@prefix fhir: <http://hl7.org/fhir/> .
@prefix loinc: <https://loinc.org/rdf/> .
@prefix owl: <http://www.w3.org/2002/07/owl#> .
@prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix sct: <http://snomed.info/id/> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

# - resource -------------------------------------------------------------------

<http://hl7.org/fhir/uv/genomics-reporting/Observation/ROS1-Fusion-therapuTrial> a fhir:Observation ;
  fhir:nodeRole fhir:treeRoot ;
  fhir:id [ fhir:v "ROS1-Fusion-therapuTrial"] ; # 
  fhir:meta [
     fhir:profile ( [
       fhir:v "http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/therapeutic-implication"^^xsd:anyURI ;
       fhir:l <http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/therapeutic-implication>
     ] )
  ] ; # 
  fhir:text [
     fhir:status [ fhir:v "extensions" ] ;
     fhir:div [ fhir:v "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p class=\"res-header-id\"><b>Generated Narrative: Observation ROS1-Fusion-therapuTrial</b></p><a name=\"ROS1-Fusion-therapuTrial\"> </a><a name=\"hcROS1-Fusion-therapuTrial\"> </a><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\"/><p style=\"margin-bottom: 0px\">Profile: <a href=\"StructureDefinition-therapeutic-implication.html\">Therapeutic Implication</a></p></div><p><b>status</b>: Final</p><p><b>category</b>: <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/observation-category laboratory}\">Laboratory</span>, <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/v2-0074 GE}\">Genetics</span></p><p><b>code</b>: <span title=\"Codes:{http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs therapeutic-implication}\">Therapeutic Implication</span></p><p><b>subject</b>: <a href=\"Patient-somaticPatient.html\">Substance Junior Hamsburg (official) Male, DoB: 1987-09-01 ( Medical record number: 1234567 (use: temp, period: 2021-01-01 --&gt; (ongoing)))</a></p><p><b>effective</b>: 2023-02-01</p><p><b>performer</b>: <a href=\"Practitioner-pathologistPractitioner.html\">Practitioner Test Dolin </a></p><p><b>derivedFrom</b>: <a href=\"Observation-ROS1-Fusion-var.html\">Observation Genetic variant assessment</a></p><blockquote><p><b>component</b></p><p><b>code</b>: <span title=\"Codes:{http://loinc.org 81259-4}\">Associated phenotype</span></p><p><b>value</b>: <span title=\"Codes:{http://snomed.info/sct 254637007}\">Non-small cell lung cancer</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: <span title=\"Codes:{http://loinc.org 51963-7}\">Medication assessed</span></p><p><b>value</b>: <span title=\"Codes:\">Taletrectinib</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: <span title=\"Codes:{http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs associated-therapy}\">Associated Therapy</span></p><p><b>value</b>: <span title=\"Codes:{http://clinicaltrials.gov NCT04919811}\">A Single-Arm, Open-Label, Multicenter Phase 2 Study to Evaluate the Efficacy and Safety of Taletrectinib in Patients With Advanced or Metastatic ROS1 Positive NSCLC and Other Solid Tumors</span></p></blockquote><blockquote><p><b>component</b></p><p><b>Related artifact</b>: No display for RelatedArtifact  (type: citation; url: https://www.cancer.net/cancer-types/lung-cancer-non-small-cell/types-treatment)</p><p><b>code</b>: <span title=\"Codes:{http://loinc.org 93044-6}\">Level of evidence</span></p><p><b>value</b>: <span title=\"Codes:\">Tier I - Level A</span></p></blockquote></div>"^^rdf:XMLLiteral ]
  ] ; # 
  fhir:status [ fhir:v "final"] ; # 
  fhir:category ( [
     fhir:coding ( [
       fhir:system [
         fhir:v "http://terminology.hl7.org/CodeSystem/observation-category"^^xsd:anyURI ;
         fhir:l <http://terminology.hl7.org/CodeSystem/observation-category>
       ] ;
       fhir:code [ fhir:v "laboratory" ]
     ] )
  ] [
     fhir:coding ( [
       fhir:system [
         fhir:v "http://terminology.hl7.org/CodeSystem/v2-0074"^^xsd:anyURI ;
         fhir:l <http://terminology.hl7.org/CodeSystem/v2-0074>
       ] ;
       fhir:code [ fhir:v "GE" ]
     ] )
  ] ) ; # 
  fhir:code [
     fhir:coding ( [
       fhir:system [
         fhir:v "http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs"^^xsd:anyURI ;
         fhir:l <http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs>
       ] ;
       fhir:code [ fhir:v "therapeutic-implication" ]
     ] )
  ] ; # 
  fhir:subject [
     fhir:l <http://hl7.org/fhir/uv/genomics-reporting/Patient/somaticPatient> ;
     fhir:reference [ fhir:v "Patient/somaticPatient" ]
  ] ; # 
  fhir:effective [
     a fhir:DateTime ;
     fhir:v "2023-02-01"^^xsd:date
  ] ; # 
  fhir:performer ( [
     fhir:l <http://hl7.org/fhir/uv/genomics-reporting/Practitioner/pathologistPractitioner> ;
     fhir:reference [ fhir:v "Practitioner/pathologistPractitioner" ]
  ] ) ; # 
  fhir:derivedFrom ( [
     fhir:l <http://hl7.org/fhir/uv/genomics-reporting/Observation/ROS1-Fusion-var> ;
     fhir:reference [ fhir:v "Observation/ROS1-Fusion-var" ]
  ] ) ; # 
  fhir:component ( [
     fhir:code [
       fhir:coding ( [
         a loinc:81259-4 ;
         fhir:system [
           fhir:v "http://loinc.org"^^xsd:anyURI ;
           fhir:l <http://loinc.org>
         ] ;
         fhir:code [ fhir:v "81259-4" ]
       ] )
     ] ;
     fhir:value [
       a fhir:CodeableConcept ;
       fhir:coding ( [
         a sct:254637007 ;
         fhir:system [
           fhir:v "http://snomed.info/sct"^^xsd:anyURI ;
           fhir:l <http://snomed.info/sct>
         ] ;
         fhir:code [ fhir:v "254637007" ] ;
         fhir:display [ fhir:v "Non-small cell lung cancer (disorder)" ]
       ] ) ;
       fhir:text [ fhir:v "Non-small cell lung cancer" ]
     ]
  ] [
     fhir:code [
       fhir:coding ( [
         a loinc:51963-7 ;
         fhir:system [
           fhir:v "http://loinc.org"^^xsd:anyURI ;
           fhir:l <http://loinc.org>
         ] ;
         fhir:code [ fhir:v "51963-7" ] ;
         fhir:display [ fhir:v "Medication assessed" ]
       ] )
     ] ;
     fhir:value [
       a fhir:CodeableConcept ;
       fhir:text [ fhir:v "Taletrectinib" ]
     ]
  ] [
     fhir:code [
       fhir:coding ( [
         fhir:system [
           fhir:v "http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs"^^xsd:anyURI ;
           fhir:l <http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs>
         ] ;
         fhir:code [ fhir:v "associated-therapy" ] ;
         fhir:display [ fhir:v "Associated Therapy" ]
       ] )
     ] ;
     fhir:value [
       a fhir:CodeableConcept ;
       fhir:coding ( [
         fhir:system [
           fhir:v "http://clinicaltrials.gov"^^xsd:anyURI ;
           fhir:l <http://clinicaltrials.gov>
         ] ;
         fhir:code [ fhir:v "NCT04919811" ] ;
         fhir:display [ fhir:v "NCT04919811" ]
       ] ) ;
       fhir:text [ fhir:v "A Single-Arm, Open-Label, Multicenter Phase 2 Study to Evaluate the Efficacy and Safety of Taletrectinib in Patients With Advanced or Metastatic ROS1 Positive NSCLC and Other Solid Tumors" ]
     ]
  ] [
     fhir:extension ( [
       fhir:url [
         fhir:v "http://hl7.org/fhir/StructureDefinition/workflow-relatedArtifact"^^xsd:anyURI ;
         fhir:l <http://hl7.org/fhir/StructureDefinition/workflow-relatedArtifact>
       ] ;
       fhir:value [
         a fhir:RelatedArtifact ;
         fhir:type [ fhir:v "citation" ] ;
         fhir:url [
           fhir:v "https://www.cancer.net/cancer-types/lung-cancer-non-small-cell/types-treatment"^^xsd:anyURI ;
           fhir:l <https://www.cancer.net/cancer-types/lung-cancer-non-small-cell/types-treatment>
         ]
       ]
     ] ) ;
     fhir:code [
       fhir:coding ( [
         a loinc:93044-6 ;
         fhir:system [
           fhir:v "http://loinc.org"^^xsd:anyURI ;
           fhir:l <http://loinc.org>
         ] ;
         fhir:code [ fhir:v "93044-6" ] ;
         fhir:display [ fhir:v "Level of evidence" ]
       ] )
     ] ;
     fhir:value [
       a fhir:CodeableConcept ;
       fhir:text [ fhir:v "Tier I - Level A" ]
     ]
  ] ) . # 

<http://hl7.org/fhir/uv/genomics-reporting/Patient/somaticPatient> a fhir:Uv .

<http://hl7.org/fhir/uv/genomics-reporting/Practitioner/pathologistPractitioner> a fhir:Uv .

<http://hl7.org/fhir/uv/genomics-reporting/Observation/ROS1-Fusion-var> a fhir:Uv .

# -------------------------------------------------------------------------------------