Genomics Reporting Implementation Guide
4.0.0-cibuild - CI Build

Genomics Reporting Implementation Guide, published by HL7 International / Clinical Genomics. This guide is not an authorized publication; it is the continuous build for version 4.0.0-cibuild built by the FHIR (HL7® FHIR® Standard) CI Build. This version is based on the current content of https://github.com/HL7/genomics-reporting/ and changes regularly. See the Directory of published versions

## : bundle-oncology-diagnostic - JSON Representation

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    {
      "resourceType" : "Bundle",
      "id" : "bundle-oncology-diagnostic",
      "type" : "transaction",
      "entry" : [
        {
          "fullUrl" : "urn:uuid:d0b4affa-91d6-46d1-af01-b30d9f16ef6d",
          "resource" : {
            "resourceType" : "Patient",
            "id" : "Inline-Instance-for-oncology-diagnostic-1",
            "text" : {
              "status" : "generated",
              "div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"Patient_Inline-Instance-for-oncology-diagnostic-1\"> </a><p class=\"res-header-id\"><b>Generated Narrative: Patient Inline-Instance-for-oncology-diagnostic-1</b></p><a name=\"Inline-Instance-for-oncology-diagnostic-1\"> </a><a name=\"hcInline-Instance-for-oncology-diagnostic-1\"> </a><p style=\"border: 1px #661aff solid; background-color: #e6e6ff; padding: 10px;\">Carrot John Mr  Male, DoB: 1962-12-31 ( 1007)</p><hr/><table class=\"grid\"><tr><td style=\"background-color: #f3f5da\" title=\"Patient Links\">Links:</td><td colspan=\"3\"><ul><li>General Practitioner: <a href=\"Bundle-bundle-oncology-diagnostic.html#urn-uuid-a48256f8-db37-44e0-a0f6-d7af16c7c9ef\">Practitioner Akerman Philip Prof </a></li></ul></td></tr></table></div>"
            },
            "identifier" : [
              {
                "value" : "1007"
              }
            ],
            "name" : [
              {
                "given" : [
                  "Carrot",
                  "John",
                  "Mr"
                ]
              }
            ],
            "gender" : "male",
            "birthDate" : "1962-12-31",
            "generalPractitioner" : [
              {
                "reference" : "urn:uuid:a48256f8-db37-44e0-a0f6-d7af16c7c9ef"
              }
            ]
          },
          "request" : {
            "method" : "POST",
            "url" : "Patient"
          }
        },
        {
          "fullUrl" : "urn:uuid:a48256f8-db37-44e0-a0f6-d7af16c7c9ef",
          "resource" : {
            "resourceType" : "Practitioner",
            "id" : "Inline-Instance-for-oncology-diagnostic-2",
            "text" : {
              "status" : "generated",
              "div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"Practitioner_Inline-Instance-for-oncology-diagnostic-2\"> </a><p class=\"res-header-id\"><b>Generated Narrative: Practitioner Inline-Instance-for-oncology-diagnostic-2</b></p><a name=\"Inline-Instance-for-oncology-diagnostic-2\"> </a><a name=\"hcInline-Instance-for-oncology-diagnostic-2\"> </a><p><b>identifier</b>: 4654765876</p><p><b>name</b>: Akerman Philip Prof </p><p><b>address</b>: Castro Valley CA </p></div>"
            },
            "identifier" : [
              {
                "value" : "4654765876"
              }
            ],
            "name" : [
              {
                "given" : [
                  "Akerman",
                  "Philip",
                  "Prof"
                ]
              }
            ],
            "address" : [
              {
                "city" : "Castro Valley",
                "state" : "CA"
              }
            ]
          },
          "request" : {
            "method" : "POST",
            "url" : "Practitioner"
          }
        },
        {
          "fullUrl" : "urn:uuid:a5d6a6a9-4859-480e-85b2-56974fef3b9d",
          "resource" : {
            "resourceType" : "Specimen",
            "id" : "Inline-Instance-for-oncology-diagnostic-3",
            "text" : {
              "status" : "generated",
