FHIR CI-Build
FoundationThis is the Continuous Integration Build of FHIR (will be incorrect/inconsistent at times).
See the Directory of published versions
| Responsible Owner: Biomedical Research and Regulation Work Group | Standards Status: Informative | Compartments: No defined compartments |
ShEx statement for substancedefinition
PREFIX fhir: <http://hl7.org/fhir/>
PREFIX fhirvs: <http://hl7.org/fhir/ValueSet/>
PREFIX xsd: <http://www.w3.org/2001/XMLSchema#>
PREFIX rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#>
# ShEx Version 2.2
IMPORT <Date.shex>
IMPORT <Range.shex>
IMPORT <Ratio.shex>
IMPORT <String.shex>
IMPORT <Boolean.shex>
IMPORT <Integer.shex>
IMPORT <DateTime.shex>
IMPORT <Markdown.shex>
IMPORT <Quantity.shex>
IMPORT <Reference.shex>
IMPORT <Annotation.shex>
IMPORT <Attachment.shex>
IMPORT <Identifier.shex>
IMPORT <Organization.shex>
IMPORT <DomainResource.shex>
IMPORT <BackboneElement.shex>
IMPORT <CodeableConcept.shex>
IMPORT <CodeableReference.shex>
IMPORT <DocumentReference.shex>
start=@<SubstanceDefinition> AND {fhir:nodeRole [fhir:treeRoot]}
# The detailed description of a substance, typically at a level beyond what is used for prescribing
<SubstanceDefinition> EXTENDS @<DomainResource> CLOSED {
a [fhir:SubstanceDefinition]?;fhir:nodeRole [fhir:treeRoot]?;
fhir:identifier @<OneOrMore_Identifier>?; # Identifier by which this substance
# is known
fhir:version @<String>?; # A business level edition or
# revision identifier
fhir:status @<CodeableConcept>?; # Status of substance within the
# catalogue e.g. active, retired
fhir:classification @<OneOrMore_CodeableConcept>?; # A categorization, high level e.g.
# polymer or nucleic acid, or food,
# chemical, biological, or lower
# e.g. polymer linear or branch
# chain, or type of impurity
fhir:domain @<CodeableConcept>?; # The applicable usage of the
# substance, as an example human or
# veterinary
fhir:grade @<OneOrMore_CodeableConcept>?; # The quality standard, established
# benchmark, to which substance
# complies (e.g. USP/NF, BP)
fhir:description @<Markdown>?; # Textual description of the
# substance
fhir:note @<OneOrMore_Annotation>?; # Textual comment about the
# substance's catalogue or registry
# record
fhir:manufacturer @<OneOrMore_Reference_Organization>?; # The entity that creates, makes,
# produces or fabricates the
# substance
fhir:supplier @<OneOrMore_Reference_Organization>?; # An entity that is the source for
# the substance. It may be different
# from the manufacturer
fhir:moiety @<OneOrMore_SubstanceDefinition.moiety>?; # Moiety, for structural
# modifications
fhir:characterization @<OneOrMore_SubstanceDefinition.characterization>?; # General specifications for this
# substance
fhir:property @<OneOrMore_SubstanceDefinition.property>?; # General specifications for this
# substance
fhir:molecularWeight @<OneOrMore_SubstanceDefinition.molecularWeight>?; # The average mass of a molecule of
# a compound
fhir:structure @<SubstanceDefinition.structure>?; # Structural information
fhir:code @<OneOrMore_SubstanceDefinition.code>?; # Codes associated with the substance
fhir:name @<OneOrMore_SubstanceDefinition.name>?; # Names applicable to this substance
fhir:relationship @<OneOrMore_SubstanceDefinition.relationship>?; # A link between this substance and
# another
fhir:sourceMaterial @<SubstanceDefinition.sourceMaterial>?; # Material or taxonomic/anatomical
# source
fhir:nucleicAcid @<SubstanceDefinition.nucleicAcid>?; # Data items specific to nucleic
# acids
fhir:polymer @<SubstanceDefinition.polymer>?; # Data items specific to polymers
fhir:protein @<SubstanceDefinition.protein>?; # Data items specific to proteins
}
# Moiety, for structural modifications
<SubstanceDefinition.moiety> EXTENDS @<BackboneElement> CLOSED {
fhir:role @<CodeableConcept>?; # Role that the moiety is playing
fhir:identifier @<OneOrMore_Identifier>?; # Identifier by which this moiety
# substance is known
fhir:name @<String>?; # Textual name for this moiety
# substance
fhir:stereochemistry @<CodeableConcept>?; # Stereochemistry type
