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14.7 Resource EffectEvidenceSynthesis - Content

Clinical Decision Support Work GroupMaturity Level: 0 Trial Use Compartments: Not linked to any defined compartments

The EffectEvidenceSynthesis resource describes the difference in an outcome between exposures states in a population where the effect estimate is derived from a combination of research studies.

The scope of the EffectEvidenceSynthesis resource is to describe the estimates of an effect of an exposure on an outcome where the effect estimates are derived from the combination of research studies. Effect estimates are a measure of difference between the exposure state and an alternative exposure state (often called the control or comparator state) Expressing effect estimates is done throughout reporting of biomedical research, systematic reviews, and clinical reference across all disciplines.

Structure

NameFlagsCard.TypeDescription & Constraintsdoco
.. EffectEvidenceSynthesis ITUDomainResourceA quantified estimate of effect based on a body of evidence
+ Warning: Name should be usable as an identifier for the module by machine processing applications such as code generation
Elements defined in Ancestors: id, meta, implicitRules, language, text, contained, extension, modifierExtension
... url Σ0..1uriCanonical identifier for this effect evidence synthesis, represented as a URI (globally unique)
... identifier Σ0..*IdentifierAdditional identifier for the effect evidence synthesis
... version Σ0..1stringBusiness version of the effect evidence synthesis
... name ΣI0..1stringName for this effect evidence synthesis (computer friendly)
... title Σ0..1stringName for this effect evidence synthesis (human friendly)
... status ?!Σ1..1codedraft | active | retired | unknown
PublicationStatus (Required)
... date Σ0..1dateTimeDate last changed
... publisher Σ0..1stringName of the publisher (organization or individual)
... contact Σ0..*ContactDetailContact details for the publisher
... description Σ0..1markdownNatural language description of the effect evidence synthesis
... note 0..*AnnotationUsed for footnotes or explanatory notes
... useContext Σ0..*UsageContextThe context that the content is intended to support
... jurisdiction Σ0..*CodeableConceptIntended jurisdiction for effect evidence synthesis (if applicable)
Jurisdiction (Extensible)
... copyright 0..1markdownUse and/or publishing restrictions
... approvalDate 0..1dateWhen the effect evidence synthesis was approved by publisher
... lastReviewDate 0..1dateWhen the effect evidence synthesis was last reviewed
... effectivePeriod Σ0..1PeriodWhen the effect evidence synthesis is expected to be used
... topic 0..*CodeableConceptThe category of the EffectEvidenceSynthesis, such as Education, Treatment, Assessment, etc.
DefinitionTopic (Example)
... author 0..*ContactDetailWho authored the content
... editor 0..*ContactDetailWho edited the content
... reviewer 0..*ContactDetailWho reviewed the content
... endorser 0..*ContactDetailWho endorsed the content
... relatedArtifact 0..*RelatedArtifactAdditional documentation, citations, etc.
... synthesisType 0..1CodeableConceptType of synthesis
SynthesisType (Extensible)
... studyType 0..1CodeableConceptType of study
StudyType (Extensible)
... population Σ1..1Reference(EvidenceVariable)What population?
... exposure Σ1..1Reference(EvidenceVariable)What exposure?
... exposureAlternative Σ1..1Reference(EvidenceVariable)What comparison exposure?
... outcome Σ1..1Reference(EvidenceVariable)What outcome?
... sampleSize 0..1BackboneElementWhat sample size was involved?
.... description 0..1stringDescription of sample size
.... numberOfStudies 0..1integerHow many studies?
.... numberOfParticipants 0..1integerHow many participants?
... resultsByExposure 0..*BackboneElementWhat was the result per exposure?
.... description 0..1stringDescription of results by exposure
.... exposureState 0..1codeexposure | exposure-alternative
ExposureState (Required)
.... variantState 0..1CodeableConceptVariant exposure states
EvidenceVariantState (Extensible)
.... riskEvidenceSynthesis 1..1Reference(RiskEvidenceSynthesis)Risk evidence synthesis
... effectEstimate Σ0..*BackboneElementWhat was the estimated effect
.... description 0..1stringDescription of effect estimate
.... type 0..1CodeableConceptType of efffect estimate
EffectEstimateType (Extensible)
.... variantState 0..1CodeableConceptVariant exposure states
EvidenceVariantState (Extensible)
.... value 0..1decimalPoint estimate
.... unitOfMeasure 0..1CodeableConceptWhat unit is the outcome described in?
UCUM Codes (Required)
.... precisionEstimate 0..*BackboneElementHow precise the estimate is
..... type 0..1CodeableConceptType of precision estimate
PrecisionEstimateType (Extensible)
..... level 0..1decimalLevel of confidence interval
..... from 0..1decimalLower bound
..... to 0..1decimalUpper bound
... certainty 0..*BackboneElementHow certain is the effect
.... rating 0..*CodeableConceptCertainty rating
QualityOfEvidenceRating (Extensible)
.... note 0..*AnnotationUsed for footnotes or explanatory notes
.... certaintySubcomponent 0..*BackboneElementA component that contributes to the overall certainty
..... type 0..1CodeableConceptType of subcomponent of certainty rating
CertaintySubcomponentType (Extensible)
..... rating 0..*CodeableConceptSubcomponent certainty rating
CertaintySubcomponentRating (Extensible)
..... note 0..*AnnotationUsed for footnotes or explanatory notes

doco Documentation for this format

UML Diagram (Legend)

