2022 CDC Clinical Practice Guideline for Prescribing Opioids Implementation Guide
2022.1.1 - Release 2022.1

2022 CDC Clinical Practice Guideline for Prescribing Opioids Implementation Guide, published by CDC / Security Risk Solutions, Inc. (SRS). This guide is not an authorized publication; it is the continuous build for version 2022.1.1 built by the FHIR (HL7® FHIR® Standard) CI Build. This version is based on the current content of https://github.com/security-rs/opioid-cds-r4/ and changes regularly. See the Directory of published versions

: Synthetic opioid urine drug screening tests - XML Representation

Active as of 2026-06-03

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<ValueSet xmlns="http://hl7.org/fhir">
  <id value="synthetic-opioid-urine-drug-screening-tests"/>
  <meta>
    <profile
             value="http://hl7.org/fhir/uv/cpg/StructureDefinition/cpg-computablevalueset"/>
    <profile
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  </meta>
  <text>
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    <div xmlns="http://www.w3.org/1999/xhtml"><p class="res-header-id"><b>Generated Narrative: ValueSet synthetic-opioid-urine-drug-screening-tests</b></p><a name="synthetic-opioid-urine-drug-screening-tests"> </a><a name="hcsynthetic-opioid-urine-drug-screening-tests"> </a><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px"/><p style="margin-bottom: 0px">Profiles: <a href="http://hl7.org/fhir/uv/cpg/STU1/StructureDefinition-cpg-computablevalueset.html">CPGComputableValueSet</a>, <a href="http://hl7.org/fhir/uv/cpg/STU1/StructureDefinition-cpg-executablevalueset.html">CPGExecutableValueSet</a></p></div><p style="border: black 1px dotted; background-color: #EEEEEE; padding: 8px; margin-bottom: 8px">Expansion based on Loinc v2.82</p><p>This value set contains 41 concepts</p><table class="codes"><tr><td><b>System</b></td><td style="white-space:nowrap"><b>Code</b></td><td><b>Display</b></td></tr><tr><td><a name="synthetic-opioid-urine-drug-screening-tests-http://loinc.org-93471-1"> </a><code>http://loinc.org</code></td><td style="white-space:nowrap">  <a href="https://loinc.org/93471-1/">93471-1</a></td><td>Acetyl norfentanyl [Mass/volume] in Urine by Confirmatory method</td></tr><tr><td><a name="synthetic-opioid-urine-drug-screening-tests-http://loinc.org-101161-8"> </a><code>http://loinc.org</code></td><td style="white-space:nowrap">  <a href="https://loinc.org/101161-8/">101161-8</a></td><td>p-Fluorofentanyl/Creatinine [Mass Ratio] in Urine by Confirmatory method</td></tr><tr><td><a name="synthetic-opioid-urine-drug-screening-tests-http://loinc.org-101162-6"> </a><code>http://loinc.org</code></td><td style="white-space:nowrap">  <a href="https://loinc.org/101162-6/">101162-6</a></td><td>p-Fluorofentanyl [Presence] in Urine by Confirmatory method</td></tr><tr><td><a name="synthetic-opioid-urine-drug-screening-tests-http://loinc.org-101163-4"> </a><code>http://loinc.org</code></td><td style="white-space:nowrap">  <a href="https://loinc.org/101163-4/">101163-4</a></td><td>Brorphine [Mass/volume] in Urine by Confirmatory method</td></tr><tr><td><a name="synthetic-opioid-urine-drug-screening-tests-http://loinc.org-101164-2"> </a><code>http://loinc.org</code></td><td style="white-space:nowrap">  <a href="https://loinc.org/101164-2/">101164-2</a></td><td>Brorphine/Creatinine [Mass Ratio] in Urine by Confirmatory method</td></tr><tr><td><a name="synthetic-opioid-urine-drug-screening-tests-http://loinc.org-101165-9"> </a><code>http://loinc.org</code></td><td style="white-space:nowrap">  <a