<?xml version="1.0" encoding="UTF-8"?>
<difference>
   <type name="Specimen" status="changed">
      <element binding-status="changed"
               binding-valueset-changed="true"
               path="Specimen.status">
         <old-binding reference="http://hl7.org/fhir/ValueSet/specimen-status|4.0.0"
                      strength="required"/>
         <new-binding reference="http://hl7.org/fhir/ValueSet/specimen-status|6.0.0-ballot4"
                      strength="required"/>
      </element>
      <element path="Specimen.subject">
         <removed-type name="Reference(Patient | Group | Device | Substance | Location)"/>
         <added-type name="Reference(Patient | Group | Device | BiologicallyDerivedProduct | Substance | Location | NutritionProduct)"/>
      </element>
      <element path="Specimen.combined" status="new"/>
      <element path="Specimen.role" status="new"/>
      <element path="Specimen.feature" status="new"/>
      <element path="Specimen.feature.type" status="new"/>
      <element path="Specimen.feature.description" status="new"/>
      <element path="Specimen.collection.collector">
         <removed-type name="Reference(Practitioner | PractitionerRole)"/>
         <added-type name="Reference(Organization | Practitioner | PractitionerRole | Patient | RelatedPerson)"/>
      </element>
      <element path="Specimen.collection.device[x]" status="new"/>
      <element path="Specimen.collection.procedure" status="new"/>
      <element path="Specimen.collection.bodySite">
         <removed-type name="CodeableConcept"/>
         <added-type name="CodeableReference"/>
      </element>
      <element old-name="procedure" path="Specimen.processing.method"/>
      <element path="Specimen.processing.performer" status="new"/>
      <element path="Specimen.processing.device[x]" status="new"/>
      <element path="Specimen.processing.additive">
         <removed-type name="Reference(Substance)"/>
         <added-type name="CodeableReference"/>
      </element>
      <element path="Specimen.processing.time[x]">
         <added-type name="Duration"/>
      </element>
      <element path="Specimen.container.device[x]" status="new"/>
      <element binding-status="removed" path="Specimen.condition">
         <old-binding reference="http://terminology.hl7.org/ValueSet/v2-0493"
                      strength="extensible"/>
      </element>
      <element path="Specimen.accessionIdentifier" status="deleted"/>
      <element path="Specimen.container.identifier" status="deleted"/>
      <element path="Specimen.container.description" status="deleted"/>
      <element path="Specimen.container.type" status="deleted"/>
      <element path="Specimen.container.capacity" status="deleted"/>
      <element path="Specimen.container.additive[x]" status="deleted"/>
   </type>
</difference>