              "div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"Specimen_Inline-Instance-for-oncology-diagnostic-3\"> </a><p class=\"res-header-id\"><b>Generated Narrative: Specimen Inline-Instance-for-oncology-diagnostic-3</b></p><a name=\"Inline-Instance-for-oncology-diagnostic-3\"> </a><a name=\"hcInline-Instance-for-oncology-diagnostic-3\"> </a><p><b>identifier</b>: 076e1948-2217-11e9-94d8-12e241dc1f66</p><p><b>status</b>: Available</p><p><b>subject</b>: <a href=\"Bundle-bundle-oncology-diagnostic.html#urn-uuid-d0b4affa-91d6-46d1-af01-b30d9f16ef6d\">Carrot John Mr  Male, DoB: 1962-12-31 ( 1007)</a></p><h3>Collections</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Collector</b></td></tr><tr><td style=\"display: none\">*</td><td><a href=\"Bundle-bundle-oncology-diagnostic.html#urn-uuid-a48256f8-db37-44e0-a0f6-d7af16c7c9ef\">Practitioner Akerman Philip Prof </a></td></tr></table></div>"
            },
            "identifier" : [
              {
                "value" : "076e1948-2217-11e9-94d8-12e241dc1f66"
              }
            ],
            "status" : "available",
            "subject" : {
              "reference" : "urn:uuid:d0b4affa-91d6-46d1-af01-b30d9f16ef6d"
            },
            "collection" : {
              "collector" : {
                "reference" : "urn:uuid:a48256f8-db37-44e0-a0f6-d7af16c7c9ef"
              }
            }
          },
          "request" : {
            "method" : "POST",
            "url" : "Specimen"
          }
        },
        {
          "fullUrl" : "urn:uuid:40e85eda-4d31-4bd2-a5a0-c39d63f9824f",
          "resource" : {
            "resourceType" : "Observation",
            "id" : "Inline-Instance-for-oncology-diagnostic-4",
            "meta" : {
              "profile" : [
                🔗 "http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/molecular-biomarker"
              ]
            },
            "text" : {
              "status" : "generated",
              "div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"Observation_Inline-Instance-for-oncology-diagnostic-4\"> </a><p class=\"res-header-id\"><b>Generated Narrative: Observation Inline-Instance-for-oncology-diagnostic-4</b></p><a name=\"Inline-Instance-for-oncology-diagnostic-4\"> </a><a name=\"hcInline-Instance-for-oncology-diagnostic-4\"> </a><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\"/><p style=\"margin-bottom: 0px\">Profile: <a href=\"StructureDefinition-molecular-biomarker.html\">Molecular Biomarker</a></p></div><p><b>status</b>: Final</p><p><b>category</b>: <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/observation-category laboratory}\">Laboratory</span>, <span title=\"Codes:{http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs biomarker-category}\">Biomarker Category</span>, <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/v2-0074 GE}\">Genetics</span></p><p><b>code</b>: <span title=\"Codes:{http://loinc.org 94076-7}\">Mutations/Megabase [# Ratio] in Tumor</span></p><p><b>subject</b>: <a href=\"Bundle-bundle-oncology-diagnostic.html#urn-uuid-d0b4affa-91d6-46d1-af01-b30d9f16ef6d\">Carrot John Mr  Male, DoB: 1962-12-31 ( 1007)</a></p><p><b>effective</b>: 2019-03-05</p><p><b>performer</b>: <a href=\"Bundle-bundle-oncology-diagnostic.html#urn-uuid-a48256f8-db37-44e0-a0f6-d7af16c7c9ef\">Practitioner Akerman Philip Prof </a></p><p><b>value</b>: 25 Mutations/Megabase<span style=\"background: LightGoldenRodYellow\"> (Details: UCUM  code1/1000000 = '1/1000000')</span></p><p><b>specimen</b>: <a href=\"Bundle-bundle-oncology-diagnostic.html#urn-uuid-a5d6a6a9-4859-480e-85b2-56974fef3b9d\">Specimen: identifier = 076e1948-2217-11e9-94d8-12e241dc1f66; status = available</a></p><h3>Components</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Code</b></td><td><b>Value[x]</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:{http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs biomarker-category}\">Biomarker Category</span></td><td><span title=\"Codes:{http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/molecular-biomarker-ontology-cs molgen}\">molecular sequence adjacent category</span></td></tr></table></div>"
            },
            "status" : "final",
            "category" : [
              {
                "coding" : [
                  {
                    "system" : "http://terminology.hl7.org/CodeSystem/observation-category",
                    "code" : "laboratory"
                  }