href="https://loinc.org/101165-9/">101165-9</a></td><td>Brorphine [Presence] in Urine by Confirmatory method</td></tr><tr><td><a name="synthetic-opioid-urine-drug-screening-tests-http://loinc.org-101166-7"> </a><code>http://loinc.org</code></td><td style="white-space:nowrap">  <a href="https://loinc.org/101166-7/">101166-7</a></td><td>Metonitazene [Mass/volume] in Urine by Confirmatory method</td></tr><tr><td><a name="synthetic-opioid-urine-drug-screening-tests-http://loinc.org-101167-5"> </a><code>http://loinc.org</code></td><td style="white-space:nowrap">  <a href="https://loinc.org/101167-5/">101167-5</a></td><td>Metonitazene/Creatinine [Mass Ratio] in Urine by Confirmatory method</td></tr><tr><td><a name="synthetic-opioid-urine-drug-screening-tests-http://loinc.org-101168-3"> </a><code>http://loinc.org</code></td><td style="white-space:nowrap">  <a href="https://loinc.org/101168-3/">101168-3</a></td><td>Metonitazene [Presence] in Urine by Confirmatory method</td></tr><tr><td><a name="synthetic-opioid-urine-drug-screening-tests-http://loinc.org-101169-1"> </a><code>http://loinc.org</code></td><td style="white-space:nowrap">  <a href="https://loinc.org/101169-1/">101169-1</a></td><td>2-methyl AP-237 [Mass/volume] in Urine by Confirmatory method</td></tr><tr><td><a name="synthetic-opioid-urine-drug-screening-tests-http://loinc.org-101171-7"> </a><code>http://loinc.org</code></td><td style="white-space:nowrap">  <a href="https://loinc.org/101171-7/">101171-7</a></td><td>2-methyl AP-237/Creatinine [Mass Ratio] in Urine by Confirmatory method</td></tr><tr><td><a name="synthetic-opioid-urine-drug-screening-tests-http://loinc.org-101180-8"> </a><code>http://loinc.org</code></td><td style="white-space:nowrap">  <a href="https://loinc.org/101180-8/">101180-8</a></td><td>2-methyl AP-237 [Presence] in Urine by Confirmatory method</td></tr><tr><td><a name="synthetic-opioid-urine-drug-screening-tests-http://loinc.org-105530-0"> </a><code>http://loinc.org</code></td><td style="white-space:nowrap">  <a href="https://loinc.org/105530-0/">105530-0</a></td><td>Beta hydroxythiofentanyl [Mass/volume] in Urine</td></tr><tr><td><a name="synthetic-opioid-urine-drug-screening-tests-http://loinc.org-105531-8"> </a><code>http://loinc.org</code></td><td style="white-space:nowrap">  <a href="https://loinc.org/105531-8/">105531-8</a></td><td>4-Methylphenethylacetylfentanyl [Mass/volume] in Urine</td></tr><tr><td><a name="synthetic-opioid-urine-drug-screening-tests-http://loinc.org-105532-6"> </a><code>http://loinc.org</code></td><td style="white-space:nowrap">  <a href="https://loinc.org/105532-6/">105532-6</a></td><td>3-Methylfentanyl [Mass/volume] in Urine</td></tr><tr><td><a name="synthetic-opioid-urine-drug-screening-tests-http://loinc.org-107609-0"> </a><code>http://loinc.org</code></td><td style="white-space:nowrap">  <a href="https://loinc.org/107609-0/">107609-0</a></td><td>Synthetic opioids [Presence] in Urine</td></tr><tr><td><a name="synthetic-opioid-urine-drug-screening-tests-http://loinc.org-93451-3"> </a><code>http://loinc.org</code></td><td style="white-space:nowrap">  <a href="https://loinc.org/93451-3/">93451-3</a></td><td>Nor-W-18+Nor-W-15 [Mass/volume] in Urine by Confirmatory method</td></tr><tr><td><a name="synthetic-opioid-urine-drug-screening-tests-http://loinc.org-93452-1"> </a><code>http://loinc.org</code></td><td style="white-space:nowrap">  <a href="https://loinc.org/93452-1/">93452-1</a></td><td>W-19 [Mass/volume] in Urine by Confirmatory method</td></tr><tr><td><a