Release 5 Preview #2

Ingredient.profile.json

Biomedical Research and Regulation Work GroupMaturity Level: N/AStandards Status: InformativeCompartments: Not linked to any defined compartments

Raw JSON (canonical form + also see JSON Format Specification)

StructureDefinition for ingredient

{
  "resourceType" : "StructureDefinition",
  "id" : "Ingredient",
  "meta" : {
    "lastUpdated" : "2020-06-01T17:23:37.692+00:00"
  },
  "text" : {
    "status" : "generated",
    "div" : "<div>!-- Snipped for Brevity --></div>"
  },
  "extension" : [{
    "url" : "http://hl7.org/fhir/StructureDefinition/structuredefinition-standards-status",
    "valueCode" : "trial-use"
  },
  {
    "url" : "http://hl7.org/fhir/StructureDefinition/structuredefinition-fmm",
    "valueInteger" : 1
  },
  {
    "url" : "http://hl7.org/fhir/StructureDefinition/structuredefinition-security-category",
    "valueCode" : "anonymous"
  },
  {
    "url" : "http://hl7.org/fhir/StructureDefinition/structuredefinition-wg",
    "valueCode" : "brr"
  }],
  "url" : "http://hl7.org/fhir/StructureDefinition/Ingredient",
  "version" : "4.4.0",
  "name" : "Ingredient",
  "status" : "draft",
  "date" : "2020-06-01T17:23:37+00:00",
  "publisher" : "Health Level Seven International (Biomedical Research and Regulation)",
  "contact" : [{
    "telecom" : [{
      "system" : "url",
      "value" : "http://hl7.org/fhir"
    }]
  },
  {
    "telecom" : [{
      "system" : "url",
      "value" : "http://www.hl7.org/Special/committees/rcrim/index.cfm"
    }]
  }],
  "description" : "An ingredient of a manufactured item or pharmaceutical product.",
  "fhirVersion" : "4.4.0",
  "mapping" : [{
    "identity" : "rim",
    "uri" : "http://hl7.org/v3",
    "name" : "RIM Mapping"
  }],
  "kind" : "resource",
  "abstract" : false,
  "type" : "Ingredient",
  "baseDefinition" : "http://hl7.org/fhir/StructureDefinition/DomainResource",
  "derivation" : "specialization",
  "snapshot" : {
    "element" : [{
      "id" : "Ingredient",
      "path" : "Ingredient",
      "short" : "An ingredient of a manufactured item or pharmaceutical product",
      "definition" : "An ingredient of a manufactured item or pharmaceutical product.",
      "min" : 0,
      "max" : "*",
      "base" : {
        "path" : "Ingredient",
        "min" : 0,
        "max" : "*"
      },
      "constraint" : [{
        "key" : "dom-2",
        "severity" : "error",
        "human" : "If the resource is contained in another resource, it SHALL NOT contain nested Resources",
        "expression" : "contained.contained.empty()",
        "xpath" : "not(parent::f:contained and f:contained)",
        "source" : "http://hl7.org/fhir/StructureDefinition/DomainResource"
      },
      {
        "key" : "dom-3",
        "severity" : "error",
        "human" : "If the resource is contained in another resource, it SHALL be referred to from elsewhere in the resource or SHALL refer to the containing resource",
        "expression" : "contained.where((('#'+id in (%resource.descendants().reference | %resource.descendants().as(canonical) | %resource.descendants().as(uri) | %resource.descendants().as(url))) or descendants().where(reference = '#').exists() or descendants().where(as(canonical) = '#').exists() or descendants().where(as(canonical) = '#').exists()).not()).trace('unmatched', id).empty()",
        "xpath" : "not(exists(for $id in f:contained/*/f:id/@value return $contained[not(parent::*/descendant::f:reference/@value=concat('#', $contained/*/id/@value) or descendant::f:reference[@value='#'])]))",
        "source" : "http://hl7.org/fhir/StructureDefinition/DomainResource"
      },
      {
        "key" : "dom-4",
        "severity" : "error",
        "human" : "If a resource is contained in another resource, it SHALL NOT have a meta.versionId or a meta.lastUpdated",
        "expression" : "contained.meta.versionId.empty() and contained.meta.lastUpdated.empty()",
        "xpath" : "not(exists(f:contained/*/f:meta/f:versionId)) and not(exists(f:contained/*/f:meta/f:lastUpdated))",
        "source" : "http://hl7.org/fhir/StructureDefinition/DomainResource"
      },
      {
        "key" : "dom-5",
        "severity" : "error",
        "human" : "If a resource is contained in another resource, it SHALL NOT have a security label",
        "expression" : "contained.meta.security.empty()",
        "xpath" : "not(exists(f:contained/*/f:meta/f:security))",
        "source" : "http://hl7.org/fhir/StructureDefinition/DomainResource"
      },
      {
        "extension" : [{
          "url" : "http://hl7.org/fhir/StructureDefinition/elementdefinition-bestpractice",
          "valueBoolean" : true
        },
        {
          "url" : "http://hl7.org/fhir/StructureDefinition/elementdefinition-bestpractice-explanation",
          "valueMarkdown" : "When a resource has no narrative, only systems that fully understand the data can display the resource to a human safely. Including a human readable representation in the resource makes for a much more robust eco-system and cheaper handling of resources by intermediary systems. Some ecosystems restrict distribution of resources to only those systems that do fully understand the resources, and as a consequence implementers may believe that the narrative is superfluous. However experience shows that such eco-systems often open up to new participants over time."
        }],
        "key" : "dom-6",
        "severity" : "warning",
        "human" : "A resource should have narrative for robust management",
        "expression" : "text.`div`.exists()",
        "xpath" : "exists(f:text/h:div)",
        "source" : "http://hl7.org/fhir/StructureDefinition/DomainResource"
      }],
      "isModifier" : false,
      "isSummary" : false,
      "mapping" : [{
        "identity" : "rim",
        "map" : "Entity. Role, or Act"
      }]
    },
    {
      "id" : "Ingredient.id",
      "path" : "Ingredient.id",
      "short" : "Logical id of this artifact",
      "definition" : "The logical id of the resource, as used in the URL for the resource. Once assigned, this value never changes.",
      "comment" : "The only time that a resource does not have an id is when it is being submitted to the server using a create operation.",
      "min" : 0,
      "max" : "1",
      "base" : {
        "path" : "Resource.id",
        "min" : 0,
        "max" : "1"
      },
      "type" : [{
        "extension" : [{
          "url" : "http://hl7.org/fhir/StructureDefinition/structuredefinition-fhir-type",
          "valueUri" : "id"
        }],
        "code" : "http://hl7.org/fhirpath/System.String"
      }],
      "isModifier" : false,
      "isSummary" : true
    },
    {
      "id" : "Ingredient.meta",
      "path" : "Ingredient.meta",
      "short" : "Metadata about the resource",
      "definition" : "The metadata about the resource. This is content that is maintained by the infrastructure. Changes to the content might not always be associated with version changes to the resource.",
      "min" : 0,
      "max" : "1",
      "base" : {
        "path" : "Resource.meta",
        "min" : 0,
        "max" : "1"
      },
      "type" : [{
        "code" : "Meta"
      }],
      "constraint" : [{
        "key" : "ele-1",
        "severity" : "error",
        "human" : "All FHIR elements must have a @value or children",
        "expression" : "hasValue() or (children().count() > id.count())",
        "xpath" : "@value|f:*|h:div",
        "source" : "http://hl7.org/fhir/StructureDefinition/Element"
      }],
      "isModifier" : false,
      "isSummary" : true
    },
    {
      "id" : "Ingredient.implicitRules",
      "path" : "Ingredient.implicitRules",
      "short" : "A set of rules under which this content was created",
      "definition" : "A reference to a set of rules that were followed when the resource was constructed, and which must be understood when processing the content. Often, this is a reference to an implementation guide that defines the special rules along with other profiles etc.",
      "comment" : "Asserting this rule set restricts the content to be only understood by a limited set of trading partners. This inherently limits the usefulness of the data in the long term. However, the existing health eco-system is highly fractured, and not yet ready to define, collect, and exchange data in a generally computable sense. Wherever possible, implementers and/or specification writers should avoid using this element. Often, when used, the URL is a reference to an implementation guide that defines these special rules as part of it's narrative along with other profiles, value sets, etc.",
      "min" : 0,
      "max" : "1",
      "base" : {
        "path" : "Resource.implicitRules",
        "min" : 0,
        "max" : "1"
      },
      "type" : [{
        "code" : "uri"
      }],
      "constraint" : [{
        "key" : "ele-1",
        "severity" : "error",
        "human" : "All FHIR elements must have a @value or children",
        "expression" : "hasValue() or (children().count() > id.count())",
        "xpath" : "@value|f:*|h:div",
        "source" : "http://hl7.org/fhir/StructureDefinition/Element"
      }],
      "isModifier" : true,
      "isModifierReason" : "This element is labeled as a modifier because the implicit rules may provide additional knowledge about the resource that modifies it's meaning or interpretation",
      "isSummary" : true
    },
    {
      "id" : "Ingredient.language",
      "path" : "Ingredient.language",
      "short" : "Language of the resource content",
      "definition" : "The base language in which the resource is written.",
      "comment" : "Language is provided to support indexing and accessibility (typically, services such as text to speech use the language tag). The html language tag in the narrative applies  to the narrative. The language tag on the resource may be used to specify the language of other presentations generated from the data in the resource. Not all the content has to be in the base language. The Resource.language should not be assumed to apply to the narrative automatically. If a language is specified, it should it also be specified on the div element in the html (see rules in HTML5 for information about the relationship between xml:lang and the html lang attribute).",
