cns-depressant-medications
type: ValueSet
node role: treeRoot
id:
  v: cns-depressant-medications
meta:
  profile:
    v: http://hl7.org/fhir/uv/cpg/StructureDefinition/cpg-computablevalueset
    l: cpg-computablevalueset
  profile:
    v: http://hl7.org/fhir/uv/cpg/StructureDefinition/cpg-executablevalueset
    l: cpg-executablevalueset
text:
  status:
    v: generated
  div:
    v: Generated Narrative: ValueSet cns-depressant-medications Profiles: CPGComputableValueSet, CPGExecutableValueSet This value set contains 116 concepts System Code Display http://www.nlm.nih.gov/research/umls/rxnorm 904368 benzphetamine hydrochloride 50 MG Oral Tablet http://www.nlm.nih.gov/research/umls/rxnorm 904372 benzphetamine hydrochloride 25 MG Oral Tablet http://www.nlm.nih.gov/research/umls/rxnorm 2698136 {7 (sodium oxybate 4500 MG Granules for Oral Suspension [Lumryz]) / 14 (sodium oxybate 6000 MG Granules for Oral Suspension [Lumryz]) / 7 (sodium oxybate 7500 MG Granules for Oral Suspension [Lumryz]) } Pack [Lumryz 28-Day Starter Pack] http://www.nlm.nih.gov/research/umls/rxnorm 2698135 {7 (sodium oxybate 4500 MG Granules for Oral Suspension) / 14 (sodium oxybate 6000 MG Granules for Oral Suspension) / 7 (sodium oxybate 7500 MG Granules for Oral Suspension) } Pack http://www.nlm.nih.gov/research/umls/rxnorm 2393794 calcium oxybate 234 MG/ML / magnesium oxybate 96 MG/ML / potassium oxybate 130 MG/ML / sodium oxybate 40 MG/ML Oral Solution [Xywav] http://www.nlm.nih.gov/research/umls/rxnorm 2636828 sodium oxybate 4500 MG Granules for Oral Suspension [Lumryz] http://www.nlm.nih.gov/research/umls/rxnorm 2636832 sodium oxybate 6000 MG Granules for Oral Suspension [Lumryz] http://www.nlm.nih.gov/research/umls/rxnorm 2636836 sodium oxybate 7500 MG Granules for Oral Suspension [Lumryz] http://www.nlm.nih.gov/research/umls/rxnorm 2636840 sodium oxybate 9000 MG Granules for Oral Suspension [Lumryz] http://www.nlm.nih.gov/research/umls/rxnorm 352257 sodium oxybate 500 MG/ML Oral Solution [Xyrem] http://www.nlm.nih.gov/research/umls/rxnorm 2393795 calcium oxybate 234 MG/ML / magnesium oxybate 96 MG/ML / potassium oxybate 130 MG/ML / sodium oxybate 40 MG/ML Oral Solution http://www.nlm.nih.gov/research/umls/rxnorm 2636822 sodium oxybate 4500 MG Granules for Oral Suspension http://www.nlm.nih.gov/research/umls/rxnorm 2636830 sodium oxybate 6000 MG Granules for Oral Suspen…
extension:
  url:
    v: http://hl7.org/fhir/StructureDefinition/valueset-author
    l: valueset-author
  value: ContactDetail
    name:
      v: MD Partners, Inc.
    telecom:
      system:
        v: email
extension:
  url:
    v: http://hl7.org/fhir/uv/cpg/StructureDefinition/cpg-knowledgeCapability
    l: cpg-knowledgeCapability
  value: Code
    v: computable
extension:
  url:
    v: http://hl7.org/fhir/uv/cpg/StructureDefinition/cpg-knowledgeCapability
    l: cpg-knowledgeCapability
  value: Code
    v: executable
extension:
  url:
    v: http://hl7.org/fhir/uv/cpg/StructureDefinition/cpg-usageWarning
    l: cpg-usageWarning
  value: String
    v: This value set contains a point-in-time expansion enumerating the codes that meet the value set intent. As new versions of the code systems used by the value set are released, the contents of this expansion will need to be updated to incorporate newly defined codes that meet the value set intent. Before, and periodically during production use, the value set expansion contents SHOULD be updated. The value set expansion specifies the timestamp when the expansion was produced, SHOULD contain the parameters used for the expansion, and SHALL contain the codes that are obtained by evaluating the value set definition. If this is ONLY an executable value set, a distributable definition of the value set must be obtained to compute the updated expansion.
extension:
  url:
    v: http://hl7.org/fhir/StructureDefinition/valueset-rules-text
    l: valueset-rules-text
  value: Markdown
    v: https://mor.nlm.nih.gov/RxMix/ Script: Step 1a Create Batch text input file (CNSD.txt) with following DailyMed identifier (for the concept "Central Nervous System Depressants") as an input within the file: N0000175728 Step 1b Submit batch job using the above CNSD.txt file to following workflow by uploading file (CNSD-wf.config) with the following in the file: <WFE><filteredOutputs>RXCUI|name|term_type</filteredOutputs> NOINPUT <FS><service>NOINPUT</service><function>getClassMembers</function><level>0</level><paramSize>5</paramSize> ? DAILYMED N/A 0 IN,MIN,PIN </FS><FS><service>NOINPUT</service><function>getRelatedByType</function><level>1</level><paramSize>2</paramSize> ? BPCK,GPCK,SBD,SCD </FS></WFE> Step 2 To remove all cough and bowel transit formulation codes and to remove the injectable codes filter out all codes with the following strings: Ingredient strings: Guaifenesin, Chlorpheniramine, Pseudoephedrine, Brompheniramine, Phenylephrine, Phenylpropanolamine, Promethazine, Bromodiphenhydramine, guaiacolsulfonate, homatropine Form strings: inject, cartridge, syringe