name="synthetic-opioid-urine-drug-screening-tests-http://loinc.org-93453-9"> </a><code>http://loinc.org</code></td><td style="white-space:nowrap">  <a href="https://loinc.org/93453-9/">93453-9</a></td><td>W-15 [Mass/volume] in Urine by Confirmatory method</td></tr><tr><td><a name="synthetic-opioid-urine-drug-screening-tests-http://loinc.org-93454-7"> </a><code>http://loinc.org</code></td><td style="white-space:nowrap">  <a href="https://loinc.org/93454-7/">93454-7</a></td><td>W-18 [Mass/volume] in Urine by Confirmatory method</td></tr><tr><td><a name="synthetic-opioid-urine-drug-screening-tests-http://loinc.org-93455-4"> </a><code>http://loinc.org</code></td><td style="white-space:nowrap">  <a href="https://loinc.org/93455-4/">93455-4</a></td><td>IC-26 [Mass/volume] in Urine by Confirmatory method</td></tr><tr><td><a name="synthetic-opioid-urine-drug-screening-tests-http://loinc.org-93456-2"> </a><code>http://loinc.org</code></td><td style="white-space:nowrap">  <a href="https://loinc.org/93456-2/">93456-2</a></td><td>MT-45 [Mass/volume] in Urine by Confirmatory method</td></tr><tr><td><a name="synthetic-opioid-urine-drug-screening-tests-http://loinc.org-93457-0"> </a><code>http://loinc.org</code></td><td style="white-space:nowrap">  <a href="https://loinc.org/93457-0/">93457-0</a></td><td>AH-8529 [Mass/volume] in Urine by Confirmatory method</td></tr><tr><td><a name="synthetic-opioid-urine-drug-screening-tests-http://loinc.org-93458-8"> </a><code>http://loinc.org</code></td><td style="white-space:nowrap">  <a href="https://loinc.org/93458-8/">93458-8</a></td><td>AH-8533 [Mass/volume] in Urine by Confirmatory method</td></tr><tr><td><a name="synthetic-opioid-urine-drug-screening-tests-http://loinc.org-93459-6"> </a><code>http://loinc.org</code></td><td style="white-space:nowrap">  <a href="https://loinc.org/93459-6/">93459-6</a></td><td>U-47700 [Mass/volume] in Urine by Confirmatory method</td></tr><tr><td><a name="synthetic-opioid-urine-drug-screening-tests-http://loinc.org-93460-4"> </a><code>http://loinc.org</code></td><td style="white-space:nowrap">  <a href="https://loinc.org/93460-4/">93460-4</a></td><td>AH-7921 [Mass/volume] in Urine by Confirmatory method</td></tr><tr><td><a name="synthetic-opioid-urine-drug-screening-tests-http://loinc.org-93461-2"> </a><code>http://loinc.org</code></td><td style="white-space:nowrap">  <a href="https://loinc.org/93461-2/">93461-2</a></td><td>4-Methoxybutyrylfentanyl [Mass/volume] in Urine by Confirmatory method</td></tr><tr><td><a name="synthetic-opioid-urine-drug-screening-tests-http://loinc.org-93462-0"> </a><code>http://loinc.org</code></td><td style="white-space:nowrap">  <a href="https://loinc.org/93462-0/">93462-0</a></td><td>Norcarfentanil [Mass/volume] in Urine by Confirmatory method</td></tr><tr><td><a name="synthetic-opioid-urine-drug-screening-tests-http://loinc.org-93463-8"> </a><code>http://loinc.org</code></td><td style="white-space:nowrap">  <a href="https://loinc.org/93463-8/">93463-8</a></td><td>Ocfentanil [Mass/volume] in Urine by Confirmatory method</td></tr><tr><td><a name="synthetic-opioid-urine-drug-screening-tests-http://loinc.org-93464-6"> </a><code>http://loinc.org</code></td><td style="white-space:nowrap">  <a href="https://loinc.org/93464-6/">93464-6</a></td><td>p-Fluorofentanyl [Mass/volume] in Urine by Confirmatory method</td></tr><tr><td><a name="synthetic-opioid-urine-drug-screening-tests-http://loinc.org-93465-3"> </a><code>http://loinc.org</code></td><td style="white-space:nowrap">  <a href="https://loinc.org/93465-3/">93465-3</a></td><td>3-Methylfentanyl [Mass/volume] in Urine by Confirmatory