Potential Drug-Drug Interaction (PDDI) CDS IG : STU1 Ballot 2, published by HL7 Clinical Decision Support Workgroup. This guide is not an authorized publication; it is the continuous build for version 1.0.0-ballot built by the FHIR (HL7® FHIR® Standard) CI Build. This version is based on the current content of https://github.com/HL7/PDDI-CDS/ and changes regularly. See the Directory of published versions

Test data defined as part of the PDDI CDS Implementation Guide

To facilitate testing and verification, this guide includes test requests for a number of sample scenarios.

Warfarin + NSAID

All scenarios invoke the CDS service – so prefetch warfarin resources overlap a new NSAID order in each scenario below.

order-select without coordination

• order-select NSAID + Warfarin no coordination

order-sign without coordination

• order-sign NSAID + Warfarin no coordination

order-select with coordination

• order-select NSAID + Warfarin with coordination

order-sign with coordination

• order-sign NSAID + Warfarin with coordination

Multiple updates to the draft orders

• order-select NSAID + Warfarin
• order-select Digoxin + Cyclosporine
• order-sign NSAID + Warfarin
• order-sign Digoxin + Cyclosporine

**Scenario 1: context: topical diclofenac – MedicationRequest; prefetch: warfarin – MedicationRequest **

• Request NSAID + Warfarin scenario 01

Scenario 2: context: systemic NSAID – MedicationRequest; prefetch: warfarin – MedicationRequest, proton pump inhibitor – MedicationRequest,

• Request NSAID + Warfarin scenario 02

Scenario 3: context: systemic NSAID – MedicationRequest; prefetch: wafarin – MedicationDispense, >65 years old – Patient, systemic corticosteroid – MedicationRequest

• Request NSAID + Warfarin scenario 03

Scenario 4: context systemic NSAID – MedicationRequest; prefetch: wafarin – MedicationAdministration, <65 years old – Patient, history of upper gastrointestinal bleed – Condition, NSAID – MedicationRequest

• Request NSAID + Warfarin scenario 04

Scenario 5: context: systemic NSAID – MedicationRequest; prefetch: wafarin – MedicationStatement, <65 years old – Patient, aldosterone antagonist – MedicationRequest

• Request NSAID + Warfarin scenario 05

Digoxin + Cyclosporine

order-select without coordination

• order-select Digoxin + Cyclosporine no coordination

order-sign without coordination

• order-sign Digoxin + Cyclosporine no coordination

order-select with coordination

• order-select Digoxin + Cyclosporine with coordination

order-sign with coordination

• order-sign Digoxin + Cyclosporine with coordination

Scenario 1: context: cyclosporine – MedicationRequest; prefetch: digoxin – MedicationDispense, digoxin level – Observation, furosemide – MedicationDispense

• Request Digoxin + Cyclosporine scenario 01

Scenario 2: context: cyclosporine – MedicationRequest; prefetch: digoxin – MedicationDispense, cyclosporine - MedicationRequest, potassium – Observation,

• Request Digoxin + Cyclosporine scenario 02

Scenario 3: context: digoxin – MedicationRequest; prefetch: cyclosporine – MedicationRequest, renal – Observation

• Request Digoxin + Cyclosporine scenario 03

Scenario 4: context: digoxin – MedicationRequest; prefetch: cyclosporine – MedicationRequest, digoxin – MedicationDispense, digoxin level – Observation

• Request Digoxin + Cyclosporine scenario 04