url:
  v: http://fhir.org/guides/cdc/opioid-cds/ValueSet/cns-depressant-medications
  l: cns-depressant-medications
version:
  v: 2022.1.0
name:
  v: CNS_DEPRESSANT_MEDICATIONS
title:
  v: CNS depressant medications
status:
  v: active
experimental:
  v: false
date:
  v: 2025-02-24T13:06:43-07:00
publisher:
  v: Centers for Disease Control and Prevention (CDC)
contact:
  telecom:
    system:
      v: url
    value:
      v: https://www.cdc.gov
description:
  v: Medications considered to have an ingredient considered to be a CNS depressant, some of which may be mild. Removed from this set are cough medications and bowl transit modifiers.
copyright:
  v: © CDC 2016+.
expansion:
  timestamp:
    v: 2025-02-24T13:06:43-07:00
  total:
    v: 116
  contains:
    system:
      v: http://www.nlm.nih.gov/research/umls/rxnorm
      l: rxnorm
    code:
      v: 904368
    display:
      v: benzphetamine hydrochloride 50 MG Oral Tablet
  contains:
    system:
      v: http://www.nlm.nih.gov/research/umls/rxnorm
      l: rxnorm
    code:
      v: 904372
    display:
      v: benzphetamine hydrochloride 25 MG Oral Tablet
  contains:
    system:
      v: http://www.nlm.nih.gov/research/umls/rxnorm
      l: rxnorm
    code:
      v: 2698136
    display:
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  contains:
    system:
      v: http://www.nlm.nih.gov/research/umls/rxnorm
      l: rxnorm
    code:
      v: 2698135
    display:
      v: {7 (sodium oxybate 4500 MG Granules for Oral Suspension) / 14 (sodium oxybate 6000 MG Granules for Oral Suspension) / 7 (sodium oxybate 7500 MG Granules for Oral Suspension) } Pack
  contains:
    system:
      v: http://www.nlm.nih.gov/research/umls/rxnorm
      l: rxnorm
    code:
      v: 2393794
    display:
      v: calcium oxybate 234 MG/ML / magnesium oxybate 96 MG/ML / potassium oxybate 130 MG/ML / sodium oxybate 40 MG/ML Oral Solution [Xywav]
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      v: http://www.nlm.nih.gov/research/umls/rxnorm
      l: rxnorm
    code:
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    display:
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      l: rxnorm
    code:
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    display:
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  contains:
    system:
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      l: rxnorm
    code:
      v: 2636836
    display:
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    system:
      v: http://www.nlm.nih.gov/research/umls/rxnorm
      l: rxnorm
    code:
      v: 2636840
    display:
      v: sodium oxybate 9000 MG Granules for Oral Suspension [Lumryz]
  contains:
    system:
      v: http://www.nlm.nih.gov/research/umls/rxnorm
      l: rxnorm
    code:
      v: 352257
    display:
      v: sodium oxybate 500 MG/ML Oral Solution [Xyrem]
  contains:
    system:
      v: http://www.nlm.nih.gov/research/umls/rxnorm
      l: rxnorm
    code:
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    display:
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  contains:
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      l: rxnorm
    code:
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    display:
      v: sodium oxybate 4500 MG Granules for Oral Suspension
  contains:
    system:
      v: http://www.nlm.nih.gov/research/umls/rxnorm
      l: rxnorm
    code:
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    display:
      v: sodium oxybate 6000 MG Granules for Oral Suspension
  contains:
    system:
      v: http://www.nlm.nih.gov/research/umls/rxnorm
      l: rxnorm
    code:
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    display:
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  contains:
    system:
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      l: rxnorm
    code:
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    display:
      v: sodium oxybate 9000 MG Granules for Oral Suspension

