# PharmGKB Evidence Level Example Codes - Genomics Reporting Implementation Guide v4.0.0-cibuild

* [**Table of Contents**](toc.md)
* [**Artifact List**](artifacts.md)
* **PharmGKB Evidence Level Example Codes**

## CodeSystem: PharmGKB Evidence Level Example Codes (Experimental) 

| | |
| :--- | :--- |
| *Official URL*:http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/pharmgkb-evidence-level-custom-cs | *Version*:4.0.0-cibuild |
| *Standards status:*[Informative](http://hl7.org/fhir/R4/versions.html#std-process) | *Computable Name*:PharmGKBEvidenceLevelCustomCS |

 
PharmGKB contains examples of evidence level concepts that are not conflated with clinical significance. These can be found on PharmGKB https://www.pharmgkb.org/page/clinAnnLevels. These examples are informational only, for copyright information contact the relevant source. 

 This Code system is referenced in the content logical definition of the following value sets: 

* [EvidenceLevelExampleVS](ValueSet-evidence-level-example-vs.md)



## Resource Content

```json
{
  "resourceType" : "CodeSystem",
  "id" : "pharmgkb-evidence-level-custom-cs",
  "extension" : [
    {
      "url" : "http://hl7.org/fhir/StructureDefinition/structuredefinition-wg",
      "valueCode" : "cg"
    },
    {
      "url" : "http://hl7.org/fhir/StructureDefinition/structuredefinition-standards-status",
      "valueCode" : "informative",
      "_valueCode" : {
        "extension" : [
          {
            "url" : "http://hl7.org/fhir/StructureDefinition/structuredefinition-conformance-derivedFrom",
            "valueCanonical" : "http://hl7.org/fhir/uv/genomics-reporting/ImplementationGuide/genomics-reporting"
          }
        ]
      }
    }
  ],
  "url" : "http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/pharmgkb-evidence-level-custom-cs",
  "version" : "4.0.0-cibuild",
  "name" : "PharmGKBEvidenceLevelCustomCS",
  "title" : "PharmGKB Evidence Level Example Codes",
  "status" : "active",
  "experimental" : true,
  "date" : "2025-11-08T00:09:50+00:00",
  "publisher" : "HL7 International / Clinical Genomics",
  "contact" : [
    {
      "name" : "HL7 International / Clinical Genomics",
      "telecom" : [
        {
          "system" : "url",
          "value" : "http://www.hl7.org/Special/committees/clingenomics"
        },
        {
          "system" : "email",
          "value" : "cg@lists.HL7.org"
        }
      ]
    }
  ],
  "description" : "PharmGKB contains examples of evidence level concepts that are not conflated with clinical significance. These can be found on PharmGKB https://www.pharmgkb.org/page/clinAnnLevels. These examples are informational only, for copyright information contact the relevant source.",
  "jurisdiction" : [
    {
      "coding" : [
        {
          "system" : "http://unstats.un.org/unsd/methods/m49/m49.htm",
          "code" : "001",
          "display" : "World"
        }
      ]
    }
  ],
  "caseSensitive" : true,
  "content" : "complete",
  "count" : 6,
  "concept" : [
    {
      "code" : "1A",
      "display" : "PGKB 1A",
      "definition" : "High level of evidence. Supported by a guideline or FDA label with variant specific prescribing guidance. Additionally, supported by at least one publication."
    },
    {
      "code" : "1B",
      "display" : "PGKB 1B",
      "definition" : "High level of evidence. But, NOT supported by a guideline or FDA label with variant specific prescribing guidance. Additionally, supported by at least one publication."
    },
    {
      "code" : "2A",
      "display" : "PGKB 2A",
      "definition" : "Moderate level of evidence. Supported by being a KNOWN pharmacogene on https://www.pharmgkb.org/vips. Also, found in multiple studies but may have a minority of studies that did not support the majority opinion. Supported by at least two indpendent publications."
    },
    {
      "code" : "2B",
      "display" : "PGKB 2B",
      "definition" : "Moderate level of evidence. NOT in the list of very important, KNOWN pharmacogenes. Found in multiple studies but may have a minority of studies that did not support the majority opinion. Supported by at least two indpendent publications."
    },
    {
      "code" : "3",
      "display" : "PGKB 3",
      "definition" : "Low-level of evidence. Where either the assocation is based on a single study, failed to be reproduced, or preliminary evidence."
    },
    {
      "code" : "4",
      "display" : "PGKB 4",
      "definition" : "The evidence does not support an association between the variant and the drug phenotype. (negative)"
    }
  ]
}

```