EffectEvidenceSynthesis (DomainResource)An absolute URI that is used to identify this effect evidence synthesis when it is referenced in a specification, model, design or an instance; also called its canonical identifier. This SHOULD be globally unique and SHOULD be a literal address at which at which an authoritative instance of this effect evidence synthesis is (or will be) published. This URL can be the target of a canonical reference. It SHALL remain the same when the effect evidence synthesis is stored on different serversurl : uri [0..1]A formal identifier that is used to identify this effect evidence synthesis when it is represented in other formats, or referenced in a specification, model, design or an instanceidentifier : Identifier [0..*]The identifier that is used to identify this version of the effect evidence synthesis when it is referenced in a specification, model, design or instance. This is an arbitrary value managed by the effect evidence synthesis author and is not expected to be globally unique. For example, it might be a timestamp (e.g. yyyymmdd) if a managed version is not available. There is also no expectation that versions can be placed in a lexicographical sequenceversion : string [0..1]A natural language name identifying the effect evidence synthesis. This name should be usable as an identifier for the module by machine processing applications such as code generationname : string [0..1]A short, descriptive, user-friendly title for the effect evidence synthesistitle : string [0..1]The status of this effect evidence synthesis. Enables tracking the life-cycle of the content (this element modifies the meaning of other elements)status : code [1..1] « The lifecycle status of an artifact. (Strength=Required)PublicationStatus! »The date (and optionally time) when the effect evidence synthesis was published. The date must change when the business version changes and it must change if the status code changes. In addition, it should change when the substantive content of the effect evidence synthesis changesdate : dateTime [0..1]The name of the organization or individual that published the effect evidence synthesispublisher : string [0..1]Contact details to assist a user in finding and communicating with the publishercontact : ContactDetail [0..*]A free text natural language description of the effect evidence synthesis from a consumer's perspectivedescription : markdown [0..1]A human-readable string to clarify or explain concepts about the resourcenote : Annotation [0..*]The content was developed with a focus and intent of supporting the contexts that are listed. These contexts may be general categories (gender, age, ...) or may be references to specific programs (insurance plans, studies, ...) and may be used to assist with indexing and searching for appropriate effect evidence synthesis instancesuseContext : UsageContext [0..*]A legal or geographic region in which the effect evidence synthesis is intended to be usedjurisdiction : CodeableConcept [0..*] « Countries and regions within which this artifact is targeted for use. (Strength=Extensible)Jurisdiction ValueSet+ »A copyright statement relating to the effect evidence synthesis and/or its contents. Copyright statements are generally legal restrictions on the use and publishing of the effect evidence synthesiscopyright : markdown [0..1]The date on which the resource content was approved by the publisher. Approval happens once when the content is officially approved for usageapprovalDate : date [0..1]The date on which the resource content was last reviewed. Review happens periodically after approval but does not change the original approval datelastReviewDate : date [0..1]The period during which the effect evidence synthesis content was or is planned to be in active useeffectivePeriod : Period [0..1]Descriptive topics related to the content of the EffectEvidenceSynthesis. Topics provide a high-level categorization grouping types of EffectEvidenceSynthesiss that can be useful for filtering and searchingtopic : CodeableConcept [0..*] « High-level categorization of the definition, used for searching, sorting, and filtering. (Strength=Example)DefinitionTopic?? »An individiual or organization primarily involved in the creation and maintenance of the contentauthor : ContactDetail [0..*]An individual or organization primarily responsible for internal coherence of the contenteditor : ContactDetail [0..*]An individual or organization primarily responsible for review of some aspect of the contentreviewer : ContactDetail [0..*]An individual or organization responsible for officially endorsing the content for use in some settingendorser : ContactDetail [0..*]Related artifacts such as additional documentation, justification, or bibliographic referencesrelatedArtifact : RelatedArtifact [0..*]Type of synthesis eg meta-analysissynthesisType : CodeableConcept [0..1] « Types of combining results from a body of evidence (eg. summary data meta-analysis). (Strength=Extensible)SynthesisType+ »Type of study eg randomized trialstudyType : CodeableConcept [0..1] « Types of research studies (types of research methods). (Strength=Extensible)StudyType+ »A reference to a EvidenceVariable resource that defines the population for the researchpopulation : Reference [1..1] « EvidenceVariable »A reference to a EvidenceVariable resource that defines the exposure for the researchexposure : Reference [1..1] « EvidenceVariable »A reference to a EvidenceVariable resource that defines the comparison exposure for the researchexposureAlternative : Reference [1..1] « EvidenceVariable »A reference to a EvidenceVariable resomece that defines the outcome for the researchoutcome : Reference [1..1] « EvidenceVariable »SampleSizeHuman-readable summary of sample sizedescription : string [0..1]Number of studies included in this evidence synthesisnumberOfStudies : integer [0..1]Number of participants included in this evidence synthesisnumberOfParticipants : integer [0..1]ResultsByExposureHuman-readable summary of results by exposure statedescription : string [0..1]Whether these results are for the exposure state or alternative exposure stateexposureState : code [0..1] « Whether the results by exposure is describing the results for the primary exposure of interest (exposure) or the alternative state (exposureAlternative). (Strength=Required)ExposureState! »Used to define variant exposure states such as low-risk statevariantState : CodeableConcept [0..1] « Used for results by exposure in variant states such as low-risk, medium-risk and high-risk states. (Strength=Extensible)EvidenceVariantState+ »Reference to a RiskEvidenceSynthesis resourceriskEvidenceSynthesis : Reference [1..1] « RiskEvidenceSynthesis »EffectEstimateHuman-readable summary of effect estimatedescription : string [0..1]Examples include relative risk and mean differencetype : CodeableConcept [0..1] « Whether the effect estimate is an absolute effect estimate (absolute difference) or a relative effect estimate (relative difference), and the specific type of effect estimate (eg relative risk or median difference). (Strength=Extensible)EffectEstimateType+ »Used to define variant exposure states such as low-risk statevariantState : CodeableConcept [0..1] « Used for results by exposure in variant states such as low-risk, medium-risk and high-risk states. (Strength=Extensible)EvidenceVariantState+ »The point estimate of the effect estimatevalue : decimal [0..1]Specifies the UCUM unit for the outcomeunitOfMeasure : CodeableConcept [0..1] « Unified Code for Units of Measure (UCUM). (Strength=Required)UCUMCodes! »PrecisionEstimateExamples include confidence interval and interquartile rangetype : CodeableConcept [0..1] « Method of reporting variability of estimates, such as confidence intervals, interquartile range or standard deviation. (Strength=Extensible)PrecisionEstimateType+ »Use 95 for a 95% confidence intervallevel : decimal [0..1]Lower bound of confidence intervalfrom : decimal [0..1]Upper bound of confidence intervalto : decimal [0..1]CertaintyA rating of the certainty of the effect estimaterating : CodeableConcept [0..*] « The quality of the evidence described. The code system used specifies the quality scale used to grade this evidence source while the code specifies the actual quality score (represented as a coded value) associated with the evidence. (Strength=Extensible)QualityOfEvidenceRating+ »A human-readable string to clarify or explain concepts about the resourcenote : Annotation [0..*]CertaintySubcomponentType of subcomponent of certainty ratingtype : CodeableConcept [0..1] « The subcomponent classification of quality of evidence rating systems. (Strength=Extensible)CertaintySubcomponentType+ »A rating of a subcomponent of rating certaintyrating : CodeableConcept [0..*] « The quality rating of the subcomponent of a quality of evidence rating. (Strength=Extensible)CertaintySubcomponentRating+ »A human-readable string to clarify or explain concepts about the resourcenote : Annotation [0..*]A description of the size of the sample involved in the synthesissampleSize[0..1]A description of the results for each exposure considered in the effect estimateresultsByExposure[0..*]A description of the precision of the estimate for the effectprecisionEstimate[0..*]The estimated effect of the exposure varianteffectEstimate[0..*]A description of a component of the overall certaintycertaintySubcomponent[0..*]A description of the certainty of the effect estimatecertainty[0..*]

XML Template

<EffectEvidenceSynthesis xmlns="http://hl7.org/fhir"> doco
 <!-- from Resource: id, meta, implicitRules, and language -->
 <!-- from DomainResource: text, contained, extension, and modifierExtension -->
 <url value="[uri]"/><!-- 0..1 Canonical identifier for this effect evidence synthesis, represented as a URI (globally unique) -->
 <identifier><!-- 0..* Identifier Additional identifier for the effect evidence synthesis --></identifier>
 <version value="[string]"/><!-- 0..1 Business version of the effect evidence synthesis -->
 <name value="[string]"/><!-- ?? 0..1 Name for this effect evidence synthesis (computer friendly) -->
 <title value="[string]"/><!-- 0..1 Name for this effect evidence synthesis (human friendly) -->
 <status value="[code]"/><!-- 1..1 draft | active | retired | unknown -->
 <date value="[dateTime]"/><!-- 0..1 Date last changed -->
 <publisher value="[string]"/><!-- 0..1 Name of the publisher (organization or individual) -->
 <contact><!-- 0..* ContactDetail Contact details for the publisher --></contact>
 <description value="[markdown]"/><!-- 0..1 Natural language description of the effect evidence synthesis -->
 <note><!-- 0..* Annotation Used for footnotes or explanatory notes --></note>
 <useContext><!-- 0..* UsageContext The context that the content is intended to support --></useContext>
 <jurisdiction><!-- 0..* CodeableConcept Intended jurisdiction for effect evidence synthesis (if applicable) --></jurisdiction>
 <copyright value="[markdown]"/><!-- 0..1 Use and/or publishing restrictions -->
 <approvalDate value="[date]"/><!-- 0..1 When the effect evidence synthesis was approved by publisher -->
 <lastReviewDate value="[date]"/><!-- 0..1 When the effect evidence synthesis was last reviewed -->
 <effectivePeriod><!-- 0..1 Period When the effect evidence synthesis is expected to be used --></effectivePeriod>
 <topic><!-- 0..* CodeableConcept The category of the EffectEvidenceSynthesis, such as Education, Treatment, Assessment, etc. --></topic>
 <author><!-- 0..* ContactDetail Who authored the content --></author>
 <editor><!-- 0..* ContactDetail Who edited the content --></editor>
 <reviewer><!-- 0..* ContactDetail Who reviewed the content --></reviewer>
 <endorser><!-- 0..* ContactDetail Who endorsed the content --></endorser>
 <relatedArtifact><!-- 0..* RelatedArtifact Additional documentation, citations, etc. --></relatedArtifact>
 <synthesisType><!-- 0..1 CodeableConcept Type of synthesis --></synthesisType>
 <studyType><!-- 0..1 CodeableConcept Type of study --></studyType>
 <population><!-- 1..1 Reference(EvidenceVariable) What population? --></population>
 <exposure><!-- 1..1 Reference(EvidenceVariable) What exposure? --></exposure>
 <exposureAlternative><!-- 1..1 Reference(EvidenceVariable) What comparison exposure? --></exposureAlternative>
 <outcome><!-- 1..1 Reference(EvidenceVariable) What outcome? --></outcome>
 <sampleSize>  <!-- 0..1 What sample size was involved? -->
  <description value="[string]"/><!-- 0..1 Description of sample size -->
  <numberOfStudies value="[integer]"/><!-- 0..1 How many studies? -->
  <numberOfParticipants value="[integer]"/><!-- 0..1 How many participants? -->
 </sampleSize>
 <resultsByExposure>  <!-- 0..* What was the result per exposure? -->
  <description value="[string]"/><!-- 0..1 Description of results by exposure -->
  <exposureState value="[code]"/><!-- 0..1 exposure | exposure-alternative -->
  <variantState><!-- 0..1 CodeableConcept Variant exposure states --></variantState>
  <riskEvidenceSynthesis><!-- 1..1 Reference(RiskEvidenceSynthesis) Risk evidence synthesis --></riskEvidenceSynthesis>
 </resultsByExposure>
 <effectEstimate>  <!-- 0..* What was the estimated effect -->
  <description value="[string]"/><!-- 0..1 Description of effect estimate -->
  <type><!-- 0..1 CodeableConcept Type of efffect estimate --></type>
  <variantState><!-- 0..1 CodeableConcept Variant exposure states --></variantState>
  <value value="[decimal]"/><!-- 0..1 Point estimate -->
  <unitOfMeasure><!-- 0..1 CodeableConcept What unit is the outcome described in? --></unitOfMeasure>
  <precisionEstimate>  <!-- 0..* How precise the estimate is -->
   <type><!-- 0..1 CodeableConcept Type of precision estimate --></type>
   <level value="[decimal]"/><!-- 0..1 Level of confidence interval -->
   <from value="[decimal]"/><!-- 0..1 Lower bound -->
   <to value="[decimal]"/><!-- 0..1 Upper bound -->
  </precisionEstimate>
 </effectEstimate>
 <certainty>  <!-- 0..* How certain is the effect -->
  <rating><!-- 0..* CodeableConcept Certainty rating --></rating>
  <note><!-- 0..* Annotation Used for footnotes or explanatory notes --></note>
  <certaintySubcomponent>  <!-- 0..* A component that contributes to the overall certainty -->
   <type><!-- 0..1 CodeableConcept Type of subcomponent of certainty rating --></type>
   <rating><!-- 0..* CodeableConcept Subcomponent certainty rating --></rating>
   <note><!-- 0..* Annotation Used for footnotes or explanatory notes --></note>
  </certaintySubcomponent>
 </certainty>
</EffectEvidenceSynthesis>