                ]
              },
              {
                "coding" : [
                  {
                    "system" : "http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs",
                    "code" : "biomarker-category"
                  }
                ]
              },
              {
                "coding" : [
                  {
                    "system" : "http://terminology.hl7.org/CodeSystem/v2-0074",
                    "code" : "GE"
                  }
                ]
              }
            ],
            "code" : {
              "coding" : [
                {
                  "system" : "http://loinc.org",
                  "code" : "94076-7",
                  "display" : "Mutations/Megabase [# Ratio] in Tumor"
                }
              ]
            },
            "subject" : {
              "reference" : "urn:uuid:d0b4affa-91d6-46d1-af01-b30d9f16ef6d"
            },
            "effectiveDateTime" : "2019-03-05",
            "performer" : [
              {
                "reference" : "urn:uuid:a48256f8-db37-44e0-a0f6-d7af16c7c9ef"
              }
            ],
            "valueQuantity" : {
              "value" : 25,
              "unit" : "Mutations/Megabase",
              "system" : "http://unitsofmeasure.org",
              "code" : "1/1000000"
            },
            "specimen" : {
              "reference" : "urn:uuid:a5d6a6a9-4859-480e-85b2-56974fef3b9d"
            },
            "component" : [
              {
                "code" : {
                  "coding" : [
                    {
                      "system" : "http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs",
                      "code" : "biomarker-category"
                    }
                  ]
                },
                "valueCodeableConcept" : {
                  "coding" : [
                    {
                      "system" : "http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/molecular-biomarker-ontology-cs",
                      "code" : "molgen",
                      "display" : "molecular sequence adjacent category"
                    }
                  ]
                }
              }
            ]
          },
          "request" : {
            "method" : "POST",
            "url" : "Observation"
          }
        },
        {
          "fullUrl" : "urn:uuid:16fdd5fc-e665-48af-99e4-48d603f3e12d",
          "resource" : {
            "resourceType" : "Observation",
            "id" : "Inline-Instance-for-oncology-diagnostic-5",
            "meta" : {
              "profile" : [
                🔗 "http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/variant"
              ]
            },
            "text" : {
              "status" : "generated",
              "div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"Observation_Inline-Instance-for-oncology-diagnostic-5\"> </a><p class=\"res-header-id\"><b>Generated Narrative: Observation Inline-Instance-for-oncology-diagnostic-5</b></p><a name=\"Inline-Instance-for-oncology-diagnostic-5\"> </a><a name=\"hcInline-Instance-for-oncology-diagnostic-5\"> </a><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\"/><p style=\"margin-bottom: 0px\">Profile: <a href=\"StructureDefinition-variant.html\">Variant</a></p></div><p><b>status</b>: Final</p><p><b>category</b>: <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/observation-category laboratory}\">Laboratory</span>, <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/v2-0074 GE}\">Genetics</span></p><p><b>code</b>: <span title=\"Codes:{http://loinc.org 69548-6}\">Genetic variant assessment</span></p><p><b>subject</b>: <a href=\"Bundle-bundle-oncology-diagnostic.html#urn-uuid-d0b4affa-91d6-46d1-af01-b30d9f16ef6d\">Carrot John Mr  Male, DoB: 1962-12-31 ( 1007)</a></p><p><b>effective</b>: 2019-03-05</p><p><b>performer</b>: <a href=\"Bundle-bundle-oncology-diagnostic.html#urn-uuid-a48256f8-db37-44e0-a0f6-d7af16c7c9ef\">Practitioner Akerman Philip Prof </a></p><p><b>value</b>: <span title=\"Codes:{http://loinc.org LA9633-4}\">Present</span></p><p><b>method</b>: <span title=\"Codes:{http://loinc.org LA26398-0}\">Sequencing</span></p><p><b>specimen</b>: <a