@prefix fhir: <http://hl7.org/fhir/> .
@prefix owl: <http://www.w3.org/2002/07/owl#> .
@prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

# - resource -------------------------------------------------------------------

<http://hl7.org/fhir/Evidence/example-stroke-3-4half-alteplase-vs-no-alteplase-mRS0-2> a fhir:Evidence ;
  fhir:nodeRole fhir:treeRoot ;
  fhir:id [ fhir:v "example-stroke-3-4half-alteplase-vs-no-alteplase-mRS0-2"] ; # 
  fhir:text [
     fhir:status [ fhir:v "generated" ] ;
     fhir:div [ fhir:v "<div xmlns=\"http://www.w3.org/1999/xhtml\">\n      \n      <p>\n        \"Effect of Alteplase vs No alteplase on mRS 0-2 at 90 days in Stroke 3-4.5 hours prior\" is a comparative effect estimate.\n      </p>\n	\n    </div>"^^rdf:XMLLiteral ]
  ] ; # 
  fhir:extension ( [
     fhir:url [
       fhir:v "http://hl7.org/fhir/StructureDefinition/structuredefinition-wg"^^xsd:anyURI ;
       fhir:l <http://hl7.org/fhir/StructureDefinition/structuredefinition-wg>
     ] ;
     fhir:value [
       a fhir:Code ;
       fhir:v "cds"
     ]
  ] ) ; # 
  fhir:url [
     fhir:v "http://hl7.org/fhir/Evidence/example-stroke-3-4half-alteplase-vs-no-alteplase-mRS0-2"^^xsd:anyURI ;
     fhir:l <http://hl7.org/fhir/Evidence/example-stroke-3-4half-alteplase-vs-no-alteplase-mRS0-2>
  ] ; # 
  fhir:identifier ( [
     fhir:system [
       fhir:v "urn:ietf:rfc:3986"^^xsd:anyURI ;
       fhir:l <urn:ietf:rfc:3986>
     ] ;
     fhir:value [ fhir:v "urn:oid:2.16.840.1.113883.4.642.10.3" ]
  ] ) ; # 
  fhir:name [ fhir:v "EffectOfAlteplaseVsNoAlteplaseOnMRS02At90DaysInStroke345HoursPrior"] ; # 
  fhir:title [ fhir:v "Effect of Alteplase vs No alteplase on mRS 0-2 at 90 days in Stroke 3-4.5 hours prior"] ; # 
  fhir:status [ fhir:v "draft"] ; # 
  fhir:publisher [ fhir:v "HL7 International / Clinical Decision Support"] ; # 
  fhir:contact ( [
     fhir:telecom ( [
       fhir:system [ fhir:v "url" ] ;
       fhir:value [ fhir:v "http://www.hl7.org/Special/committees/dss" ]
     ] )
  ] ) ; # 
  fhir:relatesTo ( [
     fhir:type [
       fhir:coding ( [
         fhir:system [
           fhir:v "http://terminology.hl7.org/CodeSystem/artifact-relationship-type"^^xsd:anyURI ;
           fhir:l <http://terminology.hl7.org/CodeSystem/artifact-relationship-type>
         ] ;
         fhir:code [ fhir:v "cites" ] ;
         fhir:display [ fhir:v "Cites" ]
       ] )
     ] ;
     fhir:target [
       a fhir:Markdown ;
       fhir:v "Figure 2 Lees 2016 <b>Citation:</b> Lees KR, Emberson J, Blackwell L, Bluhmki E, Davis SM, Donnan GA, et al; Stroke Thrombolysis Trialists’ Collaborators Group. Effects of alteplase for acute stroke on the distribution of functional outcomes: a pooled analysis of 9 trials. Stroke. 2016;47:2373-2379. PMID 27507856 <b>URL:</b> https://doi.org/10.1161/STROKEAHA.116.013644"
     ]
  ] ) ; # 
  fhir:description [ fhir:v "mRS 0-2 at 90 days Odds Ratio 1.2 for Alteplase vs. No Alteplase in patients with acute ischemic stroke 3-4.5 hours prior"] ; # 
  fhir:variableDefinition ( [
     fhir:variableRole [ fhir:v "population" ] ;
     fhir:observed [
       fhir:l <http://hl7.org/fhir/EvidenceVariable/Stroke-Thrombolysis-Trialists-2014-2016-IPD-MA-Cohort> ;
       fhir:reference [ fhir:v "EvidenceVariable/Stroke-Thrombolysis-Trialists-2014-2016-IPD-MA-Cohort" ] ;
       fhir:type [
         fhir:v "EvidenceVariable"^^xsd:anyURI ;