fhir:opticalActivity @<CodeableConcept>?; # Optical activity type
fhir:molecularFormula @<String>?; # Molecular formula for this moiety
# (e.g. with the Hill system)
fhir:amount @<Quantity> OR
@<String> ?; # Quantitative value for this moiety
fhir:measurementType @<CodeableConcept>?; # The measurement type of the
# quantitative value
}
# General specifications for this substance
<SubstanceDefinition.characterization> EXTENDS @<BackboneElement> CLOSED {
fhir:technique @<CodeableConcept>?; # The method used to find the
# characterization e.g. HPLC
fhir:form @<CodeableConcept>?; # Describes the nature of the
# chemical entity and explains, for
# instance, whether this is a base
# or a salt form
fhir:description @<Markdown>?; # The description or justification
# in support of the interpretation
# of the data file
fhir:file @<OneOrMore_Attachment>?; # The data produced by the
# analytical instrument or a
# pictorial representation of that
# data. Examples: a JCAMP, JDX, or
# ADX file, or a chromatogram or
# spectrum analysis
}
# General specifications for this substance
<SubstanceDefinition.property> EXTENDS @<BackboneElement> CLOSED {
fhir:type @<CodeableConcept>; # A code expressing the type of
# property
fhir:value @<CodeableConcept> OR
@<Quantity> OR
@<Range> OR
@<Date> OR
@<Boolean> OR
@<Attachment> ?; # A value for the property
}
# The average mass of a molecule of a compound
<SubstanceDefinition.molecularWeight> EXTENDS @<BackboneElement> CLOSED {
fhir:method @<CodeableConcept>?; # The method by which the weight was
# determined
fhir:type @<CodeableConcept>?; # Type of molecular weight e.g.
# exact, average, weight average
fhir:amount @<Quantity>; # Used to capture quantitative
# values for a variety of elements
}
# Structural information
<SubstanceDefinition.structure> EXTENDS @<BackboneElement> CLOSED {
fhir:stereochemistry @<CodeableConcept>?; # Stereochemistry type
fhir:opticalActivity @<CodeableConcept>?; # Optical activity type
fhir:molecularFormula @<String>?; # An expression which states the
# number and type of atoms present
# in a molecule of a substance
fhir:molecularFormulaByMoiety @<String>?; # Specified per moiety according to
# the Hill system
fhir:molecularWeight @<SubstanceDefinition.molecularWeight>?; # The molecular weight or weight
# range
fhir:technique @<OneOrMore_CodeableConcept>?; # The method used to find the
# structure e.g. X-ray, NMR
fhir:sourceDocument @<OneOrMore_Reference_DocumentReference>?; # Source of information for the
# structure
fhir:representation @<OneOrMore_SubstanceDefinition.structure.representation>?; # A depiction of the structure of
# the substance
}
# A depiction of the structure of the substance
<SubstanceDefinition.structure.representation> EXTENDS @<BackboneElement> CLOSED {
fhir:type @<CodeableConcept>?; # The kind of structural
# representation (e.g. full,
# partial)
fhir:representation @<String>?; # The structural representation as a
# text string in a standard format
fhir:format @<CodeableConcept>?; # The format of the representation
# e.g. InChI, SMILES, MOLFILE (note:
# not the physical file format)
fhir:document @<Reference> AND {fhir:l
@<DocumentReference> ? }?; # An attachment with the structural
# representation e.g. a structure
# graphic or AnIML file
}
# Codes associated with the substance
<SubstanceDefinition.code> EXTENDS @<BackboneElement> CLOSED {
fhir:code @<CodeableConcept>?; # The specific code
fhir:status @<CodeableConcept>?; # Status of the code assignment, for
# example 'provisional', 'approved'
fhir:statusDate @<DateTime>?; # The date at which the code status
# was changed
fhir:note @<OneOrMore_Annotation>?; # Any comment can be provided in
# this field
fhir:source @<OneOrMore_Reference_DocumentReference>?; # Supporting literature
}
# Names applicable to this substance
<SubstanceDefinition.name> EXTENDS @<BackboneElement> CLOSED {
fhir:name @<String>; # The actual name
fhir:type @<CodeableConcept>?; # Name type e.g. 'systematic',
# 'scientific, 'brand'
fhir:status @<CodeableConcept>?; # The status of the name e.g.
