{
  "resourceType" : "SubstanceDefinition",
  "id" : "trastuzumab",
  "identifier" : [{
    "system" : "http://example.europa.eu/fhir/SMSId",
    "value" : "TRAS9123H"
  }],
  "status" : {
    "coding" : [{
      "system" : "http://hl7.org/fhir/publication-status",
      "code" : "active",
      "display" : "Active"
    }]
  },
  "classification" : [{
    "coding" : [{
      "system" : "http://example.europa.eu/fhir/SubstanceType",
      "code" : "protein",
      "display" : "Protein"
    }]
  }],
  "domain" : {
    "coding" : [{
      "system" : "http://example.europa.eu/fhir/Domain",
      "code" : "human",
      "display" : "Human use"
    }]
  },
  "description" : "Trastuzumab — humanised IgG1 monoclonal antibody targeting the human epidermal growth factor receptor 2 (HER2/ErbB2). Variable regions derived from murine antibody 4D5, grafted onto human IgG1 framework. Produced in Chinese hamster ovary (CHO) cells.",
  "code" : [{
    "code" : {
      "coding" : [{
        "system" : "http://example.europa.eu/fhir/Substance",
        "code" : "TRAS9123H"
      }]
    }
  }],
  "name" : [{
    "name" : "Trastuzumab",
    "preferred" : true,
    "language" : [{
      "coding" : [{
        "system" : "urn:ietf:bcp:47",
        "code" : "en",
        "display" : "English"
      }]
    }],
    "official" : [{
      "authority" : {
        "coding" : [{
          "system" : "http://hl7.org/fhir/substance-name-authority",
          "code" : "INN",
          "display" : "INN"
        }]
      },
      "status" : {
        "coding" : [{
          "system" : "http://hl7.org/fhir/publication-status",
          "code" : "active",
          "display" : "Active"
        }]
      }
    }]
  },
  {
    "name" : "Herceptin",
    "preferred" : false
  }],
  "protein" : {
    "sequenceType" : {
      "coding" : [{
        "system" : "http://hl7.org/fhir/substance-sequence-type",
        "code" : "complete",
        "display" : "Complete"
      }]
    },
    "numberOfSubunits" : 2,
    "disulfideLinkage" : ["HC22-HC96; HC144-HC200; HC222-LC214; HC228-HC228'; HC231-HC231'; HC265-HC325; HC371-HC429"],
    "subunit" : [{
      "subunit" : 1,
      "sequence" : "EVQLVESGGGLVQPGGSLRLSCAASGFNIKDTYIHWVRQAPGKGLEWVARIYPTNGYTRYADSVKGRFTISADTSKNTAYLQMNSLRAEDTAVYYCSRWGGDGFYAMDYWGQGTLVTVSS...",
      "length" : 450,
      "nTerminalModification" : {
        "concept" : {
          "coding" : [{
            "system" : "http://example.europa.eu/fhir/Modification",
            "code" : "pyroglutamate",
            "display" : "Pyroglutamic acid (pE)"
          }]
        }
      },
      "cTerminalModification" : {
        "concept" : {
          "coding" : [{
            "system" : "http://example.europa.eu/fhir/Modification",
            "code" : "lysine-clipped",
            "display" : "C-terminal lysine clipping"
          }]
        }
      }
    },
    {
      "subunit" : 2,
      "sequence" : "DIQMTQSPSSLSASVGDRVTITCRASQDVNTAVAWYQQKPGKAPKLLIYSASFLYSGVPSRFSGSRSGTDFTLTISSLQPEDFATYYCQQHYTTPPTFGQGTKVEIK...",
      "length" : 214
    }],
    "gene" : [{
      "sequenceOrigin" : {
        "coding" : [{
          "system" : "http://hl7.org/fhir/gene-sequence-origin",
          "code" : "humanised-mouse",
          "display" : "Humanised mouse"
        }]
      },
      "gene" : {
        "concept" : {
          "coding" : [{
            "system" : "http://www.genenames.org",
            "code" : "IGHG1",
            "display" : "Immunoglobulin heavy constant gamma 1"
          }]
        }
      }
    }]
  },
  "relationship" : [{
    "substanceDefinitionReference" : {
      "reference" : "SubstanceDefinition/her2",
      "display" : "Receptor tyrosine-protein kinase erbB-2 (HER2)"
    },
    "type" : {
      "coding" : [{
        "system" : "http://hl7.org/fhir/substance-relationship-type",
        "code" : "TherapeuticTarget",
        "display" : "Therapeutic target"
      }]
    },
    "interaction" : {
      "coding" : [{
        "system" : "http://hl7.org/fhir/substance-interaction-type",
        "code" : "binding",
        "display" : "Binding"
      }]
    },
    "measurementType" : {
      "coding" : [{
        "system" : "http://hl7.org/fhir/substance-measurement-type",
        "code" : "kd",
        "display" : "Kd"
      }]
    },
    "amountQuantity" : {
      "value" : 0.1,
      "unit" : "nM",
      "system" : "http://unitsofmeasure.org",
      "code" : "nmol/L"
    }
  }]
}