system:
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  l: rxnorm
code:
  v: 349482
display:
  v: sodium oxybate 500 MG/ML Oral Solution

system:
  v: http://www.nlm.nih.gov/research/umls/rxnorm
  l: rxnorm
code:
  v: 208919
display:
  v: desflurane 1000 MG/ML Inhalation Solution [Suprane]

system:
  v: http://www.nlm.nih.gov/research/umls/rxnorm
  l: rxnorm
code:
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display:
  v: desflurane 1000 MG/ML Inhalation Solution

system:
  v: http://www.nlm.nih.gov/research/umls/rxnorm
  l: rxnorm
code:
  v: 994071
display:
  v: 24 HR phendimetrazine tartrate 105 MG Extended Release Oral Capsule [Melfiat]

system:
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  l: rxnorm
code:
  v: 979543
display:
  v: 24 HR phendimetrazine tartrate 105 MG Extended Release Oral Capsule

system:
  v: http://www.nlm.nih.gov/research/umls/rxnorm
  l: rxnorm
code:
  v: 979549
display:
  v: phendimetrazine tartrate 35 MG Oral Tablet

system:
  v: http://www.nlm.nih.gov/research/umls/rxnorm
  l: rxnorm
code:
  v: 978662
display:
  v: diethylpropion hydrochloride 25 MG Oral Tablet [Tenuate]

system:
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  l: rxnorm
code:
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display:
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system:
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  l: rxnorm
code:
  v: 978654
display:
  v: diethylpropion hydrochloride 25 MG Oral Tablet

system:
  v: http://www.nlm.nih.gov/research/umls/rxnorm
  l: rxnorm
code:
  v: 978668
display:
  v: 24 HR diethylpropion hydrochloride 75 MG Extended Release Oral Tablet

system:
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  l: rxnorm
code:
  v: 1245044
display:
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system:
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  l: rxnorm
code:
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display:
  v: sevoflurane 1000 MG/ML Inhalation Solution [Sevospire]

system:
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  l: rxnorm
code:
  v: 541963
display:
  v: sevoflurane 1000 MG/ML Inhalation Solution [Ultane]

system:
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  l: rxnorm
code:
  v: 997618
display:
  v: sevoflurane 1000 MG/ML Inhalation Solution [Petrem]

system:
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  l: rxnorm
code:
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display:
  v: sevoflurane 1000 MG/ML Inhalation Solution [Sojourn]

system:
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  l: rxnorm
code:
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display:
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system:
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  l: rxnorm
code:
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display:
  v: trimethobenzamide 100 MG Rectal Suppository

