@prefix fhir: <http://hl7.org/fhir/> .
@prefix owl: <http://www.w3.org/2002/07/owl#> .
@prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

# - resource -------------------------------------------------------------------

# Example: Trastuzumab (humanised monoclonal antibody against HER2).
#     Demonstrates the new SubstanceDefinition protein backbones added for
#     FHIR-57660: .protein.subunit (heavy + light chains), disulfide linkages,
#     N/C-terminal modifications, .protein.gene with humanised mouse origin,
#     and .relationship typed as TherapeuticTarget (HER2).

<http://hl7.org/fhir/SubstanceDefinition/trastuzumab> a fhir:SubstanceDefinition ;
  fhir:nodeRole fhir:treeRoot ;
  fhir:id [ fhir:v "trastuzumab"] ; # 
  fhir:identifier ( [
     fhir:system [
       fhir:v "http://example.europa.eu/fhir/SMSId"^^xsd:anyURI ;
       fhir:l <http://example.europa.eu/fhir/SMSId>
     ] ;
     fhir:value [ fhir:v "TRAS9123H" ]
  ] ) ; # 
  fhir:status [
     fhir:coding ( [
       fhir:system [
         fhir:v "http://hl7.org/fhir/publication-status"^^xsd:anyURI ;
         fhir:l <http://hl7.org/fhir/publication-status>
       ] ;
       fhir:code [ fhir:v "active" ] ;
       fhir:display [ fhir:v "Active" ]
     ] )
  ] ; # 
  fhir:classification ( [
     fhir:coding ( [
       fhir:system [
         fhir:v "http://example.europa.eu/fhir/SubstanceType"^^xsd:anyURI ;
         fhir:l <http://example.europa.eu/fhir/SubstanceType>
       ] ;
       fhir:code [ fhir:v "protein" ] ;
       fhir:display [ fhir:v "Protein" ]
     ] )
  ] ) ; # 
  fhir:domain [
     fhir:coding ( [
       fhir:system [
         fhir:v "http://example.europa.eu/fhir/Domain"^^xsd:anyURI ;
         fhir:l <http://example.europa.eu/fhir/Domain>
       ] ;
       fhir:code [ fhir:v "human" ] ;
       fhir:display [ fhir:v "Human use" ]
     ] )
  ] ; # 
  fhir:description [ fhir:v "Trastuzumab — humanised IgG1 monoclonal antibody targeting the human epidermal growth factor receptor 2 (HER2/ErbB2). Variable regions derived from murine antibody 4D5, grafted onto human IgG1 framework. Produced in Chinese hamster ovary (CHO) cells."] ; # 
  fhir:code ( [
     fhir:code [
       fhir:coding ( [
         fhir:system [
           fhir:v "http://example.europa.eu/fhir/Substance"^^xsd:anyURI ;
           fhir:l <http://example.europa.eu/fhir/Substance>
         ] ;
         fhir:code [ fhir:v "TRAS9123H" ]
       ] )
     ]
  ] ) ; # 
  fhir:name ( [
     fhir:name [ fhir:v "Trastuzumab" ] ;
     fhir:preferred [ fhir:v true ] ;
     fhir:language ( [
       fhir:coding ( [
         fhir:system [
           fhir:v "urn:ietf:bcp:47"^^xsd:anyURI ;
           fhir:l <urn:ietf:bcp:47>
         ] ;
         fhir:code [ fhir:v "en" ] ;
         fhir:display [ fhir:v "English" ]
       ] )
     ] ) ;
     fhir:official ( [
       fhir:authority [
         fhir:coding ( [
           fhir:system [
             fhir:v "http://hl7.org/fhir/substance-name-authority"^^xsd:anyURI ;
             fhir:l <http://hl7.org/fhir/substance-name-authority>
           ] ;
           fhir:code [ fhir:v "INN" ] ;
           fhir:display [ fhir:v "INN" ]
         ] )
       ] ;
       fhir:status [
         fhir:coding ( [
           fhir:system [
             fhir:v "http://hl7.org/fhir/publication-status"^^xsd:anyURI ;
             fhir:l <http://hl7.org/fhir/publication-status>
           ] ;
           fhir:code [ fhir:v "active" ] ;
           fhir:display [ fhir:v "Active" ]
         ] )
       ]
     ] )
  ] [
     fhir:name [ fhir:v "Herceptin" ] ;
     fhir:preferred [ fhir:v false ]
  ] ) ; # 
  fhir:protein [
     fhir:sequenceType [
       fhir:coding ( [
         fhir:system [
           fhir:v "http://hl7.org/fhir/substance-sequence-type"^^xsd:anyURI ;
           fhir:l <http://hl7.org/fhir/substance-sequence-type>
         ] ;
         fhir:code [ fhir:v "complete" ] ;
         fhir:display [ fhir:v "Complete" ]
       ] )
     ] ;
     fhir:numberOfSubunits [ fhir:v 2 ] ;
