Name	Flags	Card.	Type	Description & Constraints
SubstanceDefinition	N		DomainResource	The detailed description of a substance, typically at a level beyond what is used for prescribing Elements defined in Ancestors: id, meta, implicitRules, language, text, contained, extension, modifierExtension
identifier	Σ	0..*	Identifier	Identifier by which this substance is known
version	Σ	0..1	string	A business level edition or revision identifier
status	?! Σ	0..1	CodeableConcept	Status of substance within the catalogue e.g. active, retired Binding: PublicationStatus ( Preferred)
classification	Σ	0..*	CodeableConcept	A categorization, high level e.g. polymer or nucleic acid, or food, chemical, biological, or lower e.g. polymer linear or branch chain, or type of impurity
domain	Σ	0..1	CodeableConcept	The applicable usage of the substance, as an example human or veterinary Binding: Medicinal Product Domain ( Example)
grade	Σ	0..*	CodeableConcept	The quality standard, established benchmark, to which substance complies (e.g. USP/NF, BP) Binding: Substance Grade ( Example)
description	Σ	0..1	markdown	Textual description of the substance
note	Σ	0..*	Annotation	Textual comment about the substance's catalogue or registry record
manufacturer	Σ	0..*	Reference( Organization)	The entity that creates, makes, produces or fabricates the substance
supplier	Σ	0..*	Reference( Organization)	An entity that is the source for the substance. It may be different from the manufacturer
moiety	Σ	0..*	BackboneElement	Moiety, for structural modifications
role	Σ	0..1	CodeableConcept	Role that the moiety is playing
identifier	Σ	0..*	Identifier	Identifier by which this moiety substance is known
name	Σ	0..1	string	Textual name for this moiety substance
stereochemistry	Σ	0..1	CodeableConcept	Stereochemistry type Binding: Stereochemistry ( Example)
opticalActivity	Σ	0..1	CodeableConcept	Optical activity type Binding: Optical Activity ( Example)
molecularFormula	Σ	0..1	string	Molecular formula for this moiety (e.g. with the Hill system)
amount[x]	Σ	0..1		Quantitative value for this moiety
amountQuantity			Quantity
amountString			string
measurementType	Σ	0..1	CodeableConcept	The measurement type of the quantitative value Binding: Substance Amount Type ( Example)
characterization	Σ	0..*	BackboneElement	General specifications for this substance
technique	Σ	0..1	CodeableConcept	The method used to find the characterization e.g. HPLC Binding: Structure Technique ( Example)
form	Σ	0..1	CodeableConcept	Describes the nature of the chemical entity and explains, for instance, whether this is a base or a salt form Binding: Substance Form ( Example)
description	Σ	0..1	markdown	The description or justification in support of the interpretation of the data file
file	Σ	0..*	Attachment	The data produced by the analytical instrument or a pictorial representation of that data. Examples: a JCAMP, JDX, or ADX file, or a chromatogram or spectrum analysis
property	Σ	0..*	BackboneElement	General specifications for this substance
type	Σ	1..1	CodeableConcept	A code expressing the type of property Binding: Product Characteristic ( Example)
value[x]	Σ	0..1		A value for the property
valueCodeableConcept			CodeableConcept
valueQuantity			Quantity
valueRange			Range
valueDate			date
valueBoolean			boolean
valueAttachment			Attachment
molecularWeight	Σ	0..*	BackboneElement	The average mass of a molecule of a compound
method	Σ	0..1	CodeableConcept	The method by which the weight was determined Binding: Weight Method ( Example)
type	Σ	0..1	CodeableConcept	Type of molecular weight e.g. exact, average, weight average Binding: Weight Type ( Example)
amount	Σ	1..1	Quantity	Used to capture quantitative values for a variety of elements
structure	Σ	0..1	BackboneElement	Structural information
stereochemistry	Σ	0..1	CodeableConcept	Stereochemistry type Binding: Stereochemistry ( Example)
opticalActivity	Σ	0..1	CodeableConcept	Optical activity type Binding: Optical Activity ( Example)
molecularFormula	Σ	0..1	string	An expression which states the number and type of atoms present in a molecule of a substance
molecularFormulaByMoiety	Σ	0..1	string	Specified per moiety according to the Hill system
molecularWeight	Σ	0..1	see molecularWeight	The molecular weight or weight range
technique	Σ	0..*	CodeableConcept	The method used to find the structure e.g. X-ray, NMR Binding: Structure Technique ( Example)
