<?xml version="1.0" encoding="UTF-8"?><ActivityDefinition xmlns="http://hl7.org/fhir">
  <id value="example-alteplase-dosing"/>
  <meta>
    <security>
      <system value="http://terminology.hl7.org/CodeSystem/v3-ActReason"/>
      <code value="HTEST"/>
      <display value="test health data"/>
    </security>
  </meta>
  <text>
    <status value="generated"/><div xmlns="http://www.w3.org/1999/xhtml">
      
      <p>
        "Alteplase Dosing for Stroke" defines a dosing instruction referenced from an EvidenceVariable resource.
      </p>
	
    </div>
  </text>
  <extension url="http://hl7.org/fhir/StructureDefinition/structuredefinition-wg">
    <valueCode value="cds"/>
  </extension>
  <url value="http://example.org/fhir/ActivityDefinition/example-alteplase-dosing"/>
  <identifier>
    <system value="urn:ietf:rfc:3986"/>
    <value value="urn:oid:2.16.840.1.113883.4.642.19.3"/>
  </identifier>
  <name value="AlteplaseDosingForStroke"/>
  <title value="Alteplase Dosing for Stroke"/>
  <status value="draft"/>
  <publisher value="HL7 International / Clinical Decision Support"/>
  <contact>
    <telecom>
      <system value="url"/>
      <value value="http://www.hl7.org/Special/committees/dss"/>
    </telecom>
  </contact>
  <description value="Alteplase Dosing for Stroke"/>
  <kind value="MedicationRequest"/>
  <code>
    <coding>
      <system value="http://www.nlm.nih.gov/research/umls/rxnorm"/>
      <code value="1155608"/>
      <display value="alteplase injectable product"/>
    </coding>
  </code>
  <intent value="order"/>
  <dosageInstruction>
    <renderedInstruction value="give 10% of dose over 1 minute, give remaining 90% of dose over 1 hour"/>
    <step>
      <component>
        <text value="give 10% of dose over 1 minute"/>
        <route>
          <coding>
            <system value="http://snomed.info/sct"/>
            <code value="47625008"/>
            <display value="Intravenous use"/>
          </coding>
        </route>
        <doseAndRate>
          <type>
            <coding>
              <system value="http://terminology.hl7.org/CodeSystem/dose-rate-type"/>
              <code value="calculated"/>
              <display value="Calculated"/>
            </coding>
          </type>
          <doseQuantity>
            <value value="0.9"/>
            <system value="http://unitsofmeasure.org"/>
            <code value="mg/kg"/>
          </doseQuantity>
        </doseAndRate>
        <safety>
          <doseLimit>
            <valueQuantity>
              <value value="90"/>
              <system value="http://unitsofmeasure.org"/>
              <code value="mg"/>
            </valueQuantity>
            <scope value="administration"/>
          </doseLimit>
        </safety>
      </component>
    </step>
    <step>
      <component>
        <text value="give remaining 90% of dose over 1 hour"/>
        <route>
          <coding>
            <system value="http://snomed.info/sct"/>
            <code value="47625008"/>
            <display value="Intravenous use"/>
          </coding>
        </route>
        <doseAndRate>
          <type>
            <coding>
              <system value="http://terminology.hl7.org/CodeSystem/dose-rate-type"/>
              <code value="calculated"/>
              <display value="Calculated"/>
            </coding>
          </type>
          <doseQuantity>
            <value value="0.9"/>
            <system value="http://unitsofmeasure.org"/>
            <code value="mg/kg"/>
          </doseQuantity>
        </doseAndRate>
        <safety>
          <doseLimit>
            <valueQuantity>
              <value value="90"/>
              <system value="http://unitsofmeasure.org"/>
              <code value="mg"/>
            </valueQuantity>
            <scope value="administration"/>
          </doseLimit>
        </safety>
      </component>
    </step>
  </dosageInstruction>
</ActivityDefinition>