{
  "resourceType" : "CodeSystem",
  "id" : "ocm-protocol-markers-cs",
  "language" : "en",
  "text" : {
    "status" : "generated",
    "div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p class=\"res-header-id\"><b>Generated Narrative: CodeSystem ocm-protocol-markers-cs</b></p><a name=\"ocm-protocol-markers-cs\"> </a><a name=\"hcocm-protocol-markers-cs\"> </a><p>This case-sensitive code system <code>https://nshr-uat.sha.go.ke/fhir/CodeSystem/ocm-protocol-markers-cs</code> defines the following codes:</p><table class=\"codes\"><tr><td style=\"white-space:nowrap\"><b>Code</b></td><td><b>Display</b></td><td><b>Definition</b></td></tr><tr><td style=\"white-space:nowrap\">HER2-POSITIVE<a name=\"ocm-protocol-markers-cs-HER2-POSITIVE\"> </a></td><td>HER2 Positive</td><td>HER2/neu overexpression or amplification detected.</td></tr><tr><td style=\"white-space:nowrap\">HER2-NEGATIVE<a name=\"ocm-protocol-markers-cs-HER2-NEGATIVE\"> </a></td><td>HER2 Negative</td><td>No HER2/neu overexpression or amplification.</td></tr><tr><td style=\"white-space:nowrap\">ER-POSITIVE<a name=\"ocm-protocol-markers-cs-ER-POSITIVE\"> </a></td><td>ER Positive</td><td>Oestrogen receptor positive.</td></tr><tr><td style=\"white-space:nowrap\">ER-NEGATIVE<a name=\"ocm-protocol-markers-cs-ER-NEGATIVE\"> </a></td><td>ER Negative</td><td>Oestrogen receptor negative.</td></tr><tr><td style=\"white-space:nowrap\">PR-POSITIVE<a name=\"ocm-protocol-markers-cs-PR-POSITIVE\"> </a></td><td>PR Positive</td><td>Progesterone receptor positive.</td></tr><tr><td style=\"white-space:nowrap\">PR-NEGATIVE<a name=\"ocm-protocol-markers-cs-PR-NEGATIVE\"> </a></td><td>PR Negative</td><td>Progesterone receptor negative.</td></tr><tr><td style=\"white-space:nowrap\">TRIPLE-NEGATIVE<a name=\"ocm-protocol-markers-cs-TRIPLE-NEGATIVE\"> </a></td><td>Triple Negative</td><td>ER-, PR-, HER2- breast cancer.</td></tr><tr><td style=\"white-space:nowrap\">KRAS-MUTANT<a name=\"ocm-protocol-markers-cs-KRAS-MUTANT\"> </a></td><td>KRAS Mutant</td><td>KRAS mutation detected.</td></tr><tr><td style=\"white-space:nowrap\">KRAS-WILD-TYPE<a name=\"ocm-protocol-markers-cs-KRAS-WILD-TYPE\"> </a></td><td>KRAS Wild-type</td><td>No KRAS mutation.</td></tr><tr><td style=\"white-space:nowrap\">BRAF-V600E<a name=\"ocm-protocol-markers-cs-BRAF-V600E\"> </a></td><td>BRAF V600E Mutant</td><td>BRAF V600E mutation detected.</td></tr><tr><td style=\"white-space:nowrap\">PD-L1-POSITIVE<a name=\"ocm-protocol-markers-cs-PD-L1-POSITIVE\"> </a></td><td>PD-L1 Positive</td><td>PD-L1 expression ≥1%.</td></tr><tr><td style=\"white-space:nowrap\">PD-L1-NEGATIVE<a name=\"ocm-protocol-markers-cs-PD-L1-NEGATIVE\"> </a></td><td>PD-L1 Negative</td><td>PD-L1 expression &lt;1%.</td></tr><tr><td style=\"white-space:nowrap\">MSI-HIGH<a name=\"ocm-protocol-markers-cs-MSI-HIGH\"> </a></td><td>MSI-High</td><td>Microsatellite instability high.</td></tr><tr><td style=\"white-space:nowrap\">MSI-LOW<a name=\"ocm-protocol-markers-cs-MSI-LOW\"> </a></td><td>MSI-Low / MSS</td><td>Microsatellite instability low or stable.</td></tr><tr><td style=\"white-space:nowrap\">EGFR-MUTANT<a name=\"ocm-protocol-markers-cs-EGFR-MUTANT\"> </a></td><td>EGFR Mutant</td><td>EGFR mutation detected.</td></tr><tr><td style=\"white-space:nowrap\">ALK-POSITIVE<a name=\"ocm-protocol-markers-cs-ALK-POSITIVE\"> </a></td><td>ALK Positive</td><td>ALK rearrangement detected.</td></tr><tr><td style=\"white-space:nowrap\">NOT-TESTED<a name=\"ocm-protocol-markers-cs-NOT-TESTED\"> </a></td><td>Not Tested</td><td>Biomarker testing not performed.</td></tr></table></div>"