JSON Template

{doco
  "resourceType" : "EffectEvidenceSynthesis",
  // from Resource: id, meta, implicitRules, and language
  // from DomainResource: text, contained, extension, and modifierExtension
  "url" : "<uri>", // Canonical identifier for this effect evidence synthesis, represented as a URI (globally unique)
  "identifier" : [{ Identifier }], // Additional identifier for the effect evidence synthesis
  "version" : "<string>", // Business version of the effect evidence synthesis
  "name" : "<string>", // C? Name for this effect evidence synthesis (computer friendly)
  "title" : "<string>", // Name for this effect evidence synthesis (human friendly)
  "status" : "<code>", // R!  draft | active | retired | unknown
  "date" : "<dateTime>", // Date last changed
  "publisher" : "<string>", // Name of the publisher (organization or individual)
  "contact" : [{ ContactDetail }], // Contact details for the publisher
  "description" : "<markdown>", // Natural language description of the effect evidence synthesis
  "note" : [{ Annotation }], // Used for footnotes or explanatory notes
  "useContext" : [{ UsageContext }], // The context that the content is intended to support
  "jurisdiction" : [{ CodeableConcept }], // Intended jurisdiction for effect evidence synthesis (if applicable)
  "copyright" : "<markdown>", // Use and/or publishing restrictions
  "approvalDate" : "<date>", // When the effect evidence synthesis was approved by publisher
  "lastReviewDate" : "<date>", // When the effect evidence synthesis was last reviewed
  "effectivePeriod" : { Period }, // When the effect evidence synthesis is expected to be used
  "topic" : [{ CodeableConcept }], // The category of the EffectEvidenceSynthesis, such as Education, Treatment, Assessment, etc.
  "author" : [{ ContactDetail }], // Who authored the content
  "editor" : [{ ContactDetail }], // Who edited the content
  "reviewer" : [{ ContactDetail }], // Who reviewed the content
  "endorser" : [{ ContactDetail }], // Who endorsed the content
  "relatedArtifact" : [{ RelatedArtifact }], // Additional documentation, citations, etc.
  "synthesisType" : { CodeableConcept }, // Type of synthesis
  "studyType" : { CodeableConcept }, // Type of study
  "population" : { Reference(EvidenceVariable) }, // R!  What population?
  "exposure" : { Reference(EvidenceVariable) }, // R!  What exposure?
  "exposureAlternative" : { Reference(EvidenceVariable) }, // R!  What comparison exposure?
  "outcome" : { Reference(EvidenceVariable) }, // R!  What outcome?
  "sampleSize" : { // What sample size was involved?
    "description" : "<string>", // Description of sample size
    "numberOfStudies" : <integer>, // How many studies?
    "numberOfParticipants" : <integer> // How many participants?
  },
  "resultsByExposure" : [{ // What was the result per exposure?
    "description" : "<string>", // Description of results by exposure
    "exposureState" : "<code>", // exposure | exposure-alternative
    "variantState" : { CodeableConcept }, // Variant exposure states
    "riskEvidenceSynthesis" : { Reference(RiskEvidenceSynthesis) } // R!  Risk evidence synthesis
  }],
  "effectEstimate" : [{ // What was the estimated effect
    "description" : "<string>", // Description of effect estimate
    "type" : { CodeableConcept }, // Type of efffect estimate
    "variantState" : { CodeableConcept }, // Variant exposure states
    "value" : <decimal>, // Point estimate
    "unitOfMeasure" : { CodeableConcept }, // What unit is the outcome described in?
    "precisionEstimate" : [{ // How precise the estimate is
      "type" : { CodeableConcept }, // Type of precision estimate
      "level" : <decimal>, // Level of confidence interval
      "from" : <decimal>, // Lower bound
      "to" : <decimal> // Upper bound
    }]
  }],
  "certainty" : [{ // How certain is the effect
    "rating" : [{ CodeableConcept }], // Certainty rating
    "note" : [{ Annotation }], // Used for footnotes or explanatory notes
    "certaintySubcomponent" : [{ // A component that contributes to the overall certainty
      "type" : { CodeableConcept }, // Type of subcomponent of certainty rating
      "rating" : [{ CodeableConcept }], // Subcomponent certainty rating
      "note" : [{ Annotation }] // Used for footnotes or explanatory notes
    }]
  }]
}

Turtle Template

@prefix fhir: <http://hl7.org/fhir/> .doco


[ a fhir:EffectEvidenceSynthesis;
  fhir:nodeRole fhir:treeRoot; # if this is the parser root