sourceDocument	Σ	0..*	Reference( DocumentReference)	Source of information for the structure
representation	Σ	0..*	BackboneElement	A depiction of the structure of the substance
type	Σ	0..1	CodeableConcept	The kind of structural representation (e.g. full, partial) Binding: Substance Representation Type ( Example)
representation	Σ	0..1	string	The structural representation as a text string in a standard format
format	Σ	0..1	CodeableConcept	The format of the representation e.g. InChI, SMILES, MOLFILE (note: not the physical file format) Binding: Substance Representation Format ( Example)
document	Σ	0..1	Reference( DocumentReference)	An attachment with the structural representation e.g. a structure graphic or AnIML file
code	Σ	0..*	BackboneElement	Codes associated with the substance
code	Σ	0..1	CodeableConcept	The specific code
status	Σ	0..1	CodeableConcept	Status of the code assignment, for example 'provisional', 'approved' Binding: PublicationStatus ( Preferred)
statusDate	Σ	0..1	dateTime	The date at which the code status was changed
note	Σ	0..*	Annotation	Any comment can be provided in this field
source	Σ	0..*	Reference( DocumentReference)	Supporting literature
name	Σ	0..*	BackboneElement	Names applicable to this substance
name	Σ	1..1	string	The actual name
type	Σ	0..1	CodeableConcept	Name type e.g. 'systematic', 'scientific, 'brand' Binding: Substance Name Type ( Example)
status	Σ	0..1	CodeableConcept	The status of the name e.g. 'current', 'proposed' Binding: PublicationStatus ( Preferred)
preferred	Σ	0..1	boolean	If this is the preferred name for this substance
language	Σ	0..*	CodeableConcept	Human language that the name is written in Binding: All Languages ( Required) Additional Bindings Purpose Common Languages Starter
domain	Σ	0..*	CodeableConcept	The use context of this name e.g. as an active ingredient or as a food colour additive Binding: Substance Name Domain ( Example)
jurisdiction	Σ	0..*	CodeableConcept	The jurisdiction where this name applies Binding: Jurisdiction ValueSet ( Example)
synonym	Σ	0..*	see name	A synonym of this particular name, by which the substance is also known
translation	Σ	0..*	see name	A translation for this name into another human language
official	Σ	0..*	BackboneElement	Details of the official nature of this name
authority	Σ	0..1	CodeableConcept	Which authority uses this official name Binding: Substance Name Authority ( Preferred)
status	Σ	0..1	CodeableConcept	The status of the official name, for example 'draft', 'active' Binding: PublicationStatus ( Preferred)
date	Σ	0..1	dateTime	Date of official name change
source	Σ	0..*	Reference( DocumentReference)	Supporting literature
relationship	Σ	0..*	BackboneElement	A link between this substance and another
substanceDefinition[x]	Σ	0..1		A pointer to another substance, as a resource or a representational code
substanceDefinitionReference			Reference( SubstanceDefinition)
substanceDefinitionCodeableConcept			CodeableConcept
type	Σ	1..1	CodeableConcept	For example "salt to parent", "active moiety" Binding: Substance Relationship Type ( Example)
isDefining	Σ	0..1	boolean	For example where an enzyme strongly bonds with a particular substance, this is a defining relationship for that enzyme, out of several possible relationships
amount[x]	Σ	0..1		A numeric factor for the relationship, e.g. that a substance salt has some percentage of active substance in relation to some other
amountQuantity			Quantity
amountRatio			Ratio
amountString			string
amountRange			Range
ratioHighLimitAmount	Σ	0..1	Ratio	For use when the numeric has an uncertain range
comparator	Σ	0..1	CodeableConcept	An operator for the amount, for example "average", "approximately", "less than" Binding: Substance Amount Type ( Example)
measurementType	Σ	0..1	CodeableConcept	The kind of measurement the amount represents (e.g. IC50, Kd, Ki, mole ratio) Binding: Substance Measurement Type ( Example)
interaction	Σ	0..1	CodeableConcept	For target relationships, the kind of interaction (e.g. binding, inhibition, agonism) Binding: Substance Interaction Type ( Example)
organism	Σ	0..1	CodeableConcept	For anti-infective target relationships, the specific organism targeted Binding: Substance Target Organism ( Example)
organismType	Σ	0..1	CodeableConcept	For anti-infective target relationships, the high-level type of organism targeted Binding: Substance Target Organism Type ( Example)