# 'current', 'proposed'
fhir:preferred @<Boolean>?; # If this is the preferred name for
# this substance
fhir:language @<OneOrMore_CodeableConcept>?; # Human language that the name is
# written in
fhir:domain @<OneOrMore_CodeableConcept>?; # The use context of this name e.g.
# as an active ingredient or as a
# food colour additive
fhir:jurisdiction @<OneOrMore_CodeableConcept>?; # The jurisdiction where this name
# applies
fhir:synonym @<OneOrMore_SubstanceDefinition.name>?; # A synonym of this particular name,
# by which the substance is also
# known
fhir:translation @<OneOrMore_SubstanceDefinition.name>?; # A translation for this name into
# another human language
fhir:official @<OneOrMore_SubstanceDefinition.name.official>?; # Details of the official nature of
# this name
fhir:source @<OneOrMore_Reference_DocumentReference>?; # Supporting literature
}
# A synonym of this particular name, by which the substance is also known
<SubstanceDefinition.name.synonymnull> CLOSED {
}
# A translation for this name into another human language
<SubstanceDefinition.name.translationnull> CLOSED {
}
# Details of the official nature of this name
<SubstanceDefinition.name.official> EXTENDS @<BackboneElement> CLOSED {
fhir:authority @<CodeableConcept>?; # Which authority uses this official
# name
fhir:status @<CodeableConcept>?; # The status of the official name,
# for example 'draft', 'active'
fhir:date @<DateTime>?; # Date of official name change
}
# A link between this substance and another
<SubstanceDefinition.relationship> EXTENDS @<BackboneElement> CLOSED {
fhir:substanceDefinition (@<Reference> AND {fhir:l @<SubstanceDefinition> }) OR
@<CodeableConcept> ?; # A pointer to another substance, as
# a resource or a representational
# code
fhir:type @<CodeableConcept>; # For example "salt to parent",
# "active moiety"
fhir:isDefining @<Boolean>?; # For example where an enzyme
# strongly bonds with a particular
# substance, this is a defining
# relationship for that enzyme, out
# of several possible relationships
fhir:amount @<Quantity> OR
@<Ratio> OR
@<String> OR
@<Range> ?; # A numeric factor for the
# relationship, e.g. that a
# substance salt has some percentage
# of active substance in relation to
# some other
fhir:ratioHighLimitAmount @<Ratio>?; # For use when the numeric has an
# uncertain range
fhir:comparator @<CodeableConcept>?; # An operator for the amount, for
# example "average",
# "approximately", "less than"
fhir:measurementType @<CodeableConcept>?; # The kind of measurement the amount
# represents (e.g. IC50, Kd, Ki,
# mole ratio)
fhir:interaction @<CodeableConcept>?; # For target relationships, the kind
# of interaction (e.g. binding,
# inhibition, agonism)
fhir:organism @<CodeableConcept>?; # For anti-infective target
# relationships, the specific
# organism targeted
fhir:organismType @<CodeableConcept>?; # For anti-infective target
# relationships, the high-level type
# of organism targeted
fhir:source @<OneOrMore_Reference_DocumentReference>?; # Supporting literature
}
# Material or taxonomic/anatomical source
<SubstanceDefinition.sourceMaterial> EXTENDS @<BackboneElement> CLOSED {
fhir:type @<CodeableConcept>?; # Classification of the origin of
# the raw material. e.g. cat hair is
# an Animal source type
fhir:genus @<CodeableConcept>?; # The genus of an organism e.g. the
# Latin epithet of the plant/animal
# scientific name
fhir:species @<CodeableConcept>?; # The species of an organism e.g.
