@prefix fhir: <http://hl7.org/fhir/> .
@prefix loinc: <https://loinc.org/rdf/> .
@prefix owl: <http://www.w3.org/2002/07/owl#> .
@prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix sct: <http://snomed.info/id/> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

# - resource -------------------------------------------------------------------

<http://hl7.org/fhir/Observation/f205> a fhir:Observation ;
  fhir:nodeRole fhir:treeRoot ;
  fhir:id [ fhir:v "f205"] ; # 
  fhir:identifier ( [
     fhir:system [
       fhir:v "https://intranet.aumc.nl/labvalues"^^xsd:anyURI ;
       fhir:l <https://intranet.aumc.nl/labvalues>
     ] ;
     fhir:value [ fhir:v "1304-03720-eGFR" ] # Does not exist
  ] ) ; # 
  fhir:status [ fhir:v "final"] ; # eGFR was measured on April fourth
  fhir:code [
     a loinc:33914-3 ;
     fhir:coding ( [
       fhir:system [
         fhir:v "http://loinc.org"^^xsd:anyURI ;
         fhir:l <http://loinc.org>
       ] ;
       fhir:code [ fhir:v "33914-3" ] ;
       fhir:display [ fhir:v "Glomerular filtration rate [Volume Rate/Area] in Serum or Plasma by Creatinine-based formula (MDRD)/1.73 sq M" ]
     ] ) # Kind of observation = eGFR
  ] ; # 
  fhir:subject [
     fhir:l <http://hl7.org/fhir/Patient/f201> ;
     fhir:reference [ fhir:v "Patient/f201" ] ;
     fhir:display [ fhir:v "Roel" ]
  ] ; # 
  fhir:issued [ fhir:v "2013-04-04T14:34:00+01:00"^^xsd:dateTime] ; # 
  fhir:performer ( [
     fhir:l <http://hl7.org/fhir/Practitioner/f202> ;
     fhir:reference [ fhir:v "Practitioner/f202" ] ;
     fhir:display [ fhir:v "Luigi Maas" ]
  ] ) ; # 
  fhir:interpretation ( [
     fhir:text [ fhir:v "interpretation of results should be assigned based upon the level of kindey function" ]
  ] ) ; # no value element since have only component values and unable to interpret results needs clinical interpretation
  fhir:note ( [
     fhir:text [ fhir:v "GFR estimating equations developed by the Modification of Diet in Renal Disease (MDRD) Study Group and the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI)...." ]
  ] ) ; # 
  fhir:method [
     a sct:702668005 ;
     fhir:coding ( [
       fhir:system [
         fhir:v "http://snomed.info/sct"^^xsd:anyURI ;
         fhir:l <http://snomed.info/sct>
       ] ;
       fhir:code [ fhir:v "702668005" ] ;
       fhir:display [ fhir:v "MDRD" ]
     ] ) # Method was MDRD
  ] ; # The observation is complete, No reliability concerns
  fhir:component ( [
     fhir:code [
       a loinc:48643-1 ;
       fhir:coding ( [
         fhir:system [
           fhir:v "http://loinc.org"^^xsd:anyURI ;
           fhir:l <http://loinc.org>
         ] ;
         fhir:code [ fhir:v "48643-1" ] ;
         fhir:display [ fhir:v "Glomerular filtration rate [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (MDRD)/1.73 sq M among black population" ]
       ] ) # Kind of observation = eGFR for AA
     ] ;
     fhir:value [
       a fhir:Quantity ;
       fhir:value [ fhir:v "60"^^xsd:decimal ] ; # eGFR=54mL\/min\/1.73m2
       fhir:comparator [ fhir:v ">" ] ;
       fhir:unit [ fhir:v "mL/min/1.73m2" ] ;
       fhir:system [
         fhir:v "http://unitsofmeasure.org"^^xsd:anyURI ;
         fhir:l <http://unitsofmeasure.org>
       ] ;
       fhir:code [ fhir:v "mL/min/{1.73_m2}" ]
     ] ;
     fhir:referenceRange ( [
       fhir:low [
         fhir:value [ fhir:v "60"^^xsd:decimal ] ;
         fhir:unit [ fhir:v "mL/min/1.73m2" ] ;
         fhir:system [
           fhir:v "http://unitsofmeasure.org"^^xsd:anyURI ;
           fhir:l <http://unitsofmeasure.org>
         ] ;
         fhir:code [ fhir:v "mL/min/{1.73_m2}" ]
       ] ;
       fhir:appliesTo ( [
         fhir:text [ fhir:v "non-black/african-american" ]
       ] ) ;
       fhir:age [
         fhir:low [
           fhir:value [ fhir:v "18"^^xsd:decimal ] ;
           fhir:unit [ fhir:v "yrs" ] ;
           fhir:system [
             fhir:v "http://unitsofmeasure.org"^^xsd:anyURI ;
             fhir:l <http://unitsofmeasure.org>
           ] ;
           fhir:code [ fhir:v "a" ]
         ]
       ]
     ] )
  ] [
     fhir:code [
       a loinc:48642-3 ;
       fhir:coding ( [
         fhir:system [
           fhir:v "http://loinc.org"^^xsd:anyURI ;
           fhir:l <http://loinc.org>
         ] ;
         fhir:code [ fhir:v "48642-3" ] ;
         fhir:display [ fhir:v "GFR/BSA pr.non blk SerPlBld MDRD-ArV" ]
       ] ) # Kind of observation = eGFR for non AA
     ] ;
     fhir:value [
       a fhir:Quantity ;
       fhir:value [ fhir:v "60"^^xsd:decimal ] ; # eGFR=54mL\/min\/1.73m2
       fhir:unit [ fhir:v "mL/min/1.73m2" ] ;
       fhir:system [
         fhir:v "http://unitsofmeasure.org"^^xsd:anyURI ;
         fhir:l <http://unitsofmeasure.org>
       ] ;
       fhir:code [ fhir:v "mL/min/{1.73_m2}" ]
     ] ;
     fhir:referenceRange ( [
       fhir:low [
         fhir:value [ fhir:v "60"^^xsd:decimal ] ;
         fhir:unit [ fhir:v "mL/min/1.73m2" ] ;
         fhir:system [
           fhir:v "http://unitsofmeasure.org"^^xsd:anyURI ;
           fhir:l <http://unitsofmeasure.org>
         ] ;
         fhir:code [ fhir:v "mL/min/{1.73_m2}" ]
       ] ;
       fhir:age [
         fhir:low [
           fhir:value [ fhir:v "18"^^xsd:decimal ] ;
           fhir:unit [ fhir:v "yrs" ] ;
           fhir:system [
             fhir:v "http://unitsofmeasure.org"^^xsd:anyURI ;
             fhir:l <http://unitsofmeasure.org>
           ] ;
           fhir:code [ fhir:v "a" ]
         ]
       ]
     ] )
  ] ) . # The MDRD equation does require race (African American or non-African American), which also might not be readily available. For this reason, eGFR values for both African Americans and non-African Americans are reported. so use component elements here

<http://hl7.org/fhir/Patient/f201> a fhir:Patient .

<http://hl7.org/fhir/Practitioner/f202> a fhir:Practitioner .

# -------------------------------------------------------------------------------------