source	Σ	0..*	Reference( DocumentReference)	Supporting literature
sourceMaterial	Σ	0..1	BackboneElement	Material or taxonomic/anatomical source
type	Σ	0..1	CodeableConcept	Classification of the origin of the raw material. e.g. cat hair is an Animal source type Binding: Source Material Type ( Example)
genus	Σ	0..1	CodeableConcept	The genus of an organism e.g. the Latin epithet of the plant/animal scientific name Binding: Source Material Genus ( Example)
species	Σ	0..1	CodeableConcept	The species of an organism e.g. the Latin epithet of the species of the plant/animal Binding: Source Material Species ( Example)
part	Σ	0..1	CodeableConcept	An anatomical origin of the source material within an organism Binding: Source Material Part ( Example)
countryOfOrigin	Σ	0..*	CodeableConcept	The country or countries where the material is harvested Binding: Country ValueSet ( Required)
nucleicAcid		0..1	BackboneElement	Data items specific to nucleic acids
sequenceType	Σ	0..1	CodeableConcept	The type of the sequence (e.g. DNA, RNA) Binding: Substance Sequence Type ( Example)
numberOfSubunits	Σ	0..1	integer	The number of subunits — strands of nucleic acid that are tightly associated typically through Watson-Crick base pairing
areaOfHybridisation	Σ	0..1	string	The area of hybridisation, for double-stranded RNA or DNA. Expressed as the subunit number followed by the residue number, in increasing order
oligoNucleotideType	Σ	0..1	CodeableConcept	Type or class of the oligonucleotide Binding: Oligonucleotide Type ( Example)
subunit	Σ	0..*	BackboneElement	A subunit constituting the nucleic acid
subunit	Σ	0..1	integer	Index of the subunit in decreasing length order
sequence	Σ	0..1	string	The nucleotide sequence in 5’→3’ notation using standard single-letter codes
length	Σ	0..1	integer	The length of the sequence
sequenceAttachment	Σ	0..1	Attachment	The sequence as an attached file
fivePrime	Σ	0..1	CodeableConcept	The nucleotide present at the 5’ terminus. Since the sequence is represented 5’→3’, this is the first nucleotide in the sequence Binding: Nucleotide Terminus ( Example)
threePrime	Σ	0..1	CodeableConcept	The nucleotide present at the 3’ terminus. Since the sequence is represented 5’→3’, this is the last nucleotide in the sequence Binding: Nucleotide Terminus ( Example)
linkage	Σ	0..*	BackboneElement	The linkages between sugar residues in the nucleotide sequence
connectivity	Σ	0..1	string	The chemistry of the linkage
substance	Σ	0..1	CodeableReference( SubstanceDefinition)	The linkage substance, as a code or a reference to its SubstanceDefinition
residueSite	Σ	0..1	string	The residue positions at which this linkage applies, in 5’→3’ direction
sugar	Σ	0..*	BackboneElement	A sugar component of the nucleotide sequence
substance	Σ	0..1	CodeableReference( SubstanceDefinition)	The sugar substance, as a code or a reference to its SubstanceDefinition
residueSite	Σ	0..1	string	The residue positions at which this sugar applies, in 5’→3’ direction
gene	Σ	0..*	BackboneElement	The gene that codes for this substance
sequenceOrigin	Σ	0..1	CodeableConcept	The species or lineage from which the gene sequence originated Binding: Gene Sequence Origin ( Example)
gene	Σ	0..1	CodeableReference( SubstanceDefinition)	The gene itself, as a code or a reference to a SubstanceDefinition
source	Σ	0..*	Reference( DocumentReference)	Supporting literature for the gene information
geneElement	Σ	0..*	BackboneElement	Gene elements that comprise a nucleic acid construct (used for gene therapy)
type	Σ	0..1	CodeableConcept	The functional role of the element (e.g. promoter, enhancer, coding sequence) Binding: Gene Element Type ( Example)
element	Σ	0..1	CodeableReference( SubstanceDefinition)	The element itself, as a code or a reference to a SubstanceDefinition
source	Σ	0..*	Reference( DocumentReference)	Supporting literature for the gene element information
polymer		0..1	BackboneElement	Data items specific to polymers
class	Σ	0..1	CodeableConcept	Overall type of the polymer Binding: Polymer Class ( Example)
geometry	Σ	0..1	CodeableConcept	Polymer geometry, e.g. linear, branched, cross-linked, network or dendritic Binding: Polymer Geometry ( Example)
copolymerConnectivity	Σ	0..*	CodeableConcept	Describes the copolymer sequence type (polymer connectivity) Binding: Copolymer Connectivity ( Example)
