<SubstanceDefinition xmlns="http://hl7.org/fhir"><id value="her2"/><identifier><system value="https://www.uniprot.org"/><value value="P04626"/></identifier><status><coding><system value="http://hl7.org/fhir/publication-status"/><code value="active"/><display value="Active"/></coding></status><classification><coding><system value="http://example.europa.eu/fhir/SubstanceType"/><code value="protein"/><display value="Protein"/></coding></classification><domain><coding><system value="http://example.europa.eu/fhir/Domain"/><code value="human"/><display value="Human use"/></coding></domain><description value="Human HER2 (ErbB2, receptor tyrosine-protein kinase erbB-2). A transmembrane receptor of the EGFR family, frequently overexpressed in breast and gastric cancers. The molecular target of trastuzumab and other HER2-directed therapies."/><code><code><coding><system value="https://www.uniprot.org"/><code value="P04626"/><display value="ERBB2_HUMAN"/></coding></code></code><name><name value="Receptor tyrosine-protein kinase erbB-2"/><preferred value="true"/><language><coding><system value="urn:ietf:bcp:47"/><code value="en"/><display value="English"/></coding></language></name><name><name value="HER2"/><preferred value="false"/></name><name><name value="ErbB-2"/><preferred value="false"/></name><name><name value="CD340"/><preferred value="false"/></name><protein><sequenceType><coding><system value="http://hl7.org/fhir/substance-sequence-type"/><code value="complete"/><display value="Complete"/></coding></sequenceType><numberOfSubunits value="1"/><subunit><subunit value="1"/><length value="1255"/></subunit><gene><sequenceOrigin><coding><system value="http://hl7.org/fhir/gene-sequence-origin"/><code value="human"/><display value="Human"/></coding></sequenceOrigin><gene><concept><coding><system value="http://www.genenames.org"/><code value="ERBB2"/><display value="Erb-B2 receptor tyrosine kinase 2"/></coding></concept></gene></gene></protein></SubstanceDefinition>