         fhir:l fhir:EvidenceVariable
       ] ;
       fhir:display [ fhir:v "Stroke Thrombolysis Trialists’ 2014-2016 IPD-MA Cohort" ]
     ] ;
     fhir:intended [
       fhir:l <http://hl7.org/fhir/Group/AcuteIschemicStroke3-4halfHours> ;
       fhir:reference [ fhir:v "Group/AcuteIschemicStroke3-4halfHours" ] ;
       fhir:type [
         fhir:v "Group"^^xsd:anyURI ;
         fhir:l fhir:Group
       ] ;
       fhir:display [ fhir:v "stroke at 3-4.5 hours" ]
     ] ;
     fhir:directnessMatch [
       fhir:coding ( [
         fhir:system [
           fhir:v "http://terminology.hl7.org/CodeSystem/directness"^^xsd:anyURI ;
           fhir:l <http://terminology.hl7.org/CodeSystem/directness>
         ] ;
         fhir:code [ fhir:v "moderate" ] ;
         fhir:display [ fhir:v "Moderate quality match between observed and intended variable" ]
       ] )
     ]
  ] [
     fhir:variableRole [ fhir:v "outcome" ] ;
     fhir:observed [
       fhir:l <http://hl7.org/fhir/EvidenceVariable/example-mRS0-2-at-90days> ;
       fhir:reference [ fhir:v "EvidenceVariable/example-mRS0-2-at-90days" ] ;
       fhir:type [
         fhir:v "EvidenceVariable"^^xsd:anyURI ;
         fhir:l fhir:EvidenceVariable
       ] ;
       fhir:display [ fhir:v "mRS 0-2 at 90 days" ]
     ] ;
     fhir:intended [
       fhir:l <http://hl7.org/fhir/EvidenceVariable/example-alive-independent-90day> ;
       fhir:reference [ fhir:v "EvidenceVariable/example-alive-independent-90day" ] ;
       fhir:type [
         fhir:v "EvidenceVariable"^^xsd:anyURI ;
         fhir:l fhir:EvidenceVariable
       ] ;
       fhir:display [ fhir:v "Alive and not functionally dependent at 90 days" ]
     ]
  ] [
     fhir:variableRole [ fhir:v "exposure" ] ;
     fhir:comparatorCategory [ fhir:v "No Alteplase" ] ;
     fhir:observed [
       fhir:l <http://hl7.org/fhir/EvidenceVariable/example-group-assignment-alteplase-for-stroke-vs-no-alteplase> ;
       fhir:reference [ fhir:v "EvidenceVariable/example-group-assignment-alteplase-for-stroke-vs-no-alteplase" ] ;
       fhir:type [
         fhir:v "EvidenceVariable"^^xsd:anyURI ;
         fhir:l fhir:EvidenceVariable
       ] ;
       fhir:display [ fhir:v "Group Assignment: Alteplase for Stroke vs No Alteplase" ]
     ]
  ] ) ; # 
  fhir:synthesisType ( [
     fhir:coding ( [
       fhir:system [
         fhir:v "http://terminology.hl7.org/CodeSystem/synthesis-type"^^xsd:anyURI ;
         fhir:l <http://terminology.hl7.org/CodeSystem/synthesis-type>
       ] ;
       fhir:code [ fhir:v "IPD-MA" ] ;
       fhir:display [ fhir:v "individual patient data meta-analysis" ]
     ] )
  ] ) ; # 
  fhir:studyDesign ( [
     fhir:coding ( [
       fhir:system [
         fhir:v "https://fevir.net/sevco"^^xsd:anyURI ;
         fhir:l <https://fevir.net/sevco>
       ] ;
       fhir:code [ fhir:v "SEVCO:01003" ] ;
       fhir:display [ fhir:v "randomized assignment" ]
     ] )
  ] ) ; # 
  fhir:statistic ( [
     fhir:statisticType [
       fhir:coding ( [
         fhir:system [
           fhir:v "https://fevir.net/sevco"^^xsd:anyURI ;
           fhir:l <https://fevir.net/sevco>
         ] ;
         fhir:code [ fhir:v "STATO:0000182" ] ;
         fhir:display [ fhir:v "odds ratio" ]
       ] )
     ] ;
     fhir:quantity [
       fhir:value [ fhir:v 1.2 ]
     ] ;
     fhir:sampleSize [
       fhir:numberOfStudies [ fhir:v "9"^^xsd:nonNegativeInteger ]
