Genomics Reporting Implementation Guide
4.0.0-cibuild - CI Build

Genomics Reporting Implementation Guide, published by HL7 International / Clinical Genomics. This guide is not an authorized publication; it is the continuous build for version 4.0.0-cibuild built by the FHIR (HL7® FHIR® Standard) CI Build. This version is based on the current content of https://github.com/HL7/genomics-reporting/ and changes regularly. See the Directory of published versions

## : Genetic Therapeutic Implications - XML Representation

Page standards status: Trial-use | Maturity Level: 2

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    <ValueSet xmlns="http://hl7.org/fhir">
      <id value="genetic-therapeutic-implications-vs"/>
      <text>
        <status value="generated"/>
        <div xmlns="http://www.w3.org/1999/xhtml"><p class="res-header-id"><b>Generated Narrative: ValueSet genetic-therapeutic-implications-vs</b></p><a name="genetic-therapeutic-implications-vs"> </a><a name="hcgenetic-therapeutic-implications-vs"> </a><p>This value set includes codes based on the following rules:</p><ul><li>Include these codes as defined in <a href="http://loinc.org"><code>http://loinc.org</code></a><span title="Version is not explicity stated. No matching Code System found"> version Not Stated (use latest from terminology server)</span><table class="none"><tr><td style="white-space:nowrap"><b>Code</b></td><td><b>Display</b></td></tr><tr><td><a href="https://loinc.org/LA10315-2/">LA10315-2</a></td><td>Ultrarapid metabolizer</td></tr><tr><td><a href="https://loinc.org/LA25391-6/">LA25391-6</a></td><td>Normal metabolizer</td></tr><tr><td><a href="https://loinc.org/LA25390-8/">LA25390-8</a></td><td>Rapid metabolizer</td></tr><tr><td><a href="https://loinc.org/LA10317-8/">LA10317-8</a></td><td>Intermediate metabolizer</td></tr><tr><td><a href="https://loinc.org/LA9657-3/">LA9657-3</a></td><td>Poor metabolizer</td></tr><tr><td><a href="https://loinc.org/LA19542-2/">LA19542-2</a></td><td>Low Risk</td></tr><tr><td><a href="https://loinc.org/LA19541-4/">LA19541-4</a></td><td>High Risk</td></tr><tr><td><a href="https://loinc.org/LA6676-6/">LA6676-6</a></td><td>Resistant</td></tr><tr><td><a href="https://loinc.org/LA6677-4/">LA6677-4</a></td><td>Responsive</td></tr><tr><td><a href="https://loinc.org/LA9660-7/">LA9660-7</a></td><td>Presumed resistant</td></tr><tr><td><a href="https://loinc.org/LA9661-5/">LA9661-5</a></td><td>Presumed responsive</td></tr><tr><td><a href="https://loinc.org/LA6682-4/">LA6682-4</a></td><td>Unknown Significance</td></tr><tr><td><a href="https://loinc.org/LA6675-8/">LA6675-8</a></td><td>Benign</td></tr><tr><td><a href="https://loinc.org/LA6674-1/">LA6674-1</a></td><td>Presumed Benign</td></tr><tr><td><a href="https://loinc.org/LA9662-3/">LA9662-3</a></td><td>Presumed non-responsive</td></tr><tr><td><a href="https://loinc.org/LA25392-4/">LA25392-4</a></td><td>Increased function</td></tr><tr><td><a href="https://loinc.org/LA25393-2/">LA25393-2</a></td><td>Normal function</td></tr><tr><td><a href="https://loinc.org/LA25395-7/">LA25395-7</a></td><td>Decreased function</td></tr><tr><td><a href="https://loinc.org/LA25394-0/">LA25394-0</a></td><td>Poor function</td></tr></table></li><li>Include these codes as defined in <a href="http://www.snomed.org/"><code>http://snomed.info/sct</code></a><span title="Version is not explicity stated. No matching Code System found"> version Not Stated (use latest from terminology server)</span><table class="none"><tr><td style="white-space:nowrap"><b>Code</b></td><td><b>Display</b></td></tr><tr><td><a href="http://snomed.info/id/444734003">444734003</a></td><td>Does not meet eligibility criteria for clinical trial (finding)</td></tr><tr><td><a href="http://snomed.info/id/399223003">399223003</a></td><td>Patient eligible for clinical trial (finding)</td></tr></table></li></ul></div>
      </text>
      <extension
                 url="http://hl7.org/fhir/StructureDefinition/structuredefinition-wg">
        <valueCode value="cg"/>
      </extension>
      <extension
                 url="http://hl7.org/fhir/StructureDefinition/structuredefinition-fmm">
        <valueInteger value="2">
          <extension
                     url="http://hl7.org/fhir/StructureDefinition/structuredefinition-conformance-derivedFrom">
            <valueCanonical
                            value="http://hl7.org/fhir/uv/genomics-reporting/ImplementationGuide/genomics-reporting"/>
          </extension>
        </valueInteger>
      </extension>
      <extension
                 url="http://hl7.org/fhir/StructureDefinition/structuredefinition-standards-status">
        <valueCode value="trial-use">
          <extension
                     url="http://hl7.org/fhir/StructureDefinition/structuredefinition-conformance-derivedFrom">
            <valueCanonical
