Genomics Reporting Implementation Guide
4.0.0-cibuild - CI Build

Genomics Reporting Implementation Guide, published by HL7 International / Clinical Genomics. This guide is not an authorized publication; it is the continuous build for version 4.0.0-cibuild built by the FHIR (HL7® FHIR® Standard) CI Build. This version is based on the current content of https://github.com/HL7/genomics-reporting/ and changes regularly. See the Directory of published versions

## : Find Population Treatment Implications - XML Representation

Page standards status: Trial-use | Maturity Level: 2

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    <OperationDefinition xmlns="http://hl7.org/fhir">
      <id value="find-population-tx-implications"/>
      <text>
        <status value="generated"/>
        <div xmlns="http://www.w3.org/1999/xhtml"><p class="res-header-id"><b>Generated Narrative: OperationDefinition find-population-tx-implications</b></p><a name="find-population-tx-implications"> </a><a name="hcfind-population-tx-implications"> </a><h3>Parameters</h3><table class="grid"><tr><td><b>Use</b></td><td><b>Name</b></td><td><b>Scope</b></td><td><b>Cardinality</b></td><td><b>Type</b></td><td><b>Binding</b></td><td><b>Documentation</b></td></tr><tr><td>IN</td><td>variants</td><td/><td>0..*</td><td><a href="http://hl7.org/fhir/R4/datatypes.html#string">string</a><br/>(<a href="https://hl7.org/fhir/R4/search.html#string">string</a>)</td><td/><td><div><p>List of variants from which implications are derived. Must be in HGVS or SPDI format.</p>
    </div></td></tr><tr><td>IN</td><td>haplotypes</td><td/><td>0..*</td><td><a href="http://hl7.org/fhir/R4/datatypes.html#string">string</a><br/>(<a href="https://hl7.org/fhir/R4/search.html#token">token</a>)</td><td/><td><div><p>List of haplotypes from which implications are derived. Must be in token or codesystem|code format.</p>
    </div></td></tr><tr><td>IN</td><td>treatments</td><td/><td>0..*</td><td><a href="http://hl7.org/fhir/R4/datatypes.html#string">string</a><br/>(<a href="https://hl7.org/fhir/R4/search.html#token">token</a>)</td><td/><td><div><p>List of medications and/or other therapeutic interventions for which implications are sought. Must be in token or codesystem|code format.</p>
    </div></td></tr><tr><td>IN</td><td>conditions</td><td/><td>0..*</td><td><a href="http://hl7.org/fhir/R4/datatypes.html#string">string</a><br/>(<a href="https://hl7.org/fhir/R4/search.html#token">token</a>)</td><td/><td><div><p>List of conditions for which implications are sought. Must be in token or codesystem|code format.</p>
    </div></td></tr><tr><td>IN</td><td>genomicSourceClass</td><td/><td>0..1</td><td><a href="http://hl7.org/fhir/R4/datatypes.html#string">string</a><br/>(<a href="https://hl7.org/fhir/R4/search.html#token">token</a>)</td><td/><td><div><p>Enables an App to limit results to those that are 'germline' or 'somatic'. Default is to include variants irrespective of genomic source class.</p>
    </div></td></tr><tr><td>IN</td><td>includePatientList</td><td/><td>0..1</td><td><a href="http://hl7.org/fhir/R4/datatypes.html#boolean">boolean</a></td><td/><td><div><p>Include list of matching patients if set to true. Default=false.</p>
    </div></td></tr><tr><td>OUT</td><td>implications</td><td/><td>1..1</td><td/><td/><td/></tr><tr><td>OUT</td><td>implications.numerator</td><td/><td>1..1</td><td><a href="http://hl7.org/fhir/R4/datatypes.html#Quantity">Quantity</a></td><td/><td><div><p>Count of patients having this variant</p>
    </div></td></tr><tr><td>OUT</td><td>implications.denominator</td><td/><td>0..1</td><td><a href="http://hl7.org/fhir/R4/datatypes.html#Quantity">Quantity</a></td><td/><td><div><p>Count of patients in the cohort searched</p>
    </div></td></tr><tr><td>OUT</td><td>implications.subject</td><td/><td>0..*</td><td><a href="http://hl7.org/fhir/R4/datatypes.html#string">string</a></td><td/><td><div><p>Patient ID. Include if includePatientList=true</p>
    </div></td></tr></table></div>
      </text>
      <extension
                 url="http://hl7.org/fhir/StructureDefinition/structuredefinition-wg">
        <valueCode value="cg"/>
      </extension>
      <extension
                 url="http://hl7.org/fhir/StructureDefinition/structuredefinition-fmm">
        <valueInteger value="2">
          <extension
                     url="http://hl7.org/fhir/StructureDefinition/structuredefinition-conformance-derivedFrom">
            <valueCanonical
                            value="http://hl7.org/fhir/uv/genomics-reporting/ImplementationGuide/genomics-reporting"/>
          </extension>
        </valueInteger>
      </extension>
      <extension
                 url="http://hl7.org/fhir/StructureDefinition/structuredefinition-standards-status">
        <valueCode value="trial-use">
