<?xml version="1.0" encoding="UTF-8"?>

  <!-- Example: D&C Yellow No. 10 Aluminum Lake — a pharmaceutical colorant
     used as an excipient in tablet coatings. A real mixture substance from
     GSRS (FDA Global Substance Registration System; UNII CQ3XH3DET6,
     UUID 820db676-383b-4c64-b693-671cd181a136).

     Demonstrates one way to model a substance mixture in FHIR
     SubstanceDefinition. The mixture references its component substances via
     .relationship with type=Component. In real-world use the components
     would typically be standalone SubstanceDefinition resources referenced
     by URL; here they are inlined as contained resources purely for example
     convenience, so the file is self-contained. -->
<SubstanceDefinition xmlns="http://hl7.org/fhir">
  <id value="dc-yellow-10-al-lake"/>
  <contained>
    <SubstanceDefinition>
      <id value="comp-quinoline-6-sulfonate"/>
      <classification>
        <coding>
          <system value="http://example.europa.eu/fhir/SubstanceType"/>
          <code value="chemical"/>
          <display value="Chemical"/>
        </coding>
      </classification>
      <name>
        <name value="Aluminum 2-(1,3-dioxo-2,3-dihydro-1H-inden-2-yl)quinoline-6-sulfonate"/>
        <preferred value="true"/>
      </name>
    </SubstanceDefinition>
  </contained>
  <contained>
    <SubstanceDefinition>
      <id value="comp-quinoline-8-sulfonate"/>
      <classification>
        <coding>
          <system value="http://example.europa.eu/fhir/SubstanceType"/>
          <code value="chemical"/>
          <display value="Chemical"/>
        </coding>
      </classification>
      <name>
        <name value="Aluminum 2-(1,3-dioxo-2,3-dihydro-1H-inden-2-yl)quinoline-8-sulfonate"/>
        <preferred value="true"/>
      </name>
    </SubstanceDefinition>
  </contained>
  <contained>
    <SubstanceDefinition>
      <id value="comp-substrate"/>
      <classification>
        <coding>
          <system value="http://example.europa.eu/fhir/SubstanceType"/>
          <code value="chemical"/>
          <display value="Chemical"/>
        </coding>
      </classification>
      <name>
        <name value="Unspecified aluminum substrate"/>
        <preferred value="true"/>
      </name>
      <description value="The aluminum substrate onto which the dye is precipitated to form the lake. Unspecified in GSRS."/>
    </SubstanceDefinition>
  </contained>
  <identifier>
    <system value="http://fdasis.nlm.nih.gov"/>
    <value value="CQ3XH3DET6"/>
  </identifier>
  <status>
    <coding>
      <system value="http://hl7.org/fhir/publication-status"/>
      <code value="active"/>
      <display value="Active"/>
    </coding>
  </status>
  <classification>
    <coding>
      <system value="http://example.europa.eu/fhir/SubstanceType"/>
      <code value="mixture"/>
      <display value="Mixture"/>
    </coding>
  </classification>
  <domain>
    <coding>
      <system value="http://example.europa.eu/fhir/Domain"/>
      <code value="human"/>
      <display value="Human use"/>
    </coding>
  </domain>
  <description value="D&amp;C Yellow No. 10 Aluminum Lake — a pharmaceutical colorant produced by precipitating D&amp;C Yellow No. 10 (a mixture of the 6- and 8-sulfonate isomers of aluminum quinoline-2-yl-indanedione) onto an aluminum substrate. Used as an excipient (colourant) in solid oral dosage forms."/>
  <code>
    <code>
      <coding>
        <system value="http://fdasis.nlm.nih.gov"/>
        <code value="CQ3XH3DET6"/>
        <display value="D&amp;C YELLOW NO. 10 ALUMINUM LAKE"/>
      </coding>
    </code>
  </code>
  <name>
    <name value="D&amp;C Yellow No. 10 Aluminum Lake"/>
    <preferred value="true"/>
    <language>
      <coding>
        <system value="urn:ietf:bcp:47"/>
        <code value="en"/>
        <display value="English"/>
      </coding>
    </language>
  </name>
  <relationship>
    <substanceDefinitionReference>
      <reference value="#comp-quinoline-6-sulfonate"/>
      <display value="Aluminum quinoline-6-sulfonate isomer"/>
    </substanceDefinitionReference>
    <type>
      <coding>
        <system value="http://hl7.org/fhir/substance-relationship-type"/>
        <code value="Component"/>
        <display value="Component"/>
      </coding>
    </type>
  </relationship>
  <relationship>
    <substanceDefinitionReference>
      <reference value="#comp-quinoline-8-sulfonate"/>
      <display value="Aluminum quinoline-8-sulfonate isomer"/>
    </substanceDefinitionReference>
    <type>
      <coding>
        <system value="http://hl7.org/fhir/substance-relationship-type"/>
        <code value="Component"/>
        <display value="Component"/>
      </coding>
    </type>
  </relationship>
  <relationship>
    <substanceDefinitionReference>
      <reference value="#comp-substrate"/>
      <display value="Unspecified aluminum substrate"/>
    </substanceDefinitionReference>
    <type>
      <coding>
        <system value="http://hl7.org/fhir/substance-relationship-type"/>
        <code value="Component"/>
        <display value="Component"/>
      </coding>
    </type>
  </relationship>
</SubstanceDefinition>