<?xml version="1.0" encoding="UTF-8"?>

<CodeSystem xmlns="http://hl7.org/fhir">
  <id value="definition-method"/>
  <meta>
    <lastUpdated value="2026-03-31T18:55:04.283+00:00"/>
  </meta>
  <text>
    <status value="generated"/>
    <div xmlns="http://www.w3.org/1999/xhtml">
      <p class="res-header-id">
        <b>Generated Narrative: CodeSystem definition-method</b>
      </p>
      <a name="definition-method"> </a>
      <a name="hcdefinition-method"> </a>
      <p>This case-sensitive code system 
        <code>http://hl7.org/fhir/definition-method</code> defines the following codes:
      </p>
      <table class="codes">
        <tr>
          <td style="white-space:nowrap">
            <b>Code</b>
          </td>
          <td>
            <b>Display</b>
          </td>
          <td>
            <b>Definition</b>
          </td>
        </tr>
        <tr>
          <td style="white-space:nowrap">systematic-assessment
            <a name="definition-method-systematic-assessment"> </a>
          </td>
          <td>Systematic Assessment</td>
          <td>Any method of routinely determining whether or not specific outcomes (e.g. adverse events) have occurred, for example through a standard questionnaire, regular investigator assessment, regular laboratory testing, or other method</td>
        </tr>
        <tr>
          <td style="white-space:nowrap">non-systematic-assessment
            <a name="definition-method-non-systematic-assessment"> </a>
          </td>
          <td>Non-Systematic Assessment</td>
          <td>Any non-systematic method for determining whether or not adverse events have occurred, such as self-reporting by participants or occasional assessment/testing</td>
        </tr>
        <tr>
          <td style="white-space:nowrap">mean
            <a name="definition-method-mean"> </a>
          </td>
          <td>Mean</td>
          <td>Aggregated using mean of observed values.</td>
        </tr>
        <tr>
          <td style="white-space:nowrap">median
            <a name="definition-method-median"> </a>
          </td>
          <td>Median</td>
          <td>Aggregated using median of observed values.</td>
        </tr>
        <tr>
          <td style="white-space:nowrap">mean-of-mean
            <a name="definition-method-mean-of-mean"> </a>
          </td>
          <td>Mean of Means</td>
          <td>Aggregated using mean of means (e.g. study mean values).</td>
        </tr>
        <tr>
          <td style="white-space:nowrap">mean-of-median
            <a name="definition-method-mean-of-median"> </a>
          </td>
          <td>Mean of Medians</td>
          <td>Aggregated using mean of medians (e.g. study median values).</td>
        </tr>
        <tr>
          <td style="white-space:nowrap">median-of-mean
            <a name="definition-method-median-of-mean"> </a>
          </td>
          <td>Median of Means</td>
          <td>Aggregated using median of means (e.g. study mean values).</td>
        </tr>
        <tr>
          <td style="white-space:nowrap">median-of-median
            <a name="definition-method-median-of-median"> </a>
          </td>
          <td>Median of Medians</td>
          <td>Aggregated using median of medians (e.g. study median values).</td>
        </tr>
      </table>
    </div>
  </text>
  <extension url="http://hl7.org/fhir/StructureDefinition/structuredefinition-wg">
    <valueCode value="fhir"/>
  </extension>
  <extension url="http://hl7.org/fhir/StructureDefinition/structuredefinition-standards-status">
    <valueCode value="informative"/>
  </extension>
  <extension url="http://hl7.org/fhir/StructureDefinition/structuredefinition-fmm">
    <valueInteger value="1"/>
  </extension>
  <url value="http://hl7.org/fhir/definition-method"/>
  <identifier>
    <system value="urn:ietf:rfc:3986"/>
    <value value="urn:oid:2.16.840.1.113883.4.642.4.1953"/>
  </identifier>
  <version value="6.0.0-ballot4"/>
  <name value="DefinitionMethod"/>
  <title value="Definition Method"/>
  <status value="active"/>
  <experimental value="false"/>
  <date value="2020-12-28T16:55:11+11:00"/>
  <publisher value="HL7 (FHIR Project)"/>
  <contact>
    <telecom>
      <system value="url"/>
      <value value="http://hl7.org/fhir"/>
    </telecom>
    <telecom>
      <system value="email"/>
      <value value="fhir@lists.hl7.org"/>
    </telecom>
  </contact>
  <description value="The method used to define, describe, or determine a characteristic value."/>
  <jurisdiction>
    <coding>
      <system value="http://unstats.un.org/unsd/methods/m49/m49.htm"/>
      <code value="001"/>
      <display value="World"/>
    </coding>
  </jurisdiction>
  <caseSensitive value="true"/>
  <valueSet value="http://hl7.org/fhir/ValueSet/definition-method"/>
  <content value="complete"/>
  <concept>
    <code value="systematic-assessment"/>
    <display value="Systematic Assessment"/>
    <definition value="Any method of routinely determining whether or not specific outcomes (e.g. adverse events) have occurred, for example through a standard questionnaire, regular investigator assessment, regular laboratory testing, or other method"/>
  </concept>
  <concept>
    <code value="non-systematic-assessment"/>
    <display value="Non-Systematic Assessment"/>
    <definition value="Any non-systematic method for determining whether or not adverse events have occurred, such as self-reporting by participants or occasional assessment/testing"/>
  </concept>
  <concept>
    <code value="mean"/>
    <display value="Mean"/>
    <definition value="Aggregated using mean of observed values."/>
  </concept>
  <concept>
    <code value="median"/>
    <display value="Median"/>
    <definition value="Aggregated using median of observed values."/>
  </concept>
  <concept>
    <code value="mean-of-mean"/>
    <display value="Mean of Means"/>
    <definition value="Aggregated using mean of means (e.g. study mean values)."/>
  </concept>
  <concept>
    <code value="mean-of-median"/>
    <display value="Mean of Medians"/>
    <definition value="Aggregated using mean of medians (e.g. study median values)."/>
  </concept>
  <concept>
    <code value="median-of-mean"/>
    <display value="Median of Means"/>
    <definition value="Aggregated using median of means (e.g. study mean values)."/>
  </concept>
  <concept>
    <code value="median-of-median"/>
    <display value="Median of Medians"/>
    <definition value="Aggregated using median of medians (e.g. study median values)."/>
  </concept>
</CodeSystem>