Evidence Based Medicine on FHIR Implementation Guide
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Evidence Based Medicine on FHIR Implementation Guide, published by HL7 International / Clinical Decision Support. This guide is not an authorized publication; it is the continuous build for version 1.0.0-ballot built by the FHIR (HL7® FHIR® Standard) CI Build. This version is based on the current content of https://github.com/HL7/ebm/ and changes regularly. See the Directory of published versions

: DatasetCitation: Extrachromosomal DNA Amplification Contributes to Small Cell Lung Cancer Heterogeneity and is Associated with Worse Outcomes - TTL Representation

Active as of 2024-05-16

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@prefix fhir: <http://hl7.org/fhir/> .
@prefix owl: <http://www.w3.org/2002/07/owl#> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

# - resource -------------------------------------------------------------------

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fhir:div "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p><b>Generated Narrative: Citation</b><a name=\"179559\"> </a><a name=\"hc179559\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">ResourceCitation &quot;179559&quot; Version &quot;5&quot; Updated &quot;2023-12-02 22:30:09+0000&quot; </p><p style=\"margin-bottom: 0px\">Profile: <a href=\"StructureDefinition-dataset-citation.html\">DatasetCitation</a></p></div><p><b>url</b>: <code>https://fevir.net/resources/Citation/179559</code></p><p><b>identifier</b>: FEvIR Object Identifier/179559</p><p><b>version</b>: 1.0.0-ballot</p><p><b>title</b>: DatasetCitation: Extrachromosomal DNA Amplification Contributes to Small Cell Lung Cancer Heterogeneity and is Associated with Worse Outcomes</p><p><b>status</b>: active</p><p><b>date</b>: 2024-05-16 12:17:54+0000</p><p><b>publisher</b>: HL7 International / Clinical Decision Support</p><p><b>contact</b>: HL7 International / Clinical Decision Support: <a href=\"http://www.hl7.org/Special/committees/dss\">http://www.hl7.org/Special/committees/dss</a></p><p><b>description</b>: This Citation Resource is referenced in an example for the EBMonFHIR Implementation Guide.</p><p><b>jurisdiction</b>: World <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (m49.htm#001)</span></p><p><b>copyright</b>: https://creativecommons.org/licenses/by-nc-sa/4.0/</p><p><b>author</b>: Brian S. Alper: </p><h3>Summaries</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Style</b></td><td><b>Text</b></td></tr><tr><td style=\"display: none\">*</td><td>Computable Publishing <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://hl7.org/fhir/R5/codesystem-citation-summary-style.html\">Citation Summary Style</a>#comppub)</span></td><td>Extrachromosomal DNA Amplification Contributes to Small Cell Lung Cancer Heterogeneity and is Associated with Worse Outcomes [Dataset]. Contributors:  Anish Thomas,  Lorinc S. Pongor,  Rajesh Kumar,  Parth Desai [Authors]. In: database of Genotypes and Phenotypes, Accession Number phs003190.v1.p1. Published October 16, 2023. Available at: https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs003190.v1.p1.</td></tr></table><blockquote><p><b>citedArtifact</b></p><p><b>identifier</b>: dbGaP Study Accession/phs003190.v1.p1</p><h3>Titles</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Language</b></td><td><b>Text</b></td></tr><tr><td style=\"display: none\">*</td><td>Primary title <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://hl7.org/fhir/R5/codesystem-title-type.html\">Title Type</a>#primary)</span></td><td>English <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://terminology.hl7.org/5.5.0/CodeSystem-v3-ietf3066.html\">Tags for the Identification of Languages</a>#en)</span></td><td>Extrachromosomal DNA Amplification Contributes to Small Cell Lung Cancer Heterogeneity and is Associated with Worse Outcomes</td></tr></table><h3>Abstracts</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Language</b></td><td><b>Text</b></td></tr><tr><td style=\"display: none\">*</td><td>Study Description <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-179423.html\">Evidence Based Medicine on FHIR Implementation Guide Code System</a>#description &quot;Description&quot;)</span></td><td>English <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://terminology.hl7.org/5.5.0/CodeSystem-v3-ietf3066.html\">Tags for the Identification of Languages</a>#en)</span></td><td>Small-cell lung cancer (SCLC) is a very aggressive neuroendocrine lung cancer often associated with oncogenic MYC amplifications, which are known to drive SCLC heterogeneity marked by neuroendocrine (NE) and non-neuroendocrine (non-NE) cell states. The genetic mechanisms of MYC amplification and phenotypic plasticity between cell states is not known. Using data from cell-lines and a few patient-derived samples along with integrated whole-genome sequencing, long-range optical mapping, single-cell DNA sequencing, and fluorescence in situ hybridization, we have attempted to successfully characterize extrachromosomal DNA (ecDNA) as the primary source of MYC amplifications and driver fusions in SCLC.\n\nStudy Design:\nCross-Sectional\nStudy Type:\nObservational\nTotal number of consented subjects: 5</td></tr></table><blockquote><p><b>publicationForm</b></p><h3>PublishedIns</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Identifier</b></td><td><b>Title</b></td><td><b>Publisher</b></td><td><b>PublisherLocation</b></td></tr><tr><td style=\"display: none\">*</td><td>Database <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://hl7.org/fhir/R5/codesystem-published-in-type.html\">Published In Type</a>#D019991)</span></td><td>Abbreviation/dbGaP</td><td>database of Genotypes and Phenotypes</td><td><span>: NLM</span></td><td>Bethesda, MD, USA</td></tr></table><p><b>citedMedium</b>: Internet <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://hl7.org/fhir/R5/codesystem-cited-medium.html\">Cited Medium</a>#internet)</span></p><p><b>articleDate</b>: 2023-10-16</p><p><b>accessionNumber</b>: phs003190.v1.p1</p><p><b>pageCount</b>: Total number of consented subjects: 5</p><p><b>copyright</b>: Data access provided by: dbGaP Authorized Access. For publicly available data (public ftp), Connect to the public download site. The site contains release notes and manifests. The site also contains data dictionaries, variable summaries, documents, and truncated analyses, whenever available.</p></blockquote><blockquote><p><b>webLocation</b></p><p><b>classifier</b>: Webpage <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://hl7.org/fhir/R5/codesystem-artifact-url-classifier.html\">Artifact Url Classifier</a>#webpage)</span></p><p><b>url</b>: <a href=\"https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs003190.v1.p1\">https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs003190.v1.p1</a></p></blockquote><blockquote><p><b>webLocation</b></p><p><b>classifier</b>: public download site <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-179423.html\">Evidence Based Medicine on FHIR Implementation Guide Code System</a>#defined-in-text &quot;Defined in text&quot;)</span></p><p><b>url</b>: <a href=\"https://ftp.ncbi.nlm.nih.gov/dbgap/studies/phs003190/phs003190.v1.p1\">https://ftp.ncbi.nlm.nih.gov/dbgap/studies/phs003190/phs003190.v1.p1</a></p></blockquote><blockquote><p><b>classification</b></p><p><b>type</b>: Knowledge Artifact Type <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://hl7.org/fhir/R5/codesystem-cited-artifact-classification-type.html\">Cited Artifact Classification Type</a>#knowledge-artifact-type)</span></p><p><b>classifier</b>: Dataset <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://hl7.org/fhir/R5/codesystem-citation-artifact-classifier.html\">Citation Artifact Classifier</a>#D064886)</span></p></blockquote><blockquote><p><b>classification</b></p><p><b>type</b>: Study Design <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-179423.html\">Evidence Based Medicine on FHIR Implementation Guide Code System</a>#study-design)</span></p><p><b>classifier</b>: Cross-Sectional <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-181513.html\">Scientific Evidence Code System (SEVCO) -- EXAMPLE VERSION for EBMonFHIR Implementation Guide</a>#SEVCO:01027 &quot;Cross sectional data collection&quot;)</span>, Observational Research <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-181513.html\">Scientific Evidence Code System (SEVCO) -- EXAMPLE VERSION for EBMonFHIR Implementation Guide</a>#SEVCO:01002 &quot;observational