Evidence Based Medicine on FHIR Implementation Guide
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Evidence Based Medicine on FHIR Implementation Guide, published by HL7 International / Clinical Decision Support. This guide is not an authorized publication; it is the continuous build for version 2.0.0-ballot built by the FHIR (HL7® FHIR® Standard) CI Build. This version is based on the current content of https://github.com/HL7/ebm/ and changes regularly. See the Directory of published versions

: ComparatorDefinition_Usual_care_pharmacologic_thromboprophylaxis - TTL Representation

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@prefix fhir: <http://hl7.org/fhir/> .
@prefix owl: <http://www.w3.org/2002/07/owl#> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

# - resource -------------------------------------------------------------------

 a fhir:_Group ;
  fhir:nodeRole fhir:treeRoot ;
  fhir:id [ fhir:v "179785"] ; # 
  fhir:meta [
fhir:versionId [ fhir:v "4" ] ;
fhir:lastUpdated [ fhir:v "2023-12-04T20:30:06.799Z"^^xsd:dateTime ] ;
    ( fhir:profile [
fhir:v "http://hl7.org/fhir/uv/ebm/StructureDefinition/comparator-definition"^^xsd:anyURI ;
fhir:link <http://hl7.org/fhir/uv/ebm/StructureDefinition/comparator-definition>     ] )
  ] ; # 
  fhir:text [
fhir:status [ fhir:v "extensions" ] ;
fhir:div "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p class=\"res-header-id\"><b>Generated Narrative: Group 179785</b></p><a name=\"179785\"> </a><a name=\"hc179785\"> </a><a name=\"179785-en-US\"> </a><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">version: 4; Last updated: 2023-12-04 20:30:06+0000</p><p style=\"margin-bottom: 0px\">Profile: <a href=\"StructureDefinition-comparator-definition.html\">ComparatorDefinition</a></p></div><p><b>Artifact related artifact</b>: No display for RelatedArtifact  (type: cite-as; citation: ComparatorDefinition: Usual-care pharmacologic thromboprophylaxis [Group]. Contributors: Brian S. Alper [Authors/Creators]. In: Fast Evidence Interoperability Resources (FEvIR) Platform, FOI 179785. Revised 2023-11-30. Available at: https://fevir.net/resources/Group/179785. Computable resource at: https://fevir.net/resources/Group/179785.)</p><p><b>Artifact Title</b>: ComparatorDefinition: Usual-care pharmacologic thromboprophylaxis</p><p><b>Artifact URL</b>: <a href=\"https://fevir.net/resources/Group/179785\">https://fevir.net/resources/Group/179785</a></p><p><b>Artifact Publisher</b>: Computable Publishing LLC</p><p><b>Artifact Copyright</b>: </p><div><p>https://creativecommons.org/licenses/by-nc-sa/4.0/</p>\n</div><p><b>Artifact Contact</b>: <a href=\"mailto:support@computablepublishing.com\">support@computablepublishing.com</a></p><p><b>Artifact Author</b>: Brian S. Alper: </p><p><b>org/fhir/uv/ebm/StructureDefinition/combination-method</b>: any-of</p><p><b>Artifact Status</b>: active</p><p><b>identifier</b>: FEvIR Object Identifier/179785</p><p><b>name</b>: ComparatorDefinition_Usual_care_pharmacologic_thromboprophylaxis</p><p><b>description</b>: </p><div><p>Description: usual-care pharmacologic thromboprophylaxis\nNote: Thromboprophylaxis was provided at a dose and duration determined by the treating clinician according to local practice.\nNote: Usual-care pharmacological thromboprophylaxis included both intermediate-intensity (in 27%) and prophylactic-intensity dosing (in 72%). Subgroup analyses may be informative to determine if there is a difference related to the intensity used in the control arm of the trial.