     ] ;
     fhir:attributeEstimate ( [
       fhir:description [ fhir:v "95% CI 1.06 to 1.3" ] ;
       fhir:type [
         fhir:coding ( [
           fhir:system [
             fhir:v "http://terminology.hl7.org/CodeSystem/attribute-estimate-type"^^xsd:anyURI ;
             fhir:l <http://terminology.hl7.org/CodeSystem/attribute-estimate-type>
           ] ;
           fhir:code [ fhir:v "C53324" ] ;
           fhir:display [ fhir:v "Confidence interval" ]
         ] )
       ] ;
       fhir:level [ fhir:v 0.95 ] ;
       fhir:range [
         fhir:low [
           fhir:value [ fhir:v 1.06 ]
         ] ;
         fhir:high [
           fhir:value [ fhir:v 1.3 ]
         ]
       ]
     ] )
  ] ) ; # 
  fhir:certainty ( [
     fhir:description [ fhir:v "Very low certainty due to risk of bias, inconsistency, imprecision, and indirectness" ] ;
     fhir:type [
       fhir:coding ( [
         fhir:system [
           fhir:v "http://terminology.hl7.org/CodeSystem/certainty-type"^^xsd:anyURI ;
           fhir:l <http://terminology.hl7.org/CodeSystem/certainty-type>
         ] ;
         fhir:code [ fhir:v "Overall" ] ;
         fhir:display [ fhir:v "Overall certainty" ]
       ] )
     ] ;
     fhir:rating [
       fhir:coding ( [
         fhir:system [
           fhir:v "http://terminology.hl7.org/CodeSystem/certainty-rating"^^xsd:anyURI ;
           fhir:l <http://terminology.hl7.org/CodeSystem/certainty-rating>
         ] ;
         fhir:code [ fhir:v "very-low" ] ;
         fhir:display [ fhir:v "Very low quality" ]
       ] )
     ] ;
     fhir:subcomponent ( [
       fhir:type [
         fhir:coding ( [
           fhir:system [
             fhir:v "http://terminology.hl7.org/CodeSystem/certainty-type"^^xsd:anyURI ;
             fhir:l <http://terminology.hl7.org/CodeSystem/certainty-type>
           ] ;
           fhir:code [ fhir:v "PublicationBias" ] ;
           fhir:display [ fhir:v "Publication bias" ]
         ] )
       ] ;
       fhir:rating [
         fhir:coding ( [
           fhir:system [
             fhir:v "http://terminology.hl7.org/CodeSystem/certainty-rating"^^xsd:anyURI ;
             fhir:l <http://terminology.hl7.org/CodeSystem/certainty-rating>
           ] ;
           fhir:code [ fhir:v "no-concern" ] ;
           fhir:display [ fhir:v "no serious concern" ]
         ] )
       ]
     ] [
       fhir:note ( [
         fhir:text [ fhir:v "IST-3 had inconsistent results and contributed large proportion of data" ]
       ] ) ;
       fhir:type [
         fhir:coding ( [
           fhir:system [
             fhir:v "http://terminology.hl7.org/CodeSystem/certainty-type"^^xsd:anyURI ;
             fhir:l <http://terminology.hl7.org/CodeSystem/certainty-type>
           ] ;
           fhir:code [ fhir:v "Inconsistency" ] ;
           fhir:display [ fhir:v "Inconsistency" ]
         ] )
       ] ;
       fhir:rating [
         fhir:coding ( [
           fhir:system [
             fhir:v "http://terminology.hl7.org/CodeSystem/certainty-rating"^^xsd:anyURI ;
             fhir:l <http://terminology.hl7.org/CodeSystem/certainty-rating>
           ] ;
           fhir:code [ fhir:v "serious-concern" ] ;
           fhir:display [ fhir:v "serious concern" ]
         ] )
       ]
     ] [
       fhir:note ( [