      "min" : 0,
      "max" : "1",
      "base" : {
        "path" : "Resource.language",
        "min" : 0,
        "max" : "1"
      },
      "type" : [{
        "code" : "code"
      }],
      "constraint" : [{
        "key" : "ele-1",
        "severity" : "error",
        "human" : "All FHIR elements must have a @value or children",
        "expression" : "hasValue() or (children().count() > id.count())",
        "xpath" : "@value|f:*|h:div",
        "source" : "http://hl7.org/fhir/StructureDefinition/Element"
      }],
      "isModifier" : false,
      "isSummary" : false,
      "binding" : {
        "extension" : [{
          "url" : "http://hl7.org/fhir/StructureDefinition/elementdefinition-maxValueSet",
          "valueCanonical" : "http://hl7.org/fhir/ValueSet/all-languages"
        },
        {
          "url" : "http://hl7.org/fhir/StructureDefinition/elementdefinition-bindingName",
          "valueString" : "Language"
        },
        {
          "url" : "http://hl7.org/fhir/StructureDefinition/elementdefinition-isCommonBinding",
          "valueBoolean" : true
        }],
        "strength" : "preferred",
        "description" : "A human language.",
        "valueSet" : "http://hl7.org/fhir/ValueSet/languages"
      }
    },
    {
      "id" : "Ingredient.text",
      "path" : "Ingredient.text",
      "short" : "Text summary of the resource, for human interpretation",
      "definition" : "A human-readable narrative that contains a summary of the resource and can be used to represent the content of the resource to a human. The narrative need not encode all the structured data, but is required to contain sufficient detail to make it \"clinically safe\" for a human to just read the narrative. Resource definitions may define what content should be represented in the narrative to ensure clinical safety.",
      "comment" : "Contained resources do not have narrative. Resources that are not contained SHOULD have a narrative. In some cases, a resource may only have text with little or no additional discrete data (as long as all minOccurs=1 elements are satisfied).  This may be necessary for data from legacy systems where information is captured as a \"text blob\" or where text is additionally entered raw or narrated and encoded information is added later.",
      "alias" : ["narrative",
      "html",
      "xhtml",
      "display"],
      "min" : 0,
      "max" : "1",
      "base" : {
        "path" : "DomainResource.text",
        "min" : 0,
        "max" : "1"
      },
      "type" : [{
        "code" : "Narrative"
      }],
      "constraint" : [{
        "key" : "ele-1",
        "severity" : "error",
        "human" : "All FHIR elements must have a @value or children",
        "expression" : "hasValue() or (children().count() > id.count())",
        "xpath" : "@value|f:*|h:div",
        "source" : "http://hl7.org/fhir/StructureDefinition/Element"
      }],
      "isModifier" : false,
      "isSummary" : false,
      "mapping" : [{
        "identity" : "rim",
        "map" : "Act.text?"
      }]
    },
    {
      "id" : "Ingredient.contained",
      "path" : "Ingredient.contained",
      "short" : "Contained, inline Resources",
      "definition" : "These resources do not have an independent existence apart from the resource that contains them - they cannot be identified independently, and nor can they have their own independent transaction scope.",
      "comment" : "This should never be done when the content can be identified properly, as once identification is lost, it is extremely difficult (and context dependent) to restore it again. Contained resources may have profiles and tags In their meta elements, but SHALL NOT have security labels.",
      "alias" : ["inline resources",
      "anonymous resources",
      "contained resources"],
      "min" : 0,
      "max" : "*",
      "base" : {
        "path" : "DomainResource.contained",
        "min" : 0,
        "max" : "*"
      },
      "type" : [{
        "code" : "Resource"
      }],
      "isModifier" : false,
      "isSummary" : false,
      "mapping" : [{
        "identity" : "rim",
        "map" : "N/A"
      }]
    },
    {
      "id" : "Ingredient.extension",
      "path" : "Ingredient.extension",
      "short" : "Additional content defined by implementations",
      "definition" : "May be used to represent additional information that is not part of the basic definition of the resource. To make the use of extensions safe and manageable, there is a strict set of governance  applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.",
      "comment" : "There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions.  The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.",
      "alias" : ["extensions",
      "user content"],
      "min" : 0,
      "max" : "*",
      "base" : {
        "path" : "DomainResource.extension",
        "min" : 0,
        "max" : "*"
      },
      "type" : [{
        "code" : "Extension"
      }],
      "constraint" : [{
        "key" : "ele-1",
        "severity" : "error",
        "human" : "All FHIR elements must have a @value or children",
        "expression" : "hasValue() or (children().count() > id.count())",
        "xpath" : "@value|f:*|h:div",
        "source" : "http://hl7.org/fhir/StructureDefinition/Element"
      },
      {
        "key" : "ext-1",
        "severity" : "error",
        "human" : "Must have either extensions or value[x], not both",
        "expression" : "extension.exists() != value.exists()",
        "xpath" : "exists(f:extension)!=exists(f:*[starts-with(local-name(.), \"value\")])",
        "source" : "http://hl7.org/fhir/StructureDefinition/Extension"
      }],
      "isModifier" : false,
      "isSummary" : false,
      "mapping" : [{
        "identity" : "rim",
        "map" : "N/A"
      }]
    },
    {
      "id" : "Ingredient.modifierExtension",
      "path" : "Ingredient.modifierExtension",
      "short" : "Extensions that cannot be ignored",
      "definition" : "May be used to represent additional information that is not part of the basic definition of the resource and that modifies the understanding of the element that contains it and/or the understanding of the containing element's descendants. Usually modifier elements provide negation or qualification. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer is allowed to define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Applications processing a resource are required to check for modifier extensions.\n\nModifier extensions SHALL NOT change the meaning of any elements on Resource or DomainResource (including cannot change the meaning of modifierExtension itself).",
      "comment" : "There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions.  The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.",
      "requirements" : "Modifier extensions allow for extensions that *cannot* be safely ignored to be clearly distinguished from the vast majority of extensions which can be safely ignored.  This promotes interoperability by eliminating the need for implementers to prohibit the presence of extensions. For further information, see the [definition of modifier extensions](extensibility.html#modifierExtension).",
      "alias" : ["extensions",
      "user content"],
      "min" : 0,
      "max" : "*",
      "base" : {
        "path" : "DomainResource.modifierExtension",
        "min" : 0,
        "max" : "*"
      },
      "type" : [{
        "code" : "Extension"
      }],
      "constraint" : [{
        "key" : "ele-1",
        "severity" : "error",
        "human" : "All FHIR elements must have a @value or children",
        "expression" : "hasValue() or (children().count() > id.count())",
        "xpath" : "@value|f:*|h:div",
        "source" : "http://hl7.org/fhir/StructureDefinition/Element"
      },
      {
        "key" : "ext-1",
        "severity" : "error",
        "human" : "Must have either extensions or value[x], not both",
        "expression" : "extension.exists() != value.exists()",
        "xpath" : "exists(f:extension)!=exists(f:*[starts-with(local-name(.), \"value\")])",
        "source" : "http://hl7.org/fhir/StructureDefinition/Extension"
      }],
      "isModifier" : true,
      "isModifierReason" : "Modifier extensions are expected to modify the meaning or interpretation of the resource that contains them",
      "isSummary" : false,
      "mapping" : [{
        "identity" : "rim",
        "map" : "N/A"
      }]
    },
    {
      "id" : "Ingredient.identifier",
      "path" : "Ingredient.identifier",
      "short" : "An identifier or code by which the ingredient can be referenced",
      "definition" : "The identifier(s) of this Ingredient that are assigned by business processes and/or used to refer to it when a direct URL reference to the resource itself is not appropriate.",
      "min" : 0,
      "max" : "1",
      "base" : {
        "path" : "Ingredient.identifier",
        "min" : 0,
        "max" : "1"
      },
      "type" : [{
        "code" : "Identifier"
      }],
      "constraint" : [{
        "key" : "ele-1",
        "severity" : "error",
        "human" : "All FHIR elements must have a @value or children",
        "expression" : "hasValue() or (children().count() > id.count())",
        "xpath" : "@value|f:*|h:div",
        "source" : "http://hl7.org/fhir/StructureDefinition/Element"
      }],
      "isModifier" : false,
      "isSummary" : true
    },
    {
      "id" : "Ingredient.role",
      "path" : "Ingredient.role",
      "short" : "Ingredient role within a drug product e.g. Active ingredient, Excipient",
      "definition" : "Ingredient role within a drug product e.g. Active ingredient, Excipient.",
      "min" : 1,
      "max" : "1",
      "base" : {
        "path" : "Ingredient.role",
        "min" : 1,
        "max" : "1"
      },
      "type" : [{
        "code" : "CodeableConcept"
      }],
      "constraint" : [{
        "key" : "ele-1",
        "severity" : "error",
        "human" : "All FHIR elements must have a @value or children",
        "expression" : "hasValue() or (children().count() > id.count())",
        "xpath" : "@value|f:*|h:div",
        "source" : "http://hl7.org/fhir/StructureDefinition/Element"