  # from Resource: .id, .meta, .implicitRules, and .language
  # from DomainResource: .text, .contained, .extension, and .modifierExtension
  fhir:EffectEvidenceSynthesis.url [ uri ]; # 0..1 Canonical identifier for this effect evidence synthesis, represented as a URI (globally unique)
  fhir:EffectEvidenceSynthesis.identifier [ Identifier ], ... ; # 0..* Additional identifier for the effect evidence synthesis
  fhir:EffectEvidenceSynthesis.version [ string ]; # 0..1 Business version of the effect evidence synthesis
  fhir:EffectEvidenceSynthesis.name [ string ]; # 0..1 Name for this effect evidence synthesis (computer friendly)
  fhir:EffectEvidenceSynthesis.title [ string ]; # 0..1 Name for this effect evidence synthesis (human friendly)
  fhir:EffectEvidenceSynthesis.status [ code ]; # 1..1 draft | active | retired | unknown
  fhir:EffectEvidenceSynthesis.date [ dateTime ]; # 0..1 Date last changed
  fhir:EffectEvidenceSynthesis.publisher [ string ]; # 0..1 Name of the publisher (organization or individual)
  fhir:EffectEvidenceSynthesis.contact [ ContactDetail ], ... ; # 0..* Contact details for the publisher
  fhir:EffectEvidenceSynthesis.description [ markdown ]; # 0..1 Natural language description of the effect evidence synthesis
  fhir:EffectEvidenceSynthesis.note [ Annotation ], ... ; # 0..* Used for footnotes or explanatory notes
  fhir:EffectEvidenceSynthesis.useContext [ UsageContext ], ... ; # 0..* The context that the content is intended to support
  fhir:EffectEvidenceSynthesis.jurisdiction [ CodeableConcept ], ... ; # 0..* Intended jurisdiction for effect evidence synthesis (if applicable)
  fhir:EffectEvidenceSynthesis.copyright [ markdown ]; # 0..1 Use and/or publishing restrictions
  fhir:EffectEvidenceSynthesis.approvalDate [ date ]; # 0..1 When the effect evidence synthesis was approved by publisher
  fhir:EffectEvidenceSynthesis.lastReviewDate [ date ]; # 0..1 When the effect evidence synthesis was last reviewed
  fhir:EffectEvidenceSynthesis.effectivePeriod [ Period ]; # 0..1 When the effect evidence synthesis is expected to be used
  fhir:EffectEvidenceSynthesis.topic [ CodeableConcept ], ... ; # 0..* The category of the EffectEvidenceSynthesis, such as Education, Treatment, Assessment, etc.
  fhir:EffectEvidenceSynthesis.author [ ContactDetail ], ... ; # 0..* Who authored the content
  fhir:EffectEvidenceSynthesis.editor [ ContactDetail ], ... ; # 0..* Who edited the content
  fhir:EffectEvidenceSynthesis.reviewer [ ContactDetail ], ... ; # 0..* Who reviewed the content
  fhir:EffectEvidenceSynthesis.endorser [ ContactDetail ], ... ; # 0..* Who endorsed the content
  fhir:EffectEvidenceSynthesis.relatedArtifact [ RelatedArtifact ], ... ; # 0..* Additional documentation, citations, etc.
  fhir:EffectEvidenceSynthesis.synthesisType [ CodeableConcept ]; # 0..1 Type of synthesis
  fhir:EffectEvidenceSynthesis.studyType [ CodeableConcept ]; # 0..1 Type of study
  fhir:EffectEvidenceSynthesis.population [ Reference(EvidenceVariable) ]; # 1..1 What population?
  fhir:EffectEvidenceSynthesis.exposure [ Reference(EvidenceVariable) ]; # 1..1 What exposure?
  fhir:EffectEvidenceSynthesis.exposureAlternative [ Reference(EvidenceVariable) ]; # 1..1 What comparison exposure?
  fhir:EffectEvidenceSynthesis.outcome [ Reference(EvidenceVariable) ]; # 1..1 What outcome?
  fhir:EffectEvidenceSynthesis.sampleSize [ # 0..1 What sample size was involved?
    fhir:EffectEvidenceSynthesis.sampleSize.description [ string ]; # 0..1 Description of sample size
    fhir:EffectEvidenceSynthesis.sampleSize.numberOfStudies [ integer ]; # 0..1 How many studies?
    fhir:EffectEvidenceSynthesis.sampleSize.numberOfParticipants [ integer ]; # 0..1 How many participants?
  ];
  fhir:EffectEvidenceSynthesis.resultsByExposure [ # 0..* What was the result per exposure?
    fhir:EffectEvidenceSynthesis.resultsByExposure.description [ string ]; # 0..1 Description of results by exposure
    fhir:EffectEvidenceSynthesis.resultsByExposure.exposureState [ code ]; # 0..1 exposure | exposure-alternative
    fhir:EffectEvidenceSynthesis.resultsByExposure.variantState [ CodeableConcept ]; # 0..1 Variant exposure states
    fhir:EffectEvidenceSynthesis.resultsByExposure.riskEvidenceSynthesis [ Reference(RiskEvidenceSynthesis) ]; # 1..1 Risk evidence synthesis
  ], ...;
  fhir:EffectEvidenceSynthesis.effectEstimate [ # 0..* What was the estimated effect
    fhir:EffectEvidenceSynthesis.effectEstimate.description [ string ]; # 0..1 Description of effect estimate
    fhir:EffectEvidenceSynthesis.effectEstimate.type [ CodeableConcept ]; # 0..1 Type of efffect estimate
    fhir:EffectEvidenceSynthesis.effectEstimate.variantState [ CodeableConcept ]; # 0..1 Variant exposure states
    fhir:EffectEvidenceSynthesis.effectEstimate.value [ decimal ]; # 0..1 Point estimate
    fhir:EffectEvidenceSynthesis.effectEstimate.unitOfMeasure [ CodeableConcept ]; # 0..1 What unit is the outcome described in?
    fhir:EffectEvidenceSynthesis.effectEstimate.precisionEstimate [ # 0..* How precise the estimate is
      fhir:EffectEvidenceSynthesis.effectEstimate.precisionEstimate.type [ CodeableConcept ]; # 0..1 Type of precision estimate
      fhir:EffectEvidenceSynthesis.effectEstimate.precisionEstimate.level [ decimal ]; # 0..1 Level of confidence interval
      fhir:EffectEvidenceSynthesis.effectEstimate.precisionEstimate.from [ decimal ]; # 0..1 Lower bound
      fhir:EffectEvidenceSynthesis.effectEstimate.precisionEstimate.to [ decimal ]; # 0..1 Upper bound
    ], ...;
  ], ...;
  fhir:EffectEvidenceSynthesis.certainty [ # 0..* How certain is the effect
    fhir:EffectEvidenceSynthesis.certainty.rating [ CodeableConcept ], ... ; # 0..* Certainty rating
    fhir:EffectEvidenceSynthesis.certainty.note [ Annotation ], ... ; # 0..* Used for footnotes or explanatory notes
    fhir:EffectEvidenceSynthesis.certainty.certaintySubcomponent [ # 0..* A component that contributes to the overall certainty
      fhir:EffectEvidenceSynthesis.certainty.certaintySubcomponent.type [ CodeableConcept ]; # 0..1 Type of subcomponent of certainty rating
      fhir:EffectEvidenceSynthesis.certainty.certaintySubcomponent.rating [ CodeableConcept ], ... ; # 0..* Subcomponent certainty rating
      fhir:EffectEvidenceSynthesis.certainty.certaintySubcomponent.note [ Annotation ], ... ; # 0..* Used for footnotes or explanatory notes
    ], ...;
  ], ...;
]

Changes since R3

This resource did not exist in Release 2

This analysis is available as XML or JSON.