system:
  v: http://www.nlm.nih.gov/research/umls/rxnorm
  l: rxnorm
code:
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display:
  v: trimethobenzamide 200 MG Rectal Suppository

system:
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  l: rxnorm
code:
  v: 860745
display:
  v: benzocaine 0.02 MG/MG / trimethobenzamide hydrochloride 200 MG Rectal Suppository

system:
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  l: rxnorm
code:
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display:
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system:
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  l: rxnorm
code:
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display:
  v: trimethobenzamide hydrochloride 250 MG Oral Capsule

system:
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  l: rxnorm
code:
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display:
  v: trimethobenzamide hydrochloride 300 MG Oral Capsule

system:
  v: http://www.nlm.nih.gov/research/umls/rxnorm
  l: rxnorm
code:
  v: 828696
display:
  v: zolpidem tartrate 5 MG/ACTUAT Oral Spray [Zolpimist]

system:
  v: http://www.nlm.nih.gov/research/umls/rxnorm
  l: rxnorm
code:
  v: 836645
display:
  v: zolpidem tartrate 10 MG Sublingual Tablet [Edluar]

system:
  v: http://www.nlm.nih.gov/research/umls/rxnorm
  l: rxnorm
code:
  v: 836649
display:
  v: zolpidem tartrate 5 MG Sublingual Tablet [Edluar]

system:
  v: http://www.nlm.nih.gov/research/umls/rxnorm
  l: rxnorm
code:
  v: 854875
display:
  v: zolpidem tartrate 10 MG Oral Tablet [Ambien]

system:
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  l: rxnorm
code:
  v: 854878
display:
  v: zolpidem tartrate 5 MG Oral Tablet [Ambien]

system:
  v: http://www.nlm.nih.gov/research/umls/rxnorm
  l: rxnorm
code:
  v: 854882
display:
  v: zolpidem tartrate 12.5 MG Extended Release Oral Tablet [Ambien]

system:
  v: http://www.nlm.nih.gov/research/umls/rxnorm
  l: rxnorm
code:
  v: 854896
display:
  v: zolpidem tartrate 6.25 MG Extended Release Oral Tablet [Ambien]

system:
  v: http://www.nlm.nih.gov/research/umls/rxnorm
  l: rxnorm
code:
  v: 1232194
display:
  v: zolpidem tartrate 1.75 MG Sublingual Tablet

system:
  v: http://www.nlm.nih.gov/research/umls/rxnorm
  l: rxnorm
code:
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display:
  v: zolpidem tartrate 3.5 MG Sublingual Tablet

system:
  v: http://www.nlm.nih.gov/research/umls/rxnorm
  l: rxnorm
code:
  v: 2637353
display:
  v: zolpidem tartrate 7.5 MG Oral Capsule

system:
  v: http://www.nlm.nih.gov/research/umls/rxnorm
  l: rxnorm
code:
  v: 828692
display:
  v: zolpidem tartrate 5 MG/ACTUAT Oral Spray

system:
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  l: rxnorm
code:
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display:
  v: zolpidem tartrate 10 MG Sublingual Tablet

system:
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  l: rxnorm
code:
  v: 836647
display:
  v: zolpidem tartrate 5 MG Sublingual Tablet

system:
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  l: rxnorm
code:
  v: 854873
display:
  v: zolpidem tartrate 10 MG Oral Tablet

system:
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  l: rxnorm
code:
  v: 854876
display:
  v: zolpidem tartrate 5 MG Oral Tablet

system:
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  l: rxnorm
code:
  v: 854880
display:
  v: zolpidem tartrate 12.5 MG Extended Release Oral Tablet

system:
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  l: rxnorm
code:
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display:
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system:
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  l: rxnorm
code:
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display:
  v: zolpidem tartrate 10 MG Disintegrating Oral Tablet

system:
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  l: rxnorm
code:
  v: 854894
display:
  v: zolpidem tartrate 6.25 MG Extended Release Oral Tablet

system:
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  l: rxnorm
code:
  v: 1732674
display:
  v: dexmedetomidine 0.00009 MG/MG Oral Gel [Sileo]