      }],
      "isModifier" : false,
      "isSummary" : true
    },
    {
      "id" : "Ingredient.function",
      "path" : "Ingredient.function",
      "short" : "A classification of the ingredient identifying its precise purpose(s) in the drug product. This extends the Ingredient.role to add more detail. Example: Antioxidant, Alkalizing Agent",
      "definition" : "A classification of the ingredient identifying its precise purpose(s) in the drug product. This extends the Ingredient.role to add more detail. Example: Antioxidant, Alkalizing Agent.",
      "min" : 0,
      "max" : "*",
      "base" : {
        "path" : "Ingredient.function",
        "min" : 0,
        "max" : "*"
      },
      "type" : [{
        "code" : "CodeableConcept"
      }],
      "constraint" : [{
        "key" : "ele-1",
        "severity" : "error",
        "human" : "All FHIR elements must have a @value or children",
        "expression" : "hasValue() or (children().count() > id.count())",
        "xpath" : "@value|f:*|h:div",
        "source" : "http://hl7.org/fhir/StructureDefinition/Element"
      }],
      "isModifier" : false,
      "isSummary" : true
    },
    {
      "id" : "Ingredient.description",
      "path" : "Ingredient.description",
      "short" : "A general description of the ingredient, or any supporting text. May be used for an unstructured list of excipients",
      "definition" : "A general description of the ingredient, or any supporting text. May be used for an unstructured list of excipients.",
      "min" : 0,
      "max" : "1",
      "base" : {
        "path" : "Ingredient.description",
        "min" : 0,
        "max" : "1"
      },
      "type" : [{
        "code" : "markdown"
      }],
      "constraint" : [{
        "key" : "ele-1",
        "severity" : "error",
        "human" : "All FHIR elements must have a @value or children",
        "expression" : "hasValue() or (children().count() > id.count())",
        "xpath" : "@value|f:*|h:div",
        "source" : "http://hl7.org/fhir/StructureDefinition/Element"
      }],
      "isModifier" : false,
      "isSummary" : true
    },
    {
      "id" : "Ingredient.allergenicIndicator",
      "path" : "Ingredient.allergenicIndicator",
      "short" : "If the ingredient is a known or suspected allergen",
      "definition" : "If the ingredient is a known or suspected allergen.",
      "min" : 0,
      "max" : "1",
      "base" : {
        "path" : "Ingredient.allergenicIndicator",
        "min" : 0,
        "max" : "1"
      },
      "type" : [{
        "code" : "boolean"
      }],
      "constraint" : [{
        "key" : "ele-1",
        "severity" : "error",
        "human" : "All FHIR elements must have a @value or children",
        "expression" : "hasValue() or (children().count() > id.count())",
        "xpath" : "@value|f:*|h:div",
        "source" : "http://hl7.org/fhir/StructureDefinition/Element"
      }],
      "isModifier" : false,
      "isSummary" : true
    },
    {
      "id" : "Ingredient.manufacturer",
      "path" : "Ingredient.manufacturer",
      "short" : "The organization that manufactures this ingredient",
      "definition" : "The organization that manufactures this ingredient.",
      "min" : 0,
      "max" : "*",
      "base" : {
        "path" : "Ingredient.manufacturer",
        "min" : 0,
        "max" : "*"
      },
      "type" : [{
        "code" : "Reference",
        "targetProfile" : ["http://hl7.org/fhir/StructureDefinition/Organization"]
      }],
      "constraint" : [{
        "key" : "ele-1",
        "severity" : "error",
        "human" : "All FHIR elements must have a @value or children",
        "expression" : "hasValue() or (children().count() > id.count())",
        "xpath" : "@value|f:*|h:div",
        "source" : "http://hl7.org/fhir/StructureDefinition/Element"
      }],
      "isModifier" : false,
      "isSummary" : true
    },
    {
      "id" : "Ingredient.specifiedSubstance",
      "path" : "Ingredient.specifiedSubstance",
      "short" : "A specified substance that comprises this ingredient",
      "definition" : "A specified substance that comprises this ingredient.",
      "min" : 0,
      "max" : "*",
      "base" : {
        "path" : "Ingredient.specifiedSubstance",
        "min" : 0,
        "max" : "*"
      },
      "type" : [{
        "code" : "BackboneElement"
      }],
      "constraint" : [{
        "key" : "ele-1",
        "severity" : "error",
        "human" : "All FHIR elements must have a @value or children",
        "expression" : "hasValue() or (children().count() > id.count())",
        "xpath" : "@value|f:*|h:div",
        "source" : "http://hl7.org/fhir/StructureDefinition/Element"
      }],
      "isModifier" : false,
      "isSummary" : true
    },
    {
      "id" : "Ingredient.specifiedSubstance.id",
      "path" : "Ingredient.specifiedSubstance.id",
      "representation" : ["xmlAttr"],
      "short" : "Unique id for inter-element referencing",
      "definition" : "Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.",
      "min" : 0,
      "max" : "1",
      "base" : {
        "path" : "Element.id",
        "min" : 0,
        "max" : "1"
      },
      "type" : [{
        "extension" : [{
          "url" : "http://hl7.org/fhir/StructureDefinition/structuredefinition-fhir-type",
          "valueUri" : "id"
        }],
        "code" : "http://hl7.org/fhirpath/System.String"
      }],
      "isModifier" : false,
      "isSummary" : false,
      "mapping" : [{
        "identity" : "rim",
        "map" : "n/a"
      }]
    },
    {
      "id" : "Ingredient.specifiedSubstance.extension",
      "path" : "Ingredient.specifiedSubstance.extension",
      "short" : "Additional content defined by implementations",
      "definition" : "May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and manageable, there is a strict set of governance  applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.",
      "comment" : "There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions.  The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.",
      "alias" : ["extensions",
      "user content"],
      "min" : 0,
      "max" : "*",
      "base" : {
        "path" : "Element.extension",
        "min" : 0,
        "max" : "*"
      },
      "type" : [{
        "code" : "Extension"
      }],
      "constraint" : [{
        "key" : "ele-1",
        "severity" : "error",
        "human" : "All FHIR elements must have a @value or children",
        "expression" : "hasValue() or (children().count() > id.count())",
        "xpath" : "@value|f:*|h:div",
        "source" : "http://hl7.org/fhir/StructureDefinition/Element"
      },
      {
        "key" : "ext-1",
        "severity" : "error",
        "human" : "Must have either extensions or value[x], not both",
        "expression" : "extension.exists() != value.exists()",
        "xpath" : "exists(f:extension)!=exists(f:*[starts-with(local-name(.), \"value\")])",
        "source" : "http://hl7.org/fhir/StructureDefinition/Extension"
      }],
      "isModifier" : false,
      "isSummary" : false,
      "mapping" : [{
        "identity" : "rim",
        "map" : "n/a"
      }]
    },
    {
      "id" : "Ingredient.specifiedSubstance.modifierExtension",
      "path" : "Ingredient.specifiedSubstance.modifierExtension",
      "short" : "Extensions that cannot be ignored even if unrecognized",
      "definition" : "May be used to represent additional information that is not part of the basic definition of the element and that modifies the understanding of the element in which it is contained and/or the understanding of the containing element's descendants. Usually modifier elements provide negation or qualification. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Applications processing a resource are required to check for modifier extensions.\n\nModifier extensions SHALL NOT change the meaning of any elements on Resource or DomainResource (including cannot change the meaning of modifierExtension itself).",
      "comment" : "There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions.  The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.",
      "requirements" : "Modifier extensions allow for extensions that *cannot* be safely ignored to be clearly distinguished from the vast majority of extensions which can be safely ignored.  This promotes interoperability by eliminating the need for implementers to prohibit the presence of extensions. For further information, see the [definition of modifier extensions](extensibility.html#modifierExtension).",
      "alias" : ["extensions",
      "user content",
      "modifiers"],
      "min" : 0,
      "max" : "*",
      "base" : {
        "path" : "BackboneElement.modifierExtension",
        "min" : 0,
        "max" : "*"
      },
      "type" : [{
        "code" : "Extension"
      }],
      "constraint" : [{
        "key" : "ele-1",
        "severity" : "error",
        "human" : "All FHIR elements must have a @value or children",
        "expression" : "hasValue() or (children().count() > id.count())",
        "xpath" : "@value|f:*|h:div",
        "source" : "http://hl7.org/fhir/StructureDefinition/Element"
      },
      {
        "key" : "ext-1",
        "severity" : "error",
        "human" : "Must have either extensions or value[x], not both",
        "expression" : "extension.exists() != value.exists()",
        "xpath" : "exists(f:extension)!=exists(f:*[starts-with(local-name(.), \"value\")])",
        "source" : "http://hl7.org/fhir/StructureDefinition/Extension"
      }],
      "isModifier" : true,
      "isModifierReason" : "Modifier extensions are expected to modify the meaning or interpretation of the element that contains them",
      "isSummary" : true,
      "mapping" : [{
        "identity" : "rim",
        "map" : "N/A"
      }]
    },
    {
      "id" : "Ingredient.specifiedSubstance.code[x]",
      "path" : "Ingredient.specifiedSubstance.code[x]",
      "short" : "Substance as a 'specified substance', implying extra substance related characteristics",
      "definition" : "Substance as a 'specified substance', implying extra substance related characteristics.",
      "min" : 1,
      "max" : "1",
      "base" : {
        "path" : "Ingredient.specifiedSubstance.code[x]",