Structure

NameFlagsCard.TypeDescription & Constraintsdoco
.. EffectEvidenceSynthesis ITUDomainResourceA quantified estimate of effect based on a body of evidence
+ Warning: Name should be usable as an identifier for the module by machine processing applications such as code generation
Elements defined in Ancestors: id, meta, implicitRules, language, text, contained, extension, modifierExtension
... url Σ0..1uriCanonical identifier for this effect evidence synthesis, represented as a URI (globally unique)
... identifier Σ0..*IdentifierAdditional identifier for the effect evidence synthesis
... version Σ0..1stringBusiness version of the effect evidence synthesis
... name ΣI0..1stringName for this effect evidence synthesis (computer friendly)
... title Σ0..1stringName for this effect evidence synthesis (human friendly)
... status ?!Σ1..1codedraft | active | retired | unknown
PublicationStatus (Required)
... date Σ0..1dateTimeDate last changed
... publisher Σ0..1stringName of the publisher (organization or individual)
... contact Σ0..*ContactDetailContact details for the publisher
... description Σ0..1markdownNatural language description of the effect evidence synthesis
... note 0..*AnnotationUsed for footnotes or explanatory notes
... useContext Σ0..*UsageContextThe context that the content is intended to support
... jurisdiction Σ0..*CodeableConceptIntended jurisdiction for effect evidence synthesis (if applicable)
Jurisdiction (Extensible)
... copyright 0..1markdownUse and/or publishing restrictions
... approvalDate 0..1dateWhen the effect evidence synthesis was approved by publisher
... lastReviewDate 0..1dateWhen the effect evidence synthesis was last reviewed
... effectivePeriod Σ0..1PeriodWhen the effect evidence synthesis is expected to be used
... topic 0..*CodeableConceptThe category of the EffectEvidenceSynthesis, such as Education, Treatment, Assessment, etc.
DefinitionTopic (Example)
... author 0..*ContactDetailWho authored the content
... editor 0..*ContactDetailWho edited the content
... reviewer 0..*ContactDetailWho reviewed the content
... endorser 0..*ContactDetailWho endorsed the content
... relatedArtifact 0..*RelatedArtifactAdditional documentation, citations, etc.
... synthesisType 0..1CodeableConceptType of synthesis
SynthesisType (Extensible)
... studyType 0..1CodeableConceptType of study
StudyType (Extensible)
... population Σ1..1Reference(EvidenceVariable)What population?
... exposure Σ1..1Reference(EvidenceVariable)What exposure?
... exposureAlternative Σ1..1Reference(EvidenceVariable)What comparison exposure?
... outcome Σ1..1Reference(EvidenceVariable)What outcome?
... sampleSize 0..1BackboneElementWhat sample size was involved?
.... description 0..1stringDescription of sample size
.... numberOfStudies 0..1integerHow many studies?
.... numberOfParticipants 0..1integerHow many participants?
... resultsByExposure 0..*BackboneElementWhat was the result per exposure?
.... description 0..1stringDescription of results by exposure
.... exposureState 0..1codeexposure | exposure-alternative
ExposureState (Required)
.... variantState 0..1CodeableConceptVariant exposure states
EvidenceVariantState (Extensible)
.... riskEvidenceSynthesis 1..1Reference(RiskEvidenceSynthesis)Risk evidence synthesis
... effectEstimate Σ0..*BackboneElementWhat was the estimated effect
.... description 0..1stringDescription of effect estimate
.... type 0..1CodeableConceptType of efffect estimate
EffectEstimateType (Extensible)
.... variantState 0..1CodeableConceptVariant exposure states
EvidenceVariantState (Extensible)
.... value 0..1decimalPoint estimate
.... unitOfMeasure 0..1CodeableConceptWhat unit is the outcome described in?
UCUM Codes (Required)
.... precisionEstimate 0..*BackboneElementHow precise the estimate is
..... type 0..1CodeableConceptType of precision estimate
PrecisionEstimateType (Extensible)
..... level 0..1decimalLevel of confidence interval
..... from 0..1decimalLower bound
..... to 0..1decimalUpper bound
... certainty 0..*BackboneElementHow certain is the effect
.... rating 0..*CodeableConceptCertainty rating
QualityOfEvidenceRating (Extensible)
.... note 0..*AnnotationUsed for footnotes or explanatory notes
.... certaintySubcomponent 0..*BackboneElementA component that contributes to the overall certainty
..... type 0..1CodeableConceptType of subcomponent of certainty rating
CertaintySubcomponentType (Extensible)
..... rating 0..*CodeableConceptSubcomponent certainty rating
CertaintySubcomponentRating (Extensible)
..... note 0..*AnnotationUsed for footnotes or explanatory notes

doco Documentation for this format

UML Diagram (Legend)

EffectEvidenceSynthesis (DomainResource)An absolute URI that is used to identify this effect evidence synthesis when it is referenced in a specification, model, design or an instance; also called its canonical identifier. This SHOULD be globally unique and SHOULD be a literal address at which at which an authoritative instance of this effect evidence synthesis is (or will be) published. This URL can be the target of a canonical reference. It SHALL remain the same when the effect evidence synthesis is stored on different serversurl : uri [0..1]A formal identifier that is used to identify this effect evidence synthesis when it is represented in other formats, or referenced in a specification, model, design or an instanceidentifier : Identifier [0..*]The identifier that is used to identify this version of the effect evidence synthesis when it is referenced in a specification, model, design or instance. This is an arbitrary value managed by the effect evidence synthesis author and is not expected to be globally unique. For example, it might be a timestamp (e.g. yyyymmdd) if a managed version is not available. There is also no expectation that versions can be placed in a lexicographical sequenceversion : string [0..1]A natural language name identifying the effect evidence synthesis. This name should be usable as an identifier for the module by machine processing applications such as code generationname : string [0..1]A short, descriptive, user-friendly title for the effect evidence synthesistitle : string [0..1]The status of this effect evidence synthesis. Enables tracking the life-cycle of the content (this element modifies the meaning of other elements)status : code [1..1] « The lifecycle status of an artifact. (Strength=Required)PublicationStatus! »The date (and optionally time) when the effect evidence synthesis was published. The date must change when the business version changes and it must change if the status code changes. In addition, it should change when the substantive content of the effect evidence synthesis changesdate : dateTime [0..1]The name of the organization or individual that published the effect evidence synthesispublisher : string [0..1]Contact details to assist a user in finding and communicating with the publishercontact : ContactDetail [0..*]A free text natural language description of the effect evidence synthesis from a consumer's perspectivedescription : markdown [0..1]A human-readable string to clarify or explain concepts about the resourcenote : Annotation [0..*]The content was developed with a focus and intent of supporting the contexts that are listed. These contexts may be general categories (gender, age, ...) or may be references to specific programs (insurance plans, studies, ...) and may be used to assist with indexing and searching for appropriate effect evidence synthesis instancesuseContext : UsageContext [0..*]A legal or geographic region in which the effect evidence synthesis is intended to be usedjurisdiction : CodeableConcept [0..*] « Countries and regions within which this artifact is targeted for use. (Strength=Extensible)Jurisdiction ValueSet+ »A copyright statement relating to the effect evidence synthesis and/or its contents. Copyright statements are generally legal restrictions on the use and publishing of the effect evidence synthesiscopyright : markdown [0..1]The date on which the resource content was approved by the publisher. Approval happens once when the content is officially approved for usageapprovalDate : date [0..1]The date on which the resource content was last reviewed. Review happens periodically after approval but does not change the original approval datelastReviewDate : date [0..1]The period during which the effect evidence synthesis content was or is planned to be in active useeffectivePeriod : Period [0..1]Descriptive topics related to the content of the EffectEvidenceSynthesis. Topics provide a high-level categorization grouping types of EffectEvidenceSynthesiss that can be useful for filtering and searchingtopic : CodeableConcept [0..*] « High-level categorization of the definition, used for searching, sorting, and filtering. (Strength=Example)DefinitionTopic?? »An individiual or organization primarily involved in the creation and maintenance of the contentauthor : ContactDetail [0..*]An individual or organization primarily responsible for internal coherence of the contenteditor : ContactDetail [0..*]An individual or organization primarily responsible for review of some aspect of the contentreviewer : ContactDetail [0..*]An individual or organization responsible for officially endorsing the content for use in some settingendorser : ContactDetail [0..*]Related artifacts such as additional documentation, justification, or bibliographic referencesrelatedArtifact : RelatedArtifact [0..*]Type of synthesis eg meta-analysissynthesisType : CodeableConcept [0..1] « Types of combining results from a body of evidence (eg. summary data meta-analysis). (Strength=Extensible)SynthesisType+ »Type of study eg randomized trialstudyType : CodeableConcept [0..1] « Types of research studies (types of research methods). (Strength=Extensible)StudyType+ »A reference to a EvidenceVariable resource that defines the population for the researchpopulation : Reference [1..1] « EvidenceVariable »A reference to a EvidenceVariable resource that defines the exposure for the researchexposure : Reference [1..1] « EvidenceVariable »A reference to a EvidenceVariable resource that defines the comparison exposure for the researchexposureAlternative : Reference [1..1] « EvidenceVariable »A reference to a EvidenceVariable resomece that defines the outcome for the researchoutcome : Reference [1..1] « EvidenceVariable »SampleSizeHuman-readable summary of sample sizedescription : string [0..1]Number of studies included in this evidence synthesisnumberOfStudies : integer [0..1]Number of participants included in this evidence synthesisnumberOfParticipants : integer [0..1]ResultsByExposureHuman-readable summary of results by exposure statedescription : string [0..1]Whether these results are for the exposure state or alternative exposure stateexposureState : code [0..1] « Whether the results by exposure is describing the results for the primary exposure of interest (exposure) or the alternative state (exposureAlternative). (Strength=Required)ExposureState! »Used to define variant exposure states such as low-risk statevariantState : CodeableConcept [0..1] « Used for results by exposure in variant states such as low-risk, medium-risk and high-risk states. (Strength=Extensible)EvidenceVariantState+ »Reference to a RiskEvidenceSynthesis resourceriskEvidenceSynthesis : Reference [1..1] « RiskEvidenceSynthesis »EffectEstimateHuman-readable summary of effect estimatedescription : string [0..1]Examples include relative risk and mean differencetype : CodeableConcept [0..1] « Whether the effect estimate is an absolute effect estimate (absolute difference) or a relative effect estimate (relative difference), and the specific type of effect estimate (eg relative risk or median difference). (Strength=Extensible)EffectEstimateType+ »Used to define variant exposure states such as low-risk statevariantState : CodeableConcept [0..1] « Used for results by exposure in variant states such as low-risk, medium-risk and high-risk states. (Strength=Extensible)EvidenceVariantState+ »The point estimate of the effect estimatevalue : decimal [0..1]Specifies the UCUM unit for the outcomeunitOfMeasure : CodeableConcept [0..1] « Unified Code for Units of Measure (UCUM). (Strength=Required)UCUMCodes! »PrecisionEstimateExamples include confidence interval and interquartile rangetype : CodeableConcept [0..1] « Method of reporting variability of estimates, such as confidence intervals, interquartile range or standard deviation. (Strength=Extensible)PrecisionEstimateType+ »Use 95 for a 95% confidence intervallevel : decimal [0..1]Lower bound of confidence intervalfrom : decimal [0..1]Upper bound of confidence intervalto : decimal [0..1]CertaintyA rating of the certainty of the effect estimaterating : CodeableConcept [0..*] « The quality of the evidence described. The code system used specifies the quality scale used to grade this evidence source while the code specifies the actual quality score (represented as a coded value) associated with the evidence. (Strength=Extensible)QualityOfEvidenceRating+ »A human-readable string to clarify or explain concepts about the resourcenote : Annotation [0..*]CertaintySubcomponentType of subcomponent of certainty ratingtype : CodeableConcept [0..1] « The subcomponent classification of quality of evidence rating systems. (Strength=Extensible)CertaintySubcomponentType+ »A rating of a subcomponent of rating certaintyrating : CodeableConcept [0..*] « The quality rating of the subcomponent of a quality of evidence rating. (Strength=Extensible)CertaintySubcomponentRating+ »A human-readable string to clarify or explain concepts about the resourcenote : Annotation [0..*]A description of the size of the sample involved in the synthesissampleSize[0..1]A description of the results for each exposure considered in the effect estimateresultsByExposure[0..*]A description of the precision of the estimate for the effectprecisionEstimate[0..*]The estimated effect of the exposure varianteffectEstimate[0..*]A description of a component of the overall certaintycertaintySubcomponent[0..*]A description of the certainty of the effect estimatecertainty[0..*]

