{
  "types": [
    "ResearchSubject"
  ],
  "ResearchSubject": {
    "elements": {
      "ResearchSubject.status": {
        "binding-valueset-changed": true,
        "binding-status": "changed",
        "old-binding": {
          "reference": "http://hl7.org/fhir/ValueSet/research-subject-status|4.0.0",
          "strength": "required"
        },
        "new-binding": {
          "reference": "http://hl7.org/fhir/ValueSet/publication-status|6.0.0-ballot4",
          "strength": "required"
        }
      },
      "ResearchSubject.subject": {
        "old-name": "individual",
        "removed-types": [
          "Reference(Patient)"
        ],
        "added-types": [
          "Reference(Patient | Group | Specimen | Device | Medication | Substance | SubstanceDefinition | BiologicallyDerivedProduct)"
        ]
      },
      "ResearchSubject.subjectState": {
        "status": "new"
      },
      "ResearchSubject.subjectState.code": {
        "status": "new"
      },
      "ResearchSubject.subjectState.startDate": {
        "status": "new"
      },
      "ResearchSubject.subjectState.endDate": {
        "status": "new"
      },
      "ResearchSubject.subjectState.reason": {
        "status": "new"
      },
      "ResearchSubject.subjectMilestone": {
        "status": "new"
      },
      "ResearchSubject.subjectMilestone.milestone": {
        "status": "new"
      },
      "ResearchSubject.subjectMilestone.date": {
        "status": "new"
      },
      "ResearchSubject.subjectMilestone.reason": {
        "status": "new"
      },
      "ResearchSubject.comparisonGroup": {
        "status": "new"
      },
      "ResearchSubject.consent": {
        "old-max": "1",
        "new-max": "*"
      },
      "ResearchSubject.assignedArm": {
        "status": "deleted"
      },
      "ResearchSubject.actualArm": {
        "status": "deleted"
      }
    },
    "status": "changed"
  }
}