# the Latin epithet of the species
# of the plant/animal
fhir:part @<CodeableConcept>?; # An anatomical origin of the source
# material within an organism
fhir:countryOfOrigin @<OneOrMore_CodeableConcept>?; # The country or countries where the
# material is harvested
}
# Data items specific to nucleic acids
<SubstanceDefinition.nucleicAcid> EXTENDS @<BackboneElement> CLOSED {
fhir:sequenceType @<CodeableConcept>?; # The type of the sequence (e.g.
# DNA, RNA)
fhir:numberOfSubunits @<Integer>?; # The number of subunits — strands
# of nucleic acid that are tightly
# associated typically through
# Watson-Crick base pairing
fhir:areaOfHybridisation @<String>?; # The area of hybridisation, for
# double-stranded RNA or DNA.
# Expressed as the subunit number
# followed by the residue number, in
# increasing order
fhir:oligoNucleotideType @<CodeableConcept>?; # Type or class of the
# oligonucleotide
fhir:subunit @<OneOrMore_SubstanceDefinition.nucleicAcid.subunit>?; # A subunit constituting the nucleic
# acid
fhir:gene @<OneOrMore_SubstanceDefinition.nucleicAcid.gene>?; # The gene that codes for this
# substance
fhir:geneElement @<OneOrMore_SubstanceDefinition.nucleicAcid.geneElement>?; # Gene elements that comprise a
# nucleic acid construct (used for
# gene therapy)
}
# A subunit constituting the nucleic acid
<SubstanceDefinition.nucleicAcid.subunit> EXTENDS @<BackboneElement> CLOSED {
fhir:subunit @<Integer>?; # Index of the subunit in decreasing
# length order
fhir:sequence @<String>?; # The nucleotide sequence in 5’→3’
# notation using standard
# single-letter codes
fhir:length @<Integer>?; # The length of the sequence
fhir:sequenceAttachment @<Attachment>?; # The sequence as an attached file
fhir:fivePrime @<CodeableConcept>?; # The nucleotide present at the 5’
# terminus. Since the sequence is
# represented 5’→3’, this is the
# first nucleotide in the sequence
fhir:threePrime @<CodeableConcept>?; # The nucleotide present at the 3’
# terminus. Since the sequence is
# represented 5’→3’, this is the
# last nucleotide in the sequence
fhir:linkage @<OneOrMore_SubstanceDefinition.nucleicAcid.subunit.linkage>?; # The linkages between sugar
# residues in the nucleotide
# sequence
fhir:sugar @<OneOrMore_SubstanceDefinition.nucleicAcid.subunit.sugar>?; # A sugar component of the
# nucleotide sequence
}
# The linkages between sugar residues in the nucleotide sequence
<SubstanceDefinition.nucleicAcid.subunit.linkage> EXTENDS @<BackboneElement> CLOSED {
fhir:connectivity @<String>?; # The chemistry of the linkage
fhir:substance @<CodeableReference>?; # The linkage substance, as a code
# or a reference to its
# SubstanceDefinition
fhir:residueSite @<String>?; # The residue positions at which
# this linkage applies, in 5’→3’
# direction
}
# A sugar component of the nucleotide sequence
<SubstanceDefinition.nucleicAcid.subunit.sugar> EXTENDS @<BackboneElement> CLOSED {
fhir:substance @<CodeableReference>?; # The sugar substance, as a code or
# a reference to its
# SubstanceDefinition
fhir:residueSite @<String>?; # The residue positions at which