        "min" : 1,
        "max" : "1"
      },
      "type" : [{
        "code" : "CodeableConcept"
      },
      {
        "code" : "Reference",
        "targetProfile" : ["http://hl7.org/fhir/StructureDefinition/SubstanceDefinition",
        "http://hl7.org/fhir/StructureDefinition/Substance"]
      }],
      "constraint" : [{
        "key" : "ele-1",
        "severity" : "error",
        "human" : "All FHIR elements must have a @value or children",
        "expression" : "hasValue() or (children().count() > id.count())",
        "xpath" : "@value|f:*|h:div",
        "source" : "http://hl7.org/fhir/StructureDefinition/Element"
      }],
      "isModifier" : false,
      "isSummary" : true
    },
    {
      "id" : "Ingredient.specifiedSubstance.group",
      "path" : "Ingredient.specifiedSubstance.group",
      "short" : "The group of specified substance, e.g. group 1 to 4",
      "definition" : "The group of specified substance, e.g. group 1 to 4.",
      "min" : 1,
      "max" : "1",
      "base" : {
        "path" : "Ingredient.specifiedSubstance.group",
        "min" : 1,
        "max" : "1"
      },
      "type" : [{
        "code" : "CodeableConcept"
      }],
      "constraint" : [{
        "key" : "ele-1",
        "severity" : "error",
        "human" : "All FHIR elements must have a @value or children",
        "expression" : "hasValue() or (children().count() > id.count())",
        "xpath" : "@value|f:*|h:div",
        "source" : "http://hl7.org/fhir/StructureDefinition/Element"
      }],
      "isModifier" : false,
      "isSummary" : true
    },
    {
      "id" : "Ingredient.specifiedSubstance.confidentiality",
      "path" : "Ingredient.specifiedSubstance.confidentiality",
      "short" : "Confidentiality level of the specified substance as the ingredient",
      "definition" : "Confidentiality level of the specified substance as the ingredient.",
      "min" : 0,
      "max" : "1",
      "base" : {
        "path" : "Ingredient.specifiedSubstance.confidentiality",
        "min" : 0,
        "max" : "1"
      },
      "type" : [{
        "code" : "CodeableConcept"
      }],
      "constraint" : [{
        "key" : "ele-1",
        "severity" : "error",
        "human" : "All FHIR elements must have a @value or children",
        "expression" : "hasValue() or (children().count() > id.count())",
        "xpath" : "@value|f:*|h:div",
        "source" : "http://hl7.org/fhir/StructureDefinition/Element"
      }],
      "isModifier" : false,
      "isSummary" : true
    },
    {
      "id" : "Ingredient.specifiedSubstance.strength",
      "path" : "Ingredient.specifiedSubstance.strength",
      "short" : "Quantity of the substance or specified substance present in the manufactured item or pharmaceutical product",
      "definition" : "Quantity of the substance or specified substance present in the manufactured item or pharmaceutical product.",
      "min" : 0,
      "max" : "*",
      "base" : {
        "path" : "Ingredient.specifiedSubstance.strength",
        "min" : 0,
        "max" : "*"
      },
      "type" : [{
        "code" : "BackboneElement"
      }],
      "constraint" : [{
        "key" : "ele-1",
        "severity" : "error",
        "human" : "All FHIR elements must have a @value or children",
        "expression" : "hasValue() or (children().count() > id.count())",
        "xpath" : "@value|f:*|h:div",
        "source" : "http://hl7.org/fhir/StructureDefinition/Element"
      }],
      "isModifier" : false,
      "isSummary" : true
    },
    {
      "id" : "Ingredient.specifiedSubstance.strength.id",
      "path" : "Ingredient.specifiedSubstance.strength.id",
      "representation" : ["xmlAttr"],
      "short" : "Unique id for inter-element referencing",
      "definition" : "Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.",
      "min" : 0,
      "max" : "1",
      "base" : {
        "path" : "Element.id",
        "min" : 0,
        "max" : "1"
      },
      "type" : [{
        "extension" : [{
          "url" : "http://hl7.org/fhir/StructureDefinition/structuredefinition-fhir-type",
          "valueUri" : "id"
        }],
        "code" : "http://hl7.org/fhirpath/System.String"
      }],
      "isModifier" : false,
      "isSummary" : false,
      "mapping" : [{
        "identity" : "rim",
        "map" : "n/a"
      }]
    },
    {
      "id" : "Ingredient.specifiedSubstance.strength.extension",
      "path" : "Ingredient.specifiedSubstance.strength.extension",
      "short" : "Additional content defined by implementations",
      "definition" : "May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and manageable, there is a strict set of governance  applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.",
      "comment" : "There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions.  The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.",
      "alias" : ["extensions",
      "user content"],
      "min" : 0,
      "max" : "*",
      "base" : {
        "path" : "Element.extension",
        "min" : 0,
        "max" : "*"
      },
      "type" : [{
        "code" : "Extension"
      }],
      "constraint" : [{
        "key" : "ele-1",
        "severity" : "error",
        "human" : "All FHIR elements must have a @value or children",
        "expression" : "hasValue() or (children().count() > id.count())",
        "xpath" : "@value|f:*|h:div",
        "source" : "http://hl7.org/fhir/StructureDefinition/Element"
      },
      {
        "key" : "ext-1",
        "severity" : "error",
        "human" : "Must have either extensions or value[x], not both",
        "expression" : "extension.exists() != value.exists()",
        "xpath" : "exists(f:extension)!=exists(f:*[starts-with(local-name(.), \"value\")])",
        "source" : "http://hl7.org/fhir/StructureDefinition/Extension"
      }],
      "isModifier" : false,
      "isSummary" : false,
      "mapping" : [{
        "identity" : "rim",
        "map" : "n/a"
      }]
    },
    {
      "id" : "Ingredient.specifiedSubstance.strength.modifierExtension",
      "path" : "Ingredient.specifiedSubstance.strength.modifierExtension",
      "short" : "Extensions that cannot be ignored even if unrecognized",
      "definition" : "May be used to represent additional information that is not part of the basic definition of the element and that modifies the understanding of the element in which it is contained and/or the understanding of the containing element's descendants. Usually modifier elements provide negation or qualification. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Applications processing a resource are required to check for modifier extensions.\n\nModifier extensions SHALL NOT change the meaning of any elements on Resource or DomainResource (including cannot change the meaning of modifierExtension itself).",
      "comment" : "There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions.  The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.",
      "requirements" : "Modifier extensions allow for extensions that *cannot* be safely ignored to be clearly distinguished from the vast majority of extensions which can be safely ignored.  This promotes interoperability by eliminating the need for implementers to prohibit the presence of extensions. For further information, see the [definition of modifier extensions](extensibility.html#modifierExtension).",
      "alias" : ["extensions",
      "user content",
      "modifiers"],
      "min" : 0,
      "max" : "*",
      "base" : {
        "path" : "BackboneElement.modifierExtension",
        "min" : 0,
        "max" : "*"
      },
      "type" : [{
        "code" : "Extension"
      }],
      "constraint" : [{
        "key" : "ele-1",
        "severity" : "error",
        "human" : "All FHIR elements must have a @value or children",
        "expression" : "hasValue() or (children().count() > id.count())",
        "xpath" : "@value|f:*|h:div",
        "source" : "http://hl7.org/fhir/StructureDefinition/Element"
      },
      {
        "key" : "ext-1",
        "severity" : "error",
        "human" : "Must have either extensions or value[x], not both",
        "expression" : "extension.exists() != value.exists()",
        "xpath" : "exists(f:extension)!=exists(f:*[starts-with(local-name(.), \"value\")])",
        "source" : "http://hl7.org/fhir/StructureDefinition/Extension"
      }],
      "isModifier" : true,
      "isModifierReason" : "Modifier extensions are expected to modify the meaning or interpretation of the element that contains them",
      "isSummary" : true,
      "mapping" : [{
        "identity" : "rim",
        "map" : "N/A"
      }]
    },
    {
      "id" : "Ingredient.specifiedSubstance.strength.presentation",
      "path" : "Ingredient.specifiedSubstance.strength.presentation",
      "short" : "The quantity of substance in the unit of presentation, or in the volume (or mass) of the single pharmaceutical product or manufactured item",
      "definition" : "The quantity of substance in the unit of presentation, or in the volume (or mass) of the single pharmaceutical product or manufactured item.",
      "min" : 0,
      "max" : "1",
      "base" : {
        "path" : "Ingredient.specifiedSubstance.strength.presentation",
        "min" : 0,
        "max" : "1"
      },
      "type" : [{
        "code" : "Ratio"
      }],
      "constraint" : [{
        "key" : "ele-1",
        "severity" : "error",
        "human" : "All FHIR elements must have a @value or children",
        "expression" : "hasValue() or (children().count() > id.count())",
        "xpath" : "@value|f:*|h:div",
        "source" : "http://hl7.org/fhir/StructureDefinition/Element"
      }],
      "isModifier" : false,
      "isSummary" : true
    },
    {
      "id" : "Ingredient.specifiedSubstance.strength.presentationHighLimit",
      "path" : "Ingredient.specifiedSubstance.strength.presentationHighLimit",
      "short" : "An upper limit for the quantity of substance in the unit of presentation. For use when there is a range of strengths, this is the high limit, with the presentation attribute becoming the lower limit",
      "definition" : "An upper limit for the quantity of substance in the unit of presentation. For use when there is a range of strengths, this is the high limit, with the presentation attribute becoming the lower limit.",