XML Template

<EffectEvidenceSynthesis xmlns="http://hl7.org/fhir"> doco
 <!-- from Resource: id, meta, implicitRules, and language -->
 <!-- from DomainResource: text, contained, extension, and modifierExtension -->
 <url value="[uri]"/><!-- 0..1 Canonical identifier for this effect evidence synthesis, represented as a URI (globally unique) -->
 <identifier><!-- 0..* Identifier Additional identifier for the effect evidence synthesis --></identifier>
 <version value="[string]"/><!-- 0..1 Business version of the effect evidence synthesis -->
 <name value="[string]"/><!-- ?? 0..1 Name for this effect evidence synthesis (computer friendly) -->
 <title value="[string]"/><!-- 0..1 Name for this effect evidence synthesis (human friendly) -->
 <status value="[code]"/><!-- 1..1 draft | active | retired | unknown -->
 <date value="[dateTime]"/><!-- 0..1 Date last changed -->
 <publisher value="[string]"/><!-- 0..1 Name of the publisher (organization or individual) -->
 <contact><!-- 0..* ContactDetail Contact details for the publisher --></contact>
 <description value="[markdown]"/><!-- 0..1 Natural language description of the effect evidence synthesis -->
 <note><!-- 0..* Annotation Used for footnotes or explanatory notes --></note>
 <useContext><!-- 0..* UsageContext The context that the content is intended to support --></useContext>
 <jurisdiction><!-- 0..* CodeableConcept Intended jurisdiction for effect evidence synthesis (if applicable) --></jurisdiction>
 <copyright value="[markdown]"/><!-- 0..1 Use and/or publishing restrictions -->
 <approvalDate value="[date]"/><!-- 0..1 When the effect evidence synthesis was approved by publisher -->
 <lastReviewDate value="[date]"/><!-- 0..1 When the effect evidence synthesis was last reviewed -->
 <effectivePeriod><!-- 0..1 Period When the effect evidence synthesis is expected to be used --></effectivePeriod>
 <topic><!-- 0..* CodeableConcept The category of the EffectEvidenceSynthesis, such as Education, Treatment, Assessment, etc. --></topic>
 <author><!-- 0..* ContactDetail Who authored the content --></author>
 <editor><!-- 0..* ContactDetail Who edited the content --></editor>
 <reviewer><!-- 0..* ContactDetail Who reviewed the content --></reviewer>
 <endorser><!-- 0..* ContactDetail Who endorsed the content --></endorser>
 <relatedArtifact><!-- 0..* RelatedArtifact Additional documentation, citations, etc. --></relatedArtifact>
 <synthesisType><!-- 0..1 CodeableConcept Type of synthesis --></synthesisType>
 <studyType><!-- 0..1 CodeableConcept Type of study --></studyType>
 <population><!-- 1..1 Reference(EvidenceVariable) What population? --></population>
 <exposure><!-- 1..1 Reference(EvidenceVariable) What exposure? --></exposure>
 <exposureAlternative><!-- 1..1 Reference(EvidenceVariable) What comparison exposure? --></exposureAlternative>
 <outcome><!-- 1..1 Reference(EvidenceVariable) What outcome? --></outcome>
 <sampleSize>  <!-- 0..1 What sample size was involved? -->
  <description value="[string]"/><!-- 0..1 Description of sample size -->
  <numberOfStudies value="[integer]"/><!-- 0..1 How many studies? -->
  <numberOfParticipants value="[integer]"/><!-- 0..1 How many participants? -->
 </sampleSize>
 <resultsByExposure>  <!-- 0..* What was the result per exposure? -->
  <description value="[string]"/><!-- 0..1 Description of results by exposure -->
  <exposureState value="[code]"/><!-- 0..1 exposure | exposure-alternative -->
  <variantState><!-- 0..1 CodeableConcept Variant exposure states --></variantState>
  <riskEvidenceSynthesis><!-- 1..1 Reference(RiskEvidenceSynthesis) Risk evidence synthesis --></riskEvidenceSynthesis>
 </resultsByExposure>
 <effectEstimate>  <!-- 0..* What was the estimated effect -->
  <description value="[string]"/><!-- 0..1 Description of effect estimate -->
  <type><!-- 0..1 CodeableConcept Type of efffect estimate --></type>
  <variantState><!-- 0..1 CodeableConcept Variant exposure states --></variantState>
  <value value="[decimal]"/><!-- 0..1 Point estimate -->
  <unitOfMeasure><!-- 0..1 CodeableConcept What unit is the outcome described in? --></unitOfMeasure>
  <precisionEstimate>  <!-- 0..* How precise the estimate is -->
   <type><!-- 0..1 CodeableConcept Type of precision estimate --></type>
   <level value="[decimal]"/><!-- 0..1 Level of confidence interval -->
   <from value="[decimal]"/><!-- 0..1 Lower bound -->
   <to value="[decimal]"/><!-- 0..1 Upper bound -->
  </precisionEstimate>
 </effectEstimate>
 <certainty>  <!-- 0..* How certain is the effect -->
  <rating><!-- 0..* CodeableConcept Certainty rating --></rating>
  <note><!-- 0..* Annotation Used for footnotes or explanatory notes --></note>
  <certaintySubcomponent>  <!-- 0..* A component that contributes to the overall certainty -->
   <type><!-- 0..1 CodeableConcept Type of subcomponent of certainty rating --></type>
   <rating><!-- 0..* CodeableConcept Subcomponent certainty rating --></rating>
   <note><!-- 0..* Annotation Used for footnotes or explanatory notes --></note>
  </certaintySubcomponent>
 </certainty>
</EffectEvidenceSynthesis>