href=\"Bundle-bundle-oncology-diagnostic.html#urn-uuid-a5d6a6a9-4859-480e-85b2-56974fef3b9d\">Specimen: identifier = 076e1948-2217-11e9-94d8-12e241dc1f66; status = available</a></p><blockquote><p><b>component</b></p><p><b>code</b>: <span title=\"Codes:{http://loinc.org 62374-4}\">Human reference sequence assembly version</span></p><p><b>value</b>: <span title=\"Codes:{http://loinc.org LA14029-5}\">GRCh37</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: <span title=\"Codes:{http://loinc.org 81290-9}\">Genomic DNA change (gHGVS)</span></p><p><b>value</b>: <span title=\"Codes:{http://varnomen.hgvs.org NC_000007.13:g.140453136A&gt;T}\">NC_000007.13:g.140453136A&gt;T</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: <span title=\"Codes:{http://loinc.org 81252-9}\">Discrete genetic variant</span></p><p><b>value</b>: <span title=\"Codes:{http://www.ncbi.nlm.nih.gov/clinvar 13961}\">Clinvar ID 13961</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: <span title=\"Codes:{http://loinc.org 48005-3}\">Amino acid change (pHGVS)</span></p><p><b>value</b>: <span title=\"Codes:{http://varnomen.hgvs.org NP_004324.2:p.Val600Glu}\">NP_004324.2:p.Val600Glu</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: <span title=\"Codes:{http://loinc.org 48018-6}\">Gene studied ID</span></p><p><b>value</b>: <span title=\"Codes:{http://www.genenames.org HGNC:1097}\">BRAF</span></p></blockquote></div>"
            },
            "status" : "final",
            "category" : [
              {
                "coding" : [
                  {
                    "system" : "http://terminology.hl7.org/CodeSystem/observation-category",
                    "code" : "laboratory"
                  }
                ]
              },
              {
                "coding" : [
                  {
                    "system" : "http://terminology.hl7.org/CodeSystem/v2-0074",
                    "code" : "GE"
                  }
                ]
              }
            ],
            "code" : {
              "coding" : [
                {
                  "system" : "http://loinc.org",
                  "code" : "69548-6",
                  "display" : "Genetic variant assessment"
                }
              ]
            },
            "subject" : {
              "reference" : "urn:uuid:d0b4affa-91d6-46d1-af01-b30d9f16ef6d"
            },
            "effectiveDateTime" : "2019-03-05",
            "performer" : [
              {
                "reference" : "urn:uuid:a48256f8-db37-44e0-a0f6-d7af16c7c9ef"
              }
            ],
            "valueCodeableConcept" : {
              "coding" : [
                {
                  "system" : "http://loinc.org",
                  "code" : "LA9633-4",
                  "display" : "Present"
                }
              ]
            },
            "method" : {
              "coding" : [
                {
                  "system" : "http://loinc.org",
                  "code" : "LA26398-0",
                  "display" : "Sequencing"
                }
              ]
            },
            "specimen" : {
              "reference" : "urn:uuid:a5d6a6a9-4859-480e-85b2-56974fef3b9d"
            },
            "component" : [
              {
                "code" : {
                  "coding" : [
                    {
                      "system" : "http://loinc.org",
                      "code" : "62374-4",
                      "display" : "Human reference sequence assembly version"
                    }
                  ]
                },
                "valueCodeableConcept" : {
                  "coding" : [
                    {
                      "system" : "http://loinc.org",
                      "code" : "LA14029-5",
                      "display" : "GRCh37"
                    }
                  ]
                }
              },
              {
                "code" : {
                  "coding" : [
                    {
                      "system" : "http://loinc.org",
                      "code" : "81290-9",
                      "display" : "Genomic DNA change (gHGVS)"
                    }
                  ]
                },
                "valueCodeableConcept" : {
                  "coding" : [
                    {
                      "system" : "http://varnomen.hgvs.org",