      "min" : 0,
      "max" : "1",
      "base" : {
        "path" : "Ingredient.specifiedSubstance.strength.presentationHighLimit",
        "min" : 0,
        "max" : "1"
      },
      "type" : [{
        "code" : "Ratio"
      }],
      "constraint" : [{
        "key" : "ele-1",
        "severity" : "error",
        "human" : "All FHIR elements must have a @value or children",
        "expression" : "hasValue() or (children().count() > id.count())",
        "xpath" : "@value|f:*|h:div",
        "source" : "http://hl7.org/fhir/StructureDefinition/Element"
      }],
      "isModifier" : true,
      "isModifierReason" : "If this is present it implies that the whole strength is expressed as a range, due to uncertainty or variation",
      "isSummary" : true
    },
    {
      "id" : "Ingredient.specifiedSubstance.strength.presentationText",
      "path" : "Ingredient.specifiedSubstance.strength.presentationText",
      "short" : "A textual represention of either the whole of the presentation strength or a part of it - with the rest being in Strength.presentation as a ratio",
      "definition" : "A textual represention of either the whole of the presentation strength or a part of it - with the rest being in Strength.presentation as a ratio.",
      "min" : 0,
      "max" : "1",
      "base" : {
        "path" : "Ingredient.specifiedSubstance.strength.presentationText",
        "min" : 0,
        "max" : "1"
      },
      "type" : [{
        "code" : "string"
      }],
      "constraint" : [{
        "key" : "ele-1",
        "severity" : "error",
        "human" : "All FHIR elements must have a @value or children",
        "expression" : "hasValue() or (children().count() > id.count())",
        "xpath" : "@value|f:*|h:div",
        "source" : "http://hl7.org/fhir/StructureDefinition/Element"
      }],
      "isModifier" : false,
      "isSummary" : true
    },
    {
      "id" : "Ingredient.specifiedSubstance.strength.concentration",
      "path" : "Ingredient.specifiedSubstance.strength.concentration",
      "short" : "The strength per unitary volume (or mass)",
      "definition" : "The strength per unitary volume (or mass).",
      "min" : 0,
      "max" : "1",
      "base" : {
        "path" : "Ingredient.specifiedSubstance.strength.concentration",
        "min" : 0,
        "max" : "1"
      },
      "type" : [{
        "code" : "Ratio"
      }],
      "constraint" : [{
        "key" : "ele-1",
        "severity" : "error",
        "human" : "All FHIR elements must have a @value or children",
        "expression" : "hasValue() or (children().count() > id.count())",
        "xpath" : "@value|f:*|h:div",
        "source" : "http://hl7.org/fhir/StructureDefinition/Element"
      }],
      "isModifier" : false,
      "isSummary" : true
    },
    {
      "id" : "Ingredient.specifiedSubstance.strength.concentrationHighLimit",
      "path" : "Ingredient.specifiedSubstance.strength.concentrationHighLimit",
      "short" : "An upper limit for the strength per unitary volume (or mass), for when there is a range. The concentration attribute then becomes the lower limit",
      "definition" : "An upper limit for the strength per unitary volume (or mass), for when there is a range. The concentration attribute then becomes the lower limit.",
      "min" : 0,
      "max" : "1",
      "base" : {
        "path" : "Ingredient.specifiedSubstance.strength.concentrationHighLimit",
        "min" : 0,
        "max" : "1"
      },
      "type" : [{
        "code" : "Ratio"
      }],
      "constraint" : [{
        "key" : "ele-1",
        "severity" : "error",
        "human" : "All FHIR elements must have a @value or children",
        "expression" : "hasValue() or (children().count() > id.count())",
        "xpath" : "@value|f:*|h:div",
        "source" : "http://hl7.org/fhir/StructureDefinition/Element"
      }],
      "isModifier" : true,
      "isModifierReason" : "If this is present it implies that the whole strength is expressed as a range, due to uncertainty or variation",
      "isSummary" : true
    },
    {
      "id" : "Ingredient.specifiedSubstance.strength.concentrationText",
      "path" : "Ingredient.specifiedSubstance.strength.concentrationText",
      "short" : "A textual represention of either the whole of the concentration strength or a part of it - with the rest being in Strength.concentration as a ratio",
      "definition" : "A textual represention of either the whole of the concentration strength or a part of it - with the rest being in Strength.concentration as a ratio.",
      "min" : 0,
      "max" : "1",
      "base" : {
        "path" : "Ingredient.specifiedSubstance.strength.concentrationText",
        "min" : 0,
        "max" : "1"
      },
      "type" : [{
        "code" : "string"
      }],
      "constraint" : [{
        "key" : "ele-1",
        "severity" : "error",
        "human" : "All FHIR elements must have a @value or children",
        "expression" : "hasValue() or (children().count() > id.count())",
        "xpath" : "@value|f:*|h:div",
        "source" : "http://hl7.org/fhir/StructureDefinition/Element"
      }],
      "isModifier" : false,
      "isSummary" : true
    },
    {
      "id" : "Ingredient.specifiedSubstance.strength.measurementPoint",
      "path" : "Ingredient.specifiedSubstance.strength.measurementPoint",
      "short" : "For when strength is measured at a particular point or distance",
      "definition" : "For when strength is measured at a particular point or distance.",
      "min" : 0,
      "max" : "1",
      "base" : {
        "path" : "Ingredient.specifiedSubstance.strength.measurementPoint",
        "min" : 0,
        "max" : "1"
      },
      "type" : [{
        "code" : "string"
      }],
      "constraint" : [{
        "key" : "ele-1",
        "severity" : "error",
        "human" : "All FHIR elements must have a @value or children",
        "expression" : "hasValue() or (children().count() > id.count())",
        "xpath" : "@value|f:*|h:div",
        "source" : "http://hl7.org/fhir/StructureDefinition/Element"
      }],
      "isModifier" : false,
      "isSummary" : true
    },
    {
      "id" : "Ingredient.specifiedSubstance.strength.country",
      "path" : "Ingredient.specifiedSubstance.strength.country",
      "short" : "The country or countries for which the strength range applies",
      "definition" : "The country or countries for which the strength range applies.",
      "min" : 0,
      "max" : "*",
      "base" : {
        "path" : "Ingredient.specifiedSubstance.strength.country",
        "min" : 0,
        "max" : "*"
      },
      "type" : [{
        "code" : "CodeableConcept"
      }],
      "constraint" : [{
        "key" : "ele-1",
        "severity" : "error",
        "human" : "All FHIR elements must have a @value or children",
        "expression" : "hasValue() or (children().count() > id.count())",
        "xpath" : "@value|f:*|h:div",
        "source" : "http://hl7.org/fhir/StructureDefinition/Element"
      }],
      "isModifier" : false,
      "isSummary" : true
    },
    {
      "id" : "Ingredient.specifiedSubstance.strength.referenceStrength",
      "path" : "Ingredient.specifiedSubstance.strength.referenceStrength",
      "short" : "Strength expressed in terms of a reference substance",
      "definition" : "Strength expressed in terms of a reference substance.",
      "min" : 0,
      "max" : "*",
      "base" : {
        "path" : "Ingredient.specifiedSubstance.strength.referenceStrength",
        "min" : 0,
        "max" : "*"
      },
      "type" : [{
        "code" : "BackboneElement"
      }],
      "constraint" : [{
        "key" : "ele-1",
        "severity" : "error",
        "human" : "All FHIR elements must have a @value or children",
        "expression" : "hasValue() or (children().count() > id.count())",
        "xpath" : "@value|f:*|h:div",
        "source" : "http://hl7.org/fhir/StructureDefinition/Element"
      }],
      "isModifier" : false,
      "isSummary" : true
    },
    {
      "id" : "Ingredient.specifiedSubstance.strength.referenceStrength.id",
      "path" : "Ingredient.specifiedSubstance.strength.referenceStrength.id",
      "representation" : ["xmlAttr"],
      "short" : "Unique id for inter-element referencing",
      "definition" : "Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.",
      "min" : 0,
      "max" : "1",
      "base" : {
        "path" : "Element.id",
        "min" : 0,
        "max" : "1"
      },
      "type" : [{
        "extension" : [{
          "url" : "http://hl7.org/fhir/StructureDefinition/structuredefinition-fhir-type",
          "valueUri" : "id"
        }],
        "code" : "http://hl7.org/fhirpath/System.String"
      }],
      "isModifier" : false,
      "isSummary" : false,
      "mapping" : [{
        "identity" : "rim",
        "map" : "n/a"
      }]
    },
    {
      "id" : "Ingredient.specifiedSubstance.strength.referenceStrength.extension",
      "path" : "Ingredient.specifiedSubstance.strength.referenceStrength.extension",
      "short" : "Additional content defined by implementations",
      "definition" : "May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and manageable, there is a strict set of governance  applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.",
      "comment" : "There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions.  The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.",
      "alias" : ["extensions",
      "user content"],
      "min" : 0,
      "max" : "*",
      "base" : {
        "path" : "Element.extension",
        "min" : 0,
        "max" : "*"
      },
      "type" : [{
        "code" : "Extension"
      }],
      "constraint" : [{
        "key" : "ele-1",
        "severity" : "error",
        "human" : "All FHIR elements must have a @value or children",
        "expression" : "hasValue() or (children().count() > id.count())",
        "xpath" : "@value|f:*|h:div",
        "source" : "http://hl7.org/fhir/StructureDefinition/Element"
      },
      {
        "key" : "ext-1",
        "severity" : "error",
        "human" : "Must have either extensions or value[x], not both",
