{
  "resourceType" : "SubstanceDefinition",
  "id" : "her2",
  "identifier" : [{
    "system" : "https://www.uniprot.org",
    "value" : "P04626"
  }],
  "status" : {
    "coding" : [{
      "system" : "http://hl7.org/fhir/publication-status",
      "code" : "active",
      "display" : "Active"
    }]
  },
  "classification" : [{
    "coding" : [{
      "system" : "http://example.europa.eu/fhir/SubstanceType",
      "code" : "protein",
      "display" : "Protein"
    }]
  }],
  "domain" : {
    "coding" : [{
      "system" : "http://example.europa.eu/fhir/Domain",
      "code" : "human",
      "display" : "Human use"
    }]
  },
  "description" : "Human HER2 (ErbB2, receptor tyrosine-protein kinase erbB-2). A transmembrane receptor of the EGFR family, frequently overexpressed in breast and gastric cancers. The molecular target of trastuzumab and other HER2-directed therapies.",
  "code" : [{
    "code" : {
      "coding" : [{
        "system" : "https://www.uniprot.org",
        "code" : "P04626",
        "display" : "ERBB2_HUMAN"
      }]
    }
  }],
  "name" : [{
    "name" : "Receptor tyrosine-protein kinase erbB-2",
    "preferred" : true,
    "language" : [{
      "coding" : [{
        "system" : "urn:ietf:bcp:47",
        "code" : "en",
        "display" : "English"
      }]
    }]
  },
  {
    "name" : "HER2",
    "preferred" : false
  },
  {
    "name" : "ErbB-2",
    "preferred" : false
  },
  {
    "name" : "CD340",
    "preferred" : false
  }],
  "protein" : {
    "sequenceType" : {
      "coding" : [{
        "system" : "http://hl7.org/fhir/substance-sequence-type",
        "code" : "complete",
        "display" : "Complete"
      }]
    },
    "numberOfSubunits" : 1,
    "subunit" : [{
      "subunit" : 1,
      "length" : 1255
    }],
    "gene" : [{
      "sequenceOrigin" : {
        "coding" : [{
          "system" : "http://hl7.org/fhir/gene-sequence-origin",
          "code" : "human",
          "display" : "Human"
        }]
      },
      "gene" : {
        "concept" : {
          "coding" : [{
            "system" : "http://www.genenames.org",
            "code" : "ERBB2",
            "display" : "Erb-B2 receptor tyrosine kinase 2"
          }]
        }
      }
    }]
  }
}