# this sugar applies, in 5’→3’
# direction
}
# The gene that codes for this substance
<SubstanceDefinition.nucleicAcid.gene> EXTENDS @<BackboneElement> CLOSED {
fhir:sequenceOrigin @<CodeableConcept>?; # The species or lineage from which
# the gene sequence originated
fhir:gene @<CodeableReference>?; # The gene itself, as a code or a
# reference to a SubstanceDefinition
fhir:source @<OneOrMore_Reference_DocumentReference>?; # Supporting literature for the gene
# information
}
# Gene elements that comprise a nucleic acid construct (used for gene therapy)
<SubstanceDefinition.nucleicAcid.geneElement> EXTENDS @<BackboneElement> CLOSED {
fhir:type @<CodeableConcept>?; # The functional role of the element
# (e.g. promoter, enhancer, coding
# sequence)
fhir:element @<CodeableReference>?; # The element itself, as a code or a
# reference to a SubstanceDefinition
fhir:source @<OneOrMore_Reference_DocumentReference>?; # Supporting literature for the gene
# element information
}
# Data items specific to polymers
<SubstanceDefinition.polymer> EXTENDS @<BackboneElement> CLOSED {
fhir:class @<CodeableConcept>?; # Overall type of the polymer
fhir:geometry @<CodeableConcept>?; # Polymer geometry, e.g. linear,
# branched, cross-linked, network or
# dendritic
fhir:copolymerConnectivity @<OneOrMore_CodeableConcept>?; # Describes the copolymer sequence
# type (polymer connectivity)
fhir:modification @<String>?; # A modification applied to the
# polymer
fhir:monomerSet @<OneOrMore_SubstanceDefinition.polymer.monomerSet>?; # A set of monomers used to build
# the polymer
fhir:repeat @<OneOrMore_SubstanceDefinition.polymer.repeat>?; # Specifies and quantifies the
# repeated units and their
# configuration
}
# A set of monomers used to build the polymer
<SubstanceDefinition.polymer.monomerSet> EXTENDS @<BackboneElement> CLOSED {
fhir:ratioType @<CodeableConcept>?; # Captures the type of ratio to the
# entire polymer, e.g.
# Monomer/Polymer ratio, SRU/Polymer
# Ratio
fhir:startingMaterial @<OneOrMore_SubstanceDefinition.polymer.monomerSet.startingMaterial>?; # The starting materials -
# monomer(s) used in the synthesis
# of the polymer
}
# The starting materials - monomer(s) used in the synthesis of the polymer
<SubstanceDefinition.polymer.monomerSet.startingMaterial> EXTENDS @<BackboneElement> CLOSED {
fhir:code @<CodeableReference>?; # The substance acting as starting
# material, as a code or a reference
# to a SubstanceDefinition
fhir:category @<CodeableConcept>?; # Substance high level category,
# e.g. chemical substance
fhir:isDefining @<Boolean>?; # Whether this starting material is
# part of what defines the polymer's
# unique identity
fhir:amount @<Quantity>?; # A percentage
}
# Specifies and quantifies the repeated units and their configuration
<SubstanceDefinition.polymer.repeat> EXTENDS @<BackboneElement> CLOSED {
fhir:averageMolecularFormula @<String>?; # A representation of an (average)