        "expression" : "extension.exists() != value.exists()",
        "xpath" : "exists(f:extension)!=exists(f:*[starts-with(local-name(.), \"value\")])",
        "source" : "http://hl7.org/fhir/StructureDefinition/Extension"
      }],
      "isModifier" : false,
      "isSummary" : false,
      "mapping" : [{
        "identity" : "rim",
        "map" : "n/a"
      }]
    },
    {
      "id" : "Ingredient.specifiedSubstance.strength.referenceStrength.modifierExtension",
      "path" : "Ingredient.specifiedSubstance.strength.referenceStrength.modifierExtension",
      "short" : "Extensions that cannot be ignored even if unrecognized",
      "definition" : "May be used to represent additional information that is not part of the basic definition of the element and that modifies the understanding of the element in which it is contained and/or the understanding of the containing element's descendants. Usually modifier elements provide negation or qualification. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Applications processing a resource are required to check for modifier extensions.\n\nModifier extensions SHALL NOT change the meaning of any elements on Resource or DomainResource (including cannot change the meaning of modifierExtension itself).",
      "comment" : "There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions.  The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.",
      "requirements" : "Modifier extensions allow for extensions that *cannot* be safely ignored to be clearly distinguished from the vast majority of extensions which can be safely ignored.  This promotes interoperability by eliminating the need for implementers to prohibit the presence of extensions. For further information, see the [definition of modifier extensions](extensibility.html#modifierExtension).",
      "alias" : ["extensions",
      "user content",
      "modifiers"],
      "min" : 0,
      "max" : "*",
      "base" : {
        "path" : "BackboneElement.modifierExtension",
        "min" : 0,
        "max" : "*"
      },
      "type" : [{
        "code" : "Extension"
      }],
      "constraint" : [{
        "key" : "ele-1",
        "severity" : "error",
        "human" : "All FHIR elements must have a @value or children",
        "expression" : "hasValue() or (children().count() > id.count())",
        "xpath" : "@value|f:*|h:div",
        "source" : "http://hl7.org/fhir/StructureDefinition/Element"
      },
      {
        "key" : "ext-1",
        "severity" : "error",
        "human" : "Must have either extensions or value[x], not both",
        "expression" : "extension.exists() != value.exists()",
        "xpath" : "exists(f:extension)!=exists(f:*[starts-with(local-name(.), \"value\")])",
        "source" : "http://hl7.org/fhir/StructureDefinition/Extension"
      }],
      "isModifier" : true,
      "isModifierReason" : "Modifier extensions are expected to modify the meaning or interpretation of the element that contains them",
      "isSummary" : true,
      "mapping" : [{
        "identity" : "rim",
        "map" : "N/A"
      }]
    },
    {
      "id" : "Ingredient.specifiedSubstance.strength.referenceStrength.substance[x]",
      "path" : "Ingredient.specifiedSubstance.strength.referenceStrength.substance[x]",
      "short" : "Relevant reference substance",
      "definition" : "Relevant reference substance.",
      "min" : 0,
      "max" : "1",
      "base" : {
        "path" : "Ingredient.specifiedSubstance.strength.referenceStrength.substance[x]",
        "min" : 0,
        "max" : "1"
      },
      "type" : [{
        "code" : "CodeableConcept"
      },
      {
        "code" : "Reference",
        "targetProfile" : ["http://hl7.org/fhir/StructureDefinition/SubstanceDefinition",
        "http://hl7.org/fhir/StructureDefinition/Substance"]
      }],
      "constraint" : [{
        "key" : "ele-1",
        "severity" : "error",
        "human" : "All FHIR elements must have a @value or children",
        "expression" : "hasValue() or (children().count() > id.count())",
        "xpath" : "@value|f:*|h:div",
        "source" : "http://hl7.org/fhir/StructureDefinition/Element"
      }],
      "isModifier" : false,
      "isSummary" : true
    },
    {
      "id" : "Ingredient.specifiedSubstance.strength.referenceStrength.strength",
      "path" : "Ingredient.specifiedSubstance.strength.referenceStrength.strength",
      "short" : "Strength expressed in terms of a reference substance",
      "definition" : "Strength expressed in terms of a reference substance.",
      "min" : 1,
      "max" : "1",
      "base" : {
        "path" : "Ingredient.specifiedSubstance.strength.referenceStrength.strength",
        "min" : 1,
        "max" : "1"
      },
      "type" : [{
        "code" : "Ratio"
      }],
      "constraint" : [{
        "key" : "ele-1",
        "severity" : "error",
        "human" : "All FHIR elements must have a @value or children",
        "expression" : "hasValue() or (children().count() > id.count())",
        "xpath" : "@value|f:*|h:div",
        "source" : "http://hl7.org/fhir/StructureDefinition/Element"
      }],
      "isModifier" : false,
      "isSummary" : true
    },
    {
      "id" : "Ingredient.specifiedSubstance.strength.referenceStrength.strengthHighLimit",
      "path" : "Ingredient.specifiedSubstance.strength.referenceStrength.strengthHighLimit",
      "short" : "Strength expressed in terms of a reference substance, upper limit",
      "definition" : "Strength expressed in terms of a reference substance, upper limit.",
      "min" : 0,
      "max" : "1",
      "base" : {
        "path" : "Ingredient.specifiedSubstance.strength.referenceStrength.strengthHighLimit",
        "min" : 0,
        "max" : "1"
      },
      "type" : [{
        "code" : "Ratio"
      }],
      "constraint" : [{
        "key" : "ele-1",
        "severity" : "error",
        "human" : "All FHIR elements must have a @value or children",
        "expression" : "hasValue() or (children().count() > id.count())",
        "xpath" : "@value|f:*|h:div",
        "source" : "http://hl7.org/fhir/StructureDefinition/Element"
      }],
      "isModifier" : false,
      "isSummary" : true
    },
    {
      "id" : "Ingredient.specifiedSubstance.strength.referenceStrength.measurementPoint",
      "path" : "Ingredient.specifiedSubstance.strength.referenceStrength.measurementPoint",
      "short" : "For when strength is measured at a particular point or distance",
      "definition" : "For when strength is measured at a particular point or distance.",
      "min" : 0,
      "max" : "1",
      "base" : {
        "path" : "Ingredient.specifiedSubstance.strength.referenceStrength.measurementPoint",
        "min" : 0,
        "max" : "1"
      },
      "type" : [{
        "code" : "string"
      }],
      "constraint" : [{
        "key" : "ele-1",
        "severity" : "error",
        "human" : "All FHIR elements must have a @value or children",
        "expression" : "hasValue() or (children().count() > id.count())",
        "xpath" : "@value|f:*|h:div",
        "source" : "http://hl7.org/fhir/StructureDefinition/Element"
      }],
      "isModifier" : false,
      "isSummary" : true
    },
    {
      "id" : "Ingredient.specifiedSubstance.strength.referenceStrength.country",
      "path" : "Ingredient.specifiedSubstance.strength.referenceStrength.country",
      "short" : "The country or countries for which the strength range applies",
      "definition" : "The country or countries for which the strength range applies.",
      "min" : 0,
      "max" : "*",
      "base" : {
        "path" : "Ingredient.specifiedSubstance.strength.referenceStrength.country",
        "min" : 0,
        "max" : "*"
      },
      "type" : [{
        "code" : "CodeableConcept"
      }],
      "constraint" : [{
        "key" : "ele-1",
        "severity" : "error",
        "human" : "All FHIR elements must have a @value or children",
        "expression" : "hasValue() or (children().count() > id.count())",
        "xpath" : "@value|f:*|h:div",
        "source" : "http://hl7.org/fhir/StructureDefinition/Element"
      }],
      "isModifier" : false,
      "isSummary" : true
    },
    {
      "id" : "Ingredient.substance",
      "path" : "Ingredient.substance",
      "short" : "The substance that comprises this ingredient",
      "definition" : "The substance that comprises this ingredient.",
      "min" : 0,
      "max" : "1",
      "base" : {
        "path" : "Ingredient.substance",
        "min" : 0,
        "max" : "1"
      },
      "type" : [{
        "code" : "BackboneElement"
      }],
      "constraint" : [{
        "key" : "ele-1",
        "severity" : "error",
        "human" : "All FHIR elements must have a @value or children",
        "expression" : "hasValue() or (children().count() > id.count())",
        "xpath" : "@value|f:*|h:div",
        "source" : "http://hl7.org/fhir/StructureDefinition/Element"
      }],
      "isModifier" : false,
      "isSummary" : true
    },
    {
      "id" : "Ingredient.substance.id",
      "path" : "Ingredient.substance.id",
      "representation" : ["xmlAttr"],
      "short" : "Unique id for inter-element referencing",
      "definition" : "Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.",
      "min" : 0,
      "max" : "1",
      "base" : {
        "path" : "Element.id",
        "min" : 0,
        "max" : "1"
      },
      "type" : [{
        "extension" : [{
          "url" : "http://hl7.org/fhir/StructureDefinition/structuredefinition-fhir-type",
          "valueUri" : "id"
        }],
        "code" : "http://hl7.org/fhirpath/System.String"
      }],
      "isModifier" : false,
      "isSummary" : false,
      "mapping" : [{
        "identity" : "rim",
        "map" : "n/a"
      }]
    },
    {
      "id" : "Ingredient.substance.extension",
      "path" : "Ingredient.substance.extension",
      "short" : "Additional content defined by implementations",
      "definition" : "May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and manageable, there is a strict set of governance  applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.",
      "comment" : "There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions.  The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.",
