Generated Narrative: Patient Inline-Instance-for-oncologyexamples-r4-1 Carrot John Mr Male, DoB: 1962-12-31 ( 1007) Links: General Practitioner: Practitioner Akerman Philip Prof
Generated Narrative: Practitioner Inline-Instance-for-oncologyexamples-r4-2 identifier: 4654765876 name: Akerman Philip Prof address: Castro Valley CA
Generated Narrative: Specimen Inline-Instance-for-oncologyexamples-r4-3 identifier: 076e1948-2217-11e9-94d8-12e241dc1f66 status: Available subject: Carrot John Mr Male, DoB: 1962-12-31 ( 1007) Collections - Collector * Practitioner Akerman Philip Prof
Generated Narrative: Observation Inline-Instance-for-oncologyexamples-r4-4 Profile: Molecular Biomarker status: Final category: Laboratory, Biomarker Category, Genetics code: Mutations/Megabase [# Ratio] in Tumor subject: Carrot John Mr Male, DoB: 1962-12-31 ( 1007) effective: 2023-04-05 performer: Practitioner Akerman Philip Prof value: 25 somatic variants per megabase of sequenced DNA (Details: UCUM code1/1000000 = '1/1000000') specimen: Specimen: identifier = 076e1948-2217-11e9-94d8-12e241dc1f66; status = available Components - Code Value[x] * Biomarker Category molecular sequence adjacent category
somatic variants per megabase of sequenced DNA
Generated Narrative: Observation Inline-Instance-for-oncologyexamples-r4-5 Profile: Molecular Biomarker status: Final category: Laboratory, Biomarker Category, Genetics code: Microsatellite instability [Interpretation] in Cancer specimen Qualitative subject: Carrot John Mr Male, DoB: 1962-12-31 ( 1007) effective: 2023-04-05 performer: Practitioner Akerman Philip Prof value: Stable specimen: Specimen: identifier = 076e1948-2217-11e9-94d8-12e241dc1f66; status = available Components - Code Value[x] * Biomarker Category molecular sequence adjacent category
Microsatellite instability [Interpretation] in Cancer specimen Qualitative
Generated Narrative: Observation Inline-Instance-for-oncologyexamples-r4-6 Profile: Variant status: Final category: Laboratory, Genetics code: Genetic variant assessment subject: Carrot John Mr Male, DoB: 1962-12-31 ( 1007) effective: 2023-04-05 performer: Practitioner Akerman Philip Prof value: Present method: Sequencing specimen: Specimen: identifier = 076e1948-2217-11e9-94d8-12e241dc1f66; status = available component code: Genomic DNA change (gHGVS) value: T}">NC_000009.12:g.5073770G>T component code: Amino acid change (pHGVS) value: NP_004963.1:p.Val617Phe component code: Genomic source class value: Germline component code: Gene studied ID value: JAK2
Generated Narrative: Observation Inline-Instance-for-oncologyexamples-r4-7 Profile: Variant status: Final category: Laboratory, Genetics code: Genetic variant assessment subject: Carrot John Mr Male, DoB: 1962-12-31 ( 1007) effective: 2023-04-05 performer: Practitioner Akerman Philip Prof value: Present method: Sequencing specimen: Specimen: identifier = 076e1948-2217-11e9-94d8-12e241dc1f66; status = available component code: Genomic DNA change (gHGVS) value: A}">NC_000004.11:g.55972974T>A component code: Amino acid change (pHGVS) value: NP_002244.1:p.Gln472His component code: Genomic source class value: Germline component code: Gene studied ID value: KDR
Generated Narrative: Observation Inline-Instance-for-oncologyexamples-r4-8 Profile: Variant status: Final category: Laboratory, Genetics code: Genetic variant assessment subject: Carrot John Mr Male, DoB: 1962-12-31 ( 1007) effective: 2023-04-05 performer: Practitioner Akerman Philip Prof value: Present method: Sequencing specimen: Specimen: identifier = 076e1948-2217-11e9-94d8-12e241dc1f66; status = available component code: Genomic DNA change (gHGVS) value: NC_000002.12:g.211713666_211713668del component code: Genomic source class value: Germline component code: Gene studied ID value: ERBB4
