fhir:v "day"^^xsd:anyURI ;
                   fhir:l fhir:day
                 ] ;
                 fhir:value [
                   a fhir:Integer ;
                   fhir:v 1
                 ]
               ] )
             ] ) ;
             fhir:textEquivalent [ fhir:v "CARBOplatin AUC 5 IV over 30 minutes on Day 1" ] ;
             fhir:relatedAction ( [
               fhir:targetId [ fhir:v "action-1" ] ;
               fhir:relationship [ fhir:v "concurrent-with-start" ]
             ] ) ;
             fhir:definition [
               a fhir:Canonical ;
               fhir:v "#2222"^^xsd:anyURI ;
               fhir:l <#2222>
             ]
           ] )
         ] )
       ] )
     ] )
  ] ) . # 

# -------------------------------------------------------------------------------------