      "alias" : ["extensions",
      "user content"],
      "min" : 0,
      "max" : "*",
      "base" : {
        "path" : "Element.extension",
        "min" : 0,
        "max" : "*"
      },
      "type" : [{
        "code" : "Extension"
      }],
      "constraint" : [{
        "key" : "ele-1",
        "severity" : "error",
        "human" : "All FHIR elements must have a @value or children",
        "expression" : "hasValue() or (children().count() > id.count())",
        "xpath" : "@value|f:*|h:div",
        "source" : "http://hl7.org/fhir/StructureDefinition/Element"
      },
      {
        "key" : "ext-1",
        "severity" : "error",
        "human" : "Must have either extensions or value[x], not both",
        "expression" : "extension.exists() != value.exists()",
        "xpath" : "exists(f:extension)!=exists(f:*[starts-with(local-name(.), \"value\")])",
        "source" : "http://hl7.org/fhir/StructureDefinition/Extension"
      }],
      "isModifier" : false,
      "isSummary" : false,
      "mapping" : [{
        "identity" : "rim",
        "map" : "n/a"
      }]
    },
    {
      "id" : "Ingredient.substance.modifierExtension",
      "path" : "Ingredient.substance.modifierExtension",
      "short" : "Extensions that cannot be ignored even if unrecognized",
      "definition" : "May be used to represent additional information that is not part of the basic definition of the element and that modifies the understanding of the element in which it is contained and/or the understanding of the containing element's descendants. Usually modifier elements provide negation or qualification. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Applications processing a resource are required to check for modifier extensions.\n\nModifier extensions SHALL NOT change the meaning of any elements on Resource or DomainResource (including cannot change the meaning of modifierExtension itself).",
      "comment" : "There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions.  The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.",
      "requirements" : "Modifier extensions allow for extensions that *cannot* be safely ignored to be clearly distinguished from the vast majority of extensions which can be safely ignored.  This promotes interoperability by eliminating the need for implementers to prohibit the presence of extensions. For further information, see the [definition of modifier extensions](extensibility.html#modifierExtension).",
      "alias" : ["extensions",
      "user content",
      "modifiers"],
      "min" : 0,
      "max" : "*",
      "base" : {
        "path" : "BackboneElement.modifierExtension",
        "min" : 0,
        "max" : "*"
      },
      "type" : [{
        "code" : "Extension"
      }],
      "constraint" : [{
        "key" : "ele-1",
        "severity" : "error",
        "human" : "All FHIR elements must have a @value or children",
        "expression" : "hasValue() or (children().count() > id.count())",
        "xpath" : "@value|f:*|h:div",
        "source" : "http://hl7.org/fhir/StructureDefinition/Element"
      },
      {
        "key" : "ext-1",
        "severity" : "error",
        "human" : "Must have either extensions or value[x], not both",
        "expression" : "extension.exists() != value.exists()",
        "xpath" : "exists(f:extension)!=exists(f:*[starts-with(local-name(.), \"value\")])",
        "source" : "http://hl7.org/fhir/StructureDefinition/Extension"
      }],
      "isModifier" : true,
      "isModifierReason" : "Modifier extensions are expected to modify the meaning or interpretation of the element that contains them",
      "isSummary" : true,
      "mapping" : [{
        "identity" : "rim",
        "map" : "N/A"
      }]
    },
    {
      "id" : "Ingredient.substance.code[x]",
      "path" : "Ingredient.substance.code[x]",
      "short" : "A code that represents the ingredient substance",
      "definition" : "A code that represents the ingredient substance.",
      "min" : 1,
      "max" : "1",
      "base" : {
        "path" : "Ingredient.substance.code[x]",
        "min" : 1,
        "max" : "1"
      },
      "type" : [{
        "code" : "CodeableConcept"
      },
      {
        "code" : "Reference",
        "targetProfile" : ["http://hl7.org/fhir/StructureDefinition/SubstanceDefinition",
        "http://hl7.org/fhir/StructureDefinition/Substance"]
      }],
      "constraint" : [{
        "key" : "ele-1",
        "severity" : "error",
        "human" : "All FHIR elements must have a @value or children",
        "expression" : "hasValue() or (children().count() > id.count())",
        "xpath" : "@value|f:*|h:div",
        "source" : "http://hl7.org/fhir/StructureDefinition/Element"
      }],
      "isModifier" : false,
      "isSummary" : true
    },
    {
      "id" : "Ingredient.substance.strength",
      "path" : "Ingredient.substance.strength",
      "short" : "Quantity of the substance or specified substance present in the manufactured item or pharmaceutical product",
      "definition" : "Quantity of the substance or specified substance present in the manufactured item or pharmaceutical product.",
      "min" : 0,
      "max" : "*",
      "base" : {
        "path" : "Ingredient.substance.strength",
        "min" : 0,
        "max" : "*"
      },
      "contentReference" : "#Ingredient.specifiedSubstance.strength",
      "constraint" : [{
        "key" : "ele-1",
        "severity" : "error",
        "human" : "All FHIR elements must have a @value or children",
        "expression" : "hasValue() or (children().count() > id.count())",
        "xpath" : "@value|f:*|h:div",
        "source" : "http://hl7.org/fhir/StructureDefinition/Element"
      }],
      "isModifier" : false,
      "isSummary" : true
    }]
  },
  "differential" : {
    "element" : [{
      "id" : "Ingredient",
      "path" : "Ingredient",
      "short" : "An ingredient of a manufactured item or pharmaceutical product",
      "definition" : "An ingredient of a manufactured item or pharmaceutical product.",
      "min" : 0,
      "max" : "*"
    },
    {
      "id" : "Ingredient.identifier",
      "path" : "Ingredient.identifier",
      "short" : "An identifier or code by which the ingredient can be referenced",
      "definition" : "The identifier(s) of this Ingredient that are assigned by business processes and/or used to refer to it when a direct URL reference to the resource itself is not appropriate.",
      "min" : 0,
      "max" : "1",
      "type" : [{
        "code" : "Identifier"
      }],
      "isSummary" : true
    },
    {
      "id" : "Ingredient.role",
      "path" : "Ingredient.role",
      "short" : "Ingredient role within a drug product e.g. Active ingredient, Excipient",
      "definition" : "Ingredient role within a drug product e.g. Active ingredient, Excipient.",
      "min" : 1,
      "max" : "1",
      "type" : [{
        "code" : "CodeableConcept"
      }],
      "isSummary" : true
    },
    {
      "id" : "Ingredient.function",
      "path" : "Ingredient.function",
      "short" : "A classification of the ingredient identifying its precise purpose(s) in the drug product. This extends the Ingredient.role to add more detail. Example: Antioxidant, Alkalizing Agent",
      "definition" : "A classification of the ingredient identifying its precise purpose(s) in the drug product. This extends the Ingredient.role to add more detail. Example: Antioxidant, Alkalizing Agent.",
      "min" : 0,
      "max" : "*",
      "type" : [{
        "code" : "CodeableConcept"
      }],
      "isSummary" : true
    },
    {
      "id" : "Ingredient.description",
      "path" : "Ingredient.description",
      "short" : "A general description of the ingredient, or any supporting text. May be used for an unstructured list of excipients",
      "definition" : "A general description of the ingredient, or any supporting text. May be used for an unstructured list of excipients.",
      "min" : 0,
      "max" : "1",
      "type" : [{
        "code" : "markdown"
      }],
      "isSummary" : true
    },
    {
      "id" : "Ingredient.allergenicIndicator",
      "path" : "Ingredient.allergenicIndicator",
      "short" : "If the ingredient is a known or suspected allergen",
      "definition" : "If the ingredient is a known or suspected allergen.",
      "min" : 0,
      "max" : "1",
      "type" : [{
        "code" : "boolean"
      }],
      "isSummary" : true
    },
    {
      "id" : "Ingredient.manufacturer",
      "path" : "Ingredient.manufacturer",
      "short" : "The organization that manufactures this ingredient",
      "definition" : "The organization that manufactures this ingredient.",
      "min" : 0,
      "max" : "*",
      "type" : [{
        "code" : "Reference",
        "targetProfile" : ["http://hl7.org/fhir/StructureDefinition/Organization"]
      }],
      "isSummary" : true
    },
    {
      "id" : "Ingredient.specifiedSubstance",
      "path" : "Ingredient.specifiedSubstance",
      "short" : "A specified substance that comprises this ingredient",
      "definition" : "A specified substance that comprises this ingredient.",
      "min" : 0,
      "max" : "*",
      "type" : [{
        "code" : "BackboneElement"
      }],
      "isSummary" : true
    },
    {
      "id" : "Ingredient.specifiedSubstance.code[x]",
      "path" : "Ingredient.specifiedSubstance.code[x]",
      "short" : "Substance as a 'specified substance', implying extra substance related characteristics",
      "definition" : "Substance as a 'specified substance', implying extra substance related characteristics.",
      "min" : 1,
      "max" : "1",
      "type" : [{
        "code" : "CodeableConcept"
      },
      {
        "code" : "Reference",
        "targetProfile" : ["http://hl7.org/fhir/StructureDefinition/SubstanceDefinition",
        "http://hl7.org/fhir/StructureDefinition/Substance"]
      }],
      "isSummary" : true
    },
    {
      "id" : "Ingredient.specifiedSubstance.group",
      "path" : "Ingredient.specifiedSubstance.group",
      "short" : "The group of specified substance, e.g. group 1 to 4",
      "definition" : "The group of specified substance, e.g. group 1 to 4.",
      "min" : 1,
      "max" : "1",
      "type" : [{
