Evidence Based Medicine on FHIR Implementation Guide, published by HL7 International / Clinical Decision Support. This guide is not an authorized publication; it is the continuous build for version 2.0.0-ballot built by the FHIR (HL7® FHIR® Standard) CI Build. This version is based on the current content of https://github.com/HL7/ebm/ and changes regularly. See the Directory of published versions
Active as of 2024-11-01 |
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"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p class=\"res-header-id\"><b>Generated Narrative: Citation 179559</b></p><a name=\"179559\"> </a><a name=\"hc179559\"> </a><a name=\"179559-en-US\"> </a><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">version: 5; Last updated: 2023-12-02 22:30:09+0000</p><p style=\"margin-bottom: 0px\">Profile: <a href=\"StructureDefinition-dataset-citation.html\">DatasetCitation</a></p></div><p><b>url</b>: <a href=\"Citation-179559.html\">Citation DatasetCitation: Extrachromosomal DNA Amplification Contributes to Small Cell Lung Cancer Heterogeneity and is Associated with Worse Outcomes</a></p><p><b>identifier</b>: FEvIR Object Identifier/179559, <a href=\"http://terminology.hl7.org/6.0.2/NamingSystem-uri.html\" title=\"As defined by RFC 3986 (http://www.ietf.org/rfc/rfc3986.txt)(with many schemes defined in many RFCs). 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URIs as identifiers appear more commonly in FHIR.\r\n\r\nThis OID may also be used in CD.codeSystem.\">Uniform Resource Identifier (URI)</a>/urn:oid:2.16.840.1.113883.4.642.40.44.15.24</p><p><b>version</b>: 2.0.0-ballot</p><p><b>title</b>: DatasetCitation: Extrachromosomal DNA Amplification Contributes to Small Cell Lung Cancer Heterogeneity and is Associated with Worse Outcomes</p><p><b>status</b>: Active</p><p><b>date</b>: 2024-11-01 10:20:00+0000</p><p><b>publisher</b>: HL7 International / Clinical Decision Support</p><p><b>contact</b>: HL7 International / Clinical Decision Support: <a href=\"http://www.hl7.org/Special/committees/dss\">http://www.hl7.org/Special/committees/dss</a></p><p><b>description</b>: </p><div><p>This Citation Resource is referenced in an example for the EBMonFHIR Implementation Guide.</p>\n</div><p><b>jurisdiction</b>: <span title=\"Codes:{http://unstats.un.org/unsd/methods/m49/m49.htm 001}\">World</span></p><p><b>copyright</b>: </p><div><p>https://creativecommons.org/licenses/by-nc-sa/4.0/</p>\n</div><p><b>author</b>: Brian S. Alper: </p><h3>Summaries</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Style</b></td><td><b>Text</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:{http://hl7.org/fhir/citation-summary-style comppub}\">Computable Publishing</span></td><td><div><p>Extrachromosomal DNA Amplification Contributes to Small Cell Lung Cancer Heterogeneity and is Associated with Worse Outcomes [Dataset]. Contributors: Anish Thomas, Lorinc S. Pongor, Rajesh Kumar, Parth Desai [Authors]. In: database of Genotypes and Phenotypes, Accession Number phs003190.v1.p1. Published October 16, 2023. Available at: https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs003190.v1.p1.</p>\n</div></td></tr></table><blockquote><p><b>citedArtifact</b></p><p><b>identifier</b>: dbGaP Study Accession/phs003190.v1.p1</p><h3>Titles</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Language</b></td><td><b>Text</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:{http://hl7.org/fhir/title-type primary}\">Primary title</span></td><td><span title=\"Codes:{urn:ietf:bcp:47 en}\">English</span></td><td><div><p>Extrachromosomal DNA Amplification Contributes to Small Cell Lung Cancer Heterogeneity and is Associated with Worse Outcomes</p>\n</div></td></tr></table><h3>Abstracts</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Language</b></td><td><b>Text</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:{https://fevir.net/resources/CodeSystem/179423 description}\">Study Description</span></td><td><span title=\"Codes:{urn:ietf:bcp:47 en}\">English</span></td><td><div><p>Small-cell lung cancer (SCLC) is a very aggressive neuroendocrine lung cancer often associated with oncogenic MYC amplifications, which are known to drive SCLC heterogeneity marked by neuroendocrine (NE) and non-neuroendocrine (non-NE) cell states. The genetic mechanisms of MYC amplification and phenotypic plasticity between cell states is not known. Using data from cell-lines and a few patient-derived samples along with integrated whole-genome sequencing, long-range optical mapping, single-cell DNA sequencing, and fluorescence in situ hybridization, we have attempted to successfully characterize extrachromosomal DNA (ecDNA) as the primary source of MYC amplifications and driver fusions in SCLC.