{
  "resourceType" : "Parameters",
  "id" : "FindSubjectDxImplicationsOutput",
  "parameter" : [{
    "name" : "implication",
    "resource" : {
      "resourceType" : "Observation",
      "id" : "DiagnosticImplicationExample",
      "meta" : {
        "profile" : ["http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/diagnostic-implication"]
      },
      "text" : {
        "status" : "generated",
        "div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\">Pathogenic - Malignant hyperthermia</div>"
      },
      "status" : "final",
      "category" : [{
        "coding" : [{
          "system" : "http://terminology.hl7.org/CodeSystem/observation-category",
          "code" : "laboratory"
        }]
      },
      {
        "coding" : [{
          "system" : "http://terminology.hl7.org/CodeSystem/v2-0074",
          "code" : "GE"
        }]
      }],
      "code" : {
        "coding" : [{
          "system" : "http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs",
          "code" : "diagnostic-implication"
        }]
      },
      "subject" : {
        "reference" : "Patient/HG00403"
      },
      "effectiveDateTime" : "2023-04-01",
      "performer" : [{
        "reference" : "Organization/ExampleOrg"
      }],
      "derivedFrom" : [{
        "reference" : "Observation/VariantExample2"
      }],
      "component" : [{
        "code" : {
          "coding" : [{
            "system" : "http://loinc.org",
            "code" : "53037-8"
          }],
          "text" : "Genetic variation clinical significance"
        },
        "valueCodeableConcept" : {
          "coding" : [{
            "system" : "http://loinc.org",
            "code" : "LA6668-3",
            "display" : "Pathogenic"
          }]
        }
      },
      {
        "code" : {
          "coding" : [{
            "system" : "http://loinc.org",
            "code" : "81259-4"
          }],
          "text" : "Predicted phenotype"
        },
        "valueCodeableConcept" : {
          "coding" : [{
            "system" : "http://snomed.info/sct",
            "code" : "405501007",
            "display" : "Malignant hyperthermia"
          }]
        }
      }]
    }
  },
  {
    "name" : "variant",
    "resource" : {
      "resourceType" : "Observation",
      "id" : "variantExample2",
      "meta" : {
        "profile" : ["http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/variant"]
      },
      "text" : {
        "status" : "generated",
        "div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\">NC_000019.10:g.38499669C&gt;T</div>"
      },
      "status" : "final",
      "category" : [{
        "coding" : [{
          "system" : "http://terminology.hl7.org/CodeSystem/observation-category",
          "code" : "laboratory"
        }]
      },
      {
        "coding" : [{
          "system" : "http://terminology.hl7.org/CodeSystem/v2-0074",
          "code" : "GE"
        }]
      }],
      "code" : {
        "coding" : [{
          "system" : "http://loinc.org",
          "code" : "69548-6",
          "display" : "Genetic variant assessment"
        }]
      },
      "subject" : {
        "reference" : "Patient/HG00403"
      },
      "effectiveDateTime" : "2023-04-01",
      "performer" : [{
        "reference" : "Organization/ExampleOrg"
      }],
      "valueCodeableConcept" : {
        "coding" : [{
          "system" : "http://loinc.org",
          "code" : "LA9633-4",
          "display" : "Present"
        }]
      },
      "component" : [{
        "code" : {
          "coding" : [{
            "system" : "http://loinc.org",
            "code" : "48002-0",
            "display" : "Genomic source class [Type]"
          }]
        },
        "valueCodeableConcept" : {
          "coding" : [{
            "system" : "http://loinc.org",
            "code" : "LA6683-2",
            "display" : "Germline"
          }]
        }
      },
      {
        "code" : {
          "coding" : [{
            "system" : "http://loinc.org",
            "code" : "48013-7",
            "display" : "Genomic reference sequence ID"
          }]
        },
        "valueCodeableConcept" : {
          "coding" : [{
            "system" : "http://www.ncbi.nlm.nih.gov/refseq",
            "code" : "NC_000019.10"
          }]
        }
      },
      {
        "code" : {
          "coding" : [{
            "system" : "http://loinc.org",
            "code" : "69547-8",
            "display" : "Genomic Ref allele [ID]"
          }]
        },
        "valueString" : "C"
      },
      {
        "code" : {
          "coding" : [{
            "system" : "http://loinc.org",
            "code" : "69551-0",
            "display" : "Genomic Alt allele [ID]"
          }]
        },
        "valueString" : "T"
      },
      {
        "code" : {
          "coding" : [{
            "system" : "http://loinc.org",
            "code" : "92822-6",
            "display" : "Genomic coord system"
          }]
        },
        "valueCodeableConcept" : {
          "coding" : [{
            "system" : "http://loinc.org",
            "code" : "LA30100-4",
            "display" : "0-based interval counting"
          }]
        }
      },
      {
        "code" : {
          "coding" : [{
            "system" : "http://loinc.org",
            "code" : "81254-5"
          }],
          "text" : "Genomic allele start-end"
        },
        "valueRange" : {
          "low" : {
            "value" : 38499669
          }
        }
      }]
    }
  }]
}