## ValueSet Comparison between http://hl7.org/fhir/uv/genomics-reporting/ValueSet/molecular-biomarker-code-vs vs http://hl7.org/fhir/uv/genomics-reporting/ValueSet/molecular-biomarker-code-vs

### Messages

Error | ValueSet.version | Values for version differ: '3.0.0' vs '4.0.0-cibuild'
Information | ValueSet.date | Values for date differ: '2024-12-12T20:43:36+00:00' vs '2025-11-08T00:09:50+00:00'
Warning | ValueSet.compose.include[0].concept[0] | Code 85337-4 display changed from 'Estrogen receptor Ag Immune stain Ql (Breast cancer specimen)' to 'Estrogen receptor Ag [Presence] in Breast cancer specimen by Immune stain'
Warning | ValueSet.compose.include[0].concept[1] | Code 72382-5 display changed from 'HER2 IA Qn (Tiss)' to 'HER2 [Units/volume] in Tissue by Immunoassay'
Warning | ValueSet.compose.include[0].concept[2] | Code 77637-7 display changed from 'HLA-A and B and C (class I) IgG panel IA [Identifier]' to 'HLA-A and B and C (class I) IgG panel [Identifier] - Serum or Plasma by Immunoassay'
Warning | ValueSet.compose.include[0].concept[3] | Code 40557-1 display changed from 'Progesterone receptor Ag Immune stain Ql (Tiss)' to 'Progesterone receptor Ag [Presence] in Tissue by Immune stain'
Warning | ValueSet.compose.include[0].concept[4] | Code 85147-7 display changed from 'PD-L1 by clone 22C3 Immune stain Doc (Tiss)' to 'PD-L1 by clone 22C3 in Tissue by Immune stain Report'
Warning | ValueSet.compose.include[0].concept[5] | Code 59025-7 display changed from 'Neutrophil Ab FC Qn (S)' to 'Neutrophil Ab [Units/volume] in Serum by Flow cytometry (FC)'
Warning | ValueSet.compose.include[0].concept[6] | Code 59003-4 display changed from 'Lactoferrin Ab IA Qn (S)' to 'Lactoferrin Ab [Units/volume] in Serum by Immunoassay'
Warning | ValueSet.compose.include[0].concept[7] | Code 10495-0 display changed from 'Insulin Ag Immune stain Ql (Tiss)' to 'Insulin Ag [Presence] in Tissue by Immune stain'
Warning | ValueSet.compose.include[0].concept[8] | Code 16550-6 display changed from 'Carbohydrates Nom (U)' to 'Carbohydrates [Identifier] in Urine'
Warning | ValueSet.compose.include[0].concept[9] | Code 2569-2 display changed from 'Lipids (S) [Mass/Vol]' to 'Lipids [Mass/volume] in Serum'
Warning | ValueSet.compose.include[0].concept[10] | Code 4551-8 display changed from 'Hemoglobin A2 (Bld) [Mass fraction]' to 'Hemoglobin A2/Hemoglobin.total in Blood'
Warning | ValueSet.compose.include[0].concept[11] | Code 19195-7 display changed from 'Prostate specific Ag Qn' to 'Prostate specific Ag [Units/volume] in Serum or Plasma'
Warning | ValueSet.compose.include[0].concept[12] | Code 64083-9 display changed from 'MGMT gene methylation score Molgen (Tiss) [Ratio]' to 'MGMT gene methylation score in Tissue by Molecular genetics method'
Warning | ValueSet.compose.include[0].concept[13] | Code 62862-8 display changed from 'Microsatellite instability Immune stain Ql (Tiss)' to 'Microsatellite instability [Presence] in Tissue by Immune stain'
Warning | ValueSet.compose.include[0].concept[14] | Code 81704-9 display changed from 'Microsatellite instability marker D17S250 Ql (Cancer specimen)' to 'Microsatellite instability marker D17S250 in Cancer specimen Qualitative'
Warning | ValueSet.compose.include[0].concept[15] | Code 94077-5 display changed from 'Tumor mutation burden Ql (Tumor) [Interp]' to 'Tumor mutation burden [Interpretation]'