# molecular formula from a polymer
fhir:repeatUnitAmountType @<CodeableConcept>?; # How the quantitative amount of
# Structural Repeat Units is
# captured (e.g. Exact, Numeric,
# Average)
fhir:repeatUnit @<OneOrMore_SubstanceDefinition.polymer.repeat.repeatUnit>?; # An SRU - Structural Repeat Unit
}
# An SRU - Structural Repeat Unit
<SubstanceDefinition.polymer.repeat.repeatUnit> EXTENDS @<BackboneElement> CLOSED {
fhir:unit @<String>?; # Identification of the structural
# repeat unit (SRU)
fhir:orientation @<CodeableConcept>?; # The orientation of the
# polymerisation, e.g. head-tail,
# head-head, random
fhir:amount @<Integer>?; # Number of repeats of this unit
fhir:degreeOfPolymerisation @<OneOrMore_SubstanceDefinition.polymer.repeat.repeatUnit.degreeOfPolymerisation>?; # Applies to homopolymer and block
# co-polymers where the degree of
# polymerisation within a block can
# be described
fhir:structuralRepresentation @<OneOrMore_SubstanceDefinition.structure.representation>?; # A graphical structure for this SRU
}
# Applies to homopolymer and block co-polymers where the degree of polymerisation within a block can be described
<SubstanceDefinition.polymer.repeat.repeatUnit.degreeOfPolymerisation> EXTENDS @<BackboneElement> CLOSED {
fhir:type @<CodeableConcept>?; # The type of degree of
# polymerisation, e.g. SRU/Polymer
# ratio
fhir:average @<Integer>?; # An average amount of polymerisation
fhir:low @<Integer>?; # A low expected limit of the amount
fhir:high @<Integer>?; # A high expected limit of the amount
}
# Data items specific to proteins
<SubstanceDefinition.protein> EXTENDS @<BackboneElement> CLOSED {
fhir:sequenceType @<CodeableConcept>?; # Whether the sequence is complete
# or partial
fhir:numberOfSubunits @<Integer>?; # Number of subunits — linear
# sequences of amino acids linked
# through peptide bonds
fhir:disulfideLinkage @<OneOrMore_String>?; # Disulphide bond(s) between
# cysteine residues on the same
# subunit or across two different
# subunits. Positions are listed in
# increasing order of subunit number
# and intra-subunit position,
# followed by the amino-acid
# abbreviations. The positions
# should contain Cysteine residues
fhir:subunit @<OneOrMore_SubstanceDefinition.protein.subunit>?; # Each subunit constituting the
# protein. A subunit is a linear
# sequence of amino acids linked
# through peptide bonds. Used when
# the finished protein is a complex
# of multiple sequences (not for
# domains within a single sequence).
# Subunits are listed in order of
# decreasing length; ties resolved
# by decreasing molecular weight;
# identical sequences are repeated
fhir:gene @<OneOrMore_SubstanceDefinition.nucleicAcid.gene>?; # The gene that codes for this
# substance
}
# Each subunit constituting the protein. A subunit is a linear sequence of amino acids linked through peptide bonds. Used when the finished protein is a complex of multiple sequences (not for domains within a single sequence). Subunits are listed in order of decreasing length; ties resolved by decreasing molecular weight; identical sequences are repeated