method</td></tr><tr><td><a name="synthetic-opioid-urine-drug-screening-tests-http://loinc.org-93466-1"> </a><code>http://loinc.org</code></td><td style="white-space:nowrap">  <a href="https://loinc.org/93466-1/">93466-1</a></td><td>Valerylfentanyl [Mass/volume] in Urine by Confirmatory method</td></tr><tr><td><a name="synthetic-opioid-urine-drug-screening-tests-http://loinc.org-93467-9"> </a><code>http://loinc.org</code></td><td style="white-space:nowrap">  <a href="https://loinc.org/93467-9/">93467-9</a></td><td>Butyrylfentanyl [Mass/volume] in Urine by Confirmatory method</td></tr><tr><td><a name="synthetic-opioid-urine-drug-screening-tests-http://loinc.org-93468-7"> </a><code>http://loinc.org</code></td><td style="white-space:nowrap">  <a href="https://loinc.org/93468-7/">93468-7</a></td><td>Acrylfentanyl [Mass/volume] in Urine by Confirmatory method</td></tr><tr><td><a name="synthetic-opioid-urine-drug-screening-tests-http://loinc.org-93469-5"> </a><code>http://loinc.org</code></td><td style="white-space:nowrap">  <a href="https://loinc.org/93469-5/">93469-5</a></td><td>4-Fluorobutyrylfentanyl [Mass/volume] in Urine by Confirmatory method</td></tr><tr><td><a name="synthetic-opioid-urine-drug-screening-tests-http://loinc.org-93470-3"> </a><code>http://loinc.org</code></td><td style="white-space:nowrap">  <a href="https://loinc.org/93470-3/">93470-3</a></td><td>Furanylfentanyl [Mass/volume] in Urine by Confirmatory method</td></tr><tr><td><a name="synthetic-opioid-urine-drug-screening-tests-http://loinc.org-93472-9"> </a><code>http://loinc.org</code></td><td style="white-space:nowrap">  <a href="https://loinc.org/93472-9/">93472-9</a></td><td>4-Methylphenethylacetylfentanyl [Mass/volume] in Urine by Confirmatory method</td></tr><tr><td><a name="synthetic-opioid-urine-drug-screening-tests-http://loinc.org-93473-7"> </a><code>http://loinc.org</code></td><td style="white-space:nowrap">  <a href="https://loinc.org/93473-7/">93473-7</a></td><td>Beta hydroxythiofentanyl [Mass/volume] in Urine by Confirmatory method</td></tr><tr><td><a name="synthetic-opioid-urine-drug-screening-tests-http://loinc.org-99079-6"> </a><code>http://loinc.org</code></td><td style="white-space:nowrap">  <a href="https://loinc.org/99079-6/">99079-6</a></td><td>Acrylfentanyl [Presence] in Urine by Confirmatory method</td></tr><tr><td><a name="synthetic-opioid-urine-drug-screening-tests-http://loinc.org-99081-2"> </a><code>http://loinc.org</code></td><td style="white-space:nowrap">  <a href="https://loinc.org/99081-2/">99081-2</a></td><td>Furanylfentanyl [Presence] in Urine by Confirmatory method</td></tr><tr><td><a name="synthetic-opioid-urine-drug-screening-tests-http://loinc.org-93474-5"> </a><code>http://loinc.org</code></td><td style="white-space:nowrap">  <a href="https://loinc.org/93474-5/">93474-5</a></td><td>Synthetic opioids panel - Urine by Confirmatory method</td></tr></table></div>
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             url="http://fhir.org/guides/cdc/opioid-cds/StructureDefinition/cdc-valueset-clinical-focus">
    <valueString
                 value="Urine tests for synthetic and semi-synthetic (non-opiate) substances"/>
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  <extension
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    <valueString value="Urine test"/>
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    <valueString
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    <valueString
                 value="Codes listed in the General opiate urine drug screening tests value set and the Opiate specific urine drug screening tests value set"/>
