PREFIX fhir:
PREFIX fhirvs:
PREFIX xsd:
PREFIX rdf:
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start=@ AND {fhir:nodeRole [fhir:treeRoot]}
# A single issue - either an indication, contraindication, interaction or an undesirable effect for a medicinal product, medication, device or procedure
EXTENDS @ CLOSED {
a [fhir:ClinicalUseDefinition]?;
fhir:nodeRole [fhir:treeRoot]?;
fhir:identifier @?; # Business identifier for this issue
fhir:type @ AND
{fhir:v @fhirvs:clinical-use-definition-type}; # indication | contraindication |
# interaction | undesirable-effect |
# warning
fhir:category @?; # A categorisation of the issue,
# primarily for dividing warnings
# into subject heading areas such as
# "Pregnancy", "Overdose"
fhir:subject @?; # The medication, product,
# substance, device, procedure etc.
# for which this is an indication,
# contraindication, interaction,
# undesirable effect, or warning
fhir:status @?; # Whether this is a current issue or
# one that has been retired etc
fhir:contraindication @?; # Specifics for when this is a
# contraindication
fhir:indication @?; # Specifics for when this is an
# indication
fhir:interaction @?; # Specifics for when this is an
# interaction
fhir:population @?; # The population group to which this
# applies
fhir:library @?; # Logic used by the clinical use
# definition
fhir:undesirableEffect @?; # A possible negative outcome from
# the use of this treatment
fhir:warning @?; # Critical environmental, health or
# physical risks or hazards. For
# example 'Do not operate heavy
# machinery', 'May cause drowsiness'
}
# The specific medication, product, food etc. or laboratory test that interacts
EXTENDS @ CLOSED {
fhir:item (@ AND {fhir:link @ OR
@ OR
@ OR
@ OR
@ OR
@ }) OR
@ ; # The specific medication, product,
# food etc. or laboratory test that
# interacts
}
# Specifics for when this is an interaction
EXTENDS @ CLOSED {
fhir:interactant @?; # The specific medication, product,
# food etc. or laboratory test that
# interacts
fhir:type @?; # The type of the interaction e.g.
# drug-drug interaction, drug-lab
# test interaction
fhir:effect @?; # The effect of the interaction, for
# example "reduced gastric
# absorption of primary medication"
fhir:incidence @?; # The incidence of the interaction,
# e.g. theoretical, observed
fhir:management @?; # Actions for managing the
# interaction
}
# Information about use of the product in relation to other therapies described as part of the contraindication
EXTENDS @ CLOSED {
fhir:relationshipType @; # The type of relationship between
# the product
# indication/contraindication and
# another therapy
fhir:treatment @; # Reference to a specific
# medication, substance etc. as part
# of an indication or
# contraindication
}
# Specifics for when this is an indication
EXTENDS @ CLOSED {
fhir:diseaseSymptomProcedure @?; # The situation that is being
# documented as an indicaton for
# this item
fhir:diseaseStatus @?; # The status of the disease or
# symptom for the indication
fhir:comorbidity @?; # A comorbidity or coinfection as
# part of the indication
fhir:intendedEffect @?; # The intended effect, aim or
# strategy to be achieved
fhir:duration @ OR
@ ?; # Timing or duration information
fhir:undesirableEffect @?; # An unwanted side effect or
# negative outcome of the subject of
# this resource when being used for
# this indication
fhir:applicability @?; # An expression that returns true or
# false, indicating whether the
# indication is applicable or not,
# after having applied its other
# elements
fhir:otherTherapy @?; # The use of the medicinal product
# in relation to other therapies
# described as part of the
# indication
}
# Critical environmental, health or physical risks or hazards. For example 'Do not operate heavy machinery', 'May cause drowsiness'
EXTENDS @ CLOSED {
fhir:description @?; # A textual definition of this
# warning, with formatting
fhir:code @?; # A coded or unformatted textual
# definition of this warning
}
# Specifics for when this is a contraindication
EXTENDS @ CLOSED {
fhir:diseaseSymptomProcedure @?; # The situation that is being
# documented as contraindicating
# against this item
fhir:diseaseStatus @?; # The status of the disease or
# symptom for the contraindication
fhir:comorbidity @?; # A comorbidity (concurrent
# condition) or coinfection
fhir:indication @?; # The indication which this is a
# contraidication for
fhir:applicability @?; # An expression that returns true or
# false, indicating whether the
# indication is applicable or not,
# after having applied its other
# elements
fhir:otherTherapy @?; # Information about use of the
# product in relation to other
# therapies described as part of the
# contraindication
}
# A possible negative outcome from the use of this treatment
EXTENDS @ CLOSED {
fhir:symptomConditionEffect @?; # The situation in which the
# undesirable effect may manifest
fhir:classification @?; # High level classification of the
# effect
fhir:frequencyOfOccurrence @?; # How often the effect is seen
}
#---------------------- Cardinality Types (OneOrMore) -------------------
CLOSED {
rdf:first @ ;
rdf:rest [rdf:nil] OR @
}
CLOSED {
rdf:first @ ;
rdf:rest [rdf:nil] OR @
}
CLOSED {
rdf:first @ AND {fhir:link
@ OR
@ OR
@ OR
@ OR
@ OR
@ OR
@ OR
@ OR
@ } ;
rdf:rest [rdf:nil] OR @
}
CLOSED {
rdf:first @ AND {fhir:link
@ } ;
rdf:rest [rdf:nil] OR @
}
CLOSED {
rdf:first @ ;
rdf:rest [rdf:nil] OR @
}
CLOSED {
rdf:first @ ;
rdf:rest [rdf:nil] OR @
}
CLOSED {
rdf:first @ ;
rdf:rest [rdf:nil] OR @
}
CLOSED {
rdf:first @ AND {fhir:link
@ } ;
rdf:rest [rdf:nil] OR @
}
CLOSED {
rdf:first @ ;
rdf:rest [rdf:nil] OR @
}
#---------------------- Value Sets ------------------------
# Overall defining type of this clinical use definition.
fhirvs:clinical-use-definition-type ["indication" "contraindication" "interaction" "undesirable-effect" "warning"]