          <extension
                     url="http://hl7.org/fhir/StructureDefinition/structuredefinition-conformance-derivedFrom">
            <valueCanonical
                            value="http://hl7.org/fhir/uv/genomics-reporting/ImplementationGuide/genomics-reporting"/>
          </extension>
        </valueCode>
      </extension>
      <url
           value="http://hl7.org/fhir/uv/genomics-reporting/OperationDefinition/find-population-tx-implications"/>
      <version value="4.0.0-cibuild"/>
      <name value="FindPopulationTxImplications"/>
      <title value="Find Population Treatment Implications"/>
      <status value="active"/>
      <kind value="operation"/>
      <date value="2025-11-08T00:09:50+00:00"/>
      <publisher value="HL7 International / Clinical Genomics"/>
      <contact>
        <name value="HL7 International / Clinical Genomics"/>
        <telecom>
          <system value="url"/>
          <value value="http://www.hl7.org/Special/committees/clingenomics"/>
        </telecom>
        <telecom>
          <system value="email"/>
          <value value="cg@lists.HL7.org"/>
        </telecom>
      </contact>
      <description
                   value="Retrieve count or list of patients having therapeutic implications."/>
      <jurisdiction>
        <coding>
          <system value="http://unstats.un.org/unsd/methods/m49/m49.htm"/>
          <code value="001"/>
          <display value="World"/>
        </coding>
      </jurisdiction>
      <code value="match"/>
      <system value="false"/>
      <type value="true"/>
      <instance value="false"/>
      <parameter>
        <name value="variants"/>
        <use value="in"/>
        <min value="0"/>
        <max value="*"/>
        <documentation
                       value="List of variants from which implications are derived. Must be in HGVS or SPDI format."/>
        <type value="string"/>
        <searchType value="string"/>
      </parameter>
      <parameter>
        <name value="haplotypes"/>
        <use value="in"/>
        <min value="0"/>
        <max value="*"/>
        <documentation
                       value="List of haplotypes from which implications are derived. Must be in token or codesystem|code format."/>
        <type value="string"/>
        <searchType value="token"/>
      </parameter>
      <parameter>
        <name value="treatments"/>
        <use value="in"/>
        <min value="0"/>
        <max value="*"/>
        <documentation
                       value="List of medications and/or other therapeutic interventions for which implications are sought. Must be in token or codesystem|code format."/>
        <type value="string"/>
        <searchType value="token"/>
      </parameter>
      <parameter>
        <name value="conditions"/>
        <use value="in"/>
        <min value="0"/>
        <max value="*"/>
        <documentation
                       value="List of conditions for which implications are sought. Must be in token or codesystem|code format."/>
        <type value="string"/>
        <searchType value="token"/>
      </parameter>
      <parameter>
        <name value="genomicSourceClass"/>
        <use value="in"/>
        <min value="0"/>
        <max value="1"/>
        <documentation
                       value="Enables an App to limit results to those that are 'germline' or 'somatic'. Default is to include variants irrespective of genomic source class."/>
        <type value="string"/>
        <searchType value="token"/>
      </parameter>
      <parameter>
        <name value="includePatientList"/>
        <use value="in"/>
        <min value="0"/>
        <max value="1"/>
        <documentation
                       value="Include list of matching patients if set to true. Default=false."/>
        <type value="boolean"/>
      </parameter>
      <parameter>
        <name value="implications"/>
        <use value="out"/>
        <min value="1"/>
        <max value="1"/>
        <part>
          <name value="numerator"/>
          <use value="out"/>
          <min value="1"/>
          <max value="1"/>
          <documentation value="Count of patients having this variant"/>
          <type value="Quantity"/>
        </part>
        <part>
          <name value="denominator"/>
          <use value="out"/>
          <min value="0"/>
          <max value="1"/>
          <documentation value="Count of patients in the cohort searched"/>
          <type value="Quantity"/>
        </part>
        <part>
          <name value="subject"/>
          <use value="out"/>
          <min value="0"/>
          <max value="*"/>
          <documentation value="Patient ID. Include if includePatientList=true"/>
          <type value="string"/>
        </part>
      </parameter>
    </OperationDefinition>