<?xml version="1.0" encoding="UTF-8"?><ObservationDefinition xmlns="http://hl7.org/fhir">
  <id value="example-ck-panel"/>
  <meta>
    <security>
      <system value="http://terminology.hl7.org/CodeSystem/v3-ActReason"/>
      <code value="HTEST"/>
      <display value="test health data"/>
    </security>
  </meta>
  <extension url="http://hl7.org/fhir/StructureDefinition/structuredefinition-wg">
    <valueCode value="oo"/>
  </extension>
  <status value="active"/>
  <publisher value="HL7 International / Orders and Observations"/>
  <contact>
    <telecom>
      <system value="url"/>
      <value value="http://www.hl7.org/Special/committees/orders"/>
    </telecom>
  </contact>
  <category>
    <coding>
      <system value="http://terminology.hl7.org/CodeSystem/observation-category"/>
      <code value="laboratory"/>
      <display value="Laboratory"/>
    </coding>
  </category>
  <code>
    <coding>
      <system value="http://loinc.org"/>
      <code value="32673-6"/>
      <display value="Creatine kinase.MB [Enzymatic activity/volume] in Serum or Plasma"/>
    </coding>
    <text value="Creatine Kinase Panel"/>
  </code>
  <permittedDataType value="Quantity"/>
  <multipleResultsAllowed value="true"/>
  <!-- <method>
    <coding>
      <system value="http://snomed.info/sct"/>
      <code value="258066000"/>
      <display value="Enzymatic measurement"/>
    </coding>
  </method> -->
  <preferredReportName value="Creatine Kinase, MB and Relative Percent"/>
  <!-- Panel-level qualified value for cardiac assessment -->
  <qualifiedValue>
    <condition/>
    <context>
      <coding>
        <system value="http://terminology.hl7.org/CodeSystem/referencerange-meaning"/>
        <code value="normal"/>
        <display value="Normal Range"/>
      </coding>
    </context>
    <rangeCategory value="reference"/>
    <validCodedValueSet/>
  </qualifiedValue>
  <!-- Component 1: Total Creatine Kinase -->
  <component>
    <code>
      <coding>
        <system value="http://loinc.org"/>
        <code value="2157-6"/>
        <display value="Creatine kinase [Enzymatic activity/volume] in Serum or Plasma"/>
      </coding>
      <text value="Creatine Kinase, Total"/>
    </code>
    <permittedDataType value="Quantity"/>
    <permittedUnit>
      <system value="http://unitsofmeasure.org"/>
      <code value="U/L"/>
      <display value="U/L"/>
    </permittedUnit>
    <qualifiedValue>
      <condition/>
      <context>
        <coding>
          <system value="http://terminology.hl7.org/CodeSystem/referencerange-meaning"/>
          <code value="normal"/>
          <display value="Normal Range"/>
        </coding>
      </context>
      <rangeCategory value="reference"/>
      <range>
        <low>
          <value value="39"/>
          <unit value="U/L"/>
          <system value="http://unitsofmeasure.org"/>
          <code value="U/L"/>
        </low>
        <high>
          <value value="308"/>
          <unit value="U/L"/>
          <system value="http://unitsofmeasure.org"/>
          <code value="U/L"/>
        </high>
      </range>
    </qualifiedValue>
  </component>
  <!-- Component 2: CK-MB Isoenzyme -->
  <component>
    <code>
      <coding>
        <system value="http://loinc.org"/>
        <code value="13969-1"/>
        <display value="Creatine kinase.MB [Mass/volume] in Serum or Plasma"/>
      </coding>
      <text value="Creatine Kinase, Isoenzyme MB"/>
    </code>
    <permittedDataType value="Quantity"/>
    <permittedUnit>
      <system value="http://unitsofmeasure.org"/>
      <code value="ng/mL"/>
      <display value="ng/mL"/>
    </permittedUnit>
    <qualifiedValue>
      <condition/>
      <context>
        <coding>
          <system value="http://terminology.hl7.org/CodeSystem/referencerange-meaning"/>
          <code value="normal"/>
          <display value="Normal Range"/>
        </coding>
      </context>
      <rangeCategory value="reference"/>
      <range>
        <low>
          <value value="0.0"/>
          <unit value="ng/mL"/>
          <system value="http://unitsofmeasure.org"/>
          <code value="ng/mL"/>
        </low>
        <high>
          <value value="7.7"/>
          <unit value="ng/mL"/>
          <system value="http://unitsofmeasure.org"/>
          <code value="ng/mL"/>
        </high>
      </range>
    </qualifiedValue>
  </component>
  <!-- Component 3: CK-MB Relative Percent -->
  <component>
    <code>
      <coding>
        <system value="http://loinc.org"/>
        <code value="20569-0"/>
        <display value="Creatine kinase.MB/Creatine kinase.total in Serum or Plasma"/>
      </coding>
      <text value="CK-MB Relative Percent"/>
    </code>
    <permittedDataType value="Quantity"/>
    <permittedUnit>
      <system value="http://unitsofmeasure.org"/>
      <code value="%"/>
      <display value="%"/>
    </permittedUnit>
    <qualifiedValue>
      <condition/>
      <context>
        <coding>
          <system value="http://terminology.hl7.org/CodeSystem/referencerange-meaning"/>
          <code value="normal"/>
          <display value="Normal Range"/>
        </coding>
      </context>
      <rangeCategory value="reference"/>
      <range>
        <low>
          <value value="0.0"/>
          <unit value="%"/>
          <system value="http://unitsofmeasure.org"/>
          <code value="%"/>
        </low>
        <high>
          <value value="5.0"/>
          <unit value="%"/>
          <system value="http://unitsofmeasure.org"/>
          <code value="%"/>
        </high>
      </range>
    </qualifiedValue>
  </component>
</ObservationDefinition>