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  <extension url="http://hl7.org/fhir/StructureDefinition/valueset-author">
    <valueContactDetail>
      <name value="MD Partners, Inc."/>
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        <value value="info@mdpartners.com"/>
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       value="http://fhir.org/guides/cdc/opioid-cds/ValueSet/synthetic-opioid-urine-drug-screening-tests"/>
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  <name value="SYNTHETIC_OPIOID_URINE_DRUG_SCREENING_TESTS"/>
  <title value="Synthetic opioid urine drug screening tests"/>
  <status value="active"/>
  <experimental value="false"/>
  <date value="2026-06-03T13:39:45-06:00"/>
  <publisher value="CDC / Security Risk Solutions, Inc. (SRS)"/>
  <contact>
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      <value value="https://www.securityrisksolutions.com"/>
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  <description
               value="Urine tests for synthetic and semi-synthetic (non-opiate) substances"/>
  <purpose
           value="Identification of urine drug tests where results can be used when considering pain management therapy"/>
  <copyright value="© CDC 2016+."/>
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      <code value="101180-8"/>
      <display
               value="2-methyl AP-237 [Presence] in Urine by Confirmatory method"/>
    </contains>
    <contains>
      <system value="http://loinc.org"/>
      <code value="105530-0"/>
      <display value="Beta hydroxythiofentanyl [Mass/volume] in Urine"/>
    </contains>
    <contains>
      <system value="http://loinc.org"/>
      <code value="105531-8"/>
      <display
               value="4-Methylphenethylacetylfentanyl [Mass/volume] in Urine"/>
    </contains>
    <contains>
      <system value="http://loinc.org"/>
      <code value="105532-6"/>
      <display value="3-Methylfentanyl [Mass/volume] in Urine"/>
    </contains>
    <contains>
      <system value="http://loinc.org"/>
      <code value="107609-0"/>
      <display value="Synthetic opioids [Presence] in Urine"/>
    </contains>
    <contains>
      <system value="http://loinc.org"/>
      <code value="93451-3"/>
      <display
               value="Nor-W-18+Nor-W-15 [Mass/volume] in Urine by Confirmatory method"/>
    </contains>
    <contains>
      <system value="http://loinc.org"/>
      <code value="93452-1"/>
      <display value="W-19 [Mass/volume] in Urine by Confirmatory method"/>
    </contains>
    <contains>
      <system value="http://loinc.org"/>
      <code value="93453-9"/>
      <display value="W-15 [Mass/volume] in Urine by Confirmatory method"/>
    </contains>
    <contains>
      <system value="http://loinc.org"/>
      <code value="93454-7"/>
      <display value="W-18 [Mass/volume] in Urine by Confirmatory method"/>
    </contains>
    <contains>
      <system value="http://loinc.org"/>
      <code value="93455-4"/>
      <display value="IC-26 [Mass/volume] in Urine by Confirmatory method"/>
    </contains>
    <contains>
      <system value="http://loinc.org"/>
      <code value="93456-2"/>
      <display value="MT-45 [Mass/volume] in Urine by Confirmatory method"/>
    </contains>
    <contains>
      <system value="http://loinc.org"/>
      <code value="93457-0"/>
      <display value="AH-8529 [Mass/volume] in Urine by Confirmatory method"/>
    </contains>
    <contains>
      <system value="http://loinc.org"/>