</p>\n</div><p><b>type</b>: Animal</p><p><b>membership</b>: Definitional</p><blockquote><p><b>characteristic</b></p><p><b>org/fhir/uv/ebm/StructureDefinition/characteristic-description</b>: </p><div><p>ATTACC comparator arm</p>\n</div><blockquote><p><b>CharacteristicTiming</b></p><ul><li>contextCode: <span title=\"Codes:\">Start of trial</span></li><li>offset: 0-14</li><li>text: Up to 14 days or until hospital discharge, whichever comes first. After this period, decisions regarding thromboprophylaxis are at discretion of treating clinician.</li></ul></blockquote><p><b>code</b>: <span title=\"Codes:\">Defined by CodeableConcept</span></p><p><b>value</b>: <span title=\"Codes:\">Standard venous thromboprophylaxis according to local guidelines or usual practice. Dose of chosen agent should not be more than half of the approved therapeutic dose for the treatment of venous thromboembolism.</span></p><p><b>exclude</b>: false</p></blockquote><blockquote><p><b>characteristic</b></p><p><b>org/fhir/uv/ebm/StructureDefinition/characteristic-description</b>: </p><div><p>ACTIV-4a comparator arm</p>\n</div><blockquote><p><b>CharacteristicTiming</b></p><ul><li>contextCode: <span title=\"Codes:\">Start of trial</span></li><li>offset: 0-14</li><li>text: Up to 14 days or until hospital discharge, whichever comes first. After this period, decisions regarding thromboprophylaxis are at discretion of treating clinician.</li></ul></blockquote><p><b>code</b>: <span title=\"Codes:\">Defined by CodeableConcept</span></p><p><b>value</b>: <span title=\"Codes:\">Any one of enoxaparin, dalteparin, tinzaparin, fondaparinux, or heparin according to local preference. Dose of agent specified to be consistent with guidelines for low dose thromboprophylaxis.</span></p><p><b>exclude</b>: false</p></blockquote><blockquote><p><b>characteristic</b></p><p><b>org/fhir/uv/ebm/StructureDefinition/characteristic-description</b>: </p><div><p>REMAP-CAP comparator arm</p>\n</div><blockquote><p><b>CharacteristicTiming</b></p><ul><li>contextCode: <span title=\"Codes:\">Start of trial</span></li><li>offset: 0-14</li><li>text: Up to 14 days or until hospital discharge, whichever comes first. After this period, decisions regarding thromboprophylaxis are at discretion of treating clinician.</li></ul></blockquote><p><b>code</b>: <span title=\"Codes:\">Defined by CodeableConcept</span></p><p><b>value</b>: <span title=\"Codes:\">Standard venous thromboprophylaxis according to local guidelines or usual practice. Dose of chosen agent should not be sufficient to result in therapeutic anticoagulation.</span></p><p><b>exclude</b>: false</p></blockquote></div>"
  ] ; # 
  fhir:extension ( [
fhir:url [ fhir:v "http://hl7.org/fhir/StructureDefinition/artifact-relatedArtifact"^^xsd:anyURI ] ;
fhir:value [
a fhir:RelatedArtifact ;
fhir:type [ fhir:v "cite-as" ] ;
fhir:citation [ fhir:v "ComparatorDefinition: Usual-care pharmacologic thromboprophylaxis [Group]. Contributors: Brian S. Alper [Authors/Creators]. In: Fast Evidence Interoperability Resources (FEvIR) Platform, FOI 179785. Revised 2023-11-30. Available at: https://fevir.net/resources/Group/179785. Computable resource at: https://fevir.net/resources/Group/179785." ]     ]
  ] [
fhir:url [ fhir:v "http://hl7.org/fhir/StructureDefinition/artifact-title"^^xsd:anyURI ] ;
