Genomics Reporting Implementation Guide
4.0.0-cibuild - CI Build

Genomics Reporting Implementation Guide, published by HL7 International / Clinical Genomics. This guide is not an authorized publication; it is the continuous build for version 4.0.0-cibuild built by the FHIR (HL7® FHIR® Standard) CI Build. This version is based on the current content of https://github.com/HL7/genomics-reporting/ and changes regularly. See the Directory of published versions

## Example Observation: EGFR-L858R-therapuDrug2

Page standards status: Informative

Profile: Therapeutic Implication

status: Final

category: Laboratory, Genetics

code: Therapeutic Implication

subject: Substance Junior Hamsburg (official) Male, DoB: 1987-09-01 ( Medical record number: 1234567 (use: temp, period: 2021-01-01 --> (ongoing)))

effective: 2023-02-01

performer: Practitioner Test Dolin

derivedFrom: Observation Genetic variant assessment

> component

> code: Therapeutic Implication

> value: Responsive

> component

> Related artifact: No display for RelatedArtifact (type: citation; url: https://www.jmdjournal.org/cms/attachment/ee43a71b-81de-4cb3-ac5e-2fb9a7d41491/gr2.jpg)

> code: Level of evidence

> value: Tier I - Level A

> component

> code: Associated phenotype

> value: Non-small cell lung cancer

> component

> Related artifact: No display for RelatedArtifact (type: citation; url: https://www.cancer.net/cancer-types/lung-cancer-non-small-cell/types-treatment)

> code: Medication assessed

> value: Erlotinib

> component

> Related artifact: No display for RelatedArtifact (type: citation; url: https://civicdb.org/evidence/2994/summary)

> code: Conclusion Text

> value: Non-small cell lung cancer with EGFR L858R mutation is sensitive to erlotinib