### Metadata

Name | Value | Comments
--- | --- | ---
compose.inactive |  |
compose.lockedDate |  |
copyright | This material contains content from LOINC (http://loinc.org). LOINC is copyright © 1995-2020, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee and is available at no cost under the license at http://loinc.org/license. LOINC® is a registered United States trademark of Regenstrief Institute, Inc. This value set includes content from SNOMED CT, which is copyright © 2002+ International Health Terminology Standards Development Organisation (IHTSDO), and distributed by agreement between IHTSDO and HL7. Implementer use of SNOMED CT is not covered by this agreement. |
date | 2024-12-12T20:43:36+00:00 | 2025-11-08T00:09:50+00:00 | Values Differ
description | Value Set for terms that can be used as Biomarkers. |
experimental | false |
immutable |  |
jurisdiction |  |
jurisdiction[0] | http://unstats.un.org/unsd/methods/m49/m49.htm#001 |
name | MolecularBiomarkerCodeVS |
publisher | HL7 International / Clinical Genomics |
purpose |  |
status | active |
title | Molecular Biomarker Codes |
url | http://hl7.org/fhir/uv/genomics-reporting/ValueSet/molecular-biomarker-code-vs |
version | 3.0.0 | 4.0.0-cibuild | Values Differ

### Definition

Item | Property | Value | Comments
--- | --- | --- | ---
include | http://loinc.org |  |
Concept | 85337-4 | Estrogen receptor Ag Immune stain Ql (Breast cancer specimen) | Estrogen receptor Ag [Presence] in Breast cancer specimen by Immune stain |
Concept | 72382-5 | HER2 IA Qn (Tiss) | HER2 [Units/volume] in Tissue by Immunoassay |
Concept | 77637-7 | HLA-A and B and C (class I) IgG panel IA [Identifier] | HLA-A and B and C (class I) IgG panel [Identifier] - Serum or Plasma by Immunoassay |
Concept | 40557-1 | Progesterone receptor Ag Immune stain Ql (Tiss) | Progesterone receptor Ag [Presence] in Tissue by Immune stain |
Concept | 85147-7 | PD-L1 by clone 22C3 Immune stain Doc (Tiss) | PD-L1 by clone 22C3 in Tissue by Immune stain Report |
Concept | 59025-7 | Neutrophil Ab FC Qn (S) | Neutrophil Ab [Units/volume] in Serum by Flow cytometry (FC) |
Concept | 59003-4 | Lactoferrin Ab IA Qn (S) | Lactoferrin Ab [Units/volume] in Serum by Immunoassay |
Concept | 10495-0 | Insulin Ag Immune stain Ql (Tiss) | Insulin Ag [Presence] in Tissue by Immune stain |
Concept | 16550-6 | Carbohydrates Nom (U) | Carbohydrates [Identifier] in Urine |
Concept | 2569-2 | Lipids (S) [Mass/Vol] | Lipids [Mass/volume] in Serum |
Concept | 4551-8 | Hemoglobin A2 (Bld) [Mass fraction] | Hemoglobin A2/Hemoglobin.total in Blood |
Concept | 19195-7 | Prostate specific Ag Qn | Prostate specific Ag [Units/volume] in Serum or Plasma |
Concept | 64083-9 | MGMT gene methylation score Molgen (Tiss) [Ratio] | MGMT gene methylation score in Tissue by Molecular genetics method |
Concept | 62862-8 | Microsatellite instability Immune stain Ql (Tiss) | Microsatellite instability [Presence] in Tissue by Immune stain |
Concept | 81704-9 | Microsatellite instability marker D17S250 Ql (Cancer specimen) | Microsatellite instability marker D17S250 in Cancer specimen Qualitative |
Concept | 94077-5 | Tumor mutation burden Ql (Tumor) [Interp] | Tumor mutation burden [Interpretation] |
include | http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl |  |
Concept | C120465 | Homologous Recombination Repair Deficiency |

### Expansion

Unable to generate expansion - see errors