modification	Σ	0..1	string	A modification applied to the polymer
monomerSet	Σ	0..*	BackboneElement	A set of monomers used to build the polymer
ratioType	Σ	0..1	CodeableConcept	Captures the type of ratio to the entire polymer, e.g. Monomer/Polymer ratio, SRU/Polymer Ratio Binding: Polymer Monomer Ratio Type ( Example)
startingMaterial	Σ	0..*	BackboneElement	The starting materials - monomer(s) used in the synthesis of the polymer
code	Σ	0..1	CodeableReference( SubstanceDefinition)	The substance acting as starting material, as a code or a reference to a SubstanceDefinition Binding: Substance Code ( Example)
category	Σ	0..1	CodeableConcept	Substance high level category, e.g. chemical substance Binding: Polymer Starting Material Category ( Example)
isDefining	Σ	0..1	boolean	Whether this starting material is part of what defines the polymer's unique identity
amount	Σ	0..1	Quantity	A percentage
repeat	Σ	0..*	BackboneElement	Specifies and quantifies the repeated units and their configuration
averageMolecularFormula	Σ	0..1	string	A representation of an (average) molecular formula from a polymer
repeatUnitAmountType	Σ	0..1	CodeableConcept	How the quantitative amount of Structural Repeat Units is captured (e.g. Exact, Numeric, Average) Binding: Polymer Monomer Ratio Type ( Example)
repeatUnit	Σ	0..*	BackboneElement	An SRU - Structural Repeat Unit
unit	Σ	0..1	string	Identification of the structural repeat unit (SRU)
orientation	Σ	0..1	CodeableConcept	The orientation of the polymerisation, e.g. head-tail, head-head, random Binding: Polymerisation Orientation ( Example)
amount	Σ	0..1	integer	Number of repeats of this unit
degreeOfPolymerisation	Σ	0..*	BackboneElement	Applies to homopolymer and block co-polymers where the degree of polymerisation within a block can be described
type	Σ	0..1	CodeableConcept	The type of degree of polymerisation, e.g. SRU/Polymer ratio Binding: Degree of Polymerisation Type ( Example)
average	Σ	0..1	integer	An average amount of polymerisation
low	Σ	0..1	integer	A low expected limit of the amount
high	Σ	0..1	integer	A high expected limit of the amount
structuralRepresentation	Σ	0..*	see representation	A graphical structure for this SRU
protein		0..1	BackboneElement	Data items specific to proteins
sequenceType	Σ	0..1	CodeableConcept	Whether the sequence is complete or partial Binding: Substance Sequence Type ( Example)
numberOfSubunits	Σ	0..1	integer	Number of subunits — linear sequences of amino acids linked through peptide bonds
disulfideLinkage	Σ	0..*	string	Disulphide bond(s) between cysteine residues on the same subunit or across two different subunits. Positions are listed in increasing order of subunit number and intra-subunit position, followed by the amino-acid abbreviations. The positions should contain Cysteine residues
subunit	Σ	0..*	BackboneElement	Each subunit constituting the protein. A subunit is a linear sequence of amino acids linked through peptide bonds. Used when the finished protein is a complex of multiple sequences (not for domains within a single sequence). Subunits are listed in order of decreasing length; ties resolved by decreasing molecular weight; identical sequences are repeated
subunit	Σ	0..1	integer	Index of primary sequences of amino acids linked through peptide bonds in order of decreasing length. Sequences of the same length will be ordered by molecular weight. Subunits that have identical sequences will be repeated and have sequential subscripts
sequence	Σ	0..1	string	The amino-acid sequence, listed N- to C-terminal using standard single-letter amino-acid codes. Uppercase denotes L-amino acids, lowercase denotes D-amino acids. Transcribed proteins are described using the translated sequence; for synthetic peptides containing amino acids without a single-letter code, X is used. Modified amino acids are identified by their position in the sequence
length	Σ	0..1	integer	Length of linear sequences of amino acids contained in the subunit
sequenceAttachment	Σ	0..1	Attachment	The amino-acid sequence as an attached file
nTerminalModification	Σ	0..1	CodeableReference( SubstanceDefinition)	The modification fragment at the N-terminal of the protein
cTerminalModification	Σ	0..1	CodeableReference( SubstanceDefinition)	The modification fragment at the C-terminal of the protein
gene	Σ	0..*	see gene	The gene that codes for this substance
Documentation for this format