<?xml version="1.0" encoding="UTF-8"?>
<difference>
   <type name="ResearchSubject" status="changed">
      <element binding-status="changed"
               binding-valueset-changed="true"
               path="ResearchSubject.status">
         <old-binding reference="http://hl7.org/fhir/ValueSet/research-subject-status|4.3.0"
                      strength="required"/>
         <new-binding reference="http://hl7.org/fhir/ValueSet/publication-status|6.0.0-ballot4"
                      strength="required"/>
      </element>
      <element old-name="individual" path="ResearchSubject.subject">
         <removed-type name="Reference(Patient)"/>
         <added-type name="Reference(Patient | Group | Specimen | Device | Medication | Substance | SubstanceDefinition | BiologicallyDerivedProduct)"/>
      </element>
      <element path="ResearchSubject.subjectState" status="new"/>
      <element path="ResearchSubject.subjectState.code" status="new"/>
      <element path="ResearchSubject.subjectState.startDate" status="new"/>
      <element path="ResearchSubject.subjectState.endDate" status="new"/>
      <element path="ResearchSubject.subjectState.reason" status="new"/>
      <element path="ResearchSubject.subjectMilestone" status="new"/>
      <element path="ResearchSubject.subjectMilestone.milestone" status="new"/>
      <element path="ResearchSubject.subjectMilestone.date" status="new"/>
      <element path="ResearchSubject.subjectMilestone.reason" status="new"/>
      <element path="ResearchSubject.comparisonGroup" status="new"/>
      <element new-max="*" old-max="1" path="ResearchSubject.consent"/>
      <element path="ResearchSubject.assignedArm" status="deleted"/>
      <element path="ResearchSubject.actualArm" status="deleted"/>
   </type>
</difference>
