Genomics Reporting Implementation Guide
4.0.0-cibuild - CI Build

Genomics Reporting Implementation Guide, published by HL7 International / Clinical Genomics. This guide is not an authorized publication; it is the continuous build for version 4.0.0-cibuild built by the FHIR (HL7® FHIR® Standard) CI Build. This version is based on the current content of https://github.com/HL7/genomics-reporting/ and changes regularly. See the Directory of published versions

## ValueSet: Molecular Biomarker Codes

Official URL: http://hl7.org/fhir/uv/genomics-reporting/ValueSet/molecular-biomarker-code-vs | Version: 4.0.0-cibuild
Standards status: Trial-use | Maturity Level: 2 | Computable Name: MolecularBiomarkerCodeVS
Copyright/Legal: This material contains content from LOINC (http://loinc.org). LOINC is copyright © 1995-2020, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee and is available at no cost under the license at http://loinc.org/license. LOINC® is a registered United States trademark of Regenstrief Institute, Inc. This value set includes content from SNOMED CT, which is copyright © 2002+ International Health Terminology Standards Development Organisation (IHTSDO), and distributed by agreement between IHTSDO and HL7. Implementer use of SNOMED CT is not covered by this agreement.

Value Set for terms that can be used as Biomarkers.

References

- Molecular Biomarker

### Logical Definition (CLD)

This value set includes codes based on the following rules:

- Include these codes as defined in `http://loinc.org` version Not Stated (use latest from terminology server)

  Code | Display
  85337-4 | Estrogen receptor Ag [Presence] in Breast cancer specimen by Immune stain
  72382-5 | HER2 [Units/volume] in Tissue by Immunoassay
  77637-7 | HLA-A and B and C (class I) IgG panel [Identifier] - Serum or Plasma by Immunoassay
  40557-1 | Progesterone receptor Ag [Presence] in Tissue by Immune stain
  85147-7 | PD-L1 by clone 22C3 in Tissue by Immune stain Report
  59025-7 | Neutrophil Ab [Units/volume] in Serum by Flow cytometry (FC)
  59003-4 | Lactoferrin Ab [Units/volume] in Serum by Immunoassay
  10495-0 | Insulin Ag [Presence] in Tissue by Immune stain
  16550-6 | Carbohydrates [Identifier] in Urine
  2569-2 | Lipids [Mass/volume] in Serum
  4551-8 | Hemoglobin A2/Hemoglobin.total in Blood
  19195-7 | Prostate specific Ag [Units/volume] in Serum or Plasma
  64083-9 | MGMT gene methylation score in Tissue by Molecular genetics method
  62862-8 | Microsatellite instability [Presence] in Tissue by Immune stain
  81704-9 | Microsatellite instability marker D17S250 in Cancer specimen Qualitative
  94077-5 | Tumor mutation burden [Interpretation]

- Include these codes as defined in `http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl` version Not Stated (use latest from terminology server)

  Code | Display
  C120465 | Homologous Recombination Repair Deficiency

### Expansion

No Expansion for this valueset (not supported by Publication Tooling)

Explanation of the columns that may appear on this page:

Level | A few code lists that FHIR defines are hierarchical - each code is assigned a level. In this scheme, some codes are under other codes, and imply that the code they are under also applies
System | The source of the definition of the code (when the value set draws in codes defined elsewhere)
Code | The code (used as the code in the resource instance)
Display | The display (used in the display element of a Coding). If there is no display, implementers should not simply display the code, but map the concept into their application
Definition | An explanation of the meaning of the concept
Comments | Additional notes about how to use the code