                      "code" : "NC_000007.13:g.140453136A>T",
                      "display" : "NC_000007.13:g.140453136A>T"
                    }
                  ]
                }
              },
              {
                "code" : {
                  "coding" : [
                    {
                      "system" : "http://loinc.org",
                      "code" : "81252-9",
                      "display" : "Discrete genetic variant"
                    }
                  ]
                },
                "valueCodeableConcept" : {
                  "coding" : [
                    {
                      "system" : "http://www.ncbi.nlm.nih.gov/clinvar",
                      "code" : "13961",
                      "display" : "Clinvar ID 13961"
                    }
                  ]
                }
              },
              {
                "code" : {
                  "coding" : [
                    {
                      "system" : "http://loinc.org",
                      "code" : "48005-3",
                      "display" : "Amino acid change (pHGVS)"
                    }
                  ]
                },
                "valueCodeableConcept" : {
                  "coding" : [
                    {
                      "system" : "http://varnomen.hgvs.org",
                      "code" : "NP_004324.2:p.Val600Glu",
                      "display" : "NP_004324.2:p.Val600Glu"
                    }
                  ]
                }
              },
              {
                "code" : {
                  "coding" : [
                    {
                      "system" : "http://loinc.org",
                      "code" : "48018-6",
                      "display" : "Gene studied ID"
                    }
                  ]
                },
                "valueCodeableConcept" : {
                  "coding" : [
                    {
                      "system" : "http://www.genenames.org",
                      "code" : "HGNC:1097",
                      "display" : "BRAF"
                    }
                  ]
                }
              }
            ]
          },
          "request" : {
            "method" : "POST",
            "url" : "Observation"
          }
        },
        {
          "fullUrl" : "urn:uuid:1bf9642d-fd1c-4819-8c5d-44fae4bad524",
          "resource" : {
            "resourceType" : "Observation",
            "id" : "Inline-Instance-for-oncology-diagnostic-6",
            "meta" : {
              "profile" : [
                🔗 "http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/diagnostic-implication"
              ]
            },
            "text" : {
              "status" : "extensions",
              "div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"Observation_Inline-Instance-for-oncology-diagnostic-6\"> </a><p class=\"res-header-id\"><b>Generated Narrative: Observation Inline-Instance-for-oncology-diagnostic-6</b></p><a name=\"Inline-Instance-for-oncology-diagnostic-6\"> </a><a name=\"hcInline-Instance-for-oncology-diagnostic-6\"> </a><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\"/><p style=\"margin-bottom: 0px\">Profile: <a href=\"StructureDefinition-diagnostic-implication.html\">Diagnostic Implication</a></p></div><p><b>Related artifact</b>: No display for RelatedArtifact  (type: justification; display: https://pmkb.weill.cornell.edu/therapies/103)</p><p><b>status</b>: Final</p><p><b>category</b>: <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/observation-category laboratory}\">Laboratory</span>, <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/v2-0074 GE}\">Genetics</span></p><p><b>code</b>: <span title=\"Codes:{http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs diagnostic-implication}\">Diagnostic Implication</span></p><p><b>subject</b>: <a href=\"Bundle-bundle-oncology-diagnostic.html#urn-uuid-d0b4affa-91d6-46d1-af01-b30d9f16ef6d\">Carrot John Mr  Male, DoB: 1962-12-31 ( 1007)</a></p><p><b>effective</b>: 2019-03-05</p><p><b>performer</b>: <a href=\"Bundle-bundle-oncology-diagnostic.html#urn-uuid-a48256f8-db37-44e0-a0f6-d7af16c7c9ef\">Practitioner Akerman Philip Prof </a></p><p><b>method</b>: <span title=\"Codes:{http://loinc.org