system:
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  l: rxnorm
code:
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display:
  v: dexmedetomidine 0.12 MG Sublingual Film [Igalmi]

system:
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  l: rxnorm
code:
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display:
  v: dexmedetomidine 0.18 MG Sublingual Film [Igalmi]

system:
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  l: rxnorm
code:
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display:
  v: dexmedetomidine 0.00009 MG/MG Oral Gel

system:
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code:
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display:
  v: dexmedetomidine 0.12 MG Sublingual Film

system:
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code:
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display:
  v: dexmedetomidine 0.18 MG Sublingual Film

system:
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  l: rxnorm
code:
  v: 1540984
display:
  v: isoflurane 999 MG/ML Inhalation Solution [Fluriso]

system:
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  l: rxnorm
code:
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display:
  v: isoflurane 999 MG/ML Inhalation Solution [IsoSol]

system:
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code:
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code:
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system:
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  l: rxnorm
code:
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display:
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system:
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  l: rxnorm
code:
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display:
  v: meclizine hydrochloride 25 MG Oral Tablet [Dramamine Nausea Relief]

system:
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  l: rxnorm
code:
  v: 2176732
display:
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system:
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  l: rxnorm
code:
  v: 2273509
display:
  v: meclizine hydrochloride 25 MG Chewable Tablet [Antivert]

system:
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  l: rxnorm
code:
  v: 2540687
display:
  v: meclizine hydrochloride 25 MG Disintegrating Oral Tablet [Zentrip]

system:
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  l: rxnorm
code:
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display:
  v: meclizine hydrochloride 12.5 MG Oral Tablet [Antivert]

system:
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  l: rxnorm
code:
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display:
  v: meclizine hydrochloride 25 MG Chewable Tablet [Bonine]

system:
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  l: rxnorm
code:
  v: 995668
display:
  v: meclizine hydrochloride 25 MG Oral Tablet [Antivert]

system:
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  l: rxnorm
code:
  v: 995688
display:
  v: meclizine hydrochloride 50 MG Oral Tablet [Antivert]

system:
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  l: rxnorm
code:
  v: 995726
display:
  v: meclizine hydrochloride 25 MG Oral Tablet [Dramamine Less Drowsy]

system:
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  l: rxnorm
code:
  v: 1663815
display:
  v: meclizine hydrochloride 25 MG Disintegrating Oral Tablet

system:
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  l: rxnorm
code:
  v: 2632643
display:
  v: meclizine hydrochloride 50 MG Chewable Tablet

system:
  v: http://www.nlm.nih.gov/research/umls/rxnorm
  l: rxnorm
code:
  v: 995624
display:
  v: meclizine hydrochloride 12.5 MG Oral Tablet

system:
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  l: rxnorm
code:
  v: 995632
display:
  v: meclizine hydrochloride 25 MG Chewable Tablet

system:
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  l: rxnorm
code:
  v: 995666
display:
  v: meclizine hydrochloride 25 MG Oral Tablet

system:
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  l: rxnorm
code:
  v: 995682
display:
  v: meclizine hydrochloride 30 MG Oral Tablet

system:
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  l: rxnorm
code:
  v: 995686
display:
  v: meclizine hydrochloride 50 MG Oral Tablet

system:
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  l: rxnorm
code:
  v: 995753
display:
  v: meclizine hydrochloride 12.5 MG Oral Lozenge

system:
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  l: rxnorm
code:
  v: 977861
display:
  v: methamphetamine hydrochloride 5 MG Oral Tablet [Desoxyn]

system:
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  l: rxnorm
code:
  v: 977860
display:
  v: methamphetamine hydrochloride 5 MG Oral Tablet

system:
  v: http://www.nlm.nih.gov/research/umls/rxnorm
  l: rxnorm
code:
  v: 313761
display:
  v: zaleplon 10 MG Oral Capsule

system:
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  l: rxnorm
code:
  v: 313762
display:
  v: zaleplon 5 MG Oral Capsule

system:
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  l: rxnorm
code:
  v: 1302833
display:
  v: 24 HR phentermine 7.5 MG / topiramate 46 MG Extended Release Oral Capsule [Qsymia]