         fhir:text [ fhir:v "results derived from figure with limited data reported to support the specific effect estimate; derived odds ratio in figure does not match results from rates of mRS 0-2 reported in Supplementary Figure 3b" ]
       ] ) ;
       fhir:type [
         fhir:coding ( [
           fhir:system [
             fhir:v "http://terminology.hl7.org/CodeSystem/certainty-type"^^xsd:anyURI ;
             fhir:l <http://terminology.hl7.org/CodeSystem/certainty-type>
           ] ;
           fhir:code [ fhir:v "Imprecision" ] ;
           fhir:display [ fhir:v "Imprecision" ]
         ] )
       ] ;
       fhir:rating [
         fhir:coding ( [
           fhir:system [
             fhir:v "http://terminology.hl7.org/CodeSystem/certainty-rating"^^xsd:anyURI ;
             fhir:l <http://terminology.hl7.org/CodeSystem/certainty-rating>
           ] ;
           fhir:code [ fhir:v "serious-concern" ] ;
           fhir:display [ fhir:v "serious concern" ]
         ] )
       ]
     ] [
       fhir:note ( [
         fhir:text [ fhir:v "resuts derived for 3 - 4.5 hours assume data from 0 - 6 hours is informative" ]
       ] ) ;
       fhir:type [
         fhir:coding ( [
           fhir:system [
             fhir:v "http://terminology.hl7.org/CodeSystem/certainty-type"^^xsd:anyURI ;
             fhir:l <http://terminology.hl7.org/CodeSystem/certainty-type>
           ] ;
           fhir:code [ fhir:v "Indirectness" ] ;
           fhir:display [ fhir:v "Indirectness" ]
         ] )
       ] ;
       fhir:rating [
         fhir:coding ( [
           fhir:system [
             fhir:v "http://terminology.hl7.org/CodeSystem/certainty-rating"^^xsd:anyURI ;
             fhir:l <http://terminology.hl7.org/CodeSystem/certainty-rating>
           ] ;
           fhir:code [ fhir:v "serious-concern" ] ;
           fhir:display [ fhir:v "serious concern" ]
         ] )
       ]
     ] [
       fhir:note ( [
         fhir:text [ fhir:v "results largely influenced by IST-3 trial which was unblinded and ECASS III which had baseline imbalances" ]
       ] ) ;
       fhir:type [
         fhir:coding ( [
           fhir:system [
             fhir:v "http://terminology.hl7.org/CodeSystem/certainty-type"^^xsd:anyURI ;
             fhir:l <http://terminology.hl7.org/CodeSystem/certainty-type>
           ] ;
           fhir:code [ fhir:v "RiskOfBias" ] ;
           fhir:display [ fhir:v "Risk of bias" ]
         ] )
       ] ;
       fhir:rating [
         fhir:coding ( [
           fhir:system [
             fhir:v "http://terminology.hl7.org/CodeSystem/certainty-rating"^^xsd:anyURI ;
             fhir:l <http://terminology.hl7.org/CodeSystem/certainty-rating>
           ] ;
           fhir:code [ fhir:v "serious-concern" ] ;
           fhir:display [ fhir:v "serious concern" ]
         ] )
       ]
     ] )
  ] ) . # 

<http://hl7.org/fhir/EvidenceVariable/Stroke-Thrombolysis-Trialists-2014-2016-IPD-MA-Cohort> a fhir:EvidenceVariable .

<http://hl7.org/fhir/Group/AcuteIschemicStroke3-4halfHours> a fhir:Group .

<http://hl7.org/fhir/EvidenceVariable/example-mRS0-2-at-90days> a fhir:EvidenceVariable .

<http://hl7.org/fhir/EvidenceVariable/example-alive-independent-90day> a fhir:EvidenceVariable .

<http://hl7.org/fhir/EvidenceVariable/example-group-assignment-alteplase-for-stroke-vs-no-alteplase> a fhir:EvidenceVariable .

# -------------------------------------------------------------------------------------