JSON Template

{doco
  "resourceType" : "EffectEvidenceSynthesis",
  // from Resource: id, meta, implicitRules, and language
  // from DomainResource: text, contained, extension, and modifierExtension
  "url" : "<uri>", // Canonical identifier for this effect evidence synthesis, represented as a URI (globally unique)
  "identifier" : [{ Identifier }], // Additional identifier for the effect evidence synthesis
  "version" : "<string>", // Business version of the effect evidence synthesis
  "name" : "<string>", // C? Name for this effect evidence synthesis (computer friendly)
  "title" : "<string>", // Name for this effect evidence synthesis (human friendly)
  "status" : "<code>", // R!  draft | active | retired | unknown
  "date" : "<dateTime>", // Date last changed
  "publisher" : "<string>", // Name of the publisher (organization or individual)
  "contact" : [{ ContactDetail }], // Contact details for the publisher
  "description" : "<markdown>", // Natural language description of the effect evidence synthesis
  "note" : [{ Annotation }], // Used for footnotes or explanatory notes
  "useContext" : [{ UsageContext }], // The context that the content is intended to support
  "jurisdiction" : [{ CodeableConcept }], // Intended jurisdiction for effect evidence synthesis (if applicable)
  "copyright" : "<markdown>", // Use and/or publishing restrictions
  "approvalDate" : "<date>", // When the effect evidence synthesis was approved by publisher
  "lastReviewDate" : "<date>", // When the effect evidence synthesis was last reviewed
  "effectivePeriod" : { Period }, // When the effect evidence synthesis is expected to be used
  "topic" : [{ CodeableConcept }], // The category of the EffectEvidenceSynthesis, such as Education, Treatment, Assessment, etc.
  "author" : [{ ContactDetail }], // Who authored the content
  "editor" : [{ ContactDetail }], // Who edited the content
  "reviewer" : [{ ContactDetail }], // Who reviewed the content
  "endorser" : [{ ContactDetail }], // Who endorsed the content
  "relatedArtifact" : [{ RelatedArtifact }], // Additional documentation, citations, etc.
  "synthesisType" : { CodeableConcept }, // Type of synthesis
  "studyType" : { CodeableConcept }, // Type of study
  "population" : { Reference(EvidenceVariable) }, // R!  What population?
  "exposure" : { Reference(EvidenceVariable) }, // R!  What exposure?
  "exposureAlternative" : { Reference(EvidenceVariable) }, // R!  What comparison exposure?
  "outcome" : { Reference(EvidenceVariable) }, // R!  What outcome?
  "sampleSize" : { // What sample size was involved?
    "description" : "<string>", // Description of sample size
    "numberOfStudies" : <integer>, // How many studies?
    "numberOfParticipants" : <integer> // How many participants?
  },
  "resultsByExposure" : [{ // What was the result per exposure?
    "description" : "<string>", // Description of results by exposure
    "exposureState" : "<code>", // exposure | exposure-alternative
    "variantState" : { CodeableConcept }, // Variant exposure states
    "riskEvidenceSynthesis" : { Reference(RiskEvidenceSynthesis) } // R!  Risk evidence synthesis
  }],
  "effectEstimate" : [{ // What was the estimated effect
    "description" : "<string>", // Description of effect estimate
    "type" : { CodeableConcept }, // Type of efffect estimate
    "variantState" : { CodeableConcept }, // Variant exposure states
    "value" : <decimal>, // Point estimate
    "unitOfMeasure" : { CodeableConcept }, // What unit is the outcome described in?
    "precisionEstimate" : [{ // How precise the estimate is
      "type" : { CodeableConcept }, // Type of precision estimate
      "level" : <decimal>, // Level of confidence interval
      "from" : <decimal>, // Lower bound
      "to" : <decimal> // Upper bound
    }]
  }],
  "certainty" : [{ // How certain is the effect
    "rating" : [{ CodeableConcept }], // Certainty rating
    "note" : [{ Annotation }], // Used for footnotes or explanatory notes
    "certaintySubcomponent" : [{ // A component that contributes to the overall certainty
      "type" : { CodeableConcept }, // Type of subcomponent of certainty rating
      "rating" : [{ CodeableConcept }], // Subcomponent certainty rating
      "note" : [{ Annotation }] // Used for footnotes or explanatory notes
    }]
  }]
}

Turtle Template

@prefix fhir: <http://hl7.org/fhir/> .doco


[ a fhir:EffectEvidenceSynthesis;
  fhir:nodeRole fhir:treeRoot; # if this is the parser root

  # from Resource: .id, .meta, .implicitRules, and .language
  # from DomainResource: .text, .contained, .extension, and .modifierExtension
  fhir:EffectEvidenceSynthesis.url [ uri ]; # 0..1 Canonical identifier for this effect evidence synthesis, represented as a URI (globally unique)
  fhir:EffectEvidenceSynthesis.identifier [ Identifier ], ... ; # 0..* Additional identifier for the effect evidence synthesis
  fhir:EffectEvidenceSynthesis.version [ string ]; # 0..1 Business version of the effect evidence synthesis
  fhir:EffectEvidenceSynthesis.name [ string ]; # 0..1 Name for this effect evidence synthesis (computer friendly)
  fhir:EffectEvidenceSynthesis.title [ string ]; # 0..1 Name for this effect evidence synthesis (human friendly)
  fhir:EffectEvidenceSynthesis.status [ code ]; # 1..1 draft | active | retired | unknown
  fhir:EffectEvidenceSynthesis.date [ dateTime ]; # 0..1 Date last changed
  fhir:EffectEvidenceSynthesis.publisher [ string ]; # 0..1 Name of the publisher (organization or individual)
  fhir:EffectEvidenceSynthesis.contact [ ContactDetail ], ... ; # 0..* Contact details for the publisher
  fhir:EffectEvidenceSynthesis.description [ markdown ]; # 0..1 Natural language description of the effect evidence synthesis
  fhir:EffectEvidenceSynthesis.note [ Annotation ], ... ; # 0..* Used for footnotes or explanatory notes
  fhir:EffectEvidenceSynthesis.useContext [ UsageContext ], ... ; # 0..* The context that the content is intended to support
  fhir:EffectEvidenceSynthesis.jurisdiction [ CodeableConcept ], ... ; # 0..* Intended jurisdiction for effect evidence synthesis (if applicable)
  fhir:EffectEvidenceSynthesis.copyright [ markdown ]; # 0..1 Use and/or publishing restrictions
  fhir:EffectEvidenceSynthesis.approvalDate [ date ]; # 0..1 When the effect evidence synthesis was approved by publisher
  fhir:EffectEvidenceSynthesis.lastReviewDate [ date ]; # 0..1 When the effect evidence synthesis was last reviewed
  fhir:EffectEvidenceSynthesis.effectivePeriod [ Period ]; # 0..1 When the effect evidence synthesis is expected to be used
  fhir:EffectEvidenceSynthesis.topic [ CodeableConcept ], ... ; # 0..* The category of the EffectEvidenceSynthesis, such as Education, Treatment, Assessment, etc.
  fhir:EffectEvidenceSynthesis.author [ ContactDetail ], ... ; # 0..* Who authored the content
  fhir:EffectEvidenceSynthesis.editor [ ContactDetail ], ... ; # 0..* Who edited the content
  fhir:EffectEvidenceSynthesis.reviewer [ ContactDetail ], ... ; # 0..* Who reviewed the content
  fhir:EffectEvidenceSynthesis.endorser [ ContactDetail ], ... ; # 0..* Who endorsed the content
  fhir:EffectEvidenceSynthesis.relatedArtifact [ RelatedArtifact ], ... ; # 0..* Additional documentation, citations, etc.
  fhir:EffectEvidenceSynthesis.synthesisType [ CodeableConcept ]; # 0..1 Type of synthesis
  fhir:EffectEvidenceSynthesis.studyType [ CodeableConcept ]; # 0..1 Type of study
  fhir:EffectEvidenceSynthesis.population [ Reference(EvidenceVariable) ]; # 1..1 What population?
  fhir:EffectEvidenceSynthesis.exposure [ Reference(EvidenceVariable) ]; # 1..1 What exposure?
  fhir:EffectEvidenceSynthesis.exposureAlternative [ Reference(EvidenceVariable) ]; # 1..1 What comparison exposure?
  fhir:EffectEvidenceSynthesis.outcome [ Reference(EvidenceVariable) ]; # 1..1 What outcome?
  fhir:EffectEvidenceSynthesis.sampleSize [ # 0..1 What sample size was involved?
    fhir:EffectEvidenceSynthesis.sampleSize.description [ string ]; # 0..1 Description of sample size
    fhir:EffectEvidenceSynthesis.sampleSize.numberOfStudies [ integer ]; # 0..1 How many studies?
    fhir:EffectEvidenceSynthesis.sampleSize.numberOfParticipants [ integer ]; # 0..1 How many participants?
  ];
  fhir:EffectEvidenceSynthesis.resultsByExposure [ # 0..* What was the result per exposure?
    fhir:EffectEvidenceSynthesis.resultsByExposure.description [ string ]; # 0..1 Description of results by exposure
    fhir:EffectEvidenceSynthesis.resultsByExposure.exposureState [ code ]; # 0..1 exposure | exposure-alternative
    fhir:EffectEvidenceSynthesis.resultsByExposure.variantState [ CodeableConcept ]; # 0..1 Variant exposure states
    fhir:EffectEvidenceSynthesis.resultsByExposure.riskEvidenceSynthesis [ Reference(RiskEvidenceSynthesis) ]; # 1..1 Risk evidence synthesis
  ], ...;
  fhir:EffectEvidenceSynthesis.effectEstimate [ # 0..* What was the estimated effect
    fhir:EffectEvidenceSynthesis.effectEstimate.description [ string ]; # 0..1 Description of effect estimate
    fhir:EffectEvidenceSynthesis.effectEstimate.type [ CodeableConcept ]; # 0..1 Type of efffect estimate
    fhir:EffectEvidenceSynthesis.effectEstimate.variantState [ CodeableConcept ]; # 0..1 Variant exposure states
    fhir:EffectEvidenceSynthesis.effectEstimate.value [ decimal ]; # 0..1 Point estimate
    fhir:EffectEvidenceSynthesis.effectEstimate.unitOfMeasure [ CodeableConcept ]; # 0..1 What unit is the outcome described in?
    fhir:EffectEvidenceSynthesis.effectEstimate.precisionEstimate [ # 0..* How precise the estimate is
      fhir:EffectEvidenceSynthesis.effectEstimate.precisionEstimate.type [ CodeableConcept ]; # 0..1 Type of precision estimate
      fhir:EffectEvidenceSynthesis.effectEstimate.precisionEstimate.level [ decimal ]; # 0..1 Level of confidence interval
      fhir:EffectEvidenceSynthesis.effectEstimate.precisionEstimate.from [ decimal ]; # 0..1 Lower bound
      fhir:EffectEvidenceSynthesis.effectEstimate.precisionEstimate.to [ decimal ]; # 0..1 Upper bound
    ], ...;
  ], ...;
  fhir:EffectEvidenceSynthesis.certainty [ # 0..* How certain is the effect
    fhir:EffectEvidenceSynthesis.certainty.rating [ CodeableConcept ], ... ; # 0..* Certainty rating
    fhir:EffectEvidenceSynthesis.certainty.note [ Annotation ], ... ; # 0..* Used for footnotes or explanatory notes
    fhir:EffectEvidenceSynthesis.certainty.certaintySubcomponent [ # 0..* A component that contributes to the overall certainty
      fhir:EffectEvidenceSynthesis.certainty.certaintySubcomponent.type [ CodeableConcept ]; # 0..1 Type of subcomponent of certainty rating
      fhir:EffectEvidenceSynthesis.certainty.certaintySubcomponent.rating [ CodeableConcept ], ... ; # 0..* Subcomponent certainty rating
      fhir:EffectEvidenceSynthesis.certainty.certaintySubcomponent.note [ Annotation ], ... ; # 0..* Used for footnotes or explanatory notes
    ], ...;
  ], ...;
]