<SubstanceDefinition.protein.subunit> EXTENDS @<BackboneElement> CLOSED {
fhir:subunit @<Integer>?; # Index of primary sequences of
# amino acids linked through peptide
# bonds in order of decreasing
# length. Sequences of the same
# length will be ordered by
# molecular weight. Subunits that
# have identical sequences will be
# repeated and have sequential
# subscripts
fhir:sequence @<String>?; # The amino-acid sequence, listed N-
# to C-terminal using standard
# single-letter amino-acid codes.
# Uppercase denotes L-amino acids,
# lowercase denotes D-amino acids.
# Transcribed proteins are described
# using the translated sequence; for
# synthetic peptides containing
# amino acids without a
# single-letter code, X is used.
# Modified amino acids are
# identified by their position in
# the sequence
fhir:length @<Integer>?; # Length of linear sequences of
# amino acids contained in the
# subunit
fhir:sequenceAttachment @<Attachment>?; # The amino-acid sequence as an
# attached file
fhir:nTerminalModification @<CodeableReference>?; # The modification fragment at the
# N-terminal of the protein
fhir:cTerminalModification @<CodeableReference>?; # The modification fragment at the
# C-terminal of the protein
}
#---------------------- Cardinality Types (OneOrMore) -------------------
<OneOrMore_Identifier> CLOSED {
rdf:first @<Identifier> ;
rdf:rest [rdf:nil] OR @<OneOrMore_Identifier>
}
<OneOrMore_CodeableConcept> CLOSED {
rdf:first @<CodeableConcept> ;
rdf:rest [rdf:nil] OR @<OneOrMore_CodeableConcept>
}
<OneOrMore_Annotation> CLOSED {
rdf:first @<Annotation> ;
rdf:rest [rdf:nil] OR @<OneOrMore_Annotation>
}
<OneOrMore_Reference_Organization> CLOSED {
rdf:first @<Reference> AND {fhir:l
@<Organization> } ;
rdf:rest [rdf:nil] OR @<OneOrMore_Reference_Organization>
}
<OneOrMore_SubstanceDefinition.moiety> CLOSED {
rdf:first @<SubstanceDefinition.moiety> ;
rdf:rest [rdf:nil] OR @<OneOrMore_SubstanceDefinition.moiety>
}
<OneOrMore_SubstanceDefinition.characterization> CLOSED {
rdf:first @<SubstanceDefinition.characterization> ;
rdf:rest [rdf:nil] OR @<OneOrMore_SubstanceDefinition.characterization>
}
<OneOrMore_SubstanceDefinition.property> CLOSED {
rdf:first @<SubstanceDefinition.property> ;
rdf:rest [rdf:nil] OR @<OneOrMore_SubstanceDefinition.property>
}
<OneOrMore_SubstanceDefinition.molecularWeight> CLOSED {
rdf:first @<SubstanceDefinition.molecularWeight> ;
rdf:rest [rdf:nil] OR @<OneOrMore_SubstanceDefinition.molecularWeight>
}
<OneOrMore_SubstanceDefinition.code> CLOSED {
rdf:first @<SubstanceDefinition.code> ;
rdf:rest [rdf:nil] OR @<OneOrMore_SubstanceDefinition.code>
}
<OneOrMore_SubstanceDefinition.name> CLOSED {
rdf:first @<SubstanceDefinition.name> ;
rdf:rest [rdf:nil] OR @<OneOrMore_SubstanceDefinition.name>
}
<OneOrMore_SubstanceDefinition.relationship> CLOSED {
rdf:first @<SubstanceDefinition.relationship> ;
rdf:rest [rdf:nil] OR @<OneOrMore_SubstanceDefinition.relationship>
}
<OneOrMore_Attachment> CLOSED {
rdf:first @<Attachment> ;
rdf:rest [rdf:nil] OR @<OneOrMore_Attachment>
}
<OneOrMore_Reference_DocumentReference> CLOSED {
rdf:first @<Reference> AND {fhir:l
@<DocumentReference> } ;