LA26811-2}\">Computational analysis</span></p><p><b>specimen</b>: <a href=\"Bundle-bundle-oncology-diagnostic.html#urn-uuid-a5d6a6a9-4859-480e-85b2-56974fef3b9d\">Specimen: identifier = 076e1948-2217-11e9-94d8-12e241dc1f66; status = available</a></p><p><b>derivedFrom</b>: <a href=\"Bundle-bundle-complexVariant-nonHGVS.html#urn-uuid-16fdd5fc-e665-48af-99e4-48d603f3e12d\">Observation Genetic variant assessment</a></p><blockquote><p><b>component</b></p><p><b>code</b>: <span title=\"Codes:{http://loinc.org 53037-8}\">Genetic variation clinical significance [Imp]</span></p><p><b>value</b>: <span title=\"Codes:{http://loinc.org LA6668-3}\">Pathogenic</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: <span title=\"Codes:{http://loinc.org 93044-6}\">Level of Evidence</span></p><p><b>value</b>: <span title=\"Codes:{http://loinc.org LA30200-2}\">Very strong evidence pathogenic</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: <span title=\"Codes:{http://loinc.org 81259-4}\">Associated phenotype</span></p><p><b>value</b>: <span title=\"Codes:\">melanoma</span></p></blockquote></div>"
            },
            "extension" : [
              {
                "url" : "http://hl7.org/fhir/StructureDefinition/workflow-relatedArtifact",
                "valueRelatedArtifact" : {
                  "type" : "justification",
                  "display" : "https://pmkb.weill.cornell.edu/therapies/103"
                }
              }
            ],
            "status" : "final",
            "category" : [
              {
                "coding" : [
                  {
                    "system" : "http://terminology.hl7.org/CodeSystem/observation-category",
                    "code" : "laboratory"
                  }
                ]
              },
              {
                "coding" : [
                  {
                    "system" : "http://terminology.hl7.org/CodeSystem/v2-0074",
                    "code" : "GE"
                  }
                ]
              }
            ],
            "code" : {
              "coding" : [
                {
                  "system" : "http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs",
                  "code" : "diagnostic-implication",
                  "display" : "Diagnostic Implication"
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              ]
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            "subject" : {
              "reference" : "urn:uuid:d0b4affa-91d6-46d1-af01-b30d9f16ef6d"
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            "effectiveDateTime" : "2019-03-05",
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              {
                "reference" : "urn:uuid:a48256f8-db37-44e0-a0f6-d7af16c7c9ef"
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            "method" : {
              "coding" : [
                {
                  "system" : "http://loinc.org",
                  "code" : "LA26811-2",
                  "display" : "Computational analysis"
                }
              ]
            },
            "specimen" : {
              "reference" : "urn:uuid:a5d6a6a9-4859-480e-85b2-56974fef3b9d"
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            "derivedFrom" : [
              {
                "reference" : "urn:uuid:16fdd5fc-e665-48af-99e4-48d603f3e12d"
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            ],
            "component" : [
              {
                "code" : {
                  "coding" : [
                    {
                      "system" : "http://loinc.org",
                      "code" : "53037-8",
                      "display" : "Genetic variation clinical significance [Imp]"
                    }
                  ]
                },
                "valueCodeableConcept" : {
                  "coding" : [
                    {
                      "system" : "http://loinc.org",
                      "code" : "LA6668-3",
                      "display" : "Pathogenic"
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                  ]
                }
              },
              {
                "code" : {
                  "coding" : [
                    {
                      "system" : "http://loinc.org",