        "code" : "CodeableConcept"
      }],
      "isSummary" : true
    },
    {
      "id" : "Ingredient.specifiedSubstance.confidentiality",
      "path" : "Ingredient.specifiedSubstance.confidentiality",
      "short" : "Confidentiality level of the specified substance as the ingredient",
      "definition" : "Confidentiality level of the specified substance as the ingredient.",
      "min" : 0,
      "max" : "1",
      "type" : [{
        "code" : "CodeableConcept"
      }],
      "isSummary" : true
    },
    {
      "id" : "Ingredient.specifiedSubstance.strength",
      "path" : "Ingredient.specifiedSubstance.strength",
      "short" : "Quantity of the substance or specified substance present in the manufactured item or pharmaceutical product",
      "definition" : "Quantity of the substance or specified substance present in the manufactured item or pharmaceutical product.",
      "min" : 0,
      "max" : "*",
      "type" : [{
        "code" : "BackboneElement"
      }],
      "isSummary" : true
    },
    {
      "id" : "Ingredient.specifiedSubstance.strength.presentation",
      "path" : "Ingredient.specifiedSubstance.strength.presentation",
      "short" : "The quantity of substance in the unit of presentation, or in the volume (or mass) of the single pharmaceutical product or manufactured item",
      "definition" : "The quantity of substance in the unit of presentation, or in the volume (or mass) of the single pharmaceutical product or manufactured item.",
      "min" : 0,
      "max" : "1",
      "type" : [{
        "code" : "Ratio"
      }],
      "isSummary" : true
    },
    {
      "id" : "Ingredient.specifiedSubstance.strength.presentationHighLimit",
      "path" : "Ingredient.specifiedSubstance.strength.presentationHighLimit",
      "short" : "An upper limit for the quantity of substance in the unit of presentation. For use when there is a range of strengths, this is the high limit, with the presentation attribute becoming the lower limit",
      "definition" : "An upper limit for the quantity of substance in the unit of presentation. For use when there is a range of strengths, this is the high limit, with the presentation attribute becoming the lower limit.",
      "min" : 0,
      "max" : "1",
      "type" : [{
        "code" : "Ratio"
      }],
      "isModifier" : true,
      "isModifierReason" : "If this is present it implies that the whole strength is expressed as a range, due to uncertainty or variation",
      "isSummary" : true
    },
    {
      "id" : "Ingredient.specifiedSubstance.strength.presentationText",
      "path" : "Ingredient.specifiedSubstance.strength.presentationText",
      "short" : "A textual represention of either the whole of the presentation strength or a part of it - with the rest being in Strength.presentation as a ratio",
      "definition" : "A textual represention of either the whole of the presentation strength or a part of it - with the rest being in Strength.presentation as a ratio.",
      "min" : 0,
      "max" : "1",
      "type" : [{
        "code" : "string"
      }],
      "isSummary" : true
    },
    {
      "id" : "Ingredient.specifiedSubstance.strength.concentration",
      "path" : "Ingredient.specifiedSubstance.strength.concentration",
      "short" : "The strength per unitary volume (or mass)",
      "definition" : "The strength per unitary volume (or mass).",
      "min" : 0,
      "max" : "1",
      "type" : [{
        "code" : "Ratio"
      }],
      "isSummary" : true
    },
    {
      "id" : "Ingredient.specifiedSubstance.strength.concentrationHighLimit",
      "path" : "Ingredient.specifiedSubstance.strength.concentrationHighLimit",
      "short" : "An upper limit for the strength per unitary volume (or mass), for when there is a range. The concentration attribute then becomes the lower limit",
      "definition" : "An upper limit for the strength per unitary volume (or mass), for when there is a range. The concentration attribute then becomes the lower limit.",
      "min" : 0,
      "max" : "1",
      "type" : [{
        "code" : "Ratio"
      }],
      "isModifier" : true,
      "isModifierReason" : "If this is present it implies that the whole strength is expressed as a range, due to uncertainty or variation",
      "isSummary" : true
    },
    {
      "id" : "Ingredient.specifiedSubstance.strength.concentrationText",
      "path" : "Ingredient.specifiedSubstance.strength.concentrationText",
      "short" : "A textual represention of either the whole of the concentration strength or a part of it - with the rest being in Strength.concentration as a ratio",
      "definition" : "A textual represention of either the whole of the concentration strength or a part of it - with the rest being in Strength.concentration as a ratio.",
      "min" : 0,
      "max" : "1",
      "type" : [{
        "code" : "string"
      }],
      "isSummary" : true
    },
    {
      "id" : "Ingredient.specifiedSubstance.strength.measurementPoint",
      "path" : "Ingredient.specifiedSubstance.strength.measurementPoint",
      "short" : "For when strength is measured at a particular point or distance",
      "definition" : "For when strength is measured at a particular point or distance.",
      "min" : 0,
      "max" : "1",
      "type" : [{
        "code" : "string"
      }],
      "isSummary" : true
    },
    {
      "id" : "Ingredient.specifiedSubstance.strength.country",
      "path" : "Ingredient.specifiedSubstance.strength.country",
      "short" : "The country or countries for which the strength range applies",
      "definition" : "The country or countries for which the strength range applies.",
      "min" : 0,
      "max" : "*",
      "type" : [{
        "code" : "CodeableConcept"
      }],
      "isSummary" : true
    },
    {
      "id" : "Ingredient.specifiedSubstance.strength.referenceStrength",
      "path" : "Ingredient.specifiedSubstance.strength.referenceStrength",
      "short" : "Strength expressed in terms of a reference substance",
      "definition" : "Strength expressed in terms of a reference substance.",
      "min" : 0,
      "max" : "*",
      "type" : [{
        "code" : "BackboneElement"
      }],
      "isSummary" : true
    },
    {
      "id" : "Ingredient.specifiedSubstance.strength.referenceStrength.substance[x]",
      "path" : "Ingredient.specifiedSubstance.strength.referenceStrength.substance[x]",
      "short" : "Relevant reference substance",
      "definition" : "Relevant reference substance.",
      "min" : 0,
      "max" : "1",
      "type" : [{
        "code" : "CodeableConcept"
      },
      {
        "code" : "Reference",
        "targetProfile" : ["http://hl7.org/fhir/StructureDefinition/SubstanceDefinition",
        "http://hl7.org/fhir/StructureDefinition/Substance"]
      }],
      "isSummary" : true
    },
    {
      "id" : "Ingredient.specifiedSubstance.strength.referenceStrength.strength",
      "path" : "Ingredient.specifiedSubstance.strength.referenceStrength.strength",
      "short" : "Strength expressed in terms of a reference substance",
      "definition" : "Strength expressed in terms of a reference substance.",
      "min" : 1,
      "max" : "1",
      "type" : [{
        "code" : "Ratio"
      }],
      "isSummary" : true
    },
    {
      "id" : "Ingredient.specifiedSubstance.strength.referenceStrength.strengthHighLimit",
      "path" : "Ingredient.specifiedSubstance.strength.referenceStrength.strengthHighLimit",
      "short" : "Strength expressed in terms of a reference substance, upper limit",
      "definition" : "Strength expressed in terms of a reference substance, upper limit.",
      "min" : 0,
      "max" : "1",
      "type" : [{
        "code" : "Ratio"
      }],
      "isSummary" : true
    },
    {
      "id" : "Ingredient.specifiedSubstance.strength.referenceStrength.measurementPoint",
      "path" : "Ingredient.specifiedSubstance.strength.referenceStrength.measurementPoint",
      "short" : "For when strength is measured at a particular point or distance",
      "definition" : "For when strength is measured at a particular point or distance.",
      "min" : 0,
      "max" : "1",
      "type" : [{
        "code" : "string"
      }],
      "isSummary" : true
    },
    {
      "id" : "Ingredient.specifiedSubstance.strength.referenceStrength.country",
      "path" : "Ingredient.specifiedSubstance.strength.referenceStrength.country",
      "short" : "The country or countries for which the strength range applies",
      "definition" : "The country or countries for which the strength range applies.",
      "min" : 0,
      "max" : "*",
      "type" : [{
        "code" : "CodeableConcept"
      }],
      "isSummary" : true
    },
    {
      "id" : "Ingredient.substance",
      "path" : "Ingredient.substance",
      "short" : "The substance that comprises this ingredient",
      "definition" : "The substance that comprises this ingredient.",
      "min" : 0,
      "max" : "1",
      "type" : [{
        "code" : "BackboneElement"
      }],
      "isSummary" : true
    },
    {
      "id" : "Ingredient.substance.code[x]",
      "path" : "Ingredient.substance.code[x]",
      "short" : "A code that represents the ingredient substance",
      "definition" : "A code that represents the ingredient substance.",
      "min" : 1,
      "max" : "1",
      "type" : [{
        "code" : "CodeableConcept"
      },
      {
        "code" : "Reference",
        "targetProfile" : ["http://hl7.org/fhir/StructureDefinition/SubstanceDefinition",
        "http://hl7.org/fhir/StructureDefinition/Substance"]
      }],
      "isSummary" : true
    },
    {
      "id" : "Ingredient.substance.strength",
      "path" : "Ingredient.substance.strength",
      "short" : "Quantity of the substance or specified substance present in the manufactured item or pharmaceutical product",
      "definition" : "Quantity of the substance or specified substance present in the manufactured item or pharmaceutical product.",
      "min" : 0,
      "max" : "*",
      "contentReference" : "#Ingredient.specifiedSubstance.strength",
      "isSummary" : true
    }]
  }
}

Usage note: every effort has been made to ensure that the examples are correct and useful, but they are not a normative part of the specification.