rdf:rest [rdf:nil] OR @<OneOrMore_Reference_DocumentReference>
}
<OneOrMore_SubstanceDefinition.structure.representation> CLOSED {
rdf:first @<SubstanceDefinition.structure.representation> ;
rdf:rest [rdf:nil] OR @<OneOrMore_SubstanceDefinition.structure.representation>
}
<OneOrMore_SubstanceDefinition.name.official> CLOSED {
rdf:first @<SubstanceDefinition.name.official> ;
rdf:rest [rdf:nil] OR @<OneOrMore_SubstanceDefinition.name.official>
}
<OneOrMore_SubstanceDefinition.nucleicAcid.subunit> CLOSED {
rdf:first @<SubstanceDefinition.nucleicAcid.subunit> ;
rdf:rest [rdf:nil] OR @<OneOrMore_SubstanceDefinition.nucleicAcid.subunit>
}
<OneOrMore_SubstanceDefinition.nucleicAcid.gene> CLOSED {
rdf:first @<SubstanceDefinition.nucleicAcid.gene> ;
rdf:rest [rdf:nil] OR @<OneOrMore_SubstanceDefinition.nucleicAcid.gene>
}
<OneOrMore_SubstanceDefinition.nucleicAcid.geneElement> CLOSED {
rdf:first @<SubstanceDefinition.nucleicAcid.geneElement> ;
rdf:rest [rdf:nil] OR @<OneOrMore_SubstanceDefinition.nucleicAcid.geneElement>
}
<OneOrMore_SubstanceDefinition.nucleicAcid.subunit.linkage> CLOSED {
rdf:first @<SubstanceDefinition.nucleicAcid.subunit.linkage> ;
rdf:rest [rdf:nil] OR @<OneOrMore_SubstanceDefinition.nucleicAcid.subunit.linkage>
}
<OneOrMore_SubstanceDefinition.nucleicAcid.subunit.sugar> CLOSED {
rdf:first @<SubstanceDefinition.nucleicAcid.subunit.sugar> ;
rdf:rest [rdf:nil] OR @<OneOrMore_SubstanceDefinition.nucleicAcid.subunit.sugar>
}
<OneOrMore_SubstanceDefinition.polymer.monomerSet> CLOSED {
rdf:first @<SubstanceDefinition.polymer.monomerSet> ;
rdf:rest [rdf:nil] OR @<OneOrMore_SubstanceDefinition.polymer.monomerSet>
}
<OneOrMore_SubstanceDefinition.polymer.repeat> CLOSED {
rdf:first @<SubstanceDefinition.polymer.repeat> ;
rdf:rest [rdf:nil] OR @<OneOrMore_SubstanceDefinition.polymer.repeat>
}
<OneOrMore_SubstanceDefinition.polymer.monomerSet.startingMaterial> CLOSED {
rdf:first @<SubstanceDefinition.polymer.monomerSet.startingMaterial> ;
rdf:rest [rdf:nil] OR @<OneOrMore_SubstanceDefinition.polymer.monomerSet.startingMaterial>
}
<OneOrMore_SubstanceDefinition.polymer.repeat.repeatUnit> CLOSED {
rdf:first @<SubstanceDefinition.polymer.repeat.repeatUnit> ;
rdf:rest [rdf:nil] OR @<OneOrMore_SubstanceDefinition.polymer.repeat.repeatUnit>
}
<OneOrMore_SubstanceDefinition.polymer.repeat.repeatUnit.degreeOfPolymerisation> CLOSED {
rdf:first @<SubstanceDefinition.polymer.repeat.repeatUnit.degreeOfPolymerisation> ;
rdf:rest [rdf:nil] OR @<OneOrMore_SubstanceDefinition.polymer.repeat.repeatUnit.degreeOfPolymerisation>
}
<OneOrMore_String> CLOSED {
rdf:first @<String> ;
rdf:rest [rdf:nil] OR @<OneOrMore_String>
}
<OneOrMore_SubstanceDefinition.protein.subunit> CLOSED {
rdf:first @<SubstanceDefinition.protein.subunit> ;
rdf:rest [rdf:nil] OR @<OneOrMore_SubstanceDefinition.protein.subunit>
}
Usage note: every effort has been made to ensure that the ShEx files are correct and useful, but they are not a normative part of the specification.
FHIR ®© HL7.org 2011+. FHIR R6 hl7.fhir.r6.core#6.0.0-ballot4 generated on Wed, Jun 24, 2026 21:29+0000.
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