                      "code" : "93044-6",
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                "valueCodeableConcept" : {
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                      "system" : "http://loinc.org",
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              {
                "code" : {
                  "coding" : [
                    {
                      "system" : "http://loinc.org",
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                  ]
                },
                "valueCodeableConcept" : {
                  "text" : "melanoma"
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          "request" : {
            "method" : "POST",
            "url" : "Observation"
          }
        },
        {
          "fullUrl" : "urn:uuid:ad7a499b-a43b-4cc8-bf46-cac62d9ecae5",
          "resource" : {
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            "id" : "Inline-Instance-for-oncology-diagnostic-7",
            "meta" : {
              "profile" : [
                🔗 "http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/genomic-report"
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            },
            "text" : {
              "status" : "generated",
              "div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"DiagnosticReport_Inline-Instance-for-oncology-diagnostic-7\"> </a><p class=\"res-header-id\"><b>Generated Narrative: DiagnosticReport Inline-Instance-for-oncology-diagnostic-7</b></p><a name=\"Inline-Instance-for-oncology-diagnostic-7\"> </a><a name=\"hcInline-Instance-for-oncology-diagnostic-7\"> </a><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\"/><p style=\"margin-bottom: 0px\">Profile: <a href=\"StructureDefinition-genomic-report.html\">Genomic Report</a></p></div><h2><span title=\"Codes:{http://loinc.org 51969-4}\">Genetic analysis report</span> (<span title=\"Codes:{http://terminology.hl7.org/CodeSystem/v2-0074 GE}\">Genetics</span>) </h2><table class=\"grid\"><tr><td>Subject</td><td>Carrot John Mr  Male, DoB: 1962-12-31 ( 1007)</td></tr><tr><td>When For</td><td>2019-03-05</td></tr><tr><td>Performer</td><td> <a href=\"Bundle-bundle-oncology-diagnostic.html#urn-uuid-a48256f8-db37-44e0-a0f6-d7af16c7c9ef\">Practitioner Akerman Philip Prof </a></td></tr></table><p><b>Report Details</b></p><table class=\"grid\"><tr><td><b>Code</b></td><td><b>Value</b></td><td><b>Flags</b></td><td><b>Reported</b></td></tr><tr><td><a href=\"Bundle-bundle-complexVariant-nonHGVS.html#urn-uuid-16fdd5fc-e665-48af-99e4-48d603f3e12d\"><span title=\"Codes:{http://loinc.org 69548-6}\">Genetic variant assessment</span></a></td><td><span title=\"Codes:{http://loinc.org LA9633-4}\">Present</span></td><td>Final</td><td>2019-03-05 16:04:44+0000</td></tr><tr><td><a href=\"Bundle-bundle-oncology-diagnostic.html#urn-uuid-1bf9642d-fd1c-4819-8c5d-44fae4bad524\"><span title=\"Codes:{http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs diagnostic-implication}\">Diagnostic Implication</span></a></td><td/><td>Final</td><td/></tr></table></div>"
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            "code" : {
              "coding" : [
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                  "system" : "http://loinc.org",
                  "code" : "51969-4"
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              "text" : "Genetic analysis report"
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              "reference" : "urn:uuid:d0b4affa-91d6-46d1-af01-b30d9f16ef6d"
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                "reference" : "urn:uuid:a5d6a6a9-4859-480e-85b2-56974fef3b9d"
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            "result" : [
              {
                "reference" : "urn:uuid:16fdd5fc-e665-48af-99e4-48d603f3e12d",
                "display" : "BRAF V600E mutation observed"
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              {
                "reference" : "urn:uuid:1bf9642d-fd1c-4819-8c5d-44fae4bad524",
                "display" : "melanoma implicated"
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            "method" : "POST",
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