research&quot;)</span></p></blockquote><blockquote><p><b>classification</b></p><p><b>type</b>: Primary Phenotype <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-179423.html\">Evidence Based Medicine on FHIR Implementation Guide Code System</a>#defined-in-text &quot;Defined in text&quot;)</span></p><p><b>classifier</b>: Small Cell Lung Carcinoma <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-179423.html\">Evidence Based Medicine on FHIR Implementation Guide Code System</a>#defined-in-text &quot;Defined in text&quot;)</span></p></blockquote><blockquote><p><b>contributorship</b></p><p><b>complete</b>: true</p><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a name=\"hccontributor0\"> </a></p><blockquote><p/><p><a name=\"contributor0\"> </a></p><p><a name=\"hccontributor0\"> </a></p><p><b>name</b>: Anish Thomas </p></blockquote><p><b>affiliation</b>: <span>: Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA</span></p><p><b>contributionType</b>: Principal Investigator <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-179423.html\">Evidence Based Medicine on FHIR Implementation Guide Code System</a>#principal-investigator)</span></p><p><b>role</b>: Author/Creator <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://hl7.org/fhir/R5/codesystem-contributor-role.html\">Contributor Role</a>#author)</span></p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a name=\"hccontributor1\"> </a></p><blockquote><p/><p><a name=\"contributor1\"> </a></p><p><a name=\"hccontributor1\"> </a></p><p><b>name</b>: Lorinc S. Pongor </p></blockquote><p><b>affiliation</b>: <span>: Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA</span></p><p><b>contributionType</b>: Co-Investigator <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-179423.html\">Evidence Based Medicine on FHIR Implementation Guide Code System</a>#co-investigator)</span></p><p><b>role</b>: Author/Creator <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://hl7.org/fhir/R5/codesystem-contributor-role.html\">Contributor Role</a>#author)</span></p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a name=\"hccontributor2\"> </a></p><blockquote><p/><p><a name=\"contributor2\"> </a></p><p><a name=\"hccontributor2\"> </a></p><p><b>name</b>: Rajesh Kumar </p></blockquote><p><b>affiliation</b>: <span>: Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA</span></p><p><b>contributionType</b>: Co-Investigator <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-179423.html\">Evidence Based Medicine on FHIR Implementation Guide Code System</a>#co-investigator)</span></p><p><b>role</b>: Author/Creator <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://hl7.org/fhir/R5/codesystem-contributor-role.html\">Contributor Role</a>#author)</span></p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a name=\"hccontributor3\"> </a></p><blockquote><p/><p><a name=\"contributor3\"> </a></p><p><a name=\"hccontributor3\"> </a></p><p><b>name</b>: Parth Desai </p></blockquote><p><b>affiliation</b>: <span>: Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA</span></p><p><b>contributionType</b>: Co-Investigator <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-179423.html\">Evidence Based Medicine on FHIR Implementation Guide Code System</a>#co-investigator)</span></p><p><b>role</b>: Author/Creator <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://hl7.org/fhir/R5/codesystem-contributor-role.html\">Contributor Role</a>#author)</span></p></blockquote></blockquote></blockquote><hr/><blockquote><p><b>Generated Narrative: Practitioner #contributor0</b><a name=\"contributor0\"> </a><a name=\"hccontributor0\"> </a></p><p><b>name</b>: Anish Thomas </p></blockquote><hr/><blockquote><p><b>Generated Narrative: Practitioner #contributor1</b><a name=\"contributor1\"> </a><a name=\"hccontributor1\"> </a></p><p><b>name</b>: Lorinc S. 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fhir:system [ fhir:v "http://hl7.org/fhir/citation-artifact-classifier"^^xsd:anyURI ] ;
fhir:code [ fhir:v "D064886" ] ;
fhir:display [ fhir:v "Dataset" ]         ] )       ] )     ] [
fhir:type [
        ( fhir:coding [
fhir:system [ fhir:v "https://fevir.net/resources/CodeSystem/179423"^^xsd:anyURI ] ;
fhir:code [ fhir:v "study-design" ] ;
fhir:display [ fhir:v "Study Design" ]         ] ) ;
fhir:text [ fhir:v "Study Design" ]       ] ;