                            value="http://hl7.org/fhir/uv/genomics-reporting/ImplementationGuide/genomics-reporting"/>
          </extension>
        </valueCode>
      </extension>
      <url
           value="http://hl7.org/fhir/uv/genomics-reporting/ValueSet/genetic-therapeutic-implications-vs"/>
      <version value="4.0.0-cibuild"/>
      <name value="GeneticTherapeuticImplicationsVS"/>
      <title value="Genetic Therapeutic Implications"/>
      <status value="active"/>
      <experimental value="false"/>
      <date value="2025-11-08T00:09:50+00:00"/>
      <publisher value="HL7 International / Clinical Genomics"/>
      <contact>
        <name value="HL7 International / Clinical Genomics"/>
        <telecom>
          <system value="url"/>
          <value value="http://www.hl7.org/Special/committees/clingenomics"/>
        </telecom>
        <telecom>
          <system value="email"/>
          <value value="cg@lists.HL7.org"/>
        </telecom>
      </contact>
      <description
                   value="Value Set for terms that describe a predicted ramification based on the presence of associated molecular finding(s)."/>
      <jurisdiction>
        <coding>
          <system value="http://unstats.un.org/unsd/methods/m49/m49.htm"/>
          <code value="001"/>
          <display value="World"/>
        </coding>
      </jurisdiction>
      <copyright
                 value="This material contains content from LOINC (http://loinc.org). LOINC is copyright © 1995-2020, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee and is available at no cost under the license at http://loinc.org/license. LOINC® is a registered United States trademark of Regenstrief Institute, Inc.
    This value set includes content from SNOMED CT, which is copyright © 2002+ International Health Terminology Standards Development Organisation (IHTSDO), and distributed by agreement between IHTSDO and HL7. Implementer use of SNOMED CT is not covered by this agreement."/>
      <compose>
        <include>
          <system value="http://loinc.org"/>
          <concept>
            <code value="LA10315-2"/>
            <display value="Ultrarapid metabolizer"/>
          </concept>
          <concept>
            <code value="LA25391-6"/>
            <display value="Normal metabolizer"/>
          </concept>
          <concept>
            <code value="LA25390-8"/>
            <display value="Rapid metabolizer"/>
          </concept>
          <concept>
            <code value="LA10317-8"/>
            <display value="Intermediate metabolizer"/>
          </concept>
          <concept>
            <code value="LA9657-3"/>
            <display value="Poor metabolizer"/>
          </concept>
          <concept>
            <code value="LA19542-2"/>
            <display value="Low Risk"/>
          </concept>
          <concept>
            <code value="LA19541-4"/>
            <display value="High Risk"/>
          </concept>
          <concept>
            <code value="LA6676-6"/>
            <display value="Resistant"/>
          </concept>
          <concept>
            <code value="LA6677-4"/>
            <display value="Responsive"/>
          </concept>
          <concept>
            <code value="LA9660-7"/>
            <display value="Presumed resistant"/>
          </concept>
          <concept>
            <code value="LA9661-5"/>
            <display value="Presumed responsive"/>
          </concept>
          <concept>
            <code value="LA6682-4"/>
            <display value="Unknown Significance"/>
          </concept>
          <concept>
            <code value="LA6675-8"/>
            <display value="Benign"/>
          </concept>
          <concept>
            <code value="LA6674-1"/>
            <display value="Presumed Benign"/>
          </concept>
          <concept>
            <code value="LA9662-3"/>
            <display value="Presumed non-responsive"/>
          </concept>
          <concept>
            <code value="LA25392-4"/>
            <display value="Increased function"/>
          </concept>
          <concept>
            <code value="LA25393-2"/>
            <display value="Normal function"/>
          </concept>
          <concept>
            <code value="LA25395-7"/>
            <display value="Decreased function"/>
          </concept>
          <concept>
            <code value="LA25394-0"/>
            <display value="Poor function"/>
          </concept>
        </include>
        <include>
          <system value="http://snomed.info/sct"/>
          <concept>
            <code value="444734003"/>
            <display
                     value="Does not meet eligibility criteria for clinical trial (finding)"/>
          </concept>
          <concept>
            <code value="399223003"/>
            <display value="Patient eligible for clinical trial (finding)"/>
          </concept>
        </include>
      </compose>
    </ValueSet>