      <code value="93458-8"/>
      <display value="AH-8533 [Mass/volume] in Urine by Confirmatory method"/>
    </contains>
    <contains>
      <system value="http://loinc.org"/>
      <code value="93459-6"/>
      <display value="U-47700 [Mass/volume] in Urine by Confirmatory method"/>
    </contains>
    <contains>
      <system value="http://loinc.org"/>
      <code value="93460-4"/>
      <display value="AH-7921 [Mass/volume] in Urine by Confirmatory method"/>
    </contains>
    <contains>
      <system value="http://loinc.org"/>
      <code value="93461-2"/>
      <display
               value="4-Methoxybutyrylfentanyl [Mass/volume] in Urine by Confirmatory method"/>
    </contains>
    <contains>
      <system value="http://loinc.org"/>
      <code value="93462-0"/>
      <display
               value="Norcarfentanil [Mass/volume] in Urine by Confirmatory method"/>
    </contains>
    <contains>
      <system value="http://loinc.org"/>
      <code value="93463-8"/>
      <display
               value="Ocfentanil [Mass/volume] in Urine by Confirmatory method"/>
    </contains>
    <contains>
      <system value="http://loinc.org"/>
      <code value="93464-6"/>
      <display
               value="p-Fluorofentanyl [Mass/volume] in Urine by Confirmatory method"/>
    </contains>
    <contains>
      <system value="http://loinc.org"/>
      <code value="93465-3"/>
      <display
               value="3-Methylfentanyl [Mass/volume] in Urine by Confirmatory method"/>
    </contains>
    <contains>
      <system value="http://loinc.org"/>
      <code value="93466-1"/>
      <display
               value="Valerylfentanyl [Mass/volume] in Urine by Confirmatory method"/>
    </contains>
    <contains>
      <system value="http://loinc.org"/>
      <code value="93467-9"/>
      <display
               value="Butyrylfentanyl [Mass/volume] in Urine by Confirmatory method"/>
    </contains>
    <contains>
      <system value="http://loinc.org"/>
      <code value="93468-7"/>
      <display
               value="Acrylfentanyl [Mass/volume] in Urine by Confirmatory method"/>
    </contains>
    <contains>
      <system value="http://loinc.org"/>
      <code value="93469-5"/>
      <display
               value="4-Fluorobutyrylfentanyl [Mass/volume] in Urine by Confirmatory method"/>
    </contains>
    <contains>
      <system value="http://loinc.org"/>
      <code value="93470-3"/>
      <display
               value="Furanylfentanyl [Mass/volume] in Urine by Confirmatory method"/>
    </contains>
    <contains>
      <system value="http://loinc.org"/>
      <code value="93472-9"/>
      <display
               value="4-Methylphenethylacetylfentanyl [Mass/volume] in Urine by Confirmatory method"/>
    </contains>
    <contains>
      <system value="http://loinc.org"/>
      <code value="93473-7"/>
      <display
               value="Beta hydroxythiofentanyl [Mass/volume] in Urine by Confirmatory method"/>
    </contains>
    <contains>
      <system value="http://loinc.org"/>
      <code value="99079-6"/>
      <display
               value="Acrylfentanyl [Presence] in Urine by Confirmatory method"/>
    </contains>
    <contains>
      <system value="http://loinc.org"/>
      <code value="99081-2"/>
      <display
               value="Furanylfentanyl [Presence] in Urine by Confirmatory method"/>
    </contains>
    <contains>
      <system value="http://loinc.org"/>
      <code value="93474-5"/>
      <display
               value="Synthetic opioids panel - Urine by Confirmatory method"/>
    </contains>
  </expansion>
</ValueSet>