      ( fhir:classifier [
        ( fhir:coding [
fhir:system [ fhir:v "https://fevir.net/resources/CodeSystem/181513"^^xsd:anyURI ] ;
fhir:code [ fhir:v "SEVCO:01027" ] ;
fhir:display [ fhir:v "Cross sectional data collection" ]         ] ) ;
fhir:text [ fhir:v "Cross-Sectional" ]       ] [
        ( fhir:coding [
fhir:system [ fhir:v "https://fevir.net/resources/CodeSystem/181513"^^xsd:anyURI ] ;
fhir:code [ fhir:v "SEVCO:01002" ] ;
fhir:display [ fhir:v "observational research" ]         ] ) ;
fhir:text [ fhir:v "Observational Research" ]       ] )     ] [
fhir:type [
        ( fhir:coding [
fhir:system [ fhir:v "https://fevir.net/resources/CodeSystem/179423"^^xsd:anyURI ] ;
fhir:code [ fhir:v "defined-in-text" ] ;
fhir:display [ fhir:v "Defined in text" ]         ] ) ;
fhir:text [ fhir:v "Primary Phenotype" ]       ] ;
      ( fhir:classifier [
        ( fhir:coding [
fhir:system [ fhir:v "https://fevir.net/resources/CodeSystem/179423"^^xsd:anyURI ] ;
fhir:code [ fhir:v "defined-in-text" ] ;
fhir:display [ fhir:v "Defined in text" ]         ] ) ;
fhir:text [ fhir:v "Small Cell Lung Carcinoma" ]       ] )     ] ) ;
fhir:contributorship [
fhir:complete [ fhir:v "true"^^xsd:boolean ] ;
      ( fhir:entry [
fhir:contributor [
fhir:reference [ fhir:v "#contributor0" ] ;
fhir:type [ fhir:v "Practitioner"^^xsd:anyURI ]         ] ;
        ( fhir:affiliation [
fhir:display [ fhir:v "Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA" ]         ] ) ;
        ( fhir:contributionType [
          ( fhir:coding [
fhir:system [ fhir:v "https://fevir.net/resources/CodeSystem/179423"^^xsd:anyURI ] ;
fhir:code [ fhir:v "principal-investigator" ] ;
fhir:display [ fhir:v "Principal Investigator" ]           ] ) ;
fhir:text [ fhir:v "Principal Investigator" ]         ] ) ;
fhir:role [
          ( fhir:coding [
fhir:system [ fhir:v "http://hl7.org/fhir/contributor-role"^^xsd:anyURI ] ;
fhir:code [ fhir:v "author" ] ;
fhir:display [ fhir:v "Author/Creator" ]           ] )         ]       ] [
fhir:contributor [
fhir:reference [ fhir:v "#contributor1" ] ;
fhir:type [ fhir:v "Practitioner"^^xsd:anyURI ]         ] ;
        ( fhir:affiliation [
fhir:display [ fhir:v "Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA" ]         ] ) ;
        ( fhir:contributionType [
          ( fhir:coding [
fhir:system [ fhir:v "https://fevir.net/resources/CodeSystem/179423"^^xsd:anyURI ] ;
fhir:code [ fhir:v "co-investigator" ] ;
fhir:display [ fhir:v "Co-Investigator" ]           ] ) ;
fhir:text [ fhir:v "Co-Investigator" ]         ] ) ;
fhir:role [
          ( fhir:coding [
fhir:system [ fhir:v "http://hl7.org/fhir/contributor-role"^^xsd:anyURI ] ;
fhir:code [ fhir:v "author" ] ;
fhir:display [ fhir:v "Author/Creator" ]           ] )         ]       ] [
fhir:contributor [
fhir:reference [ fhir:v "#contributor2" ] ;
fhir:type [ fhir:v "Practitioner"^^xsd:anyURI ]         ] ;
        ( fhir:affiliation [
fhir:display [ fhir:v "Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA" ]         ] ) ;
        ( fhir:contributionType [
          ( fhir:coding [
fhir:system [ fhir:v "https://fevir.net/resources/CodeSystem/179423"^^xsd:anyURI ] ;
fhir:code [ fhir:v "co-investigator" ] ;
fhir:display [ fhir:v "Co-Investigator" ]           ] ) ;
fhir:text [ fhir:v "Co-Investigator" ]         ] ) ;
fhir:role [
          ( fhir:coding [
fhir:system [ fhir:v "http://hl7.org/fhir/contributor-role"^^xsd:anyURI ] ;
fhir:code [ fhir:v "author" ] ;
fhir:display [ fhir:v "Author/Creator" ]           ] )         ]       ] [
fhir:contributor [
fhir:reference [ fhir:v "#contributor3" ] ;
fhir:type [ fhir:v "Practitioner"^^xsd:anyURI ]         ] ;
        ( fhir:affiliation [
fhir:display [ fhir:v "Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA" ]         ] ) ;
        ( fhir:contributionType [
          ( fhir:coding [
fhir:system [ fhir:v "https://fevir.net/resources/CodeSystem/179423"^^xsd:anyURI ] ;
fhir:code [ fhir:v "co-investigator" ] ;
fhir:display [ fhir:v "Co-Investigator" ]           ] ) ;
fhir:text [ fhir:v "Co-Investigator" ]         ] ) ;
fhir:role [
          ( fhir:coding [
fhir:system [ fhir:v "http://hl7.org/fhir/contributor-role"^^xsd:anyURI ] ;
fhir:code [ fhir:v "author" ] ;
fhir:display [ fhir:v "Author/Creator" ]           ] )         ]       ] )     ]
  ] . #