Generated Narrative: Observation Inline-Instance-for-oncologyexamples-r4-9 Profile: Therapeutic Implication status: Final category: Laboratory, Genetics code: Therapeutic Implication subject: Carrot John Mr Male, DoB: 1962-12-31 ( 1007) effective: 2023-04-05 performer: Practitioner Akerman Philip Prof method: Computational analysis specimen: Specimen: identifier = 076e1948-2217-11e9-94d8-12e241dc1f66; status = available derivedFrom: Observation Genetic variant assessment component code: Therapeutic Implication value: Responsive component code: Level of Evidence value: Very strong evidence pathogenic component code: Associated phenotype value: Polycythemia vera (PV) component code: Medication assessed value: Ruxolitinib
Generated Narrative: Observation Inline-Instance-for-oncologyexamples-r4-10 Profile: Therapeutic Implication status: Final category: Laboratory, Genetics code: Therapeutic Implication subject: Carrot John Mr Male, DoB: 1962-12-31 ( 1007) effective: 2023-04-05 performer: Practitioner Akerman Philip Prof method: Computational analysis specimen: Specimen: identifier = 076e1948-2217-11e9-94d8-12e241dc1f66; status = available derivedFrom: Observation Genetic variant assessment component code: Therapeutic Implication value: Responsive component code: Level of Evidence value: Very strong evidence pathogenic component code: Associated phenotype value: Polycythemia vera (PV) component code: Medication assessed value: AT9283
Generated Narrative: Observation Inline-Instance-for-oncologyexamples-r4-11 Profile: Therapeutic Implication status: Final category: Laboratory, Genetics code: Therapeutic Implication subject: Carrot John Mr Male, DoB: 1962-12-31 ( 1007) effective: 2023-04-05 performer: Practitioner Akerman Philip Prof method: Computational analysis specimen: Specimen: identifier = 076e1948-2217-11e9-94d8-12e241dc1f66; status = available derivedFrom: Observation Genetic variant assessment component code: Therapeutic Implication value: Responsive component code: Level of Evidence value: Very strong evidence pathogenic component code: Associated phenotype value: Polycythemia vera (PV) component code: Medication assessed value: SNX-5422
Generated Narrative: Observation Inline-Instance-for-oncologyexamples-r4-12 Profile: Therapeutic Implication status: Final category: Laboratory, Genetics code: Therapeutic Implication subject: Carrot John Mr Male, DoB: 1962-12-31 ( 1007) effective: 2023-04-05 performer: Practitioner Akerman Philip Prof method: Computational analysis specimen: Specimen: identifier = 076e1948-2217-11e9-94d8-12e241dc1f66; status = available derivedFrom: Observation Genetic variant assessment component code: Therapeutic Implication value: Responsive component code: Level of Evidence value: Very strong evidence pathogenic component code: Associated phenotype value: Polycythemia vera (PV) component code: Medication assessed value: TG02
Generated Narrative: Observation Inline-Instance-for-oncologyexamples-r4-14 Profile: Therapeutic Implication status: Final category: Laboratory, Genetics code: Therapeutic Implication subject: Carrot John Mr Male, DoB: 1962-12-31 ( 1007) effective: 2023-04-05 performer: Practitioner Akerman Philip Prof derivedFrom: Observation Genetic variant assessment Components - Extension Code Value[x] * Associated Therapy Ruxolitinib Exception generating Narrative: Error in template: Root element is not 'div'
This is not a fully defined resource, just here as a place holder to show how a PlanDefinition could be packaged.
Generated Narrative: DiagnosticReport Inline-Instance-for-oncologyexamples-r4-13 Profile: Genomic Report Genetic analysis report (Genetics) Subject Carrot John Mr Male, DoB: 1962-12-31 ( 1007) Performer Practitioner Akerman Philip Prof Report Details Code Value Flags When For Reported Genetic variant assessment Present Final 2019-03-05 2019-03-05 16:04:44+0000 Genetic variant assessment Present Final 2023-05-01 Genetic variant assessment Present Final 2023-05-01 Mutations/Megabase [# Ratio] in Tumor 25 Mutations/Megabase (Details: UCUM code1/1000000 = '1/1000000') Final 2019-03-05 Microsatellite instability [Interpretation] in Cancer specimen Qualitative Stable Final 2023-05-01 Diagnostic Implication Final 2019-03-05 Therapeutic Implication Final 2023-05-01 Therapeutic Implication Final 2023-05-01 Therapeutic Implication Final 2023-05-01