fhir:value [ fhir:v "ComparatorDefinition: Usual-care pharmacologic thromboprophylaxis" ]
  ] [
fhir:url [ fhir:v "http://hl7.org/fhir/StructureDefinition/artifact-url"^^xsd:anyURI ] ;
fhir:value [ fhir:v "https://fevir.net/resources/Group/179785"^^xsd:anyURI ]
  ] [
fhir:url [ fhir:v "http://hl7.org/fhir/StructureDefinition/artifact-publisher"^^xsd:anyURI ] ;
fhir:value [ fhir:v "Computable Publishing LLC" ]
  ] [
fhir:url [ fhir:v "http://hl7.org/fhir/StructureDefinition/artifact-copyright"^^xsd:anyURI ] ;
fhir:value [ fhir:v "https://creativecommons.org/licenses/by-nc-sa/4.0/" ]
  ] [
fhir:url [ fhir:v "http://hl7.org/fhir/StructureDefinition/artifact-contact"^^xsd:anyURI ] ;
fhir:value [
a fhir:ContactDetail ;
      ( fhir:telecom [
fhir:system [ fhir:v "email" ] ;
fhir:value [ fhir:v "support@computablepublishing.com" ]       ] )     ]
  ] [
fhir:url [ fhir:v "http://hl7.org/fhir/StructureDefinition/artifact-author"^^xsd:anyURI ] ;
fhir:value [
a fhir:ContactDetail ;
fhir:name [ fhir:v "Brian S. Alper" ]     ]
  ] [
fhir:url [ fhir:v "http://hl7.org/fhir/uv/ebm/StructureDefinition/combination-method"^^xsd:anyURI ] ;
fhir:value [ fhir:v "any-of" ]
  ] ) ; # 
  fhir:modifierExtension ( [
fhir:url [ fhir:v "http://hl7.org/fhir/StructureDefinition/artifact-status"^^xsd:anyURI ] ;
fhir:value [ fhir:v "active" ]
  ] ) ; # 
  fhir:identifier ( [
fhir:type [
      ( fhir:coding [
fhir:system [ fhir:v "http://terminology.hl7.org/CodeSystem/v2-0203"^^xsd:anyURI ] ;
fhir:code [ fhir:v "ACSN" ] ;
fhir:display [ fhir:v "Accession ID" ]       ] ) ;
fhir:text [ fhir:v "FEvIR Object Identifier" ]     ] ;
fhir:system [ fhir:v "https://fevir.net"^^xsd:anyURI ] ;
fhir:value [ fhir:v "179785" ] ;
fhir:assigner [
fhir:display [ fhir:v "Computable Publishing LLC" ]     ]
  ] ) ; # 
  fhir:name [ fhir:v "ComparatorDefinition_Usual_care_pharmacologic_thromboprophylaxis"] ; # 
  fhir:description [ fhir:v "Description: usual-care pharmacologic thromboprophylaxis\nNote: Thromboprophylaxis was provided at a dose and duration determined by the treating clinician according to local practice.\nNote: Usual-care pharmacological thromboprophylaxis included both intermediate-intensity (in 27%) and prophylactic-intensity dosing (in 72%). Subgroup analyses may be informative to determine if there is a difference related to the intensity used in the control arm of the trial."] ; # 
  fhir:type [ fhir:v "animal"] ; # 
  fhir:membership [ fhir:v "definitional"] ; # 
  fhir:characteristic ( [
    ( fhir:extension [
fhir:url [ fhir:v "http://hl7.org/fhir/uv/ebm/StructureDefinition/characteristic-description"^^xsd:anyURI ] ;
fhir:value [ fhir:v "ATTACC comparator arm" ]     ] [
      ( fhir:extension [
fhir:url [ fhir:v "contextCode"^^xsd:anyURI ] ;
fhir:value [
a fhir:CodeableConcept ;
fhir:text [ fhir:v "Start of trial" ]         ]       ] [
fhir:url [ fhir:v "offset"^^xsd:anyURI ] ;
fhir:value [
a fhir:Range ;
fhir:low [
fhir:value [ fhir:v "0"^^xsd:decimal ]           ] ;
fhir:high [
fhir:value [ fhir:v "14"^^xsd:decimal ] ;
fhir:unit [ fhir:v "days" ] ;
fhir:system [ fhir:v "http://unitsofmeasure.org"^^xsd:anyURI ] ;
fhir:code [ fhir:v "d" ]           ]         ]       ] [
fhir:url [ fhir:v "text"^^xsd:anyURI ] ;
fhir:value [ fhir:v "Up to 14 days or until hospital discharge, whichever comes first. After this period, decisions regarding thromboprophylaxis are at discretion of treating clinician." ]       ] ) ;