Changes since Release 3

This resource did not exist in Release 2

This analysis is available as XML or JSON.

 

See the Profiles & Extensions and the alternate definitions: Master Definition XML + JSON, XML Schema/Schematron + JSON Schema, ShEx (for Turtle) + see the extensions & the dependency analysis

PathDefinitionTypeReference
EffectEvidenceSynthesis.status The lifecycle status of an artifact.RequiredPublicationStatus
EffectEvidenceSynthesis.jurisdiction Countries and regions within which this artifact is targeted for use.ExtensibleJurisdiction ValueSet
EffectEvidenceSynthesis.topic High-level categorization of the definition, used for searching, sorting, and filtering.ExampleDefinitionTopic
EffectEvidenceSynthesis.synthesisType Types of combining results from a body of evidence (eg. summary data meta-analysis).ExtensibleSynthesisType
EffectEvidenceSynthesis.studyType Types of research studies (types of research methods).ExtensibleStudyType
EffectEvidenceSynthesis.resultsByExposure.exposureState Whether the results by exposure is describing the results for the primary exposure of interest (exposure) or the alternative state (exposureAlternative).RequiredExposureState
EffectEvidenceSynthesis.resultsByExposure.variantState
EffectEvidenceSynthesis.effectEstimate.variantState
Used for results by exposure in variant states such as low-risk, medium-risk and high-risk states.ExtensibleEvidenceVariantState
EffectEvidenceSynthesis.effectEstimate.type Whether the effect estimate is an absolute effect estimate (absolute difference) or a relative effect estimate (relative difference), and the specific type of effect estimate (eg relative risk or median difference).ExtensibleEffectEstimateType
EffectEvidenceSynthesis.effectEstimate.unitOfMeasure Unified Code for Units of Measure (UCUM).RequiredUCUMCodes
EffectEvidenceSynthesis.effectEstimate.precisionEstimate.type Method of reporting variability of estimates, such as confidence intervals, interquartile range or standard deviation.ExtensiblePrecisionEstimateType
EffectEvidenceSynthesis.certainty.rating The quality of the evidence described. The code system used specifies the quality scale used to grade this evidence source while the code specifies the actual quality score (represented as a coded value) associated with the evidence.ExtensibleQualityOfEvidenceRating
EffectEvidenceSynthesis.certainty.certaintySubcomponent.type The subcomponent classification of quality of evidence rating systems.ExtensibleCertaintySubcomponentType
EffectEvidenceSynthesis.certainty.certaintySubcomponent.rating The quality rating of the subcomponent of a quality of evidence rating.ExtensibleCertaintySubcomponentRating

idLevelLocationDescriptionExpression
ees-0Warning (base)Name should be usable as an identifier for the module by machine processing applications such as code generationname.matches('[A-Z]([A-Za-z0-9_]){0,254}')

Search parameters for this resource. The common parameters also apply. See Searching for more information about searching in REST, messaging, and services.

NameTypeDescriptionExpressionIn Common
contexttokenA use context assigned to the effect evidence synthesis(EffectEvidenceSynthesis.useContext.value as CodeableConcept)
context-quantityquantityA quantity- or range-valued use context assigned to the effect evidence synthesis(EffectEvidenceSynthesis.useContext.value as Quantity) | (EffectEvidenceSynthesis.useContext.value as Range)
context-typetokenA type of use context assigned to the effect evidence synthesisEffectEvidenceSynthesis.useContext.code
context-type-quantitycompositeA use context type and quantity- or range-based value assigned to the effect evidence synthesisOn EffectEvidenceSynthesis.useContext:
  context-type: code
  context-quantity: value.as(Quantity) | value.as(Range)
context-type-valuecompositeA use context type and value assigned to the effect evidence synthesisOn EffectEvidenceSynthesis.useContext:
  context-type: code
  context: value.as(CodeableConcept)
datedateThe effect evidence synthesis publication dateEffectEvidenceSynthesis.date
descriptionstringThe description of the effect evidence synthesisEffectEvidenceSynthesis.description
effectivedateThe time during which the effect evidence synthesis is intended to be in useEffectEvidenceSynthesis.effectivePeriod
identifiertokenExternal identifier for the effect evidence synthesisEffectEvidenceSynthesis.identifier
jurisdictiontokenIntended jurisdiction for the effect evidence synthesisEffectEvidenceSynthesis.jurisdiction
namestringComputationally friendly name of the effect evidence synthesisEffectEvidenceSynthesis.name
publisherstringName of the publisher of the effect evidence synthesisEffectEvidenceSynthesis.publisher
statustokenThe current status of the effect evidence synthesisEffectEvidenceSynthesis.status
titlestringThe human-friendly name of the effect evidence synthesisEffectEvidenceSynthesis.title
urluriThe uri that identifies the effect evidence synthesisEffectEvidenceSynthesis.url
versiontokenThe business version of the effect evidence synthesisEffectEvidenceSynthesis.version