@prefix fhir: <http://hl7.org/fhir/> .
@prefix owl: <http://www.w3.org/2002/07/owl#> .
@prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

# - resource -------------------------------------------------------------------

# Example: Human HER2/ErbB2 — the target protein of Trastuzumab.
#     This example demonstrates a target substance that can be referenced
#     by another SubstanceDefinition's .relationship.substanceDefinition.

<http://hl7.org/fhir/SubstanceDefinition/her2> a fhir:SubstanceDefinition ;
  fhir:nodeRole fhir:treeRoot ;
  fhir:id [ fhir:v "her2"] ; # 
  fhir:identifier ( [
     fhir:system [
       fhir:v "https://www.uniprot.org"^^xsd:anyURI ;
       fhir:l <https://www.uniprot.org>
     ] ;
     fhir:value [ fhir:v "P04626" ]
  ] ) ; # 
  fhir:status [
     fhir:coding ( [
       fhir:system [
         fhir:v "http://hl7.org/fhir/publication-status"^^xsd:anyURI ;
         fhir:l <http://hl7.org/fhir/publication-status>
       ] ;
       fhir:code [ fhir:v "active" ] ;
       fhir:display [ fhir:v "Active" ]
     ] )
  ] ; # 
  fhir:classification ( [
     fhir:coding ( [
       fhir:system [
         fhir:v "http://example.europa.eu/fhir/SubstanceType"^^xsd:anyURI ;
         fhir:l <http://example.europa.eu/fhir/SubstanceType>
       ] ;
       fhir:code [ fhir:v "protein" ] ;
       fhir:display [ fhir:v "Protein" ]
     ] )
  ] ) ; # 
  fhir:domain [
     fhir:coding ( [
       fhir:system [
         fhir:v "http://example.europa.eu/fhir/Domain"^^xsd:anyURI ;
         fhir:l <http://example.europa.eu/fhir/Domain>
       ] ;
       fhir:code [ fhir:v "human" ] ;
       fhir:display [ fhir:v "Human use" ]
     ] )
  ] ; # 
  fhir:description [ fhir:v "Human HER2 (ErbB2, receptor tyrosine-protein kinase erbB-2). A transmembrane receptor of the EGFR family, frequently overexpressed in breast and gastric cancers. The molecular target of trastuzumab and other HER2-directed therapies."] ; # 
  fhir:code ( [
     fhir:code [
       fhir:coding ( [
         fhir:system [
           fhir:v "https://www.uniprot.org"^^xsd:anyURI ;
           fhir:l <https://www.uniprot.org>
         ] ;
         fhir:code [ fhir:v "P04626" ] ;
         fhir:display [ fhir:v "ERBB2_HUMAN" ]
       ] )
     ]
  ] ) ; # 
  fhir:name ( [
     fhir:name [ fhir:v "Receptor tyrosine-protein kinase erbB-2" ] ;
     fhir:preferred [ fhir:v true ] ;
     fhir:language ( [
       fhir:coding ( [
         fhir:system [
           fhir:v "urn:ietf:bcp:47"^^xsd:anyURI ;
           fhir:l <urn:ietf:bcp:47>
         ] ;
         fhir:code [ fhir:v "en" ] ;
         fhir:display [ fhir:v "English" ]
       ] )
     ] )
  ] [
     fhir:name [ fhir:v "HER2" ] ;
     fhir:preferred [ fhir:v false ]
  ] [
     fhir:name [ fhir:v "ErbB-2" ] ;
     fhir:preferred [ fhir:v false ]
  ] [
     fhir:name [ fhir:v "CD340" ] ;
     fhir:preferred [ fhir:v false ]
  ] ) ; # 
  fhir:protein [
     fhir:sequenceType [
       fhir:coding ( [
         fhir:system [
           fhir:v "http://hl7.org/fhir/substance-sequence-type"^^xsd:anyURI ;
           fhir:l <http://hl7.org/fhir/substance-sequence-type>
         ] ;
         fhir:code [ fhir:v "complete" ] ;
         fhir:display [ fhir:v "Complete" ]
       ] )
     ] ;
     fhir:numberOfSubunits [ fhir:v 1 ] ;
     fhir:subunit ( [
       fhir:subunit [ fhir:v 1 ] ;
       fhir:length [ fhir:v 1255 ]
     ] ) ;
     fhir:gene ( [
       fhir:sequenceOrigin [
         fhir:coding ( [
           fhir:system [
             fhir:v "http://hl7.org/fhir/gene-sequence-origin"^^xsd:anyURI ;
             fhir:l <http://hl7.org/fhir/gene-sequence-origin>
           ] ;
           fhir:code [ fhir:v "human" ] ;
           fhir:display [ fhir:v "Human" ]
         ] )
       ] ;
       fhir:gene [
         fhir:concept [
           fhir:coding ( [
             fhir:system [
               fhir:v "http://www.genenames.org"^^xsd:anyURI ;
               fhir:l <http://www.genenames.org>
             ] ;
             fhir:code [ fhir:v "ERBB2" ] ;
             fhir:display [ fhir:v "Erb-B2 receptor tyrosine kinase 2" ]
           ] )
         ]
       ]
     ] )
  ] . # 

# -------------------------------------------------------------------------------------