     fhir:disulfideLinkage ( [ fhir:v "HC22-HC96; HC144-HC200; HC222-LC214; HC228-HC228'; HC231-HC231'; HC265-HC325; HC371-HC429" ] ) ;
     fhir:subunit ( [
       fhir:subunit [ fhir:v 1 ] ;
       fhir:sequence [ fhir:v "EVQLVESGGGLVQPGGSLRLSCAASGFNIKDTYIHWVRQAPGKGLEWVARIYPTNGYTRYADSVKGRFTISADTSKNTAYLQMNSLRAEDTAVYYCSRWGGDGFYAMDYWGQGTLVTVSS..." ] ;
       fhir:length [ fhir:v 450 ] ;
       fhir:nTerminalModification [
         fhir:concept [
           fhir:coding ( [
             fhir:system [
               fhir:v "http://example.europa.eu/fhir/Modification"^^xsd:anyURI ;
               fhir:l <http://example.europa.eu/fhir/Modification>
             ] ;
             fhir:code [ fhir:v "pyroglutamate" ] ;
             fhir:display [ fhir:v "Pyroglutamic acid (pE)" ]
           ] )
         ]
       ] ;
       fhir:cTerminalModification [
         fhir:concept [
           fhir:coding ( [
             fhir:system [
               fhir:v "http://example.europa.eu/fhir/Modification"^^xsd:anyURI ;
               fhir:l <http://example.europa.eu/fhir/Modification>
             ] ;
             fhir:code [ fhir:v "lysine-clipped" ] ;
             fhir:display [ fhir:v "C-terminal lysine clipping" ]
           ] )
         ]
       ]
     ] [
       fhir:subunit [ fhir:v 2 ] ;
       fhir:sequence [ fhir:v "DIQMTQSPSSLSASVGDRVTITCRASQDVNTAVAWYQQKPGKAPKLLIYSASFLYSGVPSRFSGSRSGTDFTLTISSLQPEDFATYYCQQHYTTPPTFGQGTKVEIK..." ] ;
       fhir:length [ fhir:v 214 ]
     ] ) ;
     fhir:gene ( [
       fhir:sequenceOrigin [
         fhir:coding ( [
           fhir:system [
             fhir:v "http://hl7.org/fhir/gene-sequence-origin"^^xsd:anyURI ;
             fhir:l <http://hl7.org/fhir/gene-sequence-origin>
           ] ;
           fhir:code [ fhir:v "humanised-mouse" ] ;
           fhir:display [ fhir:v "Humanised mouse" ]
         ] )
       ] ;
       fhir:gene [
         fhir:concept [
           fhir:coding ( [
             fhir:system [
               fhir:v "http://www.genenames.org"^^xsd:anyURI ;
               fhir:l <http://www.genenames.org>
             ] ;
             fhir:code [ fhir:v "IGHG1" ] ;
             fhir:display [ fhir:v "Immunoglobulin heavy constant gamma 1" ]
           ] )
         ]
       ]
     ] )
  ] ; # 
  fhir:relationship ( [
     fhir:substanceDefinition [
       a fhir:Reference ;
       fhir:l <http://hl7.org/fhir/SubstanceDefinition/her2> ;
       fhir:reference [ fhir:v "SubstanceDefinition/her2" ] ;
       fhir:display [ fhir:v "Receptor tyrosine-protein kinase erbB-2 (HER2)" ]
     ] ;
     fhir:type [
       fhir:coding ( [
         fhir:system [
           fhir:v "http://hl7.org/fhir/substance-relationship-type"^^xsd:anyURI ;
           fhir:l <http://hl7.org/fhir/substance-relationship-type>
         ] ;
         fhir:code [ fhir:v "TherapeuticTarget" ] ;
         fhir:display [ fhir:v "Therapeutic target" ]
       ] )
     ] ;
     fhir:interaction [
       fhir:coding ( [
         fhir:system [
           fhir:v "http://hl7.org/fhir/substance-interaction-type"^^xsd:anyURI ;
           fhir:l <http://hl7.org/fhir/substance-interaction-type>
         ] ;
         fhir:code [ fhir:v "binding" ] ;
         fhir:display [ fhir:v "Binding" ]
       ] )
     ] ;
     fhir:measurementType [
       fhir:coding ( [
         fhir:system [
           fhir:v "http://hl7.org/fhir/substance-measurement-type"^^xsd:anyURI ;
           fhir:l <http://hl7.org/fhir/substance-measurement-type>
         ] ;
         fhir:code [ fhir:v "kd" ] ;
         fhir:display [ fhir:v "Kd" ]
       ] )
     ] ;
     fhir:amount [
       a fhir:Quantity ;
       fhir:value [ fhir:v 0.1 ] ;
       fhir:unit [ fhir:v "nM" ] ;
       fhir:system [
         fhir:v "http://unitsofmeasure.org"^^xsd:anyURI ;
         fhir:l <http://unitsofmeasure.org>
       ] ;
       fhir:code [ fhir:v "nmol/L" ]
     ]
  ] ) . # 

<http://hl7.org/fhir/SubstanceDefinition/her2> a fhir:SubstanceDefinition .

# -------------------------------------------------------------------------------------