  },
  "url" : "https://nshr-uat.sha.go.ke/fhir/CodeSystem/ocm-protocol-markers-cs",
  "version" : "0.1.0",
  "name" : "OCMProtocolMarkersCS",
  "title" : "Kenya OCM Protocol Markers Code System",
  "status" : "active",
  "experimental" : false,
  "date" : "2026-06-04T14:49:30+00:00",
  "publisher" : "Digital Health Agency (DHA), Kenya",
  "contact" : [{
    "name" : "Digital Health Agency (DHA), Kenya",
    "telecom" : [{
      "system" : "url",
      "value" : "https://dha.go.ke"
    },
    {
      "system" : "email",
      "value" : "info@dha.go.ke"
    }]
  },
  {
    "name" : "Digital Health Agency Kenya – FHIR Team",
    "telecom" : [{
      "system" : "email",
      "value" : "info@dha.go.ke",
      "use" : "work"
    },
    {
      "system" : "url",
      "value" : "https://dha.go.ke",
      "use" : "work"
    }]
  }],
  "description" : "Biomarker and molecular marker codes used for treatment protocol selection.",
  "jurisdiction" : [{
    "coding" : [{
      "system" : "urn:iso:std:iso:3166",
      "code" : "KE",
      "display" : "Kenya"
    }]
  }],
  "caseSensitive" : true,
  "content" : "complete",
  "count" : 17,
  "concept" : [{
    "code" : "HER2-POSITIVE",
    "display" : "HER2 Positive",
    "definition" : "HER2/neu overexpression or amplification detected."
  },
  {
    "code" : "HER2-NEGATIVE",
    "display" : "HER2 Negative",
    "definition" : "No HER2/neu overexpression or amplification."
  },
  {
    "code" : "ER-POSITIVE",
    "display" : "ER Positive",
    "definition" : "Oestrogen receptor positive."
  },
  {
    "code" : "ER-NEGATIVE",
    "display" : "ER Negative",
    "definition" : "Oestrogen receptor negative."
  },
  {
    "code" : "PR-POSITIVE",
    "display" : "PR Positive",
    "definition" : "Progesterone receptor positive."
  },
  {
    "code" : "PR-NEGATIVE",
    "display" : "PR Negative",
    "definition" : "Progesterone receptor negative."
  },
  {
    "code" : "TRIPLE-NEGATIVE",
    "display" : "Triple Negative",
    "definition" : "ER-, PR-, HER2- breast cancer."
  },
  {
    "code" : "KRAS-MUTANT",
    "display" : "KRAS Mutant",
    "definition" : "KRAS mutation detected."
  },
  {
    "code" : "KRAS-WILD-TYPE",
    "display" : "KRAS Wild-type",
    "definition" : "No KRAS mutation."
  },
  {
    "code" : "BRAF-V600E",
    "display" : "BRAF V600E Mutant",
    "definition" : "BRAF V600E mutation detected."
  },
  {
    "code" : "PD-L1-POSITIVE",
    "display" : "PD-L1 Positive",
    "definition" : "PD-L1 expression ≥1%."
  },
  {
    "code" : "PD-L1-NEGATIVE",
    "display" : "PD-L1 Negative",
    "definition" : "PD-L1 expression <1%."
  },
  {
    "code" : "MSI-HIGH",
    "display" : "MSI-High",
    "definition" : "Microsatellite instability high."
  },
  {
    "code" : "MSI-LOW",
    "display" : "MSI-Low / MSS",
    "definition" : "Microsatellite instability low or stable."
  },
  {
    "code" : "EGFR-MUTANT",
    "display" : "EGFR Mutant",
    "definition" : "EGFR mutation detected."
  },
  {
    "code" : "ALK-POSITIVE",
    "display" : "ALK Positive",
    "definition" : "ALK rearrangement detected."
  },
  {
    "code" : "NOT-TESTED",
    "display" : "Not Tested",
    "definition" : "Biomarker testing not performed."
  }]
}