system:
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  l: rxnorm
code:
  v: 1302845
display:
  v: 24 HR phentermine 3.75 MG / topiramate 23 MG Extended Release Oral Capsule [Qsymia]

system:
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code:
  v: 1302856
display:
  v: 24 HR phentermine 15 MG / topiramate 92 MG Extended Release Oral Capsule [Qsymia]

system:
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code:
  v: 1313061
display:
  v: 24 HR phentermine 11.25 MG / topiramate 69 MG Extended Release Oral Capsule [Qsymia]

system:
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  l: rxnorm
code:
  v: 1810304
display:
  v: phentermine hydrochloride 8 MG Oral Tablet [Lomaira]

system:
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code:
  v: 803350
display:
  v: phentermine hydrochloride 37.5 MG Oral Capsule [Adipex-P]

system:
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code:
  v: 803354
display:
  v: phentermine hydrochloride 37.5 MG Oral Tablet [Adipex-P]

system:
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code:
  v: 1112982
display:
  v: phentermine hydrochloride 15 MG Disintegrating Oral Tablet

system:
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  l: rxnorm
code:
  v: 1112987
display:
  v: phentermine hydrochloride 30 MG Disintegrating Oral Tablet

system:
  v: http://www.nlm.nih.gov/research/umls/rxnorm
  l: rxnorm
code:
  v: 1249083
display:
  v: phentermine hydrochloride 37.5 MG Disintegrating Oral Tablet

system:
  v: http://www.nlm.nih.gov/research/umls/rxnorm
  l: rxnorm
code:
  v: 1302827
display:
  v: 24 HR phentermine 7.5 MG / topiramate 46 MG Extended Release Oral Capsule

system:
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  l: rxnorm
code:
  v: 1302839
display:
  v: 24 HR phentermine 3.75 MG / topiramate 23 MG Extended Release Oral Capsule

system:
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  l: rxnorm
code:
  v: 1302850
display:
  v: 24 HR phentermine 15 MG / topiramate 92 MG Extended Release Oral Capsule

system:
  v: http://www.nlm.nih.gov/research/umls/rxnorm
  l: rxnorm
code:
  v: 1313059
display:
  v: 24 HR phentermine 11.25 MG / topiramate 69 MG Extended Release Oral Capsule

system:
  v: http://www.nlm.nih.gov/research/umls/rxnorm
  l: rxnorm
code:
  v: 803348
display:
  v: phentermine hydrochloride 37.5 MG Oral Capsule

system:
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  l: rxnorm
code:
  v: 803353
display:
  v: phentermine hydrochloride 37.5 MG Oral Tablet

system:
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  l: rxnorm
code:
  v: 826131
display:
  v: phentermine hydrochloride 18.8 MG Oral Capsule

system:
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  l: rxnorm
code:
  v: 826586
display:
  v: phentermine resin 15 MG Extended Release Oral Capsule

system:
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  l: rxnorm
code:
  v: 826600
display:
  v: phentermine resin 15 MG Oral Capsule

system:
  v: http://www.nlm.nih.gov/research/umls/rxnorm
  l: rxnorm
code:
  v: 826832
display:
  v: phentermine resin 30 MG Extended Release Oral Capsule

system:
  v: http://www.nlm.nih.gov/research/umls/rxnorm
  l: rxnorm
code:
  v: 826910
display:
  v: phentermine resin 30 MG Oral Capsule

system:
  v: http://www.nlm.nih.gov/research/umls/rxnorm
  l: rxnorm
code:
  v: 826919
display:
  v: phentermine hydrochloride 8 MG Oral Tablet

system:
  v: http://www.nlm.nih.gov/research/umls/rxnorm
  l: rxnorm
code:
  v: 900038
display:
  v: phentermine hydrochloride 30 MG Oral Capsule

system:
  v: http://www.nlm.nih.gov/research/umls/rxnorm
  l: rxnorm
code:
  v: 968766
display:
  v: phentermine hydrochloride 15 MG Oral Capsule