</p>\n<p>Study Design:\nCross-Sectional\nStudy Type:\nObservational\nTotal number of consented subjects: 5</p>\n</div></td></tr></table><blockquote><p><b>publicationForm</b></p><h3>PublishedIns</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Identifier</b></td><td><b>Title</b></td><td><b>Publisher</b></td><td><b>PublisherLocation</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:{http://hl7.org/fhir/published-in-type D019991}\">Database</span></td><td>Abbreviation/dbGaP</td><td>database of Genotypes and Phenotypes</td><td>NLM</td><td>Bethesda, MD, USA</td></tr></table><p><b>citedMedium</b>: <span title=\"Codes:{http://hl7.org/fhir/cited-medium internet}\">Internet</span></p><p><b>articleDate</b>: 2023-10-16</p><p><b>accessionNumber</b>: phs003190.v1.p1</p><p><b>pageCount</b>: Total number of consented subjects: 5</p><p><b>copyright</b>: </p><div><p>Data access provided by: dbGaP Authorized Access. 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The site also contains data dictionaries, variable summaries, documents, and truncated analyses, whenever available.</p>\n</div></blockquote><blockquote><p><b>webLocation</b></p><p><b>classifier</b>: <span title=\"Codes:{http://hl7.org/fhir/artifact-url-classifier webpage}\">Webpage</span></p><p><b>url</b>: <a href=\"https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs003190.v1.p1\">https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs003190.v1.p1</a></p></blockquote><blockquote><p><b>webLocation</b></p><p><b>classifier</b>: <span title=\"Codes:{https://fevir.net/resources/CodeSystem/179423 defined-in-text}\">public download site</span></p><p><b>url</b>: <a href=\"https://ftp.ncbi.nlm.nih.gov/dbgap/studies/phs003190/phs003190.v1.p1\">https://ftp.ncbi.nlm.nih.gov/dbgap/studies/phs003190/phs003190.v1.p1</a></p></blockquote><blockquote><p><b>classification</b></p><p><b>type</b>: <span title=\"Codes:{http://hl7.org/fhir/cited-artifact-classification-type knowledge-artifact-type}\">Knowledge Artifact Type</span></p><p><b>classifier</b>: <span title=\"Codes:{http://hl7.org/fhir/citation-artifact-classifier D064886}\">Dataset</span></p></blockquote><blockquote><p><b>classification</b></p><p><b>type</b>: <span title=\"Codes:{https://fevir.net/resources/CodeSystem/179423 study-design}\">Study Design</span></p><p><b>classifier</b>: <span title=\"Codes:{https://fevir.net/resources/CodeSystem/181513 SEVCO:01027}\">Cross-Sectional</span>, <span title=\"Codes:{https://fevir.net/resources/CodeSystem/181513 SEVCO:01002}\">Observational Research</span></p></blockquote><blockquote><p><b>classification</b></p><p><b>type</b>: <span title=\"Codes:{https://fevir.net/resources/CodeSystem/179423 defined-in-text}\">Primary Phenotype</span></p><p><b>classifier</b>: <span title=\"Codes:{https://fevir.net/resources/CodeSystem/179423 defined-in-text}\">Small Cell Lung Carcinoma</span></p></blockquote><blockquote><p><b>contributorship</b></p><p><b>complete</b>: true</p><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a href=\"#hc179559/contributor0\">Practitioner Anish Thomas </a></p><p><b>affiliation</b>: Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA</p><p><b>contributionType</b>: <span title=\"Codes:{https://fevir.net/resources/CodeSystem/179423 principal-investigator}\">Principal Investigator</span></p><p><b>role</b>: <span title=\"Codes:{http://hl7.org/fhir/contributor-role author}\">Author/Creator</span></p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a href=\"#hc179559/contributor1\">Practitioner Lorinc S. 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"display" : "Co-Investigator"
}
],
"text" : "Co-Investigator"
}
],
"role" : {
"coding" : [
{
"system" : "http://hl7.org/fhir/contributor-role",
"code" : "author",
"display" : "Author/Creator"
}
]
}
}
]
}
}
}