fhir:url [ fhir:v "http://hl7.org/fhir/uv/ebm/StructureDefinition/characteristic-timing"^^xsd:anyURI ]     ] ) ;
fhir:code [
fhir:text [ fhir:v "Defined by CodeableConcept" ]     ] ;
fhir:value [
a fhir:CodeableConcept ;
fhir:text [ fhir:v "Standard venous thromboprophylaxis according to local guidelines or usual practice. Dose of chosen agent should not be more than half of the approved therapeutic dose for the treatment of venous thromboembolism." ]     ] ;
fhir:exclude [ fhir:v "false"^^xsd:boolean ]
  ] [
    ( fhir:extension [
fhir:url [ fhir:v "http://hl7.org/fhir/uv/ebm/StructureDefinition/characteristic-description"^^xsd:anyURI ] ;
fhir:value [ fhir:v "ACTIV-4a comparator arm" ]     ] [
      ( fhir:extension [
fhir:url [ fhir:v "contextCode"^^xsd:anyURI ] ;
fhir:value [
a fhir:CodeableConcept ;
fhir:text [ fhir:v "Start of trial" ]         ]       ] [
fhir:url [ fhir:v "offset"^^xsd:anyURI ] ;
fhir:value [
a fhir:Range ;
fhir:low [
fhir:value [ fhir:v "0"^^xsd:decimal ]           ] ;
fhir:high [
fhir:value [ fhir:v "14"^^xsd:decimal ] ;
fhir:unit [ fhir:v "days" ] ;
fhir:system [ fhir:v "http://unitsofmeasure.org"^^xsd:anyURI ] ;
fhir:code [ fhir:v "d" ]           ]         ]       ] [
fhir:url [ fhir:v "text"^^xsd:anyURI ] ;
fhir:value [ fhir:v "Up to 14 days or until hospital discharge, whichever comes first. After this period, decisions regarding thromboprophylaxis are at discretion of treating clinician." ]       ] ) ;
fhir:url [ fhir:v "http://hl7.org/fhir/uv/ebm/StructureDefinition/characteristic-timing"^^xsd:anyURI ]     ] ) ;
fhir:code [
fhir:text [ fhir:v "Defined by CodeableConcept" ]     ] ;
fhir:value [
a fhir:CodeableConcept ;
fhir:text [ fhir:v "Any one of enoxaparin, dalteparin, tinzaparin, fondaparinux, or heparin according to local preference. Dose of agent specified to be consistent with guidelines for low dose thromboprophylaxis." ]     ] ;
fhir:exclude [ fhir:v "false"^^xsd:boolean ]
  ] [
    ( fhir:extension [
fhir:url [ fhir:v "http://hl7.org/fhir/uv/ebm/StructureDefinition/characteristic-description"^^xsd:anyURI ] ;
fhir:value [ fhir:v "REMAP-CAP comparator arm" ]     ] [
      ( fhir:extension [
fhir:url [ fhir:v "contextCode"^^xsd:anyURI ] ;
fhir:value [
a fhir:CodeableConcept ;
fhir:text [ fhir:v "Start of trial" ]         ]       ] [
fhir:url [ fhir:v "offset"^^xsd:anyURI ] ;
fhir:value [
a fhir:Range ;
fhir:low [
fhir:value [ fhir:v "0"^^xsd:decimal ]           ] ;
fhir:high [
fhir:value [ fhir:v "14"^^xsd:decimal ] ;
fhir:unit [ fhir:v "days" ] ;
fhir:system [ fhir:v "http://unitsofmeasure.org"^^xsd:anyURI ] ;
fhir:code [ fhir:v "d" ]           ]         ]       ] [
fhir:url [ fhir:v "text"^^xsd:anyURI ] ;
fhir:value [ fhir:v "Up to 14 days or until hospital discharge, whichever comes first. After this period, decisions regarding thromboprophylaxis are at discretion of treating clinician." ]       ] ) ;
fhir:url [ fhir:v "http://hl7.org/fhir/uv/ebm/StructureDefinition/characteristic-timing"^^xsd:anyURI ]     ] ) ;
fhir:code [
fhir:text [ fhir:v "Defined by CodeableConcept" ]     ] ;
fhir:value [
a fhir:CodeableConcept ;
fhir:text [ fhir:v "Standard venous thromboprophylaxis according to local guidelines or usual practice. Dose of chosen agent should not be sufficient to result in therapeutic anticoagulation." ]     ] ;
fhir:exclude [ fhir:v "false"^^xsd:boolean ]
  ] ) . #