<?xml version="1.0" encoding="UTF-8"?><CodeSystem xmlns="http://hl7.org/fhir"><id value="substance-relationship-type"/><meta><lastUpdated value="2026-06-24T23:10:57.715+11:00"/></meta><text><status value="generated"/><div xmlns="http://www.w3.org/1999/xhtml"><p class="res-header-id"><b>Generated Narrative: CodeSystem substance-relationship-type</b></p><a name="substance-relationship-type"> </a><a name="hcsubstance-relationship-type"> </a><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Last updated: 2021-01-05T10:01:24.148+11:00</p></div><p>This case-sensitive code system <code>http://hl7.org/fhir/substance-relationship-type</code> defines the following codes:</p><table class="codes"><tr><td style="white-space:nowrap"><b>Code</b></td><td><b>Display</b></td><td><b>Definition</b></td></tr><tr><td style="white-space:nowrap">Salt<a name="substance-relationship-type-Salt"> </a></td><td>Salt to parent</td><td/></tr><tr><td style="white-space:nowrap">ActiveMoiety<a name="substance-relationship-type-ActiveMoiety"> </a></td><td>Active moiety</td><td/></tr><tr><td style="white-space:nowrap">StartingMaterial<a name="substance-relationship-type-StartingMaterial"> </a></td><td>Starting material for</td><td/></tr><tr><td style="white-space:nowrap">Polymorph<a name="substance-relationship-type-Polymorph"> </a></td><td>Polymorph of</td><td/></tr><tr><td style="white-space:nowrap">Impurity<a name="substance-relationship-type-Impurity"> </a></td><td>Impurity of</td><td/></tr><tr><td style="white-space:nowrap">TherapeuticTarget<a name="substance-relationship-type-TherapeuticTarget"> </a></td><td>Therapeutic target</td><td>The substance acts therapeutically on the target.</td></tr><tr><td style="white-space:nowrap">MetabolicTarget<a name="substance-relationship-type-MetabolicTarget"> </a></td><td>Metabolic target</td><td>The substance is metabolised by or interacts with the target as part of metabolism.</td></tr><tr><td style="white-space:nowrap">ToxicityTarget<a name="substance-relationship-type-ToxicityTarget"> </a></td><td>Toxicity target</td><td>The substance interacts with the target in a way that contributes to toxicity.</td></tr><tr><td style="white-space:nowrap">TargetUnknownEffect<a name="substance-relationship-type-TargetUnknownEffect"> </a></td><td>Target (unknown effect)</td><td>The substance is known to interact with the target, but the effect is not characterised.</td></tr><tr><td style="white-space:nowrap">GeneOfOrigin<a name="substance-relationship-type-GeneOfOrigin"> </a></td><td>Gene of origin</td><td>The substance was derived from this gene (used e.g. for recombinant proteins and nucleic acid products).</td></tr></table></div></text><extension url="http://hl7.org/fhir/StructureDefinition/structuredefinition-wg"><valueCode value="brr"/></extension><extension url="http://hl7.org/fhir/StructureDefinition/structuredefinition-standards-status"><valueCode value="informative"/></extension><extension url="http://hl7.org/fhir/StructureDefinition/structuredefinition-fmm"><valueInteger value="1"/></extension><url value="http://hl7.org/fhir/substance-relationship-type"/><identifier><system value="urn:ietf:rfc:3986"/><value value="urn:oid:2.16.840.1.113883.4.642.4.2088"/></identifier><version value="6.0.0-ballot4"/><name value="SubstanceRelationshipTypeExample"/><title value="Substance Relationship Type"/><status value="active"/><experimental value="true"/><date value="2021-01-05T10:01:24+11:00"/><publisher value="HL7 (FHIR Project)"/><contact><telecom><system value="url"/><value value="http://hl7.org/fhir"/></telecom><telecom><system value="email"/><value value="fhir@lists.hl7.org"/></telecom></contact><description value="The relationship between two substance types."/><jurisdiction><coding><system value="http://unstats.un.org/unsd/methods/m49/m49.htm"/><code value="001"/><display value="World"/></coding></jurisdiction><caseSensitive value="true"/><valueSet value="http://hl7.org/fhir/ValueSet/substance-relationship-type"/><content value="complete"/><concept><code value="Salt"/><display value="Salt to parent"/></concept><concept><code value="ActiveMoiety"/><display value="Active moiety"/></concept><concept><code value="StartingMaterial"/><display value="Starting material for"/></concept><concept><code value="Polymorph"/><display value="Polymorph of"/></concept><concept><code value="Impurity"/><display value="Impurity of"/></concept><concept><code value="TherapeuticTarget"/><display value="Therapeutic target"/><definition value="The substance acts therapeutically on the target."/></concept><concept><code value="MetabolicTarget"/><display value="Metabolic target"/><definition value="The substance is metabolised by or interacts with the target as part of metabolism."/></concept><concept><code value="ToxicityTarget"/><display value="Toxicity target"/><definition value="The substance interacts with the target in a way that contributes to toxicity."/></concept><concept><code value="TargetUnknownEffect"/><display value="Target (unknown effect)"/><definition value="The substance is known to interact with the target, but the effect is not characterised."/></concept><concept><code value="GeneOfOrigin"/><display value="Gene of origin"/><definition value="The substance was derived from this gene (used e.g. for recombinant proteins